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Paul Mischel

January 01, 1970

Paul S. Mischel (born July 13, 1962) is an American physician-scientist whose laboratory has made pioneering discoveries in the pathogenesis of human cancer. He is currently a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM-H, Stanford University.[1][2][3] Mischel was elected into the American Society for Clinical Investigation (ASCI),[4] serving as ASCI president in 2010/11. He was inducted into the Association of American Physicians, and was elected as a fellow of the American Association for the Advancement of Science.[5][6]

Career edit

Mischel was born on July 13, 1962. After losing his father to cancer, he became committed to a career in cancer research. He attended the University of Pennsylvania and received his M.D. from Cornell University Medical College in 1991,[7] graduating Alpha Omega Alpha. Mischel completed residency training in Anatomic Pathology and Neuropathology at UCLA,[8] followed by post-doctoral research training with Louis Reichardt at HHMI-UCSF. Mischel joined the faculty of UCLA in 1998. In August 2012, he was recruited to the Ludwig Institute for Cancer Research, San Diego and UCSD. In 2021, he joined Stanford University School of Medicine, where he currently serves as a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM-H.

Research edit

Mischel’s work bridges cancer genetics, signal transduction and cellular metabolism in the pathogenesis of human cancer.[9]

Extrachromosomal oncogene amplification edit

Mischel found that tumors can dynamically change in response to changing environments at a rate that cannot be explained by classical genetics. Prior to 2017, extrachromosomal DNA was thought to be a rare, but interesting event in cancer (1.4% of tumors),[10] of unclear biological significance. Mischel and colleagues integrated whole genome sequencing, cytogenetics and structural modeling to accurately and globally quantify extrachromosomal oncogene amplification, measure its diversity, map its contents, and study its biochemical regulation. They demonstrated widespread extrachromosomal oncogene amplification across many cancer types, showed that it potently drives tumor evolution and drug resistance, and identified specific signaling, biochemical and metabolic mechanisms that control its copy number and activity in response to changing environmental conditions.[11][12][13][14][15] This ground-breaking work challenges existing chromosomal maps of cancer, provides new insights into the mechanisms controlling the level, location and activity of amplified oncogenes, and yields new paradigms in the genotype-environment interactions that promote cancer progression and drug resistance.[16][17][18][19][20]

Metabolic co-dependency pathways in cancer edit

Integrating mechanistic studies with analyses of tumor tissue from patients treated in clinical trials, Mischel and colleagues discovered signaling, transcriptional, and metabolic co-dependencies that are downstream consequences of oncogene amplification, including alterations in glucose and lipid metabolism that drive tumor growth, progression and drug resistance.[21][22][23][24][25][26][27] These studies, focused primarily on the highly lethal brain cancer, glioblastoma, resulted in new understandings of the fundamental metabolic processes by which oncogene amplification drives cancer progression and drug resistance, demonstrating a central role for EGFR and its downstream effector mTORC2, in cancer pathogenesis through metabolic reprogramming.[28][29][30][31]

Awards and honors edit

Alpha Omega Alpha, Cornell University Medical College, 1991

Pfizer New Faculty Award (one in Neuroscience in United States), 1996

The Johnny Mercer Foundation Research Award, 2004

America’s Top Doctors for Cancer (Castle Connolly and U.S. News & World Report), 2006–present[7]

Farber Award (top brain tumor research award given jointly by the American Association of Neurological Surgeons and the Society for NeuroOncology), 2007[32]

American Society for Clinical Investigation, 2007[4]

Profiled by Journal of Cell Biology in the “People and Ideas” section, 2008[33]

President, American Society for Clinical Investigation, 2010–2011

Association of American Physicians, 2012

Elected Fellow, American Association for the Advancement of Science, 2015[5][6]

Personal life edit

Mischel lives in La Jolla, California with his wife, Deborah Kado, a Professor of Medicine at UCSD, and his daughters Anna and Sarah.

References edit

  1. ^ "Team". Paul Mischel Lab. Retrieved 2021-04-15.
  2. ^ "Paul Salomon Mischel's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2021-04-15.
  3. ^ "Paul Mischel | ChEM-H". chemh.stanford.edu. Retrieved 2021-04-15.
  4. ^ a b "The American Society for Clinical Investigation". Retrieved 2019-01-31.
  5. ^ a b "Ludwig San Diego's Paul Mischel elected AAAS Fellow". EurekAlert!. Retrieved 2019-01-29.
  6. ^ a b "2015 AAAS Fellows Recognized for Contributions to Advancing Science". American Association for the Advancement of Science. Retrieved 2019-01-29.
  7. ^ a b "Dr. Paul Mischel, Pathologist in La Jolla, CA | US News Doctors".
  8. ^ "Faculty Database Production Server | David Geffen School of Medicine at UCLA". people.healthsciences.ucla.edu. Retrieved 2019-01-30.
  9. ^ "Paul Mischel Lab - University of California, San Diego". Paul Mischel Lab. Retrieved 2019-06-13.
  10. ^ "Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer". cgap.nci.nih.gov. Retrieved 2018-11-27.
  11. ^ Nathanson, David A.; Gini, Beatrice; Mottahedeh, Jack; Visnyei, Koppany; Koga, Tomoyuki; Gomez, German; Eskin, Ascia; Hwang, Kiwook; Mischel, Paul S. (2014-01-03). "Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA". Science. 343 (6166): 72–76. Bibcode:2014Sci...343...72N. doi:10.1126/science.1241328. ISSN 0036-8075. PMC 4049335. PMID 24310612.
  12. ^ Turner, Kristen M.; Deshpande, Viraj; Beyter, Doruk; Koga, Tomoyuki; Rusert, Jessica; Lee, Catherine; Li, Bin; Arden, Karen; Mischel, Paul S. (2017-02-08). "Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity". Nature. 543 (7643): 122–125. Bibcode:2017Natur.543..122T. doi:10.1038/nature21356. ISSN 0028-0836. PMC 5334176. PMID 28178237.
  13. ^ Fikes, Bradley J. (9 February 2017). "Cancer genes hide outside chromosomes". sandiegouniontribune.com. Retrieved 2019-01-31.
  14. ^ "Non-Chromosomal DNA Drives Tumor Evolution". The Scientist Magazine®. Retrieved 2019-02-01.
  15. ^ Wu, Sihan; Turner, Kristen M.; Nguyen, Nam; Raviram, Ramya; Erb, Marcella; Santini, Jennifer; Luebeck, Jens; Rajkumar, Utkrisht; Diao, Yarui; Li, Bin; Zhang, Wenjing (November 2019). "Circular ecDNA promotes accessible chromatin and high oncogene expression". Nature. 575 (7784): 699–703. Bibcode:2019Natur.575..699W. doi:10.1038/s41586-019-1763-5. ISSN 0028-0836. PMC 7094777. PMID 31748743.
  16. ^ Furnari, Frank B.; Cloughesy, Timothy F.; Cavenee, Webster K.; Mischel, Paul S. (2015-04-09). "Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma". Nature Reviews Cancer. 15 (5): 302–310. doi:10.1038/nrc3918. ISSN 1474-175X. PMC 4875778. PMID 25855404.
  17. ^ Verhaak, Roel G. W.; Bafna, Vineet; Mischel, Paul S. (May 2019). "Extrachromosomal oncogene amplification in tumour pathogenesis and evolution". Nature Reviews Cancer. 19 (5): 283–288. doi:10.1038/s41568-019-0128-6. ISSN 1474-175X. PMC 7168519. PMID 30872802.
  18. ^ Pennisi, Elizabeth (2017-06-09). "Circular DNA throws biologists for a loop". Science. 356 (6342): 996. Bibcode:2017Sci...356..996P. doi:10.1126/science.356.6342.996. ISSN 0036-8075. PMID 28596318.
  19. ^ Aranda, Victoria (2014-01-07). "Cancer: Extrachromosomal resistance". Nature Medicine. 20: 28. doi:10.1038/nm.3452. ISSN 1546-170X. S2CID 45444065.
  20. ^ Zimmer, Carl (2019-11-20). "Scientists Are Just Beginning to Understand Mysterious DNA Circles Common in Cancer Cells". The New York Times. ISSN 0362-4331. Retrieved 2020-02-05.
  21. ^ Masui, Kenta; Tanaka, Kazuhiro; Akhavan, David; Babic, Ivan; Gini, Beatrice; Matsutani, Tomoo; Iwanami, Akio; Liu, Feng; Mischel, Paul S. (2013-11-05). "mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c-Myc". Cell Metabolism. 18 (5): 726–739. doi:10.1016/j.cmet.2013.09.013. ISSN 1932-7420. PMC 3840163. PMID 24140020.
  22. ^ Masui, Kenta; Tanaka, Kazuhiro; Ikegami, Shiro; Villa, Genaro R.; Yang, Huijun; Yong, William H.; Cloughesy, Timothy F.; Yamagata, Kanato; Mischel, Paul S. (2015-07-28). "Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance". Proceedings of the National Academy of Sciences. 112 (30): 9406–9411. Bibcode:2015PNAS..112.9406M. doi:10.1073/pnas.1511759112. ISSN 0027-8424. PMC 4522814. PMID 26170313.
  23. ^ Babic, Ivan; Anderson, Erik S.; Tanaka, Kazuhiro; Guo, Deliang; Masui, Kenta; Li, Bing; Zhu, Shaojun; Gu, Yuchao; Mishcel, Paul S. (2013-06-04). "EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer". Cell Metabolism. 17 (6): 1000–1008. doi:10.1016/j.cmet.2013.04.013. ISSN 1932-7420. PMC 3679227. PMID 23707073.
  24. ^ Gu, Yuchao; Albuquerque, Claudio P.; Braas, Daniel; Zhang, Wei; Villa, Genaro R.; Bi, Junfeng; Ikegami, Shiro; Masui, Kenta; Mischel, Paul S. (2017-07-06). "mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT". Molecular Cell. 67 (1): 128–138.e7. doi:10.1016/j.molcel.2017.05.030. ISSN 1097-4164. PMC 5521991. PMID 28648777.
  25. ^ Guo, Deliang; Reinitz, Felicia; Youssef, Mary; Hong, Cynthia; Nathanson, David; Akhavan, David; Kuga, Daisuke; Amzajerdi, Ali Nael; Mischel, Paul S. (2011-10-01). "An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway". Cancer Discovery. 1 (5): 442–456. doi:10.1158/2159-8290.CD-11-0102. ISSN 2159-8274. PMC 3207317. PMID 22059152.
  26. ^ Chowdhry, Sudhir; Zanca, Ciro; Rajkumar, Utkrisht; Koga, Tomoyuki; Diao, Yarui; Raviram, Ramya; Liu, Feng; Turner, Kristen; Yang, Huijun; Brunk, Elizabeth; Bi, Junfeng (May 2019). "NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling". Nature. 569 (7757): 570–575. Bibcode:2019Natur.569..570C. doi:10.1038/s41586-019-1150-2. ISSN 0028-0836. PMC 7138021. PMID 31019297.
  27. ^ Bi, Junfeng; Ichu, Taka-Aki; Zanca, Ciro; Yang, Huijun; Zhang, Wei; Gu, Yuchao; Chowdhry, Sudhir; Reed, Alex; Ikegami, Shiro; Turner, Kristen M.; Zhang, Wenjing (September 2019). "Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling". Cell Metabolism. 30 (3): 525–538.e8. doi:10.1016/j.cmet.2019.06.014. PMC 6742496. PMID 31303424.
  28. ^ Masui, Kenta; Cavenee, Webster K.; Mischel, Paul S. (2014-07-25). "mTORC2 in the center of cancer metabolic reprogramming". Trends in Endocrinology and Metabolism. 25 (7): 364–373. doi:10.1016/j.tem.2014.04.002. ISSN 1879-3061. PMC 4077930. PMID 24856037.
  29. ^ Wu, Si-Han; Bi, Jun-Feng; Cloughesy, Timothy; Cavenee, Webster K.; Mischel, Paul S. (2014). "Emerging function of mTORC2 as a core regulator in glioblastoma: metabolic reprogramming and drug resistance". Cancer Biology & Medicine. 11 (4): 255–263. doi:10.7497/j.issn.2095-3941.2014.04.004. ISSN 2095-3941. PMC 4296088. PMID 25610711.
  30. ^ Bi, Junfeng; Wu, Sihan; Zhang, Wenjing; Mischel, Paul S. (2018-05-23). "Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1870 (1): 76–87. doi:10.1016/j.bbcan.2018.05.002. ISSN 1879-2561. PMC 6193564. PMID 29775654.
  31. ^ Bi, Junfeng; Chowdhry, Sudhir; Wu, Sihan; Zhang, Wenjing; Masui, Kenta; Mischel, Paul S. (January 2020). "Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets". Nature Reviews Cancer. 20 (1): 57–70. doi:10.1038/s41568-019-0226-5. ISSN 1474-1768. PMID 31806884. S2CID 208768689.
  32. ^ "SNO Awards". www.soc-neuro-onc.org. Retrieved 2019-01-31.
  33. ^ Williams, Ruth (2008-06-30). "Paul Mischel: All about brains". The Journal of Cell Biology. 181 (7): 1044–1045. doi:10.1083/jcb.1817pi. ISSN 0021-9525. PMC 2442209. PMID 18591424.

External links edit

  • Paul Mischell's lab website

January 01, 1970
paul, mischel, paul, mischel, born, july, 1962, american, physician, scientist, whose, laboratory, made, pioneering, discoveries, pathogenesis, human, cancer, currently, professor, vice, chair, research, department, pathology, institute, scholar, chem, stanfor. Paul S Mischel born July 13 1962 is an American physician scientist whose laboratory has made pioneering discoveries in the pathogenesis of human cancer He is currently a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM H Stanford University 1 2 3 Mischel was elected into the American Society for Clinical Investigation ASCI 4 serving as ASCI president in 2010 11 He was inducted into the Association of American Physicians and was elected as a fellow of the American Association for the Advancement of Science 5 6 Contents 1 Career 2 Research 2 1 Extrachromosomal oncogene amplification 2 2 Metabolic co dependency pathways in cancer 3 Awards and honors 4 Personal life 5 References 6 External linksCareer editMischel was born on July 13 1962 After losing his father to cancer he became committed to a career in cancer research He attended the University of Pennsylvania and received his M D from Cornell University Medical College in 1991 7 graduating Alpha Omega Alpha Mischel completed residency training in Anatomic Pathology and Neuropathology at UCLA 8 followed by post doctoral research training with Louis Reichardt at HHMI UCSF Mischel joined the faculty of UCLA in 1998 In August 2012 he was recruited to the Ludwig Institute for Cancer Research San Diego and UCSD In 2021 he joined Stanford University School of Medicine where he currently serves as a Professor and Vice Chair of Research for the Department of Pathology and Institute Scholar of ChEM H Research editMischel s work bridges cancer genetics signal transduction and cellular metabolism in the pathogenesis of human cancer 9 Extrachromosomal oncogene amplification edit Mischel found that tumors can dynamically change in response to changing environments at a rate that cannot be explained by classical genetics Prior to 2017 extrachromosomal DNA was thought to be a rare but interesting event in cancer 1 4 of tumors 10 of unclear biological significance Mischel and colleagues integrated whole genome sequencing cytogenetics and structural modeling to accurately and globally quantify extrachromosomal oncogene amplification measure its diversity map its contents and study its biochemical regulation They demonstrated widespread extrachromosomal oncogene amplification across many cancer types showed that it potently drives tumor evolution and drug resistance and identified specific signaling biochemical and metabolic mechanisms that control its copy number and activity in response to changing environmental conditions 11 12 13 14 15 This ground breaking work challenges existing chromosomal maps of cancer provides new insights into the mechanisms controlling the level location and activity of amplified oncogenes and yields new paradigms in the genotype environment interactions that promote cancer progression and drug resistance 16 17 18 19 20 Metabolic co dependency pathways in cancer edit Integrating mechanistic studies with analyses of tumor tissue from patients treated in clinical trials Mischel and colleagues discovered signaling transcriptional and metabolic co dependencies that are downstream consequences of oncogene amplification including alterations in glucose and lipid metabolism that drive tumor growth progression and drug resistance 21 22 23 24 25 26 27 These studies focused primarily on the highly lethal brain cancer glioblastoma resulted in new understandings of the fundamental metabolic processes by which oncogene amplification drives cancer progression and drug resistance demonstrating a central role for EGFR and its downstream effector mTORC2 in cancer pathogenesis through metabolic reprogramming 28 29 30 31 Awards and honors editAlpha Omega Alpha Cornell University Medical College 1991Pfizer New Faculty Award one in Neuroscience in United States 1996The Johnny Mercer Foundation Research Award 2004America s Top Doctors for Cancer Castle Connolly and U S News amp World Report 2006 present 7 Farber Award top brain tumor research award given jointly by the American Association of Neurological Surgeons and the Society for NeuroOncology 2007 32 American Society for Clinical Investigation 2007 4 Profiled by Journal of Cell Biology in the People and Ideas section 2008 33 President American Society for Clinical Investigation 2010 2011Association of American Physicians 2012Elected Fellow American Association for the Advancement of Science 2015 5 6 Personal life editMischel lives in La Jolla California with his wife Deborah Kado a Professor of Medicine at UCSD and his daughters Anna and Sarah References edit Team Paul Mischel Lab Retrieved 2021 04 15 Paul Salomon Mischel s Profile Stanford Profiles profiles stanford edu Retrieved 2021 04 15 Paul Mischel ChEM H chemh stanford edu Retrieved 2021 04 15 a b The American Society for Clinical Investigation Retrieved 2019 01 31 a b Ludwig San Diego s Paul Mischel elected AAAS Fellow EurekAlert Retrieved 2019 01 29 a b 2015 AAAS Fellows Recognized for Contributions to Advancing Science American Association for the Advancement of Science Retrieved 2019 01 29 a b Dr Paul Mischel Pathologist in La Jolla CA US News Doctors Faculty Database Production Server David Geffen School of Medicine at UCLA people healthsciences ucla edu Retrieved 2019 01 30 Paul Mischel Lab University of California San Diego Paul Mischel Lab Retrieved 2019 06 13 Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer cgap nci nih gov Retrieved 2018 11 27 Nathanson David A Gini Beatrice Mottahedeh Jack Visnyei Koppany Koga Tomoyuki Gomez German Eskin Ascia Hwang Kiwook Mischel Paul S 2014 01 03 Targeted Therapy Resistance Mediated by Dynamic Regulation of Extrachromosomal Mutant EGFR DNA Science 343 6166 72 76 Bibcode 2014Sci 343 72N doi 10 1126 science 1241328 ISSN 0036 8075 PMC 4049335 PMID 24310612 Turner Kristen M Deshpande Viraj Beyter Doruk Koga Tomoyuki Rusert Jessica Lee Catherine Li Bin Arden Karen Mischel Paul S 2017 02 08 Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity Nature 543 7643 122 125 Bibcode 2017Natur 543 122T doi 10 1038 nature21356 ISSN 0028 0836 PMC 5334176 PMID 28178237 Fikes Bradley J 9 February 2017 Cancer genes hide outside chromosomes sandiegouniontribune com Retrieved 2019 01 31 Non Chromosomal DNA Drives Tumor Evolution The Scientist Magazine Retrieved 2019 02 01 Wu Sihan Turner Kristen M Nguyen Nam Raviram Ramya Erb Marcella Santini Jennifer Luebeck Jens Rajkumar Utkrisht Diao Yarui Li Bin Zhang Wenjing November 2019 Circular ecDNA promotes accessible chromatin and high oncogene expression Nature 575 7784 699 703 Bibcode 2019Natur 575 699W doi 10 1038 s41586 019 1763 5 ISSN 0028 0836 PMC 7094777 PMID 31748743 Furnari Frank B Cloughesy Timothy F Cavenee Webster K Mischel Paul S 2015 04 09 Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma Nature Reviews Cancer 15 5 302 310 doi 10 1038 nrc3918 ISSN 1474 175X PMC 4875778 PMID 25855404 Verhaak Roel G W Bafna Vineet Mischel Paul S May 2019 Extrachromosomal oncogene amplification in tumour pathogenesis and evolution Nature Reviews Cancer 19 5 283 288 doi 10 1038 s41568 019 0128 6 ISSN 1474 175X PMC 7168519 PMID 30872802 Pennisi Elizabeth 2017 06 09 Circular DNA throws biologists for a loop Science 356 6342 996 Bibcode 2017Sci 356 996P doi 10 1126 science 356 6342 996 ISSN 0036 8075 PMID 28596318 Aranda Victoria 2014 01 07 Cancer Extrachromosomal resistance Nature Medicine 20 28 doi 10 1038 nm 3452 ISSN 1546 170X S2CID 45444065 Zimmer Carl 2019 11 20 Scientists Are Just Beginning to Understand Mysterious DNA Circles Common in Cancer Cells The New York Times ISSN 0362 4331 Retrieved 2020 02 05 Masui Kenta Tanaka Kazuhiro Akhavan David Babic Ivan Gini Beatrice Matsutani Tomoo Iwanami Akio Liu Feng Mischel Paul S 2013 11 05 mTOR complex 2 controls glycolytic metabolism in glioblastoma through FoxO acetylation and upregulation of c Myc Cell Metabolism 18 5 726 739 doi 10 1016 j cmet 2013 09 013 ISSN 1932 7420 PMC 3840163 PMID 24140020 Masui Kenta Tanaka Kazuhiro Ikegami Shiro Villa Genaro R Yang Huijun Yong William H Cloughesy Timothy F Yamagata Kanato Mischel Paul S 2015 07 28 Glucose dependent acetylation of Rictor promotes targeted cancer therapy resistance Proceedings of the National Academy of Sciences 112 30 9406 9411 Bibcode 2015PNAS 112 9406M doi 10 1073 pnas 1511759112 ISSN 0027 8424 PMC 4522814 PMID 26170313 Babic Ivan Anderson Erik S Tanaka Kazuhiro Guo Deliang Masui Kenta Li Bing Zhu Shaojun Gu Yuchao Mishcel Paul S 2013 06 04 EGFR mutation induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer Cell Metabolism 17 6 1000 1008 doi 10 1016 j cmet 2013 04 013 ISSN 1932 7420 PMC 3679227 PMID 23707073 Gu Yuchao Albuquerque Claudio P Braas Daniel Zhang Wei Villa Genaro R Bi Junfeng Ikegami Shiro Masui Kenta Mischel Paul S 2017 07 06 mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine Glutamate Antiporter xCT Molecular Cell 67 1 128 138 e7 doi 10 1016 j molcel 2017 05 030 ISSN 1097 4164 PMC 5521991 PMID 28648777 Guo Deliang Reinitz Felicia Youssef Mary Hong Cynthia Nathanson David Akhavan David Kuga Daisuke Amzajerdi Ali Nael Mischel Paul S 2011 10 01 An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR AKT SREBP 1 LDLR Dependent Pathway Cancer Discovery 1 5 442 456 doi 10 1158 2159 8290 CD 11 0102 ISSN 2159 8274 PMC 3207317 PMID 22059152 Chowdhry Sudhir Zanca Ciro Rajkumar Utkrisht Koga Tomoyuki Diao Yarui Raviram Ramya Liu Feng Turner Kristen Yang Huijun Brunk Elizabeth Bi Junfeng May 2019 NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling Nature 569 7757 570 575 Bibcode 2019Natur 569 570C doi 10 1038 s41586 019 1150 2 ISSN 0028 0836 PMC 7138021 PMID 31019297 Bi Junfeng Ichu Taka Aki Zanca Ciro Yang Huijun Zhang Wei Gu Yuchao Chowdhry Sudhir Reed Alex Ikegami Shiro Turner Kristen M Zhang Wenjing September 2019 Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling Cell Metabolism 30 3 525 538 e8 doi 10 1016 j cmet 2019 06 014 PMC 6742496 PMID 31303424 Masui Kenta Cavenee Webster K Mischel Paul S 2014 07 25 mTORC2 in the center of cancer metabolic reprogramming Trends in Endocrinology and Metabolism 25 7 364 373 doi 10 1016 j tem 2014 04 002 ISSN 1879 3061 PMC 4077930 PMID 24856037 Wu Si Han Bi Jun Feng Cloughesy Timothy Cavenee Webster K Mischel Paul S 2014 Emerging function of mTORC2 as a core regulator in glioblastoma metabolic reprogramming and drug resistance Cancer Biology amp Medicine 11 4 255 263 doi 10 7497 j issn 2095 3941 2014 04 004 ISSN 2095 3941 PMC 4296088 PMID 25610711 Bi Junfeng Wu Sihan Zhang Wenjing Mischel Paul S 2018 05 23 Targeting cancer s metabolic co dependencies A landscape shaped by genotype and tissue context Biochimica et Biophysica Acta BBA Reviews on Cancer 1870 1 76 87 doi 10 1016 j bbcan 2018 05 002 ISSN 1879 2561 PMC 6193564 PMID 29775654 Bi Junfeng Chowdhry Sudhir Wu Sihan Zhang Wenjing Masui Kenta Mischel Paul S January 2020 Altered cellular metabolism in gliomas an emerging landscape of actionable co dependency targets Nature Reviews Cancer 20 1 57 70 doi 10 1038 s41568 019 0226 5 ISSN 1474 1768 PMID 31806884 S2CID 208768689 SNO Awards www soc neuro onc org Retrieved 2019 01 31 Williams Ruth 2008 06 30 Paul Mischel All about brains The Journal of Cell Biology 181 7 1044 1045 doi 10 1083 jcb 1817pi ISSN 0021 9525 PMC 2442209 PMID 18591424 External links editPaul Mischell s lab website Retrieved from https en wikipedia org w index php title Paul Mischel amp oldid 1217699453, wikipedia, wiki, book, books, library,

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