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Wikipedia

PPP1CC

April 11, 2024

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.[5]

PPP1CC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP1CC, PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDsOMIM: 176914 MGI: 3647492 HomoloGene: 100608 GeneCards: PPP1CC
Orthologs
SpeciesHumanMouse
Entrez

5501

434233

Ensembl

ENSG00000186298

ENSMUSG00000004455

UniProt

P36873

P63087

RefSeq (mRNA)

NM_001244974
NM_002710

XM_006508415

RefSeq (protein)

NP_001231903
NP_002701

NP_038664

Location (UCSC)Chr 12: 110.72 – 110.74 MbChr 5: 122.16 – 122.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

PPP1CC has been shown to interact with PPP1R15A,[6][7] SMARCB1,[6] TLX1[8] and PPP1R9B.[9][10]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186298 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004455 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".
  6. ^ a b Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
  7. ^ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
  8. ^ Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.
  9. ^ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
  10. ^ Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

Further reading edit

  • Van Eynde A, Wera S, Beullens M, et al. (1996). "Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing". J. Biol. Chem. 270 (47): 28068–74. doi:10.1074/jbc.270.47.28068. PMID 7499293.
  • Egloff MP, Cohen PT, Reinemer P, Barford D (1996). "Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate". J. Mol. Biol. 254 (5): 942–59. doi:10.1006/jmbi.1995.0667. PMID 7500362.
  • MacKintosh RW, Dalby KN, Campbell DG, et al. (1995). "The cyanobacterial toxin microcystin binds covalently to cysteine-273 on protein phosphatase 1". FEBS Lett. 371 (3): 236–40. doi:10.1016/0014-5793(95)00888-G. PMID 7556599. S2CID 42021604.
  • Norman SA, Mott DM (1994). "Molecular cloning and chromosomal localization of a human skeletal muscle PP-1 gamma 1 cDNA". Mamm. Genome. 5 (1): 41–5. doi:10.1007/BF00360567. PMID 8111128. S2CID 21566111.
  • Barker HM, Craig SP, Spurr NK, Cohen PT (1993). "Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2". Biochim. Biophys. Acta. 1178 (2): 228–33. doi:10.1016/0167-4889(93)90014-G. PMID 8394140.
  • Helps NR, Barker HM, Elledge SJ, Cohen PT (1996). "Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53". FEBS Lett. 377 (3): 295–300. doi:10.1016/0014-5793(95)01347-4. PMID 8549741. S2CID 3010008.
  • Saadat M, Nomoto K, Mizuno Y, et al. (1996). "Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit (PPP1CC) on human, rat, and mouse chromosomes". Jpn. J. Hum. Genet. 41 (1): 159–65. doi:10.1007/BF01892623. PMID 8914631.
  • Armstrong CG, Browne GJ, Cohen P, Cohen PT (1998). "PPP1R6, a novel member of the family of glycogen-targeting subunits of protein phosphatase 1". FEBS Lett. 418 (1–2): 210–4. doi:10.1016/S0014-5793(97)01385-9. PMID 9414128. S2CID 21169749.
  • Andreassen PR, Lacroix FB, Villa-Moruzzi E, Margolis RL (1998). "Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cells". J. Cell Biol. 141 (5): 1207–15. doi:10.1083/jcb.141.5.1207. PMC 2137188. PMID 9606212.
  • Ajuh PM, Browne GJ, Hawkes NA, et al. (2000). "Association of a protein phosphatase 1 activity with the human factor C1 (HCF) complex". Nucleic Acids Res. 28 (3): 678–86. doi:10.1093/nar/28.3.678. PMC 102561. PMID 10637318.
  • Yang J, Hurley TD, DePaoli-Roach AA (2000). "Interaction of inhibitor-2 with the catalytic subunit of type 1 protein phosphatase. Identification of a sequence analogous to the consensus type 1 protein phosphatase-binding motif". J. Biol. Chem. 275 (30): 22635–44. doi:10.1074/jbc.M003082200. PMID 10807923.
  • Katayama H, Zhou H, Li Q, et al. (2002). "Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle". J. Biol. Chem. 276 (49): 46219–24. doi:10.1074/jbc.M107540200. PMID 11551964.
  • Patel KG, Liu C, Cameron PL, Cameron RS (2001). "Myr 8, a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1". J. Neurosci. 21 (20): 7954–68. doi:10.1523/JNEUROSCI.21-20-07954.2001. PMC 6763852. PMID 11588169.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Jones JA, Hannun YA (2002). "Tight binding inhibition of protein phosphatase-1 by phosphatidic acid. Specificity of inhibition by the phospholipid". J. Biol. Chem. 277 (18): 15530–8. doi:10.1074/jbc.M111555200. PMID 11856740.
  • Wu DY, Tkachuck DC, Roberson RS, Schubach WH (2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. PMID 12016208.
  • Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi:10.1006/viro.2002.1438. PMID 12036313.
  • Tan SL, Tareen SU, Melville MW, et al. (2002). "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation". J. Biol. Chem. 277 (39): 36109–17. doi:10.1074/jbc.M205109200. PMID 12138106.
  • Eto M, Elliott E, Prickett TD, Brautigan DL (2003). "Inhibitor-2 regulates protein phosphatase-1 complexed with NimA-related kinase to induce centrosome separation". J. Biol. Chem. 277 (46): 44013–20. doi:10.1074/jbc.M208035200. PMID 12221103.
  • Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.
 

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

April 11, 2024
ppp1cc, serine, threonine, protein, phosphatase, gamma, catalytic, subunit, enzyme, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes1it6, 1jk7, 1u32, 2bcd, 2bdx, 4ut2, 4ut3identifiersaliases, pp1c, ppp1g, protein, ph. Serine threonine protein phosphatase PP1 gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene 5 PPP1CCAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes1IT6 1JK7 1U32 2BCD 2BDX 4UT2 4UT3IdentifiersAliasesPPP1CC PP 1G PP1C PPP1G protein phosphatase 1 catalytic subunit gammaExternal IDsOMIM 176914 MGI 3647492 HomoloGene 100608 GeneCards PPP1CCGene location Human Chr Chromosome 12 human 1 Band12q24 11Start110 719 680 bp 1 End110 742 939 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band7 7 F2Start122 158 278 bp 2 End122 175 273 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosaright ventricleparotid glandsecondary oocytesuperficial temporal arteryduodenumspermoral cavitygerminal epitheliumtibiaTop expressed inspermatocytespermatidolfactory bulbganglionic eminencethymuscerebellar cortexbone marrowovaryuterussuperior frontal gyrusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionphosphoprotein phosphatase activity protein domain specific binding protein N terminus binding phosphatase activity protein containing complex binding protein serine threonine phosphatase activity metal ion binding protein phosphatase 1 binding protein C terminus binding protein binding protein phosphatase binding hydrolase activity protein kinase binding lamin binding RNA bindingCellular componentcytoplasm cytosol nuclear speck focal adhesion dendritic spine chromosome nucleoplasm mitochondrial outer membrane midbody PTW PP1 phosphatase complex nucleolus mitochondrion cleavage furrow chromosome centromeric region nucleus kinetochore protein phosphatase type 1 complex protein containing complex presynapse postsynapse glutamatergic synapseBiological processregulation of nucleocytoplasmic transport rhythmic process protein dephosphorylation circadian regulation of gene expression cell division regulation of circadian rhythm neuron differentiation glycogen metabolic process cell cycle entrainment of circadian clock by photoperiod sister chromatid cohesion carbohydrate metabolic process positive regulation of glial cell proliferationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5501434233EnsemblENSG00000186298ENSMUSG00000004455UniProtP36873P63087RefSeq mRNA NM 001244974NM 002710XM 006508415RefSeq protein NP 001231903NP 002701NP 038664Location UCSC Chr 12 110 72 110 74 MbChr 5 122 16 122 18 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseInteractions editPPP1CC has been shown to interact with PPP1R15A 6 7 SMARCB1 6 TLX1 8 and PPP1R9B 9 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000186298 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000004455 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene PPP1CC Protein phosphatase 1 catalytic subunit gamma isoform a b Wu DY Tkachuck Douglas C Roberson Rachel S Schubach William H Aug 2002 The human SNF5 INI1 protein facilitates the function of the growth arrest and DNA damage inducible protein GADD34 and modulates GADD34 bound protein phosphatase 1 activity J Biol Chem 277 31 United States 27706 15 doi 10 1074 jbc M200955200 ISSN 0021 9258 PMID 12016208 Connor JH Weiser D C Li S Hallenbeck J M Shenolikar S Oct 2001 Growth arrest and DNA damage inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1 Mol Cell Biol 21 20 United States 6841 50 doi 10 1128 MCB 21 20 6841 6850 2001 ISSN 0270 7306 PMC 99861 PMID 11564868 Kawabe T Muslin A J Korsmeyer S J Jan 1997 HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2 M cell cycle checkpoint Nature 385 6615 ENGLAND 454 8 Bibcode 1997Natur 385 454K doi 10 1038 385454a0 ISSN 0028 0836 PMID 9009195 S2CID 608633 Hsieh Wilson LC Allen P B Watanabe T Nairn A C Greengard P Apr 1999 Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase 1 Biochemistry 38 14 UNITED STATES 4365 73 doi 10 1021 bi982900m ISSN 0006 2960 PMID 10194355 Smith FD Oxford G S Milgram S L Jul 1999 Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin a protein phosphatase 1 interacting protein J Biol Chem 274 28 UNITED STATES 19894 900 doi 10 1074 jbc 274 28 19894 ISSN 0021 9258 PMID 10391935 Further reading editVan Eynde A Wera S Beullens M et al 1996 Molecular cloning of NIPP 1 a nuclear inhibitor of protein phosphatase 1 reveals homology with polypeptides involved in RNA processing J Biol Chem 270 47 28068 74 doi 10 1074 jbc 270 47 28068 PMID 7499293 Egloff MP Cohen PT Reinemer P Barford D 1996 Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate J Mol Biol 254 5 942 59 doi 10 1006 jmbi 1995 0667 PMID 7500362 MacKintosh RW Dalby KN Campbell DG et al 1995 The cyanobacterial toxin microcystin binds covalently to cysteine 273 on protein phosphatase 1 FEBS Lett 371 3 236 40 doi 10 1016 0014 5793 95 00888 G PMID 7556599 S2CID 42021604 Norman SA Mott DM 1994 Molecular cloning and chromosomal localization of a human skeletal muscle PP 1 gamma 1 cDNA Mamm Genome 5 1 41 5 doi 10 1007 BF00360567 PMID 8111128 S2CID 21566111 Barker HM Craig SP Spurr NK Cohen PT 1993 Sequence of human protein serine threonine phosphatase 1 gamma and localization of the gene PPP1CC encoding it to chromosome bands 12q24 1 q24 2 Biochim Biophys Acta 1178 2 228 33 doi 10 1016 0167 4889 93 90014 G PMID 8394140 Helps NR Barker HM Elledge SJ Cohen PT 1996 Protein phosphatase 1 interacts with p53BP2 a protein which binds to the tumour suppressor p53 FEBS Lett 377 3 295 300 doi 10 1016 0014 5793 95 01347 4 PMID 8549741 S2CID 3010008 Saadat M Nomoto K Mizuno Y et al 1996 Assignment of the gene encoding type 1 gamma protein phosphatase catalytic subunit PPP1CC on human rat and mouse chromosomes Jpn J Hum Genet 41 1 159 65 doi 10 1007 BF01892623 PMID 8914631 Armstrong CG Browne GJ Cohen P Cohen PT 1998 PPP1R6 a novel member of the family of glycogen targeting subunits of protein phosphatase 1 FEBS Lett 418 1 2 210 4 doi 10 1016 S0014 5793 97 01385 9 PMID 9414128 S2CID 21169749 Andreassen PR Lacroix FB Villa Moruzzi E Margolis RL 1998 Differential subcellular localization of protein phosphatase 1 alpha gamma1 and delta isoforms during both interphase and mitosis in mammalian cells J Cell Biol 141 5 1207 15 doi 10 1083 jcb 141 5 1207 PMC 2137188 PMID 9606212 Ajuh PM Browne GJ Hawkes NA et al 2000 Association of a protein phosphatase 1 activity with the human factor C1 HCF complex Nucleic Acids Res 28 3 678 86 doi 10 1093 nar 28 3 678 PMC 102561 PMID 10637318 Yang J Hurley TD DePaoli Roach AA 2000 Interaction of inhibitor 2 with the catalytic subunit of type 1 protein phosphatase Identification of a sequence analogous to the consensus type 1 protein phosphatase binding motif J Biol Chem 275 30 22635 44 doi 10 1074 jbc M003082200 PMID 10807923 Katayama H Zhou H Li Q et al 2002 Interaction and feedback regulation between STK15 BTAK Aurora A kinase and protein phosphatase 1 through mitotic cell division cycle J Biol Chem 276 49 46219 24 doi 10 1074 jbc M107540200 PMID 11551964 Patel KG Liu C Cameron PL Cameron RS 2001 Myr 8 a novel unconventional myosin expressed during brain development associates with the protein phosphatase catalytic subunits 1alpha and 1gamma1 J Neurosci 21 20 7954 68 doi 10 1523 JNEUROSCI 21 20 07954 2001 PMC 6763852 PMID 11588169 Andersen JS Lyon CE Fox AH et al 2002 Directed proteomic analysis of the human nucleolus Curr Biol 12 1 1 11 Bibcode 2002CBio 12 1A doi 10 1016 S0960 9822 01 00650 9 PMID 11790298 S2CID 14132033 Jones JA Hannun YA 2002 Tight binding inhibition of protein phosphatase 1 by phosphatidic acid Specificity of inhibition by the phospholipid J Biol Chem 277 18 15530 8 doi 10 1074 jbc M111555200 PMID 11856740 Wu DY Tkachuck DC Roberson RS Schubach WH 2002 The human SNF5 INI1 protein facilitates the function of the growth arrest and DNA damage inducible protein GADD34 and modulates GADD34 bound protein phosphatase 1 activity J Biol Chem 277 31 27706 15 doi 10 1074 jbc M200955200 PMID 12016208 Bharucha DC Zhou M Nekhai S et al 2002 A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long terminal repeat Virology 296 1 6 16 doi 10 1006 viro 2002 1438 PMID 12036313 Tan SL Tareen SU Melville MW et al 2002 The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation J Biol Chem 277 39 36109 17 doi 10 1074 jbc M205109200 PMID 12138106 Eto M Elliott E Prickett TD Brautigan DL 2003 Inhibitor 2 regulates protein phosphatase 1 complexed with NimA related kinase to induce centrosome separation J Biol Chem 277 46 44013 20 doi 10 1074 jbc M208035200 PMID 12221103 Ceulemans H Vulsteke V De Maeyer M et al 2003 Binding of the concave surface of the Sds22 superhelix to the alpha 4 alpha 5 alpha 6 triangle of protein phosphatase 1 J Biol Chem 277 49 47331 7 doi 10 1074 jbc M206838200 PMID 12226088 nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PPP1CC amp oldid 1218124492, wikipedia, wiki, book, books, library,

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