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Wikipedia

PEX19

April 10, 2024

Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene.[5][6][7]

PEX19
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPEX19, D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1, peroxisomal biogenesis factor 19
External IDsOMIM: 600279 MGI: 1334458 HomoloGene: 134253 GeneCards: PEX19
Orthologs
SpeciesHumanMouse
Entrez

5824

19298

Ensembl

ENSG00000162735

ENSMUSG00000003464

UniProt

P40855

Q8VCI5

RefSeq (mRNA)

NM_001131039
NM_001193644
NM_002857

NM_001159525
NM_023041
NM_001356513
NM_001356514

RefSeq (protein)

NP_001180573
NP_002848

NP_001152997
NP_075528
NP_001343442
NP_001343443

Location (UCSC)Chr 1: 160.28 – 160.29 MbChr 1: 171.95 – 171.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

PEX19 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000162735 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003464 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kammerer S, Arnold N, Gutensohn W, Mewes HW, Kunau WH, Höfler G, Roscher AA, Braun A (November 1997). "Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein". Genomics. 45 (1): 200–10. doi:10.1006/geno.1997.4914. PMID 9339377.
  6. ^ Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, Wanders RJ, Suzuki Y, Kondo N, Fujiki Y (April 1999). "Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly". Proc Natl Acad Sci U S A. 96 (5): 2116–21. Bibcode:1999PNAS...96.2116M. doi:10.1073/pnas.96.5.2116. PMC 26746. PMID 10051604.
  7. ^ "Entrez Gene: PEX19 peroxisomal biogenesis factor 19".
  8. ^ a b c d Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
  9. ^ a b c Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
  10. ^ a b c d e f Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  11. ^ Biermanns M, Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.
  12. ^ a b c d e f Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (July 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
  13. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading edit

  • Braun A, Kammerer S, Weissenhorn W, Weiss EH, Cleve H (1994). "Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1". Gene. 146 (2): 291–5. doi:10.1016/0378-1119(94)90308-5. PMID 8076834.
  • Götte K, Girzalsky W, Linkert M, Baumgart E, Kammerer S, Kunau WH, Erdmann R (1998). "Pex19p, a Farnesylated Protein Essential for Peroxisome Biogenesis". Mol. Cell. Biol. 18 (1): 616–28. doi:10.1128/MCB.18.1.616. PMC 121529. PMID 9418908.
  • Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  • Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
  • Sugihara T, Kaul SC, Kato J, Reddel RR, Nomura H, Wadhwa R (2001). "Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway". J. Biol. Chem. 276 (22): 18649–52. doi:10.1074/jbc.C100011200. PMID 11259404.
  • Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
  • Biermanns M, Gärtner J (2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.
  • Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
  • Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
  • Ito M, Iidawa S, Izuka M, Haito S, Segawa H, Kuwahata M, Ohkido I, Ohno H, Miyamoto K (2004). "Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate". Biochem. J. 377 (Pt 3): 607–16. doi:10.1042/BJ20031223. PMC 1223893. PMID 14558883.
  • Jones JM, Morrell JC, Gould SJ (2004). "PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins". J. Cell Biol. 164 (1): 57–67. doi:10.1083/jcb.200304111. PMC 2171958. PMID 14709540.
  • Muntau AC, Roscher AA, Kunau WH, Dodt G (2003). "Interaction of PEX3 and PEX19 Visualized by Fluorescence Resonance Energy Transfer (FRET)". Peroxisomal Disorders and Regulation of Genes. Advances in Experimental Medicine and Biology. Vol. 544. pp. 221–4. doi:10.1007/978-1-4419-9072-3_27. ISBN 978-1-4613-4782-8. PMID 14713233.
  • Fransen M, Vastiau I, Brees C, Brys V, Mannaerts GP, Van Veldhoven PP (2004). "Potential role for Pex19p in assembly of PTS-receptor docking complexes". J. Biol. Chem. 279 (13): 12615–24. doi:10.1074/jbc.M304941200. PMID 14715663.
  • Fang Y, Morrell JC, Jones JM, Gould SJ (2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins". J. Cell Biol. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC 2172291. PMID 15007061.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Shibata H, Kashiwayama Y, Imanaka T, Kato H (2004). "Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins". J. Biol. Chem. 279 (37): 38486–94. doi:10.1074/jbc.M402204200. PMID 15252024.

External links edit

  • GeneReviews/NCBI/NIH/UW entry on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
  • OMIM entries on Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
  • Overview of all the structural information available in the PDB for UniProt: P40855 (Peroxisomal biogenesis factor 19) at the PDBe-KB.

April 10, 2024
pex19, peroxisomal, biogenesis, factor, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2w85, 2wl8, 3ajb, 3mk4identifiersaliases, d1s2223e, hk33, pbd12a, pmp1, pmpi, pxmp1, peroxisomal, biogenesis, factor, 1. Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene 5 6 7 PEX19Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2W85 2WL8 3AJB 3MK4IdentifiersAliasesPEX19 D1S2223E HK33 PBD12A PMP1 PMPI PXF PXMP1 peroxisomal biogenesis factor 19External IDsOMIM 600279 MGI 1334458 HomoloGene 134253 GeneCards PEX19Gene location Human Chr Chromosome 1 human 1 Band1q23 2Start160 276 807 bp 1 End160 286 348 bp 1 Gene location Mouse Chr Chromosome 1 mouse 2 Band1 H3 1 79 54 cMStart171 954 322 bp 2 End171 964 060 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleabdominal fatthoracic diaphragmsubcutaneous adipose tissueislet of Langerhansright lobe of liverprefrontal cortexrectumleft ventricleleft adrenal glandTop expressed inyolk saclipdigastric muscletemporal musclebrown adipose tissuetriceps brachii musclesternocleidomastoid muscleproximal tubuleinterventricular septumskeletal muscle tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionperoxisome membrane class 1 targeting sequence binding protein N terminus binding ATPase binding protein bindingCellular componentcytoplasm integral component of membrane cytosol membrane peroxisomal membrane peroxisome nucleoplasm brush border membrane nucleus protein containing complexBiological processprotein targeting to peroxisome peroxisome organization protein stabilization peroxisome membrane biogenesis peroxisome fission protein import into peroxisome membrane transmembrane transport establishment of protein localization to peroxisome negative regulation of lipid binding chaperone mediated protein foldingSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez582419298EnsemblENSG00000162735ENSMUSG00000003464UniProtP40855Q8VCI5RefSeq mRNA NM 001131039NM 001193644NM 002857NM 001159525NM 023041NM 001356513NM 001356514RefSeq protein NP 001180573NP 002848NP 001152997NP 075528NP 001343442NP 001343443Location UCSC Chr 1 160 28 160 29 MbChr 1 171 95 171 96 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editPEX19 has been shown to interact with ABCD1 8 9 ABCD2 8 9 ABCD3 8 9 10 11 PEX10 10 12 PEX11B 10 12 PEX12 10 12 PEX13 10 12 PEX16 12 and PEX3 8 10 12 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000162735 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000003464 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Kammerer S Arnold N Gutensohn W Mewes HW Kunau WH Hofler G Roscher AA Braun A November 1997 Genomic organization and molecular characterization of a gene encoding HsPXF a human peroxisomal farnesylated protein Genomics 45 1 200 10 doi 10 1006 geno 1997 4914 PMID 9339377 Matsuzono Y Kinoshita N Tamura S Shimozawa N Hamasaki M Ghaedi K Wanders RJ Suzuki Y Kondo N Fujiki Y April 1999 Human PEX19 cDNA cloning by functional complementation mutation analysis in a patient with Zellweger syndrome and potential role in peroxisomal membrane assembly Proc Natl Acad Sci U S A 96 5 2116 21 Bibcode 1999PNAS 96 2116M doi 10 1073 pnas 96 5 2116 PMC 26746 PMID 10051604 Entrez Gene PEX19 peroxisomal biogenesis factor 19 a b c d Mayerhofer PU Kattenfeld T Roscher AA Muntau AC March 2002 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly Biochem Biophys Res Commun 291 5 1180 6 doi 10 1006 bbrc 2002 6568 PMID 11883941 a b c Gloeckner CJ Mayerhofer PU Landgraf P Muntau AC Holzinger A Gerber JK Kammerer S Adamski J Roscher AA April 2000 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Biochem Biophys Res Commun 271 1 144 50 doi 10 1006 bbrc 2000 2572 PMID 10777694 a b c d e f Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ March 2000 PEX19 binds multiple peroxisomal membrane proteins is predominantly cytoplasmic and is required for peroxisome membrane synthesis J Cell Biol 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Biermanns M Gartner J July 2001 Targeting elements in the amino terminal part direct the human 70 kDa peroxisomal integral membrane protein PMP70 to peroxisomes Biochem Biophys Res Commun 285 3 649 55 doi 10 1006 bbrc 2001 5220 PMID 11453642 a b c d e f Fransen M Wylin T Brees C Mannaerts GP Van Veldhoven PP July 2001 Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences Mol Cell Biol 21 13 4413 24 doi 10 1128 MCB 21 13 4413 4424 2001 PMC 87101 PMID 11390669 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Further reading editBraun A Kammerer S Weissenhorn W Weiss EH Cleve H 1994 Sequence of a putative human housekeeping gene HK33 localized on chromosome 1 Gene 146 2 291 5 doi 10 1016 0378 1119 94 90308 5 PMID 8076834 Gotte K Girzalsky W Linkert M Baumgart E Kammerer S Kunau WH Erdmann R 1998 Pex19p a Farnesylated Protein Essential for Peroxisome Biogenesis Mol Cell Biol 18 1 616 28 doi 10 1128 MCB 18 1 616 PMC 121529 PMID 9418908 Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ 2000 Pex19 Binds Multiple Peroxisomal Membrane Proteins Is Predominantly Cytoplasmic and Is Required for Peroxisome Membrane Synthesis J Cell Biol 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Gloeckner CJ Mayerhofer PU Landgraf P Muntau AC Holzinger A Gerber JK Kammerer S Adamski J Roscher AA 2000 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Biochem Biophys Res Commun 271 1 144 50 doi 10 1006 bbrc 2000 2572 PMID 10777694 Sugihara T Kaul SC Kato J Reddel RR Nomura H Wadhwa R 2001 Pex19p dampens the p19ARF p53 p21WAF1 tumor suppressor pathway J Biol Chem 276 22 18649 52 doi 10 1074 jbc C100011200 PMID 11259404 Fransen M Wylin T Brees C Mannaerts GP Van Veldhoven PP 2001 Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences Mol Cell Biol 21 13 4413 24 doi 10 1128 MCB 21 13 4413 4424 2001 PMC 87101 PMID 11390669 Biermanns M Gartner J 2001 Targeting elements in the amino terminal part direct the human 70 kDa peroxisomal integral membrane protein PMP70 to peroxisomes Biochem Biophys Res Commun 285 3 649 55 doi 10 1006 bbrc 2001 5220 PMID 11453642 Mayerhofer PU Kattenfeld T Roscher AA Muntau AC 2002 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly Biochem Biophys Res Commun 291 5 1180 6 doi 10 1006 bbrc 2002 6568 PMID 11883941 Fransen M Brees C Ghys K Amery L Mannaerts GP Ladant D Van Veldhoven PP 2002 Analysis of mammalian peroxin interactions using a non transcription based bacterial two hybrid assay Mol Cell Proteomics 1 3 243 52 doi 10 1074 mcp M100025 MCP200 PMID 12096124 Ito M Iidawa S Izuka M Haito S Segawa H Kuwahata M Ohkido I Ohno H Miyamoto K 2004 Interaction of a farnesylated protein with renal type IIa Na Pi co transporter in response to parathyroid hormone and dietary phosphate Biochem J 377 Pt 3 607 16 doi 10 1042 BJ20031223 PMC 1223893 PMID 14558883 Jones JM Morrell JC Gould SJ 2004 PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins J Cell Biol 164 1 57 67 doi 10 1083 jcb 200304111 PMC 2171958 PMID 14709540 Muntau AC Roscher AA Kunau WH Dodt G 2003 Interaction of PEX3 and PEX19 Visualized by Fluorescence Resonance Energy Transfer FRET Peroxisomal Disorders and Regulation of Genes Advances in Experimental Medicine and Biology Vol 544 pp 221 4 doi 10 1007 978 1 4419 9072 3 27 ISBN 978 1 4613 4782 8 PMID 14713233 Fransen M Vastiau I Brees C Brys V Mannaerts GP Van Veldhoven PP 2004 Potential role for Pex19p in assembly of PTS receptor docking complexes J Biol Chem 279 13 12615 24 doi 10 1074 jbc M304941200 PMID 14715663 Fang Y Morrell JC Jones JM Gould SJ 2004 PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins J Cell Biol 164 6 863 75 doi 10 1083 jcb 200311131 PMC 2172291 PMID 15007061 Colland F Jacq X Trouplin V Mougin C Groizeleau C Hamburger A Meil A Wojcik J Legrain P Gauthier JM 2004 Functional Proteomics Mapping of a Human Signaling Pathway Genome Res 14 7 1324 32 doi 10 1101 gr 2334104 PMC 442148 PMID 15231748 Shibata H Kashiwayama Y Imanaka T Kato H 2004 Domain architecture and activity of human Pex19p a chaperone like protein for intracellular trafficking of peroxisomal membrane proteins J Biol Chem 279 37 38486 94 doi 10 1074 jbc M402204200 PMID 15252024 External links editGeneReviews NCBI NIH UW entry on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum OMIM entries on Peroxisome Biogenesis Disorders Zellweger Syndrome Spectrum Overview of all the structural information available in the PDB for UniProt P40855 Peroxisomal biogenesis factor 19 at the PDBe KB Retrieved from https en wikipedia org w index php title PEX19 amp oldid 1172341116, wikipedia, wiki, book, books, library,

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