fbpx
Wikipedia

ABCD3

April 12, 2024

ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene.[5][6][7]

ABCD3
Identifiers
AliasesABCD3, ABC43, PMP70, PXMP1, ZWS2, CBAS5, ATP binding cassette subfamily D member 3
External IDsOMIM: 170995 MGI: 1349216 HomoloGene: 2140 GeneCards: ABCD3
Orthologs
SpeciesHumanMouse
Entrez

5825

19299

Ensembl

ENSG00000117528

ENSMUSG00000028127

UniProt

P28288

P55096

RefSeq (mRNA)

NM_001122674
NM_002858

NM_008991
NM_001355756

RefSeq (protein)

NP_001116146
NP_002849

NP_033017
NP_001342685

Location (UCSC)Chr 1: 94.42 – 94.52 MbChr 3: 121.55 – 121.61 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis.

Clinical significance edit

Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders.[7] However, this association was denied [8] and congenital bile acid synthesis defect-5 (CBAS5) was recently shown to be caused by homozygous mutation in the ABCD3 gene [9]

See also edit

Interactions edit

ABCD3 has been shown to interact with PEX19.[10][11][12][13]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117528 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028127 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Gärtner J, Moser H, Valle D (June 1993). "Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome". Nat Genet. 1 (1): 16–23. doi:10.1038/ng0492-16. PMID 1301993. S2CID 5779170.
  6. ^ Gärtner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D (April 1993). "Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3". Genomics. 15 (2): 412–4. doi:10.1006/geno.1993.1076. PMID 8449508.
  7. ^ a b "Entrez Gene: ABCD3 ATP-binding cassette, sub-family D (ALD), member 3".
  8. ^ Paton, B. C.; Heron, S. E.; Nelson, P. V.; Morris, C. P.; Poulos, A. (1997). "Absence of mutations raises doubts about the role of the 70-kD peroxisomal membrane protein in Zellweger syndrome". American Journal of Human Genetics. 60 (6): 1535–9. doi:10.1016/S0002-9297(07)64247-5. PMC 1716138. PMID 9199576.
  9. ^ Ferdinandusse, S.; Jimenez-Sanchez, G.; Koster, J.; Denis, S.; Van Roermund, C. W.; Silva-Zolezzi, I.; Moser, A. B.; Visser, W. F.; Gulluoglu, M.; Durmaz, O.; Demirkol, M.; Waterham, H. R.; Gökcay, G.; Wanders, R. J.; Valle, D. (2015). "A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3". Human Molecular Genetics. 24 (2): 361–70. doi:10.1093/hmg/ddu448. PMID 25168382.
  10. ^ Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (March 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
  11. ^ Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (April 2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
  12. ^ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (March 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  13. ^ Biermanns M, Gärtner J (July 2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.

Further reading edit

  • Gärtner J, Valle D (1993). "The 70 kDa peroxisomal membrane protein: an ATP-binding cassette transporter protein involved in peroxisome biogenesis". Semin. Cell Biol. 4 (1): 45–52. doi:10.1006/scel.1993.1006. PMID 8453064.
  • Gärtner J, Obie C, Moser H, Valle D (1993). "A polymorphic synonymous mutation (K54K) in the human 70 kD peroxisomal membrane protein gene (PMP1)". Hum. Mol. Genet. 1 (8): 654. doi:10.1093/hmg/1.8.654. PMID 1301179.
  • Kamijo K, Kamijo T, Ueno I, Osumi T, Hashimoto T (1992). "Nucleotide sequence of the human 70 kDa peroxisomal membrane protein: a member of ATP-binding cassette transporters". Biochim. Biophys. Acta. 1129 (3): 323–7. doi:10.1016/0167-4781(92)90510-7. PMID 1536884.
  • Gärtner J, Kearns W, Rosenberg C, Pearson P, Copeland NG, Gilbert DJ, Jenkins NA, Valle D (1993). "Localization of the 70-kDa peroxisomal membrane protein to human 1p21-p22 and mouse 3". Genomics. 15 (2): 412–4. doi:10.1006/geno.1993.1076. PMID 8449508.
  • Shimozawa N, Suzuki Y, Tomatsu S, Tsukamoto T, Osumi T, Fujiki Y, Kamijo K, Hashimoto T, Kondo N, Orii T (1996). "Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients". Pediatr. Res. 39 (5): 812–5. doi:10.1203/00006450-199605000-00011. PMID 8726233.
  • Kobayashi T, Shinnoh N, Kondo A, Yamada T (1997). "Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism". Biochem. Biophys. Res. Commun. 232 (3): 631–6. doi:10.1006/bbrc.1997.6340. PMID 9126326.
  • Paton BC, Heron SE, Nelson PV, Morris CP, Poulos A (1997). "Absence of mutations raises doubts about the role of the 70-kD peroxisomal membrane protein in Zellweger syndrome". Am. J. Hum. Genet. 60 (6): 1535–9. doi:10.1016/S0002-9297(07)64247-5. PMC 1716138. PMID 9199576.
  • Gärtner J, Jimenez-Sanchez G, Roerig P, Valle D (1998). "Genomic organization of the 70-kDa peroxisomal membrane protein gene (PXMP1)". Genomics. 48 (2): 203–8. doi:10.1006/geno.1997.5177. PMID 9521874.
  • Collins CS, Gould SJ (1999). "Identification of a common PEX1 mutation in Zellweger syndrome". Hum. Mutat. 14 (1): 45–53. doi:10.1002/(SICI)1098-1004(1999)14:1<45::AID-HUMU6>3.0.CO;2-J. PMID 10447258. S2CID 22153024.
  • Liu LX, Janvier K, Berteaux-Lecellier V, Cartier N, Benarous R, Aubourg P (2000). "Homo- and heterodimerization of peroxisomal ATP-binding cassette half-transporters". J. Biol. Chem. 274 (46): 32738–43. doi:10.1074/jbc.274.46.32738. PMID 10551832.
  • Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  • Gloeckner CJ, Mayerhofer PU, Landgraf P, Muntau AC, Holzinger A, Gerber JK, Kammerer S, Adamski J, Roscher AA (2000). "Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p". Biochem. Biophys. Res. Commun. 271 (1): 144–50. doi:10.1006/bbrc.2000.2572. PMID 10777694.
  • Roerig P, Mayerhofer P, Holzinger A, Gärtner J (2001). "Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters". FEBS Lett. 492 (1–2): 66–72. doi:10.1016/S0014-5793(01)02235-9. PMID 11248239.
  • Biermanns M, Gärtner J (2001). "Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes". Biochem. Biophys. Res. Commun. 285 (3): 649–55. doi:10.1006/bbrc.2001.5220. PMID 11453642.
  • Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochem. Biophys. Res. Commun. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
  • Tanaka AR, Tanabe K, Morita M, Kurisu M, Kasiwayama Y, Matsuo M, Kioka N, Amachi T, Imanaka T, Ueda K (2002). "ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)". J. Biol. Chem. 277 (42): 40142–7. doi:10.1074/jbc.M205079200. PMID 12176987.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links edit

  • ABCD3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • ABCD3 at The GDB Human Genome Database
  • Human ABCD3 genome location and ABCD3 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

April 12, 2024
abcd3, binding, cassette, family, member, protein, that, humans, encoded, gene, identifiersaliases, abc43, pmp70, pxmp1, zws2, cbas5, binding, cassette, subfamily, member, 3external, idsomim, 170995, 1349216, homologene, 2140, genecards, gene, location, human,. ATP binding cassette sub family D member 3 is a protein that in humans is encoded by the ABCD3 gene 5 6 7 ABCD3IdentifiersAliasesABCD3 ABC43 PMP70 PXMP1 ZWS2 CBAS5 ATP binding cassette subfamily D member 3External IDsOMIM 170995 MGI 1349216 HomoloGene 2140 GeneCards ABCD3Gene location Human Chr Chromosome 1 human 1 Band1p21 3Start94 418 389 bp 1 End94 518 666 bp 1 Gene location Mouse Chr Chromosome 3 mouse 2 Band3 G1 3 52 94 cMStart121 552 423 bp 2 End121 608 951 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed insecondary oocytejejunal mucosabronchial epithelial cellkidney tubuleretinal pigment epitheliumpalpebral conjunctivacaput epididymisrenal medullatrigeminal ganglionduodenumTop expressed inepithelium of stomachleft lobe of liverconjunctival fornixsacculeretinal pigment epitheliummucous cell of stomachlacrimal glandgallbladderpyloric antrumciliary bodyMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionATPase coupled transmembrane transporter activity nucleotide binding protein homodimerization activity protein self association ATPase activity protein binding ATP binding long chain fatty acid transporter activityCellular componentintegral component of membrane cytosol membrane intracellular membrane bounded organelle peroxisomal membrane peroxisome peroxisomal matrix mitochondrion mitochondrial inner membraneBiological processlong chain fatty acid import into peroxisome peroxisome organization response to organic cyclic compound fatty acid biosynthetic process transmembrane transport very long chain fatty acid catabolic process fatty acid beta oxidation transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez582519299EnsemblENSG00000117528ENSMUSG00000028127UniProtP28288P55096RefSeq mRNA NM 001122674NM 002858NM 008991NM 001355756RefSeq protein NP 001116146NP 002849NP 033017NP 001342685Location UCSC Chr 1 94 42 94 52 MbChr 3 121 55 121 61 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Clinical significance 3 See also 4 Interactions 5 References 6 Further reading 7 External linksFunction editThe protein encoded by this gene is a member of the superfamily of ATP binding cassette ABC transporters ABC proteins transport various molecules across extra and intra cellular membranes ABC genes are divided into seven distinct subfamilies ABC1 MDR TAP MRP ALD OABP GCN20 White This protein is a member of the ALD subfamily which is involved in peroxisomal import of fatty acids and or fatty acyl CoAs in the organelle All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis Clinical significance editMutations have been associated with some forms of Zellweger syndrome a heterogeneous group of peroxisome assembly disorders 7 However this association was denied 8 and congenital bile acid synthesis defect 5 CBAS5 was recently shown to be caused by homozygous mutation in the ABCD3 gene 9 See also editATP binding cassette transporterInteractions editABCD3 has been shown to interact with PEX19 10 11 12 13 References edit a b c GRCh38 Ensembl release 89 ENSG00000117528 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000028127 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Gartner J Moser H Valle D June 1993 Mutations in the 70K peroxisomal membrane protein gene in Zellweger syndrome Nat Genet 1 1 16 23 doi 10 1038 ng0492 16 PMID 1301993 S2CID 5779170 Gartner J Kearns W Rosenberg C Pearson P Copeland NG Gilbert DJ Jenkins NA Valle D April 1993 Localization of the 70 kDa peroxisomal membrane protein to human 1p21 p22 and mouse 3 Genomics 15 2 412 4 doi 10 1006 geno 1993 1076 PMID 8449508 a b Entrez Gene ABCD3 ATP binding cassette sub family D ALD member 3 Paton B C Heron S E Nelson P V Morris C P Poulos A 1997 Absence of mutations raises doubts about the role of the 70 kD peroxisomal membrane protein in Zellweger syndrome American Journal of Human Genetics 60 6 1535 9 doi 10 1016 S0002 9297 07 64247 5 PMC 1716138 PMID 9199576 Ferdinandusse S Jimenez Sanchez G Koster J Denis S Van Roermund C W Silva Zolezzi I Moser A B Visser W F Gulluoglu M Durmaz O Demirkol M Waterham H R Gokcay G Wanders R J Valle D 2015 A novel bile acid biosynthesis defect due to a deficiency of peroxisomal ABCD3 Human Molecular Genetics 24 2 361 70 doi 10 1093 hmg ddu448 PMID 25168382 Mayerhofer PU Kattenfeld T Roscher AA Muntau AC March 2002 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly Biochem Biophys Res Commun 291 5 1180 6 doi 10 1006 bbrc 2002 6568 PMID 11883941 Gloeckner CJ Mayerhofer PU Landgraf P Muntau AC Holzinger A Gerber JK Kammerer S Adamski J Roscher AA April 2000 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Biochem Biophys Res Commun 271 1 144 50 doi 10 1006 bbrc 2000 2572 PMID 10777694 Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ March 2000 PEX19 binds multiple peroxisomal membrane proteins is predominantly cytoplasmic and is required for peroxisome membrane synthesis J Cell Biol 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Biermanns M Gartner J July 2001 Targeting elements in the amino terminal part direct the human 70 kDa peroxisomal integral membrane protein PMP70 to peroxisomes Biochem Biophys Res Commun 285 3 649 55 doi 10 1006 bbrc 2001 5220 PMID 11453642 Further reading editGartner J Valle D 1993 The 70 kDa peroxisomal membrane protein an ATP binding cassette transporter protein involved in peroxisome biogenesis Semin Cell Biol 4 1 45 52 doi 10 1006 scel 1993 1006 PMID 8453064 Gartner J Obie C Moser H Valle D 1993 A polymorphic synonymous mutation K54K in the human 70 kD peroxisomal membrane protein gene PMP1 Hum Mol Genet 1 8 654 doi 10 1093 hmg 1 8 654 PMID 1301179 Kamijo K Kamijo T Ueno I Osumi T Hashimoto T 1992 Nucleotide sequence of the human 70 kDa peroxisomal membrane protein a member of ATP binding cassette transporters Biochim Biophys Acta 1129 3 323 7 doi 10 1016 0167 4781 92 90510 7 PMID 1536884 Gartner J Kearns W Rosenberg C Pearson P Copeland NG Gilbert DJ Jenkins NA Valle D 1993 Localization of the 70 kDa peroxisomal membrane protein to human 1p21 p22 and mouse 3 Genomics 15 2 412 4 doi 10 1006 geno 1993 1076 PMID 8449508 Shimozawa N Suzuki Y Tomatsu S Tsukamoto T Osumi T Fujiki Y Kamijo K Hashimoto T Kondo N Orii T 1996 Correction by gene expression of biochemical abnormalities in fibroblasts from Zellweger patients Pediatr Res 39 5 812 5 doi 10 1203 00006450 199605000 00011 PMID 8726233 Kobayashi T Shinnoh N Kondo A Yamada T 1997 Adrenoleukodystrophy protein deficient mice represent abnormality of very long chain fatty acid metabolism Biochem Biophys Res Commun 232 3 631 6 doi 10 1006 bbrc 1997 6340 PMID 9126326 Paton BC Heron SE Nelson PV Morris CP Poulos A 1997 Absence of mutations raises doubts about the role of the 70 kD peroxisomal membrane protein in Zellweger syndrome Am J Hum Genet 60 6 1535 9 doi 10 1016 S0002 9297 07 64247 5 PMC 1716138 PMID 9199576 Gartner J Jimenez Sanchez G Roerig P Valle D 1998 Genomic organization of the 70 kDa peroxisomal membrane protein gene PXMP1 Genomics 48 2 203 8 doi 10 1006 geno 1997 5177 PMID 9521874 Collins CS Gould SJ 1999 Identification of a common PEX1 mutation in Zellweger syndrome Hum Mutat 14 1 45 53 doi 10 1002 SICI 1098 1004 1999 14 1 lt 45 AID HUMU6 gt 3 0 CO 2 J PMID 10447258 S2CID 22153024 Liu LX Janvier K Berteaux Lecellier V Cartier N Benarous R Aubourg P 2000 Homo and heterodimerization of peroxisomal ATP binding cassette half transporters J Biol Chem 274 46 32738 43 doi 10 1074 jbc 274 46 32738 PMID 10551832 Sacksteder KA Jones JM South ST Li X Liu Y Gould SJ 2000 PEX19 binds multiple peroxisomal membrane proteins is predominantly cytoplasmic and is required for peroxisome membrane synthesis J Cell Biol 148 5 931 44 doi 10 1083 jcb 148 5 931 PMC 2174547 PMID 10704444 Gloeckner CJ Mayerhofer PU Landgraf P Muntau AC Holzinger A Gerber JK Kammerer S Adamski J Roscher AA 2000 Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p Biochem Biophys Res Commun 271 1 144 50 doi 10 1006 bbrc 2000 2572 PMID 10777694 Roerig P Mayerhofer P Holzinger A Gartner J 2001 Characterization and functional analysis of the nucleotide binding fold in human peroxisomal ATP binding cassette transporters FEBS Lett 492 1 2 66 72 doi 10 1016 S0014 5793 01 02235 9 PMID 11248239 Biermanns M Gartner J 2001 Targeting elements in the amino terminal part direct the human 70 kDa peroxisomal integral membrane protein PMP70 to peroxisomes Biochem Biophys Res Commun 285 3 649 55 doi 10 1006 bbrc 2001 5220 PMID 11453642 Mayerhofer PU Kattenfeld T Roscher AA Muntau AC 2002 Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly Biochem Biophys Res Commun 291 5 1180 6 doi 10 1006 bbrc 2002 6568 PMID 11883941 Tanaka AR Tanabe K Morita M Kurisu M Kasiwayama Y Matsuo M Kioka N Amachi T Imanaka T Ueda K 2002 ATP binding hydrolysis by and phosphorylation of peroxisomal ATP binding cassette proteins PMP70 ABCD3 and adrenoleukodystrophy protein ABCD1 J Biol Chem 277 42 40142 7 doi 10 1074 jbc M205079200 PMID 12176987 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editABCD3 protein human at the U S National Library of Medicine Medical Subject Headings MeSH ABCD3 at The GDB Human Genome Database Human ABCD3 genome location and ABCD3 gene details page in the UCSC Genome Browser This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ABCD3 amp oldid 1136432028, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.