Polycomb group RING finger protein 1, PCGF1, also known as NSPC1 or RNF68 is a RING finger domainprotein that in humans is encoded by the PCGF1gene.[5][6]
PCGF1 is a component defining the non-canonical polycomb repressive complex 1.1 (ncPRC1) interacting with RING1A/B, RYBP, BCOR and KDM2B. [7] PCGF1-BCOR assembles via the ubiquitin-like RAWUL domain of PCGF1 and is recruited on the chromatin at KDM2B sites.[8][9][10] Within the PRC1-like complex, PCGF1 regulates RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A, [11] which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression. [12][13][14]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000115289 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000069678 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nunes M, Blanc I, Maes J, Fellous M, Robert B, McElreavey K (April 2001). "NSPc1, a novel mammalian Polycomb gene, is expressed in neural crest-derived structures of the peripheral nervous system". Mechanisms of Development. 102 (1–2): 219–22. doi:10.1016/S0925-4773(01)00288-X. PMID 11287196. S2CID 8344430.
^"Entrez Gene: PCGF1 polycomb group ring finger 1".
^Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. (February 2012). "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes". Molecular Cell. 45 (3): 344–56. doi:10.1016/j.molcel.2012.01.002. PMC3293217. PMID 22325352.
^Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, et al. (October 2016). "KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1". Structure. 24 (10): 1795–1801. doi:10.1016/j.str.2016.07.011. PMC5088048. PMID 27568929.
^Junco SE, Wang R, Gaipa JC, Taylor AB, Schirf V, Gearhart MD, et al. (April 2013). "Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs". Structure. 21 (4): 665–71. doi:10.1016/j.str.2013.02.013. PMC4003909. PMID 23523425.
^Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, et al. (December 2012). Struhl K (ed.). "KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands". eLife. 1: e00205. doi:10.7554/eLife.00205. PMC3524939. PMID 23256043.
^Taherbhoy AM, Huang OW, Cochran AG (July 2015). "BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase". Nature Communications. 6: 7621. Bibcode:2015NatCo...6.7621T. doi:10.1038/ncomms8621. PMID 26151332.
^Tamburri S, Lavarone E, Fernández-Pérez D, Conway E, Zanotti M, Manganaro D, Pasini D (February 2020). "Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression". Molecular Cell. 77 (4): 840–856.e5. doi:10.1016/j.molcel.2019.11.021. PMC7033561. PMID 31883952.
^Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, et al. (June 2019). "Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression". Molecular Cell. 74 (5): 1020–1036.e8. doi:10.1016/j.molcel.2019.03.024. PMC6561741. PMID 31029541.
Valk-Lingbeek ME, Bruggeman SW, van Lohuizen M (August 2004). "Stem cells and cancer; the polycomb connection". Cell. 118 (4): 409–18. doi:10.1016/j.cell.2004.08.005. PMID 15315754. S2CID 16542938.
Gong Y, Yue J, Wu X, Wang X, Wen J, Lu L, et al. (2007). "NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1/Cip1 via the RARE element". Nucleic Acids Research. 34 (21): 6158–69. doi:10.1093/nar/gkl834. PMC1693893. PMID 17088287.
Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (September 2006). "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets". Molecular and Cellular Biology. 26 (18): 6880–9. doi:10.1128/MCB.00630-06. PMC1592854. PMID 16943429.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gong Y, Wang X, Liu J, Shi L, Yin B, Peng X, et al. (January 2005). "NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183". FEBS Letters. 579 (1): 115–21. doi:10.1016/j.febslet.2004.11.056. PMID 15620699. S2CID 28187618.
Sugishita H, Kondo T, Ito S, et al. (September 2021). "Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes". Nat Commun. 12 (5341): 5341. Bibcode:2021NatCo..12.5341S. doi:10.1038/s41467-021-24894-z. PMC8429492. PMID 34504070.
This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.
pcgf1, polycomb, group, ring, finger, protein, also, known, nspc1, rnf68, ring, finger, domain, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes4hpl, 4hpmidentifiersaliases, 2010002k04rik, nspc1, rnf3a, rnf6. Polycomb group RING finger protein 1 PCGF1 also known as NSPC1 or RNF68 is a RING finger domain protein that in humans is encoded by the PCGF1 gene 5 6 PCGF1Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes4HPL 4HPMIdentifiersAliasesPCGF1 2010002K04Rik NSPC1 RNF3A 2 RNF68 polycomb group ring finger 1External IDsOMIM 610231 MGI 1917087 HomoloGene 13090 GeneCards PCGF1Gene location Human Chr Chromosome 2 human 1 Band2p13 1Start74 505 043 bp 1 End74 507 695 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 C3 6 35 94 cMStart83 054 850 bp 2 End83 057 836 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocyteright lobe of liverpituitary glandbody of stomachbody of pancreasright uterine tubeanterior pituitarymonocyteleft lobe of thyroid glandTop expressed insecondary oocyteadrenal glandbone marrowmorulaolfactory bulbpancreasneural tubeislet of LangerhanstesticlecerebellumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionprotein C terminus binding protein binding metal ion binding promoter specific chromatin bindingCellular componentPcG protein complex nucleus nucleoplasm PRC1 complexBiological processhistone H2A monoubiquitination transcription DNA templated regulation of transcription DNA templated histone H2A K119 monoubiquitination negative regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8475969837EnsemblENSG00000115289ENSMUSG00000069678UniProtQ9BSM1Q8R023RefSeq mRNA NM 032673NM 197992RefSeq protein NP 116062NP 932109NP 001390487NP 001390488NP 001390489NP 001390490Location UCSC Chr 2 74 51 74 51 MbChr 6 83 05 83 06 MbPubMed search 3 4 WikidataView Edit HumanView Edit MousePCGF1 is a component defining the non canonical polycomb repressive complex 1 1 ncPRC1 interacting with RING1A B RYBP BCOR and KDM2B 7 PCGF1 BCOR assembles via the ubiquitin like RAWUL domain of PCGF1 and is recruited on the chromatin at KDM2B sites 8 9 10 Within the PRC1 like complex PCGF1 regulates RING1B ubiquitin ligase activity that catalyzes the ubiquitination of Lys119 on histone H2A 11 which then leads to recruitment of PRC2 and H3K27me3 to effectively initiate a polycomb domain and mediate gene repression 12 13 14 References edit a b c GRCh38 Ensembl release 89 ENSG00000115289 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000069678 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nunes M Blanc I Maes J Fellous M Robert B McElreavey K April 2001 NSPc1 a novel mammalian Polycomb gene is expressed in neural crest derived structures of the peripheral nervous system Mechanisms of Development 102 1 2 219 22 doi 10 1016 S0925 4773 01 00288 X PMID 11287196 S2CID 8344430 Entrez Gene PCGF1 polycomb group ring finger 1 Gao Z Zhang J Bonasio R Strino F Sawai A Parisi F et al February 2012 PCGF homologs CBX proteins and RYBP define functionally distinct PRC1 family complexes Molecular Cell 45 3 344 56 doi 10 1016 j molcel 2012 01 002 PMC 3293217 PMID 22325352 Wong SJ Gearhart MD Taylor AB Nanyes DR Ha DJ Robinson AK et al October 2016 KDM2B Recruitment of the Polycomb Group Complex PRC1 1 Requires Cooperation between PCGF1 and BCORL1 Structure 24 10 1795 1801 doi 10 1016 j str 2016 07 011 PMC 5088048 PMID 27568929 Junco SE Wang R Gaipa JC Taylor AB Schirf V Gearhart MD et al April 2013 Structure of the polycomb group protein PCGF1 in complex with BCOR reveals basis for binding selectivity of PCGF homologs Structure 21 4 665 71 doi 10 1016 j str 2013 02 013 PMC 4003909 PMID 23523425 Farcas AM Blackledge NP Sudbery I Long HK McGouran JF Rose NR et al December 2012 Struhl K ed KDM2B links the Polycomb Repressive Complex 1 PRC1 to recognition of CpG islands eLife 1 e00205 doi 10 7554 eLife 00205 PMC 3524939 PMID 23256043 Taherbhoy AM Huang OW Cochran AG July 2015 BMI1 RING1B is an autoinhibited RING E3 ubiquitin ligase Nature Communications 6 7621 Bibcode 2015NatCo 6 7621T doi 10 1038 ncomms8621 PMID 26151332 Tamburri S Lavarone E Fernandez Perez D Conway E Zanotti M Manganaro D Pasini D February 2020 Histone H2AK119 Mono Ubiquitination Is Essential for Polycomb Mediated Transcriptional Repression Molecular Cell 77 4 840 856 e5 doi 10 1016 j molcel 2019 11 021 PMC 7033561 PMID 31883952 Fursova NA Blackledge NP Nakayama M Ito S Koseki Y Farcas AM et al June 2019 Synergy between Variant PRC1 Complexes Defines Polycomb Mediated Gene Repression Molecular Cell 74 5 1020 1036 e8 doi 10 1016 j molcel 2019 03 024 PMC 6561741 PMID 31029541 Blackledge NP Farcas AM Kondo T King HW McGouran JF Hanssen LL et al June 2014 Variant PRC1 complex dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation Cell 157 6 1445 1459 doi 10 1016 j cell 2014 05 004 PMC 4048464 PMID 24856970 Further reading editValk Lingbeek ME Bruggeman SW van Lohuizen M August 2004 Stem cells and cancer the polycomb connection Cell 118 4 409 18 doi 10 1016 j cell 2004 08 005 PMID 15315754 S2CID 16542938 Gong Y Yue J Wu X Wang X Wen J Lu L et al 2007 NSPc1 is a cell growth regulator that acts as a transcriptional repressor of p21Waf1 Cip1 via the RARE element Nucleic Acids Research 34 21 6158 69 doi 10 1093 nar gkl834 PMC 1693893 PMID 17088287 Gearhart MD Corcoran CM Wamstad JA Bardwell VJ September 2006 Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets Molecular and Cellular Biology 26 18 6880 9 doi 10 1128 MCB 00630 06 PMC 1592854 PMID 16943429 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N et al October 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Gong Y Wang X Liu J Shi L Yin B Peng X et al January 2005 NSPc1 a mainly nuclear localized protein of novel PcG family members has a transcription repression activity related to its PKC phosphorylation site at S183 FEBS Letters 579 1 115 21 doi 10 1016 j febslet 2004 11 056 PMID 15620699 S2CID 28187618 Sugishita H Kondo T Ito S et al September 2021 Variant PCGF1 PRC1 links PRC2 recruitment with differentiation associated transcriptional inactivation at target genes Nat Commun 12 5341 5341 Bibcode 2021NatCo 12 5341S doi 10 1038 s41467 021 24894 z PMC 8429492 PMID 34504070 nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title PCGF1 amp oldid 1188052543, wikipedia, wiki, book, books, library,
