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Wikipedia

KDM2B

January 01, 1970

The human KDM2B gene encodes the protein lysine (K)-specific demethylase 2B.[5]

KDM2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKDM2B, CXXC2, FBXL10, Fbl10, JHDM1B, PCCX2, lysine demethylase 2B
External IDsOMIM: 609078; MGI: 1354737; HomoloGene: 13069; GeneCards: KDM2B; OMA:KDM2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

84678

30841

Ensembl

ENSG00000089094

ENSMUSG00000029475

UniProt

Q8NHM5

Q6P1G2

RefSeq (mRNA)

NM_001005366
NM_032590

RefSeq (protein)

NP_001005366
NP_115979

NP_001003953
NP_038938
NP_001365792
NP_001365793
NP_001365794

Location (UCSC)Chr 12: 121.43 – 121.58 MbChr 5: 123.01 – 123.13 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tissue and subcellular distribution edit

KDM2B is broadly and highly expressed in embryonic tissues (especially in the developing central nervous system of vertebrates). Expression of KDM2B is also retained in most organs in adults.[6] The protein is present in the nucleoplasm and is enriched in the nucleolus where it binds the transcribed region of ribosomal RNA to represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation.[7]

Structure edit

KDM2B protein has several domains including a JmjC domain that has a histone demethylase activity demethylating trimethylated Lys-4 and dimethylated Lys-36 of histone H3.[8][7] KDM2B specifically recognizes and bind non-methylated DNA in CpG islands through its ZF-CxxC DNA binding domain.[9] KDM2B consequently recruits the non-canonical polycomb repressive complex 1.1 (ncPRC1) to unmethylated CpG islands via a direct interaction with BCOR and PCGF1[10] leading to the mono-ubiquitylation of histone H2A on K119 and gene repression.[11][12][13][14][15]

Function edit

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.[5]

As part of the ncPRC1.1 complex, KDM2B was found to be rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELESS-dependent manner to promote mono-ubiquitylation of histone H2A on K119 with concomitant local decrease of H2A levels and an increase of H2A.Z. These events promote transcriptional repression at DNA lesions, double strand break signaling, and homologous recombination repair. The activity of the ncPRC1.1 complex at DNA lesions was necessary for the proper recruitment of the two canonical PRC1 complexes (cPRC1.2 and cPRC1.4), defined by their PCGF subunits, MEL18 and BMI1 respectively. Therefore, recruitment of the ncPRC1.1 complex represents an early and critical regulatory step in homologous recombination repair.[16]

Clinical significance edit

Loss of KDM2B leads to severe developmental defects (growth defects in the brain, including failure of neural tube closure and craniofacial malformations, hematopoietic development) leading to embryonic lethality[17]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000089094 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029475 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Lysine (K)-specific demethylase 2B".
  6. ^ Saritas-Yildirim B, Pliner HA, Ochoa A, Silva EM (2015). "Genome-Wide Identification and Expression of Xenopus F-Box Family of Proteins". PLOS ONE. 10 (9): e0136929. Bibcode:2015PLoSO..1036929S. doi:10.1371/journal.pone.0136929. PMC 4556705. PMID 26327321.
  7. ^ a b Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M (November 2007). "JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes". Nature. 450 (7167): 309–13. Bibcode:2007Natur.450..309F. doi:10.1038/nature06255. PMID 17994099. S2CID 4325942.
  8. ^ Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (February 2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature. 439 (7078): 811–6. Bibcode:2006Natur.439..811T. doi:10.1038/nature04433. PMID 16362057. S2CID 4415889.
  9. ^ Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, et al. (December 2012). Struhl K (ed.). "KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands". eLife. 1: e00205. doi:10.7554/eLife.00205. PMC 3524939. PMID 23256043.
  10. ^ Wong SJ, Gearhart MD, Taylor AB, Nanyes DR, Ha DJ, Robinson AK, et al. (October 2016). "KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1". Structure. 24 (10): 1795–1801. doi:10.1016/j.str.2016.07.011. PMC 5088048. PMID 27568929.
  11. ^ Gao Z, Zhang J, Bonasio R, Strino F, Sawai A, Parisi F, et al. (February 2012). "PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes". Molecular Cell. 45 (3): 344–56. doi:10.1016/j.molcel.2012.01.002. PMC 3293217. PMID 22325352.
  12. ^ Sánchez C, Sánchez I, Demmers JA, Rodriguez P, Strouboulis J, Vidal M (May 2007). "Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor". Molecular & Cellular Proteomics. 6 (5): 820–34. doi:10.1074/mcp.M600275-MCP200. PMID 17296600.
  13. ^ Gearhart MD, Corcoran CM, Wamstad JA, Bardwell VJ (September 2006). "Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets". Molecular and Cellular Biology. 26 (18): 6880–9. doi:10.1128/MCB.00630-06. PMC 1592854. PMID 16943429.
  14. ^ Andricovich J, Kai Y, Peng W, Foudi A, Tzatsos A (March 2016). "Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis". The Journal of Clinical Investigation. 126 (3): 905–20. doi:10.1172/JCI84014. PMC 4767361. PMID 26808549.
  15. ^ Tamburri S, Lavarone E, Fernández-Pérez D, Conway E, Zanotti M, Manganaro D, Pasini D (February 2020). "Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression". Molecular Cell. 77 (4): 840–856.e5. doi:10.1016/j.molcel.2019.11.021. PMC 7033561. PMID 31883952.
  16. ^ Rona G, Roberti D, Yin Y, Pagan JK, Homer H, Sassani E, Zeke A, Busino L, Rothenberg E, Pagano M (July 2018). "PARP1-dependent recruitment of the FBXL10-RNF68-RNF2 ubiquitin ligase to sites of DNA damage controls H2A.Z loading". eLife. 7. doi:10.7554/eLife.38771. PMC 6037479. PMID 29985131.
  17. ^ Boulard, M; Edwards, JR; Bestor, TH (May 2015). "FBXL10 protects Polycomb-bound genes from hypermethylation". Nature Genetics. 45 (5): 479–485. doi:10.1038/ng.3272. PMID 25848754. S2CID 205349859.

Further reading edit

  • Fujino T, Hasegawa M, Shibata S, Kishimoto T, Imai S, Takano T (May 2000). "PCCX1, a novel DNA-binding protein with PHD finger and CXXC domain, is regulated by proteolysis". Biochemical and Biophysical Research Communications. 271 (2): 305–10. doi:10.1006/bbrc.2000.2614. PMID 10799292.
  • Tzatsos A, Paskaleva P, Ferrari F, Deshpande V, Stoykova S, Contino G, Wong KK, Lan F, Trojer P, Park PJ, Bardeesy N (February 2013). "KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs". The Journal of Clinical Investigation. 123 (2): 727–39. doi:10.1172/JCI64535. PMC 3561797. PMID 23321669.
  • Tzatsos A, Pfau R, Kampranis SC, Tsichlis PN (February 2009). "Ndy1/KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a/Arf locus". Proceedings of the National Academy of Sciences of the United States of America. 106 (8): 2641–6. Bibcode:2009PNAS..106.2641T. doi:10.1073/pnas.0813139106. PMC 2650317. PMID 19202064.
  • Janzer A, Stamm K, Becker A, Zimmer A, Buettner R, Kirfel J (September 2012). "The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts". The Journal of Biological Chemistry. 287 (37): 30984–92. doi:10.1074/jbc.M112.341040. PMC 3438931. PMID 22825849.
  • Frescas D, Guardavaccaro D, Bassermann F, Koyama-Nasu R, Pagano M (November 2007). "JHDM1B/FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes". Nature. 450 (7167): 309–13. Bibcode:2007Natur.450..309F. doi:10.1038/nature06255. PMID 17994099. S2CID 4325942.
  • Koyama-Nasu R, David G, Tanese N (September 2007). "The F-box protein Fbl10 is a novel transcriptional repressor of c-Jun". Nature Cell Biology. 9 (9): 1074–80. doi:10.1038/ncb1628. PMID 17704768. S2CID 30551299.
  • Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology. 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.
  • Tsukada Y, Fang J, Erdjument-Bromage H, Warren ME, Borchers CH, Tempst P, Zhang Y (February 2006). "Histone demethylation by a family of JmjC domain-containing proteins". Nature. 439 (7078): 811–6. Bibcode:2006Natur.439..811T. doi:10.1038/nature04433. PMID 16362057. S2CID 4415889.
  • Ge R, Wang Z, Zeng Q, Xu X, Olumi AF (July 2011). "F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway". Cell Death and Differentiation. 18 (7): 1184–95. doi:10.1038/cdd.2010.185. PMC 3131965. PMID 21252908.

External links edit

  • Overview of all the structural information available in the PDB for UniProt: Q8NHM5 (Lysine-specific demethylase 2B) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
kdm2b, human, gene, encodes, protein, lysine, specific, demethylase, available, structurespdbortholog, search, pdbe, rcsblist, codes4o64identifiersaliases, cxxc2, fbxl10, fbl10, jhdm1b, pccx2, lysine, demethylase, 2bexternal, idsomim, 609078, 1354737, homologe. The human KDM2B gene encodes the protein lysine K specific demethylase 2B 5 KDM2BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes4O64IdentifiersAliasesKDM2B CXXC2 FBXL10 Fbl10 JHDM1B PCCX2 lysine demethylase 2BExternal IDsOMIM 609078 MGI 1354737 HomoloGene 13069 GeneCards KDM2B OMA KDM2B orthologsGene location Human Chr Chromosome 12 human 1 Band12q24 31Start121 429 096 bp 1 End121 581 023 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 FStart123 008 728 bp 2 End123 127 886 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inganglionic eminencecerebellar vermisthymusmonocytetibialis anterior musclelymph nodeappendixtibiasuperficial temporal arterypancreatic ductal cellTop expressed inganglionic eminencesecondary oocytespermatocytemorulaspermatidmesencephalonneural tubeliptesticleplacentaMore reference expression dataBioGPSn aGene ontologyMolecular functionDNA binding rRNA binding zinc ion binding dioxygenase activity metal ion binding histone demethylase activity protein binding histone H3 methyl lysine 36 demethylase activity RNA binding oxidoreductase activity RNA polymerase II cis regulatory region sequence specific DNA bindingCellular componentnucleoplasm nucleolus PcG protein complex nucleus chromosomeBiological processnegative regulation of neuron apoptotic process midbrain hindbrain boundary morphogenesis regulation of transcription DNA templated lateral ventricle development histone H2A monoubiquitination negative regulation of neural precursor cell proliferation hindbrain development negative regulation of transcription by RNA polymerase II transcription DNA templated third ventricle development positive regulation of cell growth embryonic camera type eye morphogenesis histone H3 K36 demethylation spermatogenesis forebrain development positive regulation of stem cell population maintenance initiation of neural tube closure midbrain development fourth ventricle development chromatin organizationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez8467830841EnsemblENSG00000089094ENSMUSG00000029475UniProtQ8NHM5Q6P1G2RefSeq mRNA NM 001005366NM 032590NM 001003953NM 001005866NM 013910NM 001378863NM 001378864NM 001378865RefSeq protein NP 001005366NP 115979NP 001003953NP 038938NP 001365792NP 001365793NP 001365794Location UCSC Chr 12 121 43 121 58 MbChr 5 123 01 123 13 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Tissue and subcellular distribution 2 Structure 3 Function 4 Clinical significance 5 References 6 Further reading 7 External linksTissue and subcellular distribution editKDM2B is broadly and highly expressed in embryonic tissues especially in the developing central nervous system of vertebrates Expression of KDM2B is also retained in most organs in adults 6 The protein is present in the nucleoplasm and is enriched in the nucleolus where it binds the transcribed region of ribosomal RNA to represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation 7 Structure editKDM2B protein has several domains including a JmjC domain that has a histone demethylase activity demethylating trimethylated Lys 4 and dimethylated Lys 36 of histone H3 8 7 KDM2B specifically recognizes and bind non methylated DNA in CpG islands through its ZF CxxC DNA binding domain 9 KDM2B consequently recruits the non canonical polycomb repressive complex 1 1 ncPRC1 to unmethylated CpG islands via a direct interaction with BCOR and PCGF1 10 leading to the mono ubiquitylation of histone H2A on K119 and gene repression 11 12 13 14 15 Function editThis gene encodes a member of the F box protein family which is characterized by an approximately 40 amino acid motif the F box The F box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs SKP1 cullin F box which function in phosphorylation dependent ubiquitination The F box proteins are divided into 3 classes Fbws containing WD 40 domains Fbls containing leucine rich repeats and Fbxs containing either different protein protein interaction modules or no recognizable motifs The protein encoded by this gene belongs to the Fbls class Multiple alternatively spliced transcript variants have been found for this gene but the full length nature of some variants has not been determined 5 As part of the ncPRC1 1 complex KDM2B was found to be rapidly and transiently recruited to sites of DNA damage in a PARP1 and TIMELESS dependent manner to promote mono ubiquitylation of histone H2A on K119 with concomitant local decrease of H2A levels and an increase of H2A Z These events promote transcriptional repression at DNA lesions double strand break signaling and homologous recombination repair The activity of the ncPRC1 1 complex at DNA lesions was necessary for the proper recruitment of the two canonical PRC1 complexes cPRC1 2 and cPRC1 4 defined by their PCGF subunits MEL18 and BMI1 respectively Therefore recruitment of the ncPRC1 1 complex represents an early and critical regulatory step in homologous recombination repair 16 Clinical significance editLoss of KDM2B leads to severe developmental defects growth defects in the brain including failure of neural tube closure and craniofacial malformations hematopoietic development leading to embryonic lethality 17 References edit a b c GRCh38 Ensembl release 89 ENSG00000089094 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029475 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene Lysine K specific demethylase 2B Saritas Yildirim B Pliner HA Ochoa A Silva EM 2015 Genome Wide Identification and Expression of Xenopus F Box Family of Proteins PLOS ONE 10 9 e0136929 Bibcode 2015PLoSO 1036929S doi 10 1371 journal pone 0136929 PMC 4556705 PMID 26327321 a b Frescas D Guardavaccaro D Bassermann F Koyama Nasu R Pagano M November 2007 JHDM1B FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes Nature 450 7167 309 13 Bibcode 2007Natur 450 309F doi 10 1038 nature06255 PMID 17994099 S2CID 4325942 Tsukada Y Fang J Erdjument Bromage H Warren ME Borchers CH Tempst P Zhang Y February 2006 Histone demethylation by a family of JmjC domain containing proteins Nature 439 7078 811 6 Bibcode 2006Natur 439 811T doi 10 1038 nature04433 PMID 16362057 S2CID 4415889 Farcas AM Blackledge NP Sudbery I Long HK McGouran JF Rose NR et al December 2012 Struhl K ed KDM2B links the Polycomb Repressive Complex 1 PRC1 to recognition of CpG islands eLife 1 e00205 doi 10 7554 eLife 00205 PMC 3524939 PMID 23256043 Wong SJ Gearhart MD Taylor AB Nanyes DR Ha DJ Robinson AK et al October 2016 KDM2B Recruitment of the Polycomb Group Complex PRC1 1 Requires Cooperation between PCGF1 and BCORL1 Structure 24 10 1795 1801 doi 10 1016 j str 2016 07 011 PMC 5088048 PMID 27568929 Gao Z Zhang J Bonasio R Strino F Sawai A Parisi F et al February 2012 PCGF homologs CBX proteins and RYBP define functionally distinct PRC1 family complexes Molecular Cell 45 3 344 56 doi 10 1016 j molcel 2012 01 002 PMC 3293217 PMID 22325352 Sanchez C Sanchez I Demmers JA Rodriguez P Strouboulis J Vidal M May 2007 Proteomics analysis of Ring1B Rnf2 interactors identifies a novel complex with the Fbxl10 Jhdm1B histone demethylase and the Bcl6 interacting corepressor Molecular amp Cellular Proteomics 6 5 820 34 doi 10 1074 mcp M600275 MCP200 PMID 17296600 Gearhart MD Corcoran CM Wamstad JA Bardwell VJ September 2006 Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets Molecular and Cellular Biology 26 18 6880 9 doi 10 1128 MCB 00630 06 PMC 1592854 PMID 16943429 Andricovich J Kai Y Peng W Foudi A Tzatsos A March 2016 Histone demethylase KDM2B regulates lineage commitment in normal and malignant hematopoiesis The Journal of Clinical Investigation 126 3 905 20 doi 10 1172 JCI84014 PMC 4767361 PMID 26808549 Tamburri S Lavarone E Fernandez Perez D Conway E Zanotti M Manganaro D Pasini D February 2020 Histone H2AK119 Mono Ubiquitination Is Essential for Polycomb Mediated Transcriptional Repression Molecular Cell 77 4 840 856 e5 doi 10 1016 j molcel 2019 11 021 PMC 7033561 PMID 31883952 Rona G Roberti D Yin Y Pagan JK Homer H Sassani E Zeke A Busino L Rothenberg E Pagano M July 2018 PARP1 dependent recruitment of the FBXL10 RNF68 RNF2 ubiquitin ligase to sites of DNA damage controls H2A Z loading eLife 7 doi 10 7554 eLife 38771 PMC 6037479 PMID 29985131 Boulard M Edwards JR Bestor TH May 2015 FBXL10 protects Polycomb bound genes from hypermethylation Nature Genetics 45 5 479 485 doi 10 1038 ng 3272 PMID 25848754 S2CID 205349859 Further reading editFujino T Hasegawa M Shibata S Kishimoto T Imai S Takano T May 2000 PCCX1 a novel DNA binding protein with PHD finger and CXXC domain is regulated by proteolysis Biochemical and Biophysical Research Communications 271 2 305 10 doi 10 1006 bbrc 2000 2614 PMID 10799292 Tzatsos A Paskaleva P Ferrari F Deshpande V Stoykova S Contino G Wong KK Lan F Trojer P Park PJ Bardeesy N February 2013 KDM2B promotes pancreatic cancer via Polycomb dependent and independent transcriptional programs The Journal of Clinical Investigation 123 2 727 39 doi 10 1172 JCI64535 PMC 3561797 PMID 23321669 Tzatsos A Pfau R Kampranis SC Tsichlis PN February 2009 Ndy1 KDM2B immortalizes mouse embryonic fibroblasts by repressing the Ink4a Arf locus Proceedings of the National Academy of Sciences of the United States of America 106 8 2641 6 Bibcode 2009PNAS 106 2641T doi 10 1073 pnas 0813139106 PMC 2650317 PMID 19202064 Janzer A Stamm K Becker A Zimmer A Buettner R Kirfel J September 2012 The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression cellular morphology and the metabolome of fibroblasts The Journal of Biological Chemistry 287 37 30984 92 doi 10 1074 jbc M112 341040 PMC 3438931 PMID 22825849 Frescas D Guardavaccaro D Bassermann F Koyama Nasu R Pagano M November 2007 JHDM1B FBXL10 is a nucleolar protein that represses transcription of ribosomal RNA genes Nature 450 7167 309 13 Bibcode 2007Natur 450 309F doi 10 1038 nature06255 PMID 17994099 S2CID 4325942 Koyama Nasu R David G Tanese N September 2007 The F box protein Fbl10 is a novel transcriptional repressor of c Jun Nature Cell Biology 9 9 1074 80 doi 10 1038 ncb1628 PMID 17704768 S2CID 30551299 Szafranski K Schindler S Taudien S Hiller M Huse K Jahn N Schreiber S Backofen R Platzer M 2007 Violating the splicing rules TG dinucleotides function as alternative 3 splice sites in U2 dependent introns Genome Biology 8 8 R154 doi 10 1186 gb 2007 8 8 r154 PMC 2374985 PMID 17672918 Tsukada Y Fang J Erdjument Bromage H Warren ME Borchers CH Tempst P Zhang Y February 2006 Histone demethylation by a family of JmjC domain containing proteins Nature 439 7078 811 6 Bibcode 2006Natur 439 811T doi 10 1038 nature04433 PMID 16362057 S2CID 4415889 Ge R Wang Z Zeng Q Xu X Olumi AF July 2011 F box protein 10 an NF kB dependent anti apoptotic protein regulates TRAIL induced apoptosis through modulating c Fos c FLIP pathway Cell Death and Differentiation 18 7 1184 95 doi 10 1038 cdd 2010 185 PMC 3131965 PMID 21252908 External links editOverview of all the structural information available in the PDB for UniProt Q8NHM5 Lysine specific demethylase 2B at the PDBe KB This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 12 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title KDM2B amp oldid 1187731330, wikipedia, wiki, book, books, library,

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