OIH was first labelled with 131I by Tubis and colleagues (Tubis, Posnick and Nordyke in 1960) and for many years this was the only radiopharmaceutical for renography. 131I has a half-life of 8 days and emits high-energy γ rays (364 keV) in addition to β particles. These physical characteristics were acceptable for probe studies when quantities of the order 1-2 MBq (25-50 μCi) were administered, but they are far from ideal for γ-camera studies which demand a higher activity and a γ ray emission of lower energy. The introduction of OIH labelled with 123I, with its short physical half-life (13 hours) and its gamma emission of 159 keV has greatly improved the diagnostic potential of renal studies by combining the production of high-quality functional images with the ability to derive a renogram. The only factor limiting its widespread use is restricted availability and the expense involved in its cyclotron production.[2]
Referencesedit
^Pubchem. "Compound Summary for CID 8614: 2-Iodohippuric acid". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Testa HJ (22 October 2013). "Radiopharmaceuticals". In O'Reilly PH, Shields RA, Testa HJ (eds.). Nuclear Medicine in Urology and Nephrology (2nd ed.). Butterworth-Heinemann. p. 239. ISBN978-1483162416.
April 13, 2024
ortho, iodohippuric, acid, ortho, iodohippurate, analog, aminohippuric, acid, determination, effective, renal, plasma, flow, labelled, significantly, higher, clearance, than, other, radiopharmaceutical, developed, eminently, suitable, renography, eliminated, m. ortho Iodohippuric acid ortho iodohippurate OIH is an analog of p aminohippuric acid for the determination of effective renal plasma flow Labelled OIH has a significantly higher clearance than other radiopharmaceutical yet developed and is eminently suitable for renography It is eliminated mainly by tubular secretion In patients with normally functioning kidneys 85 of the OIH may be found in the urine 30 minutes after intravenous injection ortho Iodohippuric acidClinical dataOther namesIodohippuric acid I Hippuran I OIH I Hippuran I OIH Iodobenzoylglycine Sodium iodohippurate Sodium o iodohippurate ortho Iodohippurate ortho Iodohippurate Orthoiodohippurate Radio Hippuran Radio Hippuran RadioHippuran Sodium Iodohippurate 1 Routes ofadministrationintravenousPharmacokinetic dataExcretionrenalIdentifiersIUPAC name 2 2 Iodobenzoyl amino acetic acidCAS Number147 58 0PubChem CID8614ChemSpider8295UNII3Y68K91A3MCompTox Dashboard EPA DTXSID8046161ECHA InfoCard100 005 176Chemical and physical dataFormulaC 9H 8I N O 3Molar mass305 071 g mol 13D model JSmol Interactive imageSMILES C1 CC C C C1 C O NCC O O IInChI InChI 1S C9H8INO3 c10 7 4 2 1 3 6 7 9 14 11 5 8 12 13 h1 4H 5H2 H 11 14 H 12 13 Key CORFWQGVBFFZHF UHFFFAOYSA NOIH was first labelled with 131I by Tubis and colleagues Tubis Posnick and Nordyke in 1960 and for many years this was the only radiopharmaceutical for renography 131I has a half life of 8 days and emits high energy g rays 364 keV in addition to b particles These physical characteristics were acceptable for probe studies when quantities of the order 1 2 MBq 25 50 mCi were administered but they are far from ideal for g camera studies which demand a higher activity and a g ray emission of lower energy The introduction of OIH labelled with 123I with its short physical half life 13 hours and its gamma emission of 159 keV has greatly improved the diagnostic potential of renal studies by combining the production of high quality functional images with the ability to derive a renogram The only factor limiting its widespread use is restricted availability and the expense involved in its cyclotron production 2 References edit Pubchem Compound Summary for CID 8614 2 Iodohippuric acid National Center for Biotechnology Information U S National Library of Medicine Testa HJ 22 October 2013 Radiopharmaceuticals In O Reilly PH Shields RA Testa HJ eds Nuclear Medicine in Urology and Nephrology 2nd ed Butterworth Heinemann p 239 ISBN 978 1483162416 Retrieved from https en wikipedia org w index php title Ortho Iodohippuric acid amp oldid 1203340648, wikipedia, wiki, book, books, library,
