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ORAI2

January 01, 1970

Protein orai-2 is a protein that in humans is encoded by the ORAI2 gene.[5][6]

ORAI2
Identifiers
AliasesORAI2, C7orf19, CBCIP2, MEM142B, TMEM142B, ORAI calcium release-activated calcium modulator 2
External IDsOMIM: 610929; MGI: 2443195; HomoloGene: 32799; GeneCards: ORAI2; OMA:ORAI2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

80228

269717

Ensembl

ENSG00000160991

ENSMUSG00000039747

UniProt

Q96SN7

Q8BH10

RefSeq (mRNA)

NM_032831
NM_001126340
NM_001271818
NM_001271819

NM_178751

RefSeq (protein)

NP_001119812
NP_001258747
NP_001258748
NP_116220

NP_848866

Location (UCSC)Chr 7: 102.43 – 102.46 MbChr 5: 136.18 – 136.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039747 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, Hogan PG, Lewis RS, Daly M, Rao A (May 2006). "A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function". Nature. 441 (7090): 179–85. Bibcode:2006Natur.441..179F. doi:10.1038/nature04702. PMID 16582901. S2CID 1605392.
  6. ^ "Entrez Gene: TMEM142B transmembrane protein 142B".

Further reading edit

  • DeHaven WI, Smyth JT, Boyles RR, Putney JW (2007). "Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels". J. Biol. Chem. 282 (24): 17548–56. doi:10.1074/jbc.M611374200. PMID 17452328.
  • Mercer JC, Dehaven WI, Smyth JT, et al. (2006). "Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1". J. Biol. Chem. 281 (34): 24979–90. doi:10.1074/jbc.M604589200. PMC 1633822. PMID 16807233.
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.


 

This protein-related article is a stub. You can help Wikipedia by expanding it.

January 01, 1970
orai2, protein, orai, protein, that, humans, encoded, gene, identifiersaliases, c7orf19, cbcip2, mem142b, tmem142b, orai, calcium, release, activated, calcium, modulator, 2external, idsomim, 610929, 2443195, homologene, 32799, genecards, orthologsgene, locatio. Protein orai 2 is a protein that in humans is encoded by the ORAI2 gene 5 6 ORAI2IdentifiersAliasesORAI2 C7orf19 CBCIP2 MEM142B TMEM142B ORAI calcium release activated calcium modulator 2External IDsOMIM 610929 MGI 2443195 HomoloGene 32799 GeneCards ORAI2 OMA ORAI2 orthologsGene location Human Chr Chromosome 7 human 1 Band7q22 1Start102 433 106 bp 1 End102 456 825 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 G2Start136 176 313 bp 2 End136 199 567 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inrenal medullaventral tegmental areapylorussuperior vestibular nucleusnippleinferior ganglion of vagus nervesuperior surface of tonguetrigeminal ganglionpericardiumsubthalamic nucleusTop expressed indentate gyrushippocampus propersuperior frontal gyruspiriform cortexthymusolfactory tuberclecerebellar cortexmolarlipbloodMore reference expression dataBioGPSn aGene ontologyMolecular functionstore operated calcium channel activity protein bindingCellular componentgrowth cone integral component of membrane membraneBiological processstore operated calcium entry calcium ion transmembrane transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez80228269717EnsemblENSG00000160991ENSMUSG00000039747UniProtQ96SN7Q8BH10RefSeq mRNA NM 032831NM 001126340NM 001271818NM 001271819NM 178751RefSeq protein NP 001119812NP 001258747NP 001258748NP 116220NP 848866Location UCSC Chr 7 102 43 102 46 MbChr 5 136 18 136 2 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseReferences edit a b c GRCh38 Ensembl release 89 ENSG00000160991 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000039747 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Feske S Gwack Y Prakriya M Srikanth S Puppel SH Tanasa B Hogan PG Lewis RS Daly M Rao A May 2006 A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function Nature 441 7090 179 85 Bibcode 2006Natur 441 179F doi 10 1038 nature04702 PMID 16582901 S2CID 1605392 Entrez Gene TMEM142B transmembrane protein 142B Further reading editDeHaven WI Smyth JT Boyles RR Putney JW 2007 Calcium inhibition and calcium potentiation of Orai1 Orai2 and Orai3 calcium release activated calcium channels J Biol Chem 282 24 17548 56 doi 10 1074 jbc M611374200 PMID 17452328 Mercer JC Dehaven WI Smyth JT et al 2006 Large Store operated Calcium Selective Currents Due to Co expression of Orai1 or Orai2 with the Intracellular Calcium Sensor Stim1 J Biol Chem 281 34 24979 90 doi 10 1074 jbc M604589200 PMC 1633822 PMID 16807233 Wan D Gong Y Qin W et al 2004 Large scale cDNA transfection screening for genes related to cancer development and progression Proc Natl Acad Sci U S A 101 44 15724 9 Bibcode 2004PNAS 10115724W doi 10 1073 pnas 0404089101 PMC 524842 PMID 15498874 Gerhard DS Wagner L Feingold EA et al 2004 The Status Quality and Expansion of the NIH Full Length cDNA Project The Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Hillier LW Fulton RS Fulton LA et al 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 lt Please add first missing authors to populate metadata gt 1999 Toward a complete human genome sequence Genome Res 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 nbsp This protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title ORAI2 amp oldid 1142711986, wikipedia, wiki, book, books, library,

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