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Sodium–hydrogen antiporter

January 01, 1970

The sodium–hydrogen antiporter or sodium–proton exchanger (Na+/H+ exchanger or NHX) is a membrane protein that transports Na+ into the cell, and H+ out of the cell (antiport).

Na+/H+ antiporter 1
Identifiers
SymbolNa_H_antiport_1
PfamPF06965
InterProIPR004670
TCDB2.A.36
OPM superfamily106
OPM protein1zcd
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Function edit

They are found in the membranes of many cells, and especially in those of the nephron of the kidney, specifically in the intercalary cells of the collecting duct and in the epithelial cells of the proximal convoluted tubule. The membrane pump is primarily responsible for maintaining homeostasis of pH and sodium.[1] Defects in Na+/H+ antiporters may result in heart or kidney failure.[2] Angiotensin II upregulates this antiporter in the proximal convoluted tubule in order to promote Na+ reabsorption and H+ secretion. Na+/H+ exchangers are thought to be implicated in other disorders such as hypertension. In one study, transgenic mice over expressing this membrane protein were shown to have increased reabsorption and retention of sodium after increased salt intake.[3]

In dopamine receptor signalling,[4] the widely expressed Na+/H+ exchanger NHE-1 is activated downstream of the D2,[5] D3,[6][7] and D4 receptors.[8]

Isoforms edit

There are several isoforms of the antiporter:

Families edit

There are several families of sodium/proton antiporters that facilitate the exchange of sodium ions with protons across the lipid membrane. Some of them include:[9]

References edit

  1. ^ Padan E, Landau M (2016). "Chapter 12: Sodium-Proton (Na+/H+) Antiporters:Properties and Roles in Health and Disease". In Sigel A, Sigel H, Sigel RK (eds.). The Alkali Metal Ions: Their Role in Life. Metal Ions in Life Sciences. Vol. 16. Springer. pp. 391–458. doi:10.1007/978-3-319-21756-7_12. ISBN 978-3-319-21755-0. PMID 26860308.
  2. ^ Bobulescu IA, Moe OW (September 2006). "Na+/H+ exchangers in renal regulation of acid-base balance". Seminars in Nephrology. 26 (5): 334–44. doi:10.1016/j.semnephrol.2006.07.001. PMC 2878276. PMID 17071327.
  3. ^ Kuro-o, M (January 1995). "Salt-sensitive hypertension in transgenic mice overexpressing Na(+)-proton exchanger". Circulation Research. 76 (1): 148–153. doi:10.1161/01.res.76.1.148. PMID 8001273.
  4. ^ Yun CH, Tse CM, Nath SK, Levine SA, Brant SR, Donowitz M (July 1995). "Mammalian Na+/H+ exchanger gene family: structure and function studies". The American Journal of Physiology. 269 (1 Pt 1): G1–11. doi:10.1152/ajpgi.1995.269.1.G1. PMID 7631785.
  5. ^ Neve KA, Kozlowski MR, Rosser MP (December 1992). "Dopamine D2 receptor stimulation of Na+/H+ exchange assessed by quantification of extracellular acidification". The Journal of Biological Chemistry. 267 (36): 25748–53. PMID 1361188.
  6. ^ Cox BA, Rosser MP, Kozlowski MR, Duwe KM, Neve RL, Neve KA (September 1995). "Regulation and functional characterization of a rat recombinant dopamine D3 receptor". Synapse. 21 (1): 1–9. doi:10.1002/syn.890210102. PMID 8525456.
  7. ^ Chio CL, Lajiness ME, Huff RM (January 1994). "Activation of heterologously expressed D3 dopamine receptors: comparison with D2 dopamine receptors". Molecular Pharmacology. 45 (1): 51–60. PMID 8302280.
  8. ^ Chio CL, Drong RF, Riley DT, Gill GS, Slightom JL, Huff RM (April 1994). "D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells". The Journal of Biological Chemistry. 269 (16): 11813–9. PMID 7512953.
  9. ^ "TCDB » HOME". Transporter Classification Database. Retrieved 2016-03-14.

External links edit

This article incorporates text from the public domain Pfam and InterPro: IPR004670


 

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

January 01, 1970
sodium, hydrogen, antiporter, sodium, hydrogen, antiporter, sodium, proton, exchanger, exchanger, membrane, protein, that, transports, into, cell, cell, antiport, antiporter, 1identifierssymbolna, antiport, 1pfampf06965interproipr004670tcdb2, 36opm, superfamil. The sodium hydrogen antiporter or sodium proton exchanger Na H exchanger or NHX is a membrane protein that transports Na into the cell and H out of the cell antiport Na H antiporter 1IdentifiersSymbolNa H antiport 1PfamPF06965InterProIPR004670TCDB2 A 36OPM superfamily106OPM protein1zcdAvailable protein structures Pfam structures ECOD PDBRCSB PDB PDBe PDBjPDBsumstructure summary Contents 1 Function 2 Isoforms 3 Families 4 References 5 External linksFunction editThey are found in the membranes of many cells and especially in those of the nephron of the kidney specifically in the intercalary cells of the collecting duct and in the epithelial cells of the proximal convoluted tubule The membrane pump is primarily responsible for maintaining homeostasis of pH and sodium 1 Defects in Na H antiporters may result in heart or kidney failure 2 Angiotensin II upregulates this antiporter in the proximal convoluted tubule in order to promote Na reabsorption and H secretion Na H exchangers are thought to be implicated in other disorders such as hypertension In one study transgenic mice over expressing this membrane protein were shown to have increased reabsorption and retention of sodium after increased salt intake 3 In dopamine receptor signalling 4 the widely expressed Na H exchanger NHE 1 is activated downstream of the D2 5 D3 6 7 and D4 receptors 8 Isoforms editThere are several isoforms of the antiporter Sodium hydrogen antiporter 1 Sodium hydrogen antiporter 2 Sodium hydrogen antiporter 3 Sodium hydrogen antiporter 4 Sodium hydrogen antiporter 5 Sodium hydrogen antiporter 6 Sodium hydrogen antiporter 7 Sodium hydrogen antiporter 8 Sodium hydrogen antiporter 9Families editThere are several families of sodium proton antiporters that facilitate the exchange of sodium ions with protons across the lipid membrane Some of them include 9 TC 2 A 33 Na H Antiporter NhaA Family TC 2 A 34 Na H Antiporter NhaB Family TC 2 A 35 Na H Antiporter NhaC Family TC 2 A 36 Monovalent Cation Proton Antiporter 1 CPA1 Family TC 2 A 37 Monovalent Cation Proton Antiporter 2 CPA2 Family TC 2 A 62 Na H Antiporter NhaD Family TC 2 A 63 Monovalent Cation K or Na Proton Antiporter 3 CPA3 Family TC 2 A 111 Na H Antiporter NhaE FamilyReferences edit Padan E Landau M 2016 Chapter 12 Sodium Proton Na H Antiporters Properties and Roles in Health and Disease In Sigel A Sigel H Sigel RK eds The Alkali Metal Ions Their Role in Life Metal Ions in Life Sciences Vol 16 Springer pp 391 458 doi 10 1007 978 3 319 21756 7 12 ISBN 978 3 319 21755 0 PMID 26860308 Bobulescu IA Moe OW September 2006 Na H exchangers in renal regulation of acid base balance Seminars in Nephrology 26 5 334 44 doi 10 1016 j semnephrol 2006 07 001 PMC 2878276 PMID 17071327 Kuro o M January 1995 Salt sensitive hypertension in transgenic mice overexpressing Na proton exchanger Circulation Research 76 1 148 153 doi 10 1161 01 res 76 1 148 PMID 8001273 Yun CH Tse CM Nath SK Levine SA Brant SR Donowitz M July 1995 Mammalian Na H exchanger gene family structure and function studies The American Journal of Physiology 269 1 Pt 1 G1 11 doi 10 1152 ajpgi 1995 269 1 G1 PMID 7631785 Neve KA Kozlowski MR Rosser MP December 1992 Dopamine D2 receptor stimulation of Na H exchange assessed by quantification of extracellular acidification The Journal of Biological Chemistry 267 36 25748 53 PMID 1361188 Cox BA Rosser MP Kozlowski MR Duwe KM Neve RL Neve KA September 1995 Regulation and functional characterization of a rat recombinant dopamine D3 receptor Synapse 21 1 1 9 doi 10 1002 syn 890210102 PMID 8525456 Chio CL Lajiness ME Huff RM January 1994 Activation of heterologously expressed D3 dopamine receptors comparison with D2 dopamine receptors Molecular Pharmacology 45 1 51 60 PMID 8302280 Chio CL Drong RF Riley DT Gill GS Slightom JL Huff RM April 1994 D4 dopamine receptor mediated signaling events determined in transfected Chinese hamster ovary cells The Journal of Biological Chemistry 269 16 11813 9 PMID 7512953 TCDB HOME Transporter Classification Database Retrieved 2016 03 14 External links editSodium Hydrogen Exchanger at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the public domain Pfam and InterPro IPR004670 nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Sodium hydrogen antiporter amp oldid 1211401775, wikipedia, wiki, book, books, library,

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