The NhaD family (TC# 2.A.62) belongs to the Ion Transporter (IT) Superfamily.[1] A representative list of proteins belonging to the NhaD family can be found in the Transporter Classification Database.
The NhaD Na+/H+ antiporter has been characterized from two Vibrio species: V. parahaemolyticus and V. cholerae and in the haloalkaliphile, Alkalimonas amylolytica.[2][3] These proteins and their homologues are 400-500 aas long and exhibit 10-13 TMSs. They catalyze Na+/H+ and Li+/H+ antiport. They exhibit activity at basic pH (8-10) with no activity at pH 7.5. The Amylolytica antiporter has low Na+ affinity and has optimal activity at 600 mM Na+. Homologues are found in Pseudomonadota of all groups, Flavobacteriia, and Chlamydia. Distant homologues of the IT superfamily are ubiquitous.
Barrero-Gil, Javier; Rodríguez-Navarro, Alonso; Benito, Begoña (2007-01-01). "Cloning of the PpNHAD1 transporter of Physcomitrella patens, a chloroplast transporter highly conserved in photosynthetic eukaryotic organisms". Journal of Experimental Botany58(11): 2839–2849. doi:10.1093/jxb/erm094. ISSN 0022-0957. PMID 17617660.
Kurz, Matthias; Brünig, Anika N. S.; Galinski, Erwin A. (2006-01-01). "NhaD type sodium/proton-antiporter of Halomonas elongata: a salt stress response mechanism in marine habitats?". Saline Systems2: 10.doi:10.1186/1746-1448-2-10. ISSN 1746-1448.PMC 1552076. PMID 16872527.
Liu, Jun; Xue, Yanfen; Wang, Quanhui; Wei, Yi; Swartz, Talia H.; Hicks, David B.; Ito, Masahiro; Ma, Yanhe; Krulwich, Terry A. (2005-11-01). "The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment". Journal of Bacteriology187 (22): 7589–7595.doi:10.1128/JB.187.22.7589-7595.2005. ISSN 0021-9193.
Melo, Ana M. P.; Felix, Nuno A. M.; Carita, João N.; Saraiva, Lígia M.; Teixeira, Miguel (2006-09-29)."The Na+/H+ antiporter of the thermohalophilic bacterium Rhodothermus marinus". Biochemical and Biophysical Research Communications348 (3): 1011–1017.doi:10.1016/j.bbrc.2006.07.134. ISSN 0006-291X.PMID 16904646.
Zhong, Nai-Qin; Han, Li-Bo; Wu, Xiao-Min; Wang, Li-Li; Wang, Fang; Ma, Yan-He; Xia, Gui-Xian (2012-06-01). "Ectopic expression of a bacterium NhaD-type Na+/H+ antiporter leads to increased tolerance to combined salt/alkali stresses". Journal of Integrative Plant Biology54 (6): 412–421. doi:10.1111/j.1744-7909.2012.01129.x. ISSN 1744-7909. PMID 22583823.
Referencesedit
^Prakash, Shraddha; Cooper, Garret; Singhi, Soumya; Saier, Milton H. (2003-12-03). "The ion transporter superfamily". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1618 (1): 79–92. doi:10.1016/j.bbamem.2003.10.010. ISSN 0006-3002. PMID 14643936.
^Nozaki, K.; Kuroda, T.; Mizushima, T.; Tsuchiya, T. (1998-03-02). "A new Na+/H+ antiporter, NhaD, of Vibrio parahaemolyticus". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1369 (2): 213–220. doi:10.1016/s0005-2736(97)00223-x. ISSN 0006-3002. PMID 9518619.
^Ostroumov, Elena; Dzioba, Judith; Loewen, Peter C.; Dibrov, Pavel (2002-08-19). "Asp(344) and Thr(345) are critical for cation exchange mediated by NhaD, Na(+)/H(+) antiporter of Vibrio cholerae". Biochimica et Biophysica Acta. 1564 (1): 99–106. doi:10.1016/s0005-2736(02)00407-8. ISSN 0006-3002. PMID 12101001.
As of this edit, this article uses content from "2.A.62 The NhaD Na+:H+ Antiporter (NhaD) Family", which is licensed in a way that permits reuse under the Creative Commons Attribution-ShareAlike 3.0 Unported License, but not under the GFDL. All relevant terms must be followed.
December 17, 2023
nhad, family, belongs, transporter, superfamily, representative, list, proteins, belonging, found, transporter, classification, database, nhad, antiporter, been, characterized, from, vibrio, species, parahaemolyticus, cholerae, haloalkaliphile, alkalimonas, am. The NhaD family TC 2 A 62 belongs to the Ion Transporter IT Superfamily 1 A representative list of proteins belonging to the NhaD family can be found in the Transporter Classification Database The NhaD Na H antiporter has been characterized from two Vibrio species V parahaemolyticus and V cholerae and in the haloalkaliphile Alkalimonas amylolytica 2 3 These proteins and their homologues are 400 500 aas long and exhibit 10 13 TMSs They catalyze Na H and Li H antiport They exhibit activity at basic pH 8 10 with no activity at pH 7 5 The Amylolytica antiporter has low Na affinity and has optimal activity at 600 mM Na Homologues are found in Pseudomonadota of all groups Flavobacteriia and Chlamydia Distant homologues of the IT superfamily are ubiquitous The generalized reaction catalyzed by NhaD is nH in mNa out nH out mNa in See also editSodium Proton antiporter Antiporter Transporter Classification DatabaseFurther reading editBarrero Gil Javier Rodriguez Navarro Alonso Benito Begona 2007 01 01 Cloning of the PpNHAD1 transporter of Physcomitrella patens a chloroplast transporter highly conserved in photosynthetic eukaryotic organisms Journal of Experimental Botany 58 11 2839 2849 doi 10 1093 jxb erm094 ISSN 0022 0957 PMID 17617660 Kurz Matthias Brunig Anika N S Galinski Erwin A 2006 01 01 NhaD type sodium proton antiporter of Halomonas elongata a salt stress response mechanism in marine habitats Saline Systems 2 10 doi 10 1186 1746 1448 2 10 ISSN 1746 1448 PMC 1552076 PMID 16872527 Liu Jun Xue Yanfen Wang Quanhui Wei Yi Swartz Talia H Hicks David B Ito Masahiro Ma Yanhe Krulwich Terry A 2005 11 01 The activity profile of the NhaD type Na Li H antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment Journal of Bacteriology 187 22 7589 7595 doi 10 1128 JB 187 22 7589 7595 2005 ISSN 0021 9193 Melo Ana M P Felix Nuno A M Carita Joao N Saraiva Ligia M Teixeira Miguel 2006 09 29 The Na H antiporter of the thermohalophilic bacterium Rhodothermus marinus Biochemical and Biophysical Research Communications 348 3 1011 1017 doi 10 1016 j bbrc 2006 07 134 ISSN 0006 291X PMID 16904646 Zhong Nai Qin Han Li Bo Wu Xiao Min Wang Li Li Wang Fang Ma Yan He Xia Gui Xian 2012 06 01 Ectopic expression of a bacterium NhaD type Na H antiporter leads to increased tolerance to combined salt alkali stresses Journal of Integrative Plant Biology 54 6 412 421 doi 10 1111 j 1744 7909 2012 01129 x ISSN 1744 7909 PMID 22583823 References edit Prakash Shraddha Cooper Garret Singhi Soumya Saier Milton H 2003 12 03 The ion transporter superfamily Biochimica et Biophysica Acta BBA Biomembranes 1618 1 79 92 doi 10 1016 j bbamem 2003 10 010 ISSN 0006 3002 PMID 14643936 Nozaki K Kuroda T Mizushima T Tsuchiya T 1998 03 02 A new Na H antiporter NhaD of Vibrio parahaemolyticus Biochimica et Biophysica Acta BBA Biomembranes 1369 2 213 220 doi 10 1016 s0005 2736 97 00223 x ISSN 0006 3002 PMID 9518619 Ostroumov Elena Dzioba Judith Loewen Peter C Dibrov Pavel 2002 08 19 Asp 344 and Thr 345 are critical for cation exchange mediated by NhaD Na H antiporter of Vibrio cholerae Biochimica et Biophysica Acta 1564 1 99 106 doi 10 1016 s0005 2736 02 00407 8 ISSN 0006 3002 PMID 12101001 Portal nbsp Biology As of this edit this article uses content from 2 A 62 The NhaD Na H Antiporter NhaD Family which is licensed in a way that permits reuse under the Creative Commons Attribution ShareAlike 3 0 Unported License but not under the GFDL All relevant terms must be followed Retrieved from https en wikipedia org w index php title NhaD family amp oldid 1170650593, wikipedia, wiki, book, books, library,
