NS-398

NS-398 is a COX-2 inhibitor used in the study of the function of cyclooxygenases.^[2]

NS-398

Names
Preferred IUPAC name N-[2-(Cyclohexyloxy)-4-nitrophenyl]methanesulfonamide
Identifiers
CAS Number	123653-11-2^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:73458^Y
ChEMBL	ChEMBL7162
ChemSpider	4393^Y
DrugBank	DB14060
IUPHAR/BPS	8976
PubChem CID	4553
CompTox Dashboard (EPA)	DTXSID8041084
InChI InChI=1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3^Y Key: KTDZCOWXCWUPEO-UHFFFAOYSA-N^N InChI=1/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3 Key: KTDZCOWXCWUPEO-UHFFFAOYAY
SMILES CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2CCCCC2
Properties
Chemical formula	C13H18N2O5S
Molar mass	314.36 g·mol^−1
Appearance	Off-white solid
Solubility in water	Insoluble
Solubility in DMSO	5 mg/mL
Hazards
GHS labelling:^[1]
Pictograms
Signal word	Warning
Hazard statements	H302, H312, H332
Precautionary statements	P280
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is ^YN ?) Infobox references

See also

• Celecoxib
• Tilmacoxib (JTE-522)

References

1. "N194 NS-398". Sigma-Aldrich. Retrieved 13 December 2021.
2. Wei Shen; Yong Li; Ying Tang; James Cummins; Johnny Huard (2005). "NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal Muscle Healing by Decreasing Regeneration and Promoting Fibrosis". American Journal of Pathology. 167 (4): 1105–1117. doi:10.1016/S0002-9440(10)61199-6. PMC 1603662. PMID 16192645.