A multilocus genotype is the combination of alleles found at two or more loci in a single individual.
For example, in a diploid species, if there are two SNP loci and the first locus has alleles A and G, while the second locus has alleles T and C, the multilocus genotype can be represented as {A/G,T/C}. If the genome is not haploid then the multilocus genotype does not necessarily determine which alleles co-occur on chromosomes. In the example, if the two loci are located on the same chromosome the possibilities are either {A-T,G-C} or {A-C,G-T}. Where A-T represents a haplotype with alleles A and T together on one chromosome and G and C together on the other. If the haplotypes are determined the multilocus genotype is referred to as a phased genotype, otherwise it is referred to as unphased. Some authors[1][2] suggest that the term multilocus genotype should only be applied to phased multilocus data while others[3] apply it to unphased multilocus data as well. The combination of alleles at two or more loci on a single chromosome make up a haplotype and the two haplotypes in a diploid individual make up the diplotype (a synonym for a phased multilocus genotype).
Referencesedit
^Thompson, Elizabeth A. (2000). "Statistical Inference from Genetic Data on Pedigrees". NSF-CBMS Regional Conference Series in Probability and Statistics. 6. doi:10.1214/cbms/1462106037. ISBN0-94-0600-49-8. JSTOR 4153187.
^Lange, Kenneth (2003). Mathematical and Statistical Methods for Genetic Analysis. New York: Springer-Verlag. p. 4. ISBN0-387-95389-2.
^Pritchard, Jonathan K.; Stephens, Matthew; Donnelly, Peter (2000). "Inference of population structure using multilocus genotype data". Genetics. 155 (2): 945–959. doi:10.1093/genetics/155.2.945. PMC1461096. PMID 10835412.
January 01, 1970
multilocus, genotype, multilocus, genotype, combination, alleles, found, more, loci, single, individual, example, diploid, species, there, loci, first, locus, alleles, while, second, locus, alleles, multilocus, genotype, represented, genome, haploid, then, mul. A multilocus genotype is the combination of alleles found at two or more loci in a single individual For example in a diploid species if there are two SNP loci and the first locus has alleles A and G while the second locus has alleles T and C the multilocus genotype can be represented as A G T C If the genome is not haploid then the multilocus genotype does not necessarily determine which alleles co occur on chromosomes In the example if the two loci are located on the same chromosome the possibilities are either A T G C or A C G T Where A T represents a haplotype with alleles A and T together on one chromosome and G and C together on the other If the haplotypes are determined the multilocus genotype is referred to as a phased genotype otherwise it is referred to as unphased Some authors 1 2 suggest that the term multilocus genotype should only be applied to phased multilocus data while others 3 apply it to unphased multilocus data as well The combination of alleles at two or more loci on a single chromosome make up a haplotype and the two haplotypes in a diploid individual make up the diplotype a synonym for a phased multilocus genotype References edit Thompson Elizabeth A 2000 Statistical Inference from Genetic Data on Pedigrees NSF CBMS Regional Conference Series in Probability and Statistics 6 doi 10 1214 cbms 1462106037 ISBN 0 94 0600 49 8 JSTOR 4153187 Lange Kenneth 2003 Mathematical and Statistical Methods for Genetic Analysis New York Springer Verlag p 4 ISBN 0 387 95389 2 Pritchard Jonathan K Stephens Matthew Donnelly Peter 2000 Inference of population structure using multilocus genotype data Genetics 155 2 945 959 doi 10 1093 genetics 155 2 945 PMC 1461096 PMID 10835412 Retrieved from https en wikipedia org w index php title Multilocus genotype amp oldid 1221676908, wikipedia, wiki, book, books, library,
