fbpx
Wikipedia

Michael Stuart Brown

October 14, 2023

For other people named Michael Brown, see Michael Brown (disambiguation).

Michael Stuart Brown ForMemRS NAS AAA&S APS (born April 13, 1941) is an American geneticist and Nobel laureate. He was awarded the Nobel Prize in Physiology or Medicine with Joseph L. Goldstein in 1985 for describing the regulation of cholesterol metabolism.[2][3][4][5]

Michael Brown
Born
Michael Stuart Brown

(1941-04-13) April 13, 1941 (age 82)
Brooklyn, New York, United States
NationalityAmerican
Alma mater
Known forRegulation of cholesterol metabolism
Spouse
Alice Lapin
​
(m. 1964)​
[citation needed]
Childrentwo[citation needed]
Awards
Scientific career
FieldsBiology
Websiteprofiles.utsouthwestern.edu/profile/10894/michael-brown.html

Education and early life Edit

Brown was born in Brooklyn, New York, the son of Evelyn, a homemaker, and Harvey Brown, a textile salesman.[4][6] His family is Jewish.[7] He graduated from Cheltenham High School (Wyncote, Pennsylvania). Brown graduated from the University of Pennsylvania in 1962 and received his M.D. from the University of Pennsylvania School of Medicine in 1966.[citation needed]

Career and research Edit

Moving to the University of Texas Michael liked vann Warner Health Science Center in Dallas, now the UT Southwestern Medical Center, Brown and colleague Joseph L. Goldstein researched cholesterol metabolism and discovered that human cells have low-density lipoprotein (LDL) receptors that extract cholesterol from the bloodstream. The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia, which predisposes heavily for cholesterol-related diseases. In addition to explaining the underlying pathology of this disease, their work uncovered a fundamental aspect of cell biology - receptor-mediated endocytosis. Their findings led to the development of statin drugs, the cholesterol-lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States.[citation needed] Their discoveries are improving more lives every year, both in the US and around the world.[citation needed] New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol, reducing the risk of heart disease and stroke for countless people. Following these important advances, their team of dedicated researchers elucidated the role of lipid modification of proteins (protein prenylation) in cancer. In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L. Goldstein (co-recipient of 1985 Nobel Prize in Physiology or Medicine). In 1988, Brown received the National Medal of Science for his contributions to medicine.

In 1993, their trainees Xiaodong Wang and Michael Briggs purified the sterol regulatory element binding proteins (SREBPs). Since 1993, Brown, Goldstein, and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances.

Brown holds the W. A. (Monty) Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research; is a Regental Professor of the University of Texas; holds the Paul J. Thomas Chair in Medicine.[citation needed]

Brown is also on the Prix Galien USA Committee that "recognizes the technical, scientific and clinical research skills necessary to develop innovative medicines".[citation needed]

Awards and honors Edit

Brown has won numerous awards and honors, including:

Bibliography Edit

  • Brown MS, Goldstein JL (Jul 1974). "Expression of the familial hypercholesterolemia gene in heterozygotes: mechanism for a dominant disorder in man". Science. 185 (4145): 61–3. Bibcode:1974Sci...185...61B. doi:10.1126/science.185.4145.61. PMID 4366052. S2CID 31493564.
  • Brown MS, Goldstein JL (Nov 1975). "Regulation of the activity of the low density lipoprotein receptor in human fibroblasts". Cell. 6 (3): 307–16. doi:10.1016/0092-8674(75)90182-8. PMID 212203. S2CID 28312936.
  • Goldstein JL, Basu SK, Brunschede GY, Brown MS (Jan 1976). "Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans". Cell. 7 (1): 85–95. doi:10.1016/0092-8674(76)90258-0. PMID 181140. S2CID 23110979.
  • Brown MS, Goldstein JL (Jan 1976). "Receptor-mediated control of cholesterol metabolism". Science. 191 (4223): 150–4. Bibcode:1976Sci...191..150B. doi:10.1126/science.174194. PMID 174194.
  • Goldstein JL, Sobhani MK, Faust JR, Brown MS (Oct 1976). "Heterozygous familial hypercholesterolemia: failure of normal allele to compensate for mutant allele at a regulated genetic locus". Cell. 9 (2): 195–203. doi:10.1016/0092-8674(76)90110-0. PMID 184960. S2CID 26944871.
  • Brown MS, Goldstein JL (Dec 1976). "Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor-bound low density lipoprotein". Cell. 9 (4 PT 2): 663–74. doi:10.1016/0092-8674(76)90130-6. PMID 189940. S2CID 6706608.
  • Anderson RG, Brown MS, Goldstein JL (Mar 1977). "Role of the coated endocytic vesicle in the uptake of receptor-bound low density lipoprotein in human fibroblasts". Cell. 10 (3): 351–64. doi:10.1016/0092-8674(77)90022-8. PMID 191195. S2CID 25657719.
  • Goldstein JL, Brown MS, Stone NJ (Nov 1977). "Genetics of the LDL receptor: evidence that the mutations affecting binding and internalization are allelic". Cell. 12 (3): 629–41. doi:10.1016/0092-8674(77)90263-X. PMID 200368. S2CID 13211975.
  • Anderson RG, Goldstein JL, Brown MS (1977). "A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts". Nature. 270 (5639): 695–9. Bibcode:1977Natur.270..695A. doi:10.1038/270695a0. PMID 201867. S2CID 4152556.
  • Anderson RG, Vasile E, Mello RJ, Brown MS, Goldstein JL (Nov 1978). "Immunocytochemical visualization of coated pits and vesicles in human fibroblasts: relation to low density lipoprotein receptor distribution". Cell. 15 (3): 919–33. doi:10.1016/0092-8674(78)90276-3. PMID 215316. S2CID 35345591.
  • Goldstein JL, Anderson RG, Brown MS (Jun 1979). "Coated pits, coated vesicles, and receptor-mediated endocytosis". Nature. 279 (5715): 679–85. Bibcode:1979Natur.279..679G. doi:10.1038/279679a0. PMID 221835. S2CID 4353842.
  • Mello RJ, Brown MS, Goldstein JL, Anderson RG (Jul 1980). "LDL receptors in coated vesicles isolated from bovine adrenal cortex: binding sites unmasked by detergent treatment". Cell. 20 (3): 829–37. doi:10.1016/0092-8674(80)90329-3. PMID 6251975. S2CID 23996668.
  • Brown MS, Kovanen PT, Goldstein JL (May 1981). "Regulation of plasma cholesterol by lipoprotein receptors". Science. 212 (4495): 628–35. Bibcode:1981Sci...212..628B. doi:10.1126/science.6261329. PMID 6261329.
  • Basu SK, Goldstein JL, Anderson RG, Brown MS (May 1981). "Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts". Cell. 24 (2): 493–502. doi:10.1016/0092-8674(81)90340-8. PMID 6263497. S2CID 29553611.
  • Tolleshaug H, Goldstein JL, Schneider WJ, Brown MS (Oct 1982). "Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia". Cell. 30 (3): 715–24. doi:10.1016/0092-8674(82)90276-8. PMID 6291781. S2CID 30013697.
  • Basu SK, Goldstein JL, Brown MS (Feb 1983). "Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages". Science. 219 (4586): 871–3. Bibcode:1983Sci...219..871B. doi:10.1126/science.6823554. PMID 6823554.
  • Brown MS, Anderson RG, Goldstein JL (Mar 1983). "Recycling receptors: the round-trip itinerary of migrant membrane proteins". Cell. 32 (3): 663–7. doi:10.1016/0092-8674(83)90052-1. PMID 6299572. S2CID 34919831.
  • Tolleshaug H, Hobgood KK, Brown MS, Goldstein JL (Mar 1983). "The LDL receptor locus in familial hypercholesterolemia: multiple mutations disrupt transport and processing of a membrane receptor". Cell. 32 (3): 941–51. doi:10.1016/0092-8674(83)90079-X. PMID 6299582. S2CID 39955408.
  • Larkin JM, Brown MS, Goldstein JL, Anderson RG (May 1983). "Depletion of intracellular potassium arrests coated pit formation and receptor-mediated endocytosis in fibroblasts". Cell. 33 (1): 273–85. doi:10.1016/0092-8674(83)90356-2. PMID 6147196. S2CID 22848187.
  • Orci L, Brown MS, Goldstein JL, Garcia-Segura LM, Anderson RG (Apr 1984). "Increase in membrane cholesterol: a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT-1 cells". Cell. 36 (4): 835–45. doi:10.1016/0092-8674(84)90033-3. PMID 6705048. S2CID 24586649.
  • Chin DJ, Gil G, Russell DW, et al. (1984). "Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum". Nature. 308 (5960): 613–7. Bibcode:1984Natur.308..613C. doi:10.1038/308613a0. PMID 6546784. S2CID 4308995.
  • Russell DW, Schneider WJ, Yamamoto T, Luskey KL, Brown MS, Goldstein JL (Jun 1984). "Domain map of the LDL receptor: sequence homology with the epidermal growth factor precursor". Cell. 37 (2): 577–85. doi:10.1016/0092-8674(84)90388-X. PMID 6327078. S2CID 29839468.
  • Reynolds GA, Basu SK, Osborne TF, et al. (Aug 1984). "HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions". Cell. 38 (1): 275–85. doi:10.1016/0092-8674(84)90549-X. PMID 6088070. S2CID 11644830.
  • Yamamoto T, Davis CG, Brown MS, et al. (Nov 1984). "The human LDL receptor: a cysteine-rich protein with multiple Alu sequences in its mRNA". Cell. 39 (1): 27–38. doi:10.1016/0092-8674(84)90188-0. PMID 6091915. S2CID 25822170.
  • Lehrman MA, Schneider WJ, Südhof TC, Brown MS, Goldstein JL, Russell DW (Jan 1985). "Mutation in LDL receptor: Alu-Alu recombination deletes exons encoding transmembrane and cytoplasmic domains". Science. 227 (4683): 140–6. Bibcode:1985Sci...227..140L. doi:10.1126/science.3155573. PMC 4449727. PMID 3155573.
  • Südhof TC, Goldstein JL, Brown MS, Russell DW (May 1985). "The LDL receptor gene: a mosaic of exons shared with different proteins". Science. 228 (4701): 815–22. Bibcode:1985Sci...228..815S. doi:10.1126/science.2988123. PMC 4450672. PMID 2988123.
  • Südhof TC, Russell DW, Goldstein JL, Brown MS, Sanchez-Pescador R, Bell GI (May 1985). "Cassette of eight exons shared by genes for LDL receptor and EGF precursor". Science. 228 (4701): 893–5. Bibcode:1985Sci...228..893S. doi:10.1126/science.3873704. PMID 3873704.
  • Gil G, Faust JR, Chin DJ, Goldstein JL, Brown MS (May 1985). "Membrane-bound domain of HMG CoA reductase is required for sterol-enhanced degradation of the enzyme". Cell. 41 (1): 249–58. doi:10.1016/0092-8674(85)90078-9. PMID 3995584. S2CID 22530611.
  • Lehrman MA, Goldstein JL, Brown MS, Russell DW, Schneider WJ (Jul 1985). "Internalization-defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain". Cell. 41 (3): 735–43. doi:10.1016/S0092-8674(85)80054-4. PMID 3924410. S2CID 27773467.
  • Osborne TF, Goldstein JL, Brown MS (Aug 1985). "5' end of HMG CoA reductase gene contains sequences responsible for cholesterol-mediated inhibition of transcription". Cell. 42 (1): 203–12. doi:10.1016/S0092-8674(85)80116-1. PMID 3860301. S2CID 37319421.
  • Brown MS, Goldstein JL (1985). "Scavenger cell receptor shared". Nature. 316 (6030): 680–1. doi:10.1038/316680a0. PMID 4033768. S2CID 4349775.
  • Brown MS, Goldstein JL (Apr 1986). "A receptor-mediated pathway for cholesterol homeostasis". Science. 232 (4746): 34–47. Bibcode:1986Sci...232...34B. doi:10.1126/science.3513311. PMID 3513311.
  • Davis CG, Lehrman MA, Russell DW, Anderson RG, Brown MS, Goldstein JL (Apr 1986). "The J.D. mutation in familial hypercholesterolemia: amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors". Cell. 45 (1): 15–24. doi:10.1016/0092-8674(86)90533-7. PMID 3955657. S2CID 8147673.
  • Yamamoto T, Bishop RW, Brown MS, Goldstein JL, Russell DW (Jun 1986). "Deletion in cysteine-rich region of LDL receptor impedes transport to cell surface in WHHL rabbit". Science. 232 (4755): 1230–7. Bibcode:1986Sci...232.1230Y. doi:10.1126/science.3010466. PMC 4451858. PMID 3010466.
  • Lehrman MA, Goldstein JL, Russell DW, Brown MS (Mar 1987). "Duplication of seven exons in LDL receptor gene caused by Alu-Alu recombination in a subject with familial hypercholesterolemia". Cell. 48 (5): 827–35. doi:10.1016/0092-8674(87)90079-1. PMID 3815525. S2CID 35887205.
  • Südhof TC, Russell DW, Brown MS, Goldstein JL (Mar 1987). "42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter". Cell. 48 (6): 1061–9. doi:10.1016/0092-8674(87)90713-6. PMID 3030558. S2CID 42788737.
  • Davis CG, Goldstein JL, Südhof TC, Anderson RG, Russell DW, Brown MS (1987). "Acid-dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region". Nature. 326 (6115): 760–5. Bibcode:1987Natur.326..760D. doi:10.1038/326760a0. PMID 3494949. S2CID 4347695.
  • Hofmann SL, Russell DW, Brown MS, Goldstein JL, Hammer RE (Mar 1988). "Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice". Science. 239 (4845): 1277–81. Bibcode:1988Sci...239.1277H. doi:10.1126/science.3344433. PMID 3344433.
  • Reiss Y, Goldstein JL, Seabra MC, Casey PJ, Brown MS (Jul 1990). "Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides". Cell. 62 (1): 81–8. doi:10.1016/0092-8674(90)90242-7. PMID 2194674. S2CID 30887422.
  • Yokode M, Hammer RE, Ishibashi S, Brown MS, Goldstein JL (Nov 1990). "Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors". Science. 250 (4985): 1273–5. Bibcode:1990Sci...250.1273Y. doi:10.1126/science.2244210. PMID 2244210.
  • Seabra MC, Reiss Y, Casey PJ, Brown MS, Goldstein JL (May 1991). "Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit". Cell. 65 (3): 429–34. doi:10.1016/0092-8674(91)90460-G. PMID 2018975. S2CID 54388220.
  • Chen WJ, Andres DA, Goldstein JL, Russell DW, Brown MS (Jul 1991). "cDNA cloning and expression of the peptide-binding beta subunit of rat p21ras farnesyltransferase, the counterpart of yeast DPR1/RAM1". Cell. 66 (2): 327–34. doi:10.1016/0092-8674(91)90622-6. PMID 1855253. S2CID 36722957.
  • Seabra MC, Brown MS, Slaughter CA, Südhof TC, Goldstein JL (Sep 1992). "Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product". Cell. 70 (6): 1049–57. doi:10.1016/0092-8674(92)90253-9. PMID 1525821. S2CID 26223659.
  • Brown MS, Goldstein JL (Oct 1992). "Koch's postulates for cholesterol". Cell. 71 (2): 187–8. doi:10.1016/0092-8674(92)90346-E. PMID 1423585. S2CID 33048207.
  • Andres DA, Seabra MC, Brown MS, et al. (Jun 1993). "cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein". Cell. 73 (6): 1091–9. doi:10.1016/0092-8674(93)90639-8. PMID 8513495. S2CID 26120573.
  • Yokoyama C, Wang X, Briggs MR, et al. (Oct 1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene". Cell. 75 (1): 187–97. doi:10.1016/S0092-8674(05)80095-9. PMID 8402897. S2CID 2784016.
  • Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS (Mar 1994). "Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle". Cell. 76 (5): 865–73. doi:10.1016/0092-8674(94)90361-1. PMID 8124722. S2CID 22137883.
  • Wang X, Sato R, Brown MS, Hua X, Goldstein JL (Apr 1994). "SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis". Cell. 77 (1): 53–62. doi:10.1016/0092-8674(94)90234-8. PMID 8156598. S2CID 44899129.
  • Sakai J, Duncan EA, Rawson RB, Hua X, Brown MS, Goldstein JL (Jun 1996). "Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment". Cell. 85 (7): 1037–46. doi:10.1016/S0092-8674(00)81304-5. PMID 8674110. S2CID 6130686.
  • Hua X, Nohturfft A, Goldstein JL, Brown MS (Nov 1996). "Sterol resistance in CHO cells traced to point mutation in SREBP cleavage-activating protein". Cell. 87 (3): 415–26. doi:10.1016/S0092-8674(00)81362-8. PMID 8898195. S2CID 1963192.
  • Brown MS, Goldstein JL (May 1997). "The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor". Cell. 89 (3): 331–40. doi:10.1016/S0092-8674(00)80213-5. PMID 9150132. S2CID 17882616.
  • DeBose-Boyd RA, Brown MS, Li WP, Nohturfft A, Goldstein JL, Espenshade PJ (Dec 1999). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi". Cell. 99 (7): 703–12. doi:10.1016/S0092-8674(00)81668-2. PMID 10619424.
  • Brown MS, Ye J, Rawson RB, Goldstein JL (Feb 2000). "Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans". Cell. 100 (4): 391–8. doi:10.1016/S0092-8674(00)80675-3. PMID 10693756. S2CID 12194770.
  • Nohturfft A, Yabe D, Goldstein JL, Brown MS, Espenshade PJ (Aug 2000). "Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes". Cell. 102 (3): 315–23. doi:10.1016/S0092-8674(00)00037-4. PMID 10975522. S2CID 18054832.
  • Yang T, Espenshade PJ, Wright ME, et al. (Aug 2002). "Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER". Cell. 110 (4): 489–500. doi:10.1016/S0092-8674(02)00872-3. PMID 12202038. S2CID 15052132.

See also Edit

References Edit

  1. ^ a b . London: Royal Society. Archived from the original on 2015-11-06.
  2. ^ "Biography: Michael S. Brown". The Notable Names Database. Soylent Communications. 2008. Retrieved 2008-06-15.
  3. ^ "Michael Brown - Nobel Prize Inspiration Initiative". Nobelprizeii.org. Retrieved 2015-11-06.
  4. ^ a b "Michael S. Brown - Biographical". Nobelprize.org. 1941-04-13. Retrieved 2015-11-06.
  5. ^ "Michael S. Brown - Nobel Lecture: A Receptor-Mediated Pathway for Cholesterol Homeostasis". Nobelprize.org. 1985-12-08. Retrieved 2015-11-06.
  6. ^ "BROWN (Brown), Michael, photo, biography". Persona.rin.ru. 1941-04-13. Retrieved 2015-11-06.
  7. ^ "Jewish Nobel Prize Winners in Medicine". www.jinfo.org. Retrieved 2023-03-30.
  8. ^ "Earl and Thressa Stadtman Distinguished Scientist Award". Asbmb.org. Retrieved 2015-11-06.
  9. ^ "University of Texas Southwestern Medical Center Leaders to Receive Research!America Advocacy Award". Research!America. 2007-03-21. Retrieved 2015-11-06.
  10. ^ [1] October 8, 2013, at the Wayback Machine
  11. ^ "Herbert Tabor Research Award". Asbmb.org. Retrieved 2015-11-06.
  12. ^ "Albany Medical College: 2003". Amc.edu. 2015-08-14. Retrieved 2015-11-06.
  13. ^ Daniel W. Foster; Jean D. Wilson. "Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown" (PDF). Jci.org. Retrieved 2015-11-06.
  14. ^ [2] April 10, 2012, at the Wayback Machine
  15. ^ "APS Member History".
  16. ^ "Golden Plate Awardees of the American Academy of Achievement". www.achievement.org. American Academy of Achievement.
  17. ^ "The Nobel Prize in Physiology or Medicine 1985". nobelprize.org. The Nobel Foundation. Retrieved 18 October 2022.
  18. ^ . The Lasker Foundation. 2007-09-16. Archived from the original on 2015-09-13. Retrieved 2015-11-06.
  19. ^ . ASHG. Archived from the original on 2014-10-03. Retrieved 2015-11-06.
  20. ^ "Horwitz Prize Awardees". cuimc.columbia.edu. Columbia University. 20 June 2018. Retrieved 18 October 2022.
  21. ^ "Joseph L. Goldstein". Gairdner. Retrieved 2015-11-06.
  22. ^ "Michael Stuart Brown".
  23. ^ "Michael Brown". www.nasonline.org. Retrieved 23 March 2018.
  24. ^ "Richard Lounsbery Award". Nasonline.org. Retrieved 2015-11-06.
  25. ^ [3] October 7, 2012, at the Wayback Machine
  26. ^ "Pfizer Award in Enzyme Chemistry". Divbiolchem.org. Retrieved 2015-11-06.
  27. ^ "Heinrich Wieland Prize Laureates 1970 - 1979". Boehringer Ingelheim Stiftung. Boehringer Ingelheim Stiftung. Retrieved 18 October 2022.

External links Edit

  • Michael S. Brown on Nobelprize.org  
 
Wikimedia Commons has media related to Michael S. Brown.

October 14, 2023
michael, stuart, brown, other, people, named, michael, brown, michael, brown, disambiguation, this, biography, living, person, needs, additional, citations, verification, please, help, adding, reliable, sources, contentious, material, about, living, persons, t. For other people named Michael Brown see Michael Brown disambiguation This biography of a living person needs additional citations for verification Please help by adding reliable sources Contentious material about living persons that is unsourced or poorly sourced must be removed immediately from the article and its talk page especially if potentially libelous Find sources Michael Stuart Brown news newspapers books scholar JSTOR July 2023 Learn how and when to remove this template message Michael Stuart Brown ForMemRS NAS AAA amp S APS born April 13 1941 is an American geneticist and Nobel laureate He was awarded the Nobel Prize in Physiology or Medicine with Joseph L Goldstein in 1985 for describing the regulation of cholesterol metabolism 2 3 4 5 Michael BrownBornMichael Stuart Brown 1941 04 13 April 13 1941 age 82 Brooklyn New York United StatesNationalityAmericanAlma materUniversity of Pennsylvania University of Pennsylvania School of MedicineKnown forRegulation of cholesterol metabolismSpouseAlice Lapin m 1964 wbr citation needed Childrentwo citation needed AwardsHeinrich Wieland Prize 1974 Richard Lounsbery Award 1979 William Allan Award 1985 Nobel Prize in Physiology or Medicine 1985 National Medal of Science 1988 ForMemRS 1991 1 Scientific careerFieldsBiologyWebsiteprofiles wbr utsouthwestern wbr edu wbr profile wbr 10894 wbr michael brown wbr html Contents 1 Education and early life 2 Career and research 3 Awards and honors 4 Bibliography 5 See also 6 References 7 External linksEducation and early life EditBrown was born in Brooklyn New York the son of Evelyn a homemaker and Harvey Brown a textile salesman 4 6 His family is Jewish 7 He graduated from Cheltenham High School Wyncote Pennsylvania Brown graduated from the University of Pennsylvania in 1962 and received his M D from the University of Pennsylvania School of Medicine in 1966 citation needed Career and research EditMoving to the University of Texas Michael liked vann Warner Health Science Center in Dallas now the UT Southwestern Medical Center Brown and colleague Joseph L Goldstein researched cholesterol metabolism and discovered that human cells have low density lipoprotein LDL receptors that extract cholesterol from the bloodstream The lack of sufficient LDL receptors is implicated in familial hypercholesterolemia which predisposes heavily for cholesterol related diseases In addition to explaining the underlying pathology of this disease their work uncovered a fundamental aspect of cell biology receptor mediated endocytosis Their findings led to the development of statin drugs the cholesterol lowering compounds that today are used by 16 million Americans and are the most widely prescribed medications in the United States citation needed Their discoveries are improving more lives every year both in the US and around the world citation needed New federal cholesterol guidelines will triple the number of Americans taking statin drugs to lower their cholesterol reducing the risk of heart disease and stroke for countless people Following these important advances their team of dedicated researchers elucidated the role of lipid modification of proteins protein prenylation in cancer In 1984 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Joseph L Goldstein co recipient of 1985 Nobel Prize in Physiology or Medicine In 1988 Brown received the National Medal of Science for his contributions to medicine In 1993 their trainees Xiaodong Wang and Michael Briggs purified the sterol regulatory element binding proteins SREBPs Since 1993 Brown Goldstein and their colleagues have described the unexpectedly complex machinery by which cells maintain the necessary levels of fats and cholesterol in the face of varying environmental circumstances Brown holds the W A Monty Moncrief Distinguished Chair in Cholesterol and Arteriosclerosis Research is a Regental Professor of the University of Texas holds the Paul J Thomas Chair in Medicine citation needed Brown is also on the Prix Galien USA Committee that recognizes the technical scientific and clinical research skills necessary to develop innovative medicines citation needed Awards and honors EditBrown has won numerous awards and honors including 2016 Keynote Speaker at the Congress of Future Medical Leaders 2011 Stadtman Distinguished Scientist Award American Society for Biochemistry and Molecular Biology 8 2007 Builders of Science Award Research America 9 2005 Woodrow Wilson Award for Public Service 10 2005 Herbert Tabor Award American Society for Biochemistry and Molecular Biology 11 2003 Albany Medical Center Prize 12 2002 Kober Medal Association of American Physicians 13 1999 Warren Alpert Foundation Prize Harvard Medical School 14 1991 Elected a Foreign Member of the Royal Society ForMemRS 1 1987 Elected member of the American Philosophical Society 15 1986 Golden Plate Award of the American Academy of Achievement 16 1985 Nobel Prize for physiology and medicine 17 1985 Albert Lasker Award for Basic Medical Research 18 1985 William Allan Award American Society of Human Genetics 19 1984 Louisa Gross Horwitz Prize 20 1981 Gairdner Foundation International Award 21 1981 Elected member of the American Academy of Arts and Sciences 22 1980 elected member of the National Academy of Sciences 23 1979 Lounsbery Award U S National Academy of Sciences 24 1978 Passano Award Johns Hopkins University 25 1976 Pfizer Award in Enzyme Chemistry American Chemical Society 26 1974 Heinrich Wieland Prize 27 Bibliography EditBrown MS Goldstein JL Jul 1974 Expression of the familial hypercholesterolemia gene in heterozygotes mechanism for a dominant disorder in man Science 185 4145 61 3 Bibcode 1974Sci 185 61B doi 10 1126 science 185 4145 61 PMID 4366052 S2CID 31493564 Brown MS Goldstein JL Nov 1975 Regulation of the activity of the low density lipoprotein receptor in human fibroblasts Cell 6 3 307 16 doi 10 1016 0092 8674 75 90182 8 PMID 212203 S2CID 28312936 Goldstein JL Basu SK Brunschede GY Brown MS Jan 1976 Release of low density lipoprotein from its cell surface receptor by sulfated glycosaminoglycans Cell 7 1 85 95 doi 10 1016 0092 8674 76 90258 0 PMID 181140 S2CID 23110979 Brown MS Goldstein JL Jan 1976 Receptor mediated control of cholesterol metabolism Science 191 4223 150 4 Bibcode 1976Sci 191 150B doi 10 1126 science 174194 PMID 174194 Goldstein JL Sobhani MK Faust JR Brown MS Oct 1976 Heterozygous familial hypercholesterolemia failure of normal allele to compensate for mutant allele at a regulated genetic locus Cell 9 2 195 203 doi 10 1016 0092 8674 76 90110 0 PMID 184960 S2CID 26944871 Brown MS Goldstein JL Dec 1976 Analysis of a mutant strain of human fibroblasts with a defect in the internalization of receptor bound low density lipoprotein Cell 9 4 PT 2 663 74 doi 10 1016 0092 8674 76 90130 6 PMID 189940 S2CID 6706608 Anderson RG Brown MS Goldstein JL Mar 1977 Role of the coated endocytic vesicle in the uptake of receptor bound low density lipoprotein in human fibroblasts Cell 10 3 351 64 doi 10 1016 0092 8674 77 90022 8 PMID 191195 S2CID 25657719 Goldstein JL Brown MS Stone NJ Nov 1977 Genetics of the LDL receptor evidence that the mutations affecting binding and internalization are allelic Cell 12 3 629 41 doi 10 1016 0092 8674 77 90263 X PMID 200368 S2CID 13211975 Anderson RG Goldstein JL Brown MS 1977 A mutation that impairs the ability of lipoprotein receptors to localise in coated pits on the cell surface of human fibroblasts Nature 270 5639 695 9 Bibcode 1977Natur 270 695A doi 10 1038 270695a0 PMID 201867 S2CID 4152556 Anderson RG Vasile E Mello RJ Brown MS Goldstein JL Nov 1978 Immunocytochemical visualization of coated pits and vesicles in human fibroblasts relation to low density lipoprotein receptor distribution Cell 15 3 919 33 doi 10 1016 0092 8674 78 90276 3 PMID 215316 S2CID 35345591 Goldstein JL Anderson RG Brown MS Jun 1979 Coated pits coated vesicles and receptor mediated endocytosis Nature 279 5715 679 85 Bibcode 1979Natur 279 679G doi 10 1038 279679a0 PMID 221835 S2CID 4353842 Mello RJ Brown MS Goldstein JL Anderson RG Jul 1980 LDL receptors in coated vesicles isolated from bovine adrenal cortex binding sites unmasked by detergent treatment Cell 20 3 829 37 doi 10 1016 0092 8674 80 90329 3 PMID 6251975 S2CID 23996668 Brown MS Kovanen PT Goldstein JL May 1981 Regulation of plasma cholesterol by lipoprotein receptors Science 212 4495 628 35 Bibcode 1981Sci 212 628B doi 10 1126 science 6261329 PMID 6261329 Basu SK Goldstein JL Anderson RG Brown MS May 1981 Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts Cell 24 2 493 502 doi 10 1016 0092 8674 81 90340 8 PMID 6263497 S2CID 29553611 Tolleshaug H Goldstein JL Schneider WJ Brown MS Oct 1982 Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia Cell 30 3 715 24 doi 10 1016 0092 8674 82 90276 8 PMID 6291781 S2CID 30013697 Basu SK Goldstein JL Brown MS Feb 1983 Independent pathways for secretion of cholesterol and apolipoprotein E by macrophages Science 219 4586 871 3 Bibcode 1983Sci 219 871B doi 10 1126 science 6823554 PMID 6823554 Brown MS Anderson RG Goldstein JL Mar 1983 Recycling receptors the round trip itinerary of migrant membrane proteins Cell 32 3 663 7 doi 10 1016 0092 8674 83 90052 1 PMID 6299572 S2CID 34919831 Tolleshaug H Hobgood KK Brown MS Goldstein JL Mar 1983 The LDL receptor locus in familial hypercholesterolemia multiple mutations disrupt transport and processing of a membrane receptor Cell 32 3 941 51 doi 10 1016 0092 8674 83 90079 X PMID 6299582 S2CID 39955408 Larkin JM Brown MS Goldstein JL Anderson RG May 1983 Depletion of intracellular potassium arrests coated pit formation and receptor mediated endocytosis in fibroblasts Cell 33 1 273 85 doi 10 1016 0092 8674 83 90356 2 PMID 6147196 S2CID 22848187 Orci L Brown MS Goldstein JL Garcia Segura LM Anderson RG Apr 1984 Increase in membrane cholesterol a possible trigger for degradation of HMG CoA reductase and crystalloid endoplasmic reticulum in UT 1 cells Cell 36 4 835 45 doi 10 1016 0092 8674 84 90033 3 PMID 6705048 S2CID 24586649 Chin DJ Gil G Russell DW et al 1984 Nucleotide sequence of 3 hydroxy 3 methyl glutaryl coenzyme A reductase a glycoprotein of endoplasmic reticulum Nature 308 5960 613 7 Bibcode 1984Natur 308 613C doi 10 1038 308613a0 PMID 6546784 S2CID 4308995 Russell DW Schneider WJ Yamamoto T Luskey KL Brown MS Goldstein JL Jun 1984 Domain map of the LDL receptor sequence homology with the epidermal growth factor precursor Cell 37 2 577 85 doi 10 1016 0092 8674 84 90388 X PMID 6327078 S2CID 29839468 Reynolds GA Basu SK Osborne TF et al Aug 1984 HMG CoA reductase a negatively regulated gene with unusual promoter and 5 untranslated regions Cell 38 1 275 85 doi 10 1016 0092 8674 84 90549 X PMID 6088070 S2CID 11644830 Yamamoto T Davis CG Brown MS et al Nov 1984 The human LDL receptor a cysteine rich protein with multiple Alu sequences in its mRNA Cell 39 1 27 38 doi 10 1016 0092 8674 84 90188 0 PMID 6091915 S2CID 25822170 Lehrman MA Schneider WJ Sudhof TC Brown MS Goldstein JL Russell DW Jan 1985 Mutation in LDL receptor Alu Alu recombination deletes exons encoding transmembrane and cytoplasmic domains Science 227 4683 140 6 Bibcode 1985Sci 227 140L doi 10 1126 science 3155573 PMC 4449727 PMID 3155573 Sudhof TC Goldstein JL Brown MS Russell DW May 1985 The LDL receptor gene a mosaic of exons shared with different proteins Science 228 4701 815 22 Bibcode 1985Sci 228 815S doi 10 1126 science 2988123 PMC 4450672 PMID 2988123 Sudhof TC Russell DW Goldstein JL Brown MS Sanchez Pescador R Bell GI May 1985 Cassette of eight exons shared by genes for LDL receptor and EGF precursor Science 228 4701 893 5 Bibcode 1985Sci 228 893S doi 10 1126 science 3873704 PMID 3873704 Gil G Faust JR Chin DJ Goldstein JL Brown MS May 1985 Membrane bound domain of HMG CoA reductase is required for sterol enhanced degradation of the enzyme Cell 41 1 249 58 doi 10 1016 0092 8674 85 90078 9 PMID 3995584 S2CID 22530611 Lehrman MA Goldstein JL Brown MS Russell DW Schneider WJ Jul 1985 Internalization defective LDL receptors produced by genes with nonsense and frameshift mutations that truncate the cytoplasmic domain Cell 41 3 735 43 doi 10 1016 S0092 8674 85 80054 4 PMID 3924410 S2CID 27773467 Osborne TF Goldstein JL Brown MS Aug 1985 5 end of HMG CoA reductase gene contains sequences responsible for cholesterol mediated inhibition of transcription Cell 42 1 203 12 doi 10 1016 S0092 8674 85 80116 1 PMID 3860301 S2CID 37319421 Brown MS Goldstein JL 1985 Scavenger cell receptor shared Nature 316 6030 680 1 doi 10 1038 316680a0 PMID 4033768 S2CID 4349775 Brown MS Goldstein JL Apr 1986 A receptor mediated pathway for cholesterol homeostasis Science 232 4746 34 47 Bibcode 1986Sci 232 34B doi 10 1126 science 3513311 PMID 3513311 Davis CG Lehrman MA Russell DW Anderson RG Brown MS Goldstein JL Apr 1986 The J D mutation in familial hypercholesterolemia amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors Cell 45 1 15 24 doi 10 1016 0092 8674 86 90533 7 PMID 3955657 S2CID 8147673 Yamamoto T Bishop RW Brown MS Goldstein JL Russell DW Jun 1986 Deletion in cysteine rich region of LDL receptor impedes transport to cell surface in WHHL rabbit Science 232 4755 1230 7 Bibcode 1986Sci 232 1230Y doi 10 1126 science 3010466 PMC 4451858 PMID 3010466 Lehrman MA Goldstein JL Russell DW Brown MS Mar 1987 Duplication of seven exons in LDL receptor gene caused by Alu Alu recombination in a subject with familial hypercholesterolemia Cell 48 5 827 35 doi 10 1016 0092 8674 87 90079 1 PMID 3815525 S2CID 35887205 Sudhof TC Russell DW Brown MS Goldstein JL Mar 1987 42 bp element from LDL receptor gene confers end product repression by sterols when inserted into viral TK promoter Cell 48 6 1061 9 doi 10 1016 0092 8674 87 90713 6 PMID 3030558 S2CID 42788737 Davis CG Goldstein JL Sudhof TC Anderson RG Russell DW Brown MS 1987 Acid dependent ligand dissociation and recycling of LDL receptor mediated by growth factor homology region Nature 326 6115 760 5 Bibcode 1987Natur 326 760D doi 10 1038 326760a0 PMID 3494949 S2CID 4347695 Hofmann SL Russell DW Brown MS Goldstein JL Hammer RE Mar 1988 Overexpression of low density lipoprotein LDL receptor eliminates LDL from plasma in transgenic mice Science 239 4845 1277 81 Bibcode 1988Sci 239 1277H doi 10 1126 science 3344433 PMID 3344433 Reiss Y Goldstein JL Seabra MC Casey PJ Brown MS Jul 1990 Inhibition of purified p21ras farnesyl protein transferase by Cys AAX tetrapeptides Cell 62 1 81 8 doi 10 1016 0092 8674 90 90242 7 PMID 2194674 S2CID 30887422 Yokode M Hammer RE Ishibashi S Brown MS Goldstein JL Nov 1990 Diet induced hypercholesterolemia in mice prevention by overexpression of LDL receptors Science 250 4985 1273 5 Bibcode 1990Sci 250 1273Y doi 10 1126 science 2244210 PMID 2244210 Seabra MC Reiss Y Casey PJ Brown MS Goldstein JL May 1991 Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit Cell 65 3 429 34 doi 10 1016 0092 8674 91 90460 G PMID 2018975 S2CID 54388220 Chen WJ Andres DA Goldstein JL Russell DW Brown MS Jul 1991 cDNA cloning and expression of the peptide binding beta subunit of rat p21ras farnesyltransferase the counterpart of yeast DPR1 RAM1 Cell 66 2 327 34 doi 10 1016 0092 8674 91 90622 6 PMID 1855253 S2CID 36722957 Seabra MC Brown MS Slaughter CA Sudhof TC Goldstein JL Sep 1992 Purification of component A of Rab geranylgeranyl transferase possible identity with the choroideremia gene product Cell 70 6 1049 57 doi 10 1016 0092 8674 92 90253 9 PMID 1525821 S2CID 26223659 Brown MS Goldstein JL Oct 1992 Koch s postulates for cholesterol Cell 71 2 187 8 doi 10 1016 0092 8674 92 90346 E PMID 1423585 S2CID 33048207 Andres DA Seabra MC Brown MS et al Jun 1993 cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein Cell 73 6 1091 9 doi 10 1016 0092 8674 93 90639 8 PMID 8513495 S2CID 26120573 Yokoyama C Wang X Briggs MR et al Oct 1993 SREBP 1 a basic helix loop helix leucine zipper protein that controls transcription of the low density lipoprotein receptor gene Cell 75 1 187 97 doi 10 1016 S0092 8674 05 80095 9 PMID 8402897 S2CID 2784016 Garcia CK Goldstein JL Pathak RK Anderson RG Brown MS Mar 1994 Molecular characterization of a membrane transporter for lactate pyruvate and other monocarboxylates implications for the Cori cycle Cell 76 5 865 73 doi 10 1016 0092 8674 94 90361 1 PMID 8124722 S2CID 22137883 Wang X Sato R Brown MS Hua X Goldstein JL Apr 1994 SREBP 1 a membrane bound transcription factor released by sterol regulated proteolysis Cell 77 1 53 62 doi 10 1016 0092 8674 94 90234 8 PMID 8156598 S2CID 44899129 Sakai J Duncan EA Rawson RB Hua X Brown MS Goldstein JL Jun 1996 Sterol regulated release of SREBP 2 from cell membranes requires two sequential cleavages one within a transmembrane segment Cell 85 7 1037 46 doi 10 1016 S0092 8674 00 81304 5 PMID 8674110 S2CID 6130686 Hua X Nohturfft A Goldstein JL Brown MS Nov 1996 Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein Cell 87 3 415 26 doi 10 1016 S0092 8674 00 81362 8 PMID 8898195 S2CID 1963192 Brown MS Goldstein JL May 1997 The SREBP pathway regulation of cholesterol metabolism by proteolysis of a membrane bound transcription factor Cell 89 3 331 40 doi 10 1016 S0092 8674 00 80213 5 PMID 9150132 S2CID 17882616 DeBose Boyd RA Brown MS Li WP Nohturfft A Goldstein JL Espenshade PJ Dec 1999 Transport dependent proteolysis of SREBP relocation of site 1 protease from Golgi to ER obviates the need for SREBP transport to Golgi Cell 99 7 703 12 doi 10 1016 S0092 8674 00 81668 2 PMID 10619424 Brown MS Ye J Rawson RB Goldstein JL Feb 2000 Regulated intramembrane proteolysis a control mechanism conserved from bacteria to humans Cell 100 4 391 8 doi 10 1016 S0092 8674 00 80675 3 PMID 10693756 S2CID 12194770 Nohturfft A Yabe D Goldstein JL Brown MS Espenshade PJ Aug 2000 Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes Cell 102 3 315 23 doi 10 1016 S0092 8674 00 00037 4 PMID 10975522 S2CID 18054832 Yang T Espenshade PJ Wright ME et al Aug 2002 Crucial step in cholesterol homeostasis sterols promote binding of SCAP to INSIG 1 a membrane protein that facilitates retention of SREBPs in ER Cell 110 4 489 500 doi 10 1016 S0092 8674 02 00872 3 PMID 12202038 S2CID 15052132 See also EditList of Jewish Nobel laureatesReferences Edit a b Professor Michael Brown ForMemRS London Royal Society Archived from the original on 2015 11 06 Biography Michael S Brown The Notable Names Database Soylent Communications 2008 Retrieved 2008 06 15 Michael Brown Nobel Prize Inspiration Initiative Nobelprizeii org Retrieved 2015 11 06 a b Michael S Brown Biographical Nobelprize org 1941 04 13 Retrieved 2015 11 06 Michael S Brown Nobel Lecture A Receptor Mediated Pathway for Cholesterol Homeostasis Nobelprize org 1985 12 08 Retrieved 2015 11 06 BROWN Brown Michael photo biography Persona rin ru 1941 04 13 Retrieved 2015 11 06 Jewish Nobel Prize Winners in Medicine www jinfo org Retrieved 2023 03 30 Earl and Thressa Stadtman Distinguished Scientist Award Asbmb org Retrieved 2015 11 06 University of Texas Southwestern Medical Center Leaders to Receive Research America Advocacy Award Research America 2007 03 21 Retrieved 2015 11 06 1 Archived October 8 2013 at the Wayback Machine Herbert Tabor Research Award Asbmb org Retrieved 2015 11 06 Albany Medical College 2003 Amc edu 2015 08 14 Retrieved 2015 11 06 Daniel W Foster Jean D Wilson Presentation of the Kober Medal to Joseph L Goldstein and Michael S Brown PDF Jci org Retrieved 2015 11 06 2 Archived April 10 2012 at the Wayback Machine APS Member History Golden Plate Awardees of the American Academy of Achievement www achievement org American Academy of Achievement The Nobel Prize in Physiology or Medicine 1985 nobelprize org The Nobel Foundation Retrieved 18 October 2022 1985 Basic Medical Research Award The Lasker Foundation 2007 09 16 Archived from the original on 2015 09 13 Retrieved 2015 11 06 Past ASHG Award Recipients ASHG Archived from the original on 2014 10 03 Retrieved 2015 11 06 Horwitz Prize Awardees cuimc columbia edu Columbia University 20 June 2018 Retrieved 18 October 2022 Joseph L Goldstein Gairdner Retrieved 2015 11 06 Michael Stuart Brown Michael Brown www nasonline org Retrieved 23 March 2018 Richard Lounsbery Award Nasonline org Retrieved 2015 11 06 3 Archived October 7 2012 at the Wayback Machine Pfizer Award in Enzyme Chemistry Divbiolchem org Retrieved 2015 11 06 Heinrich Wieland Prize Laureates 1970 1979 Boehringer Ingelheim Stiftung Boehringer Ingelheim Stiftung Retrieved 18 October 2022 External links EditMichael S Brown on Nobelprize org nbsp nbsp Wikimedia Commons has media related to Michael S Brown Retrieved from https en wikipedia org w index php title Michael Stuart Brown amp oldid 1165805772, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.