fbpx
Wikipedia

Melanocortin 5 receptor

January 01, 1970

Melanocortin 5 receptor (MC5R) is a protein that in humans is encoded by the MC5R gene.[5][6] It is located on the chromosome 18 in the human genome.[6] When the MC5R was disrupted in transgenic mice, it induced disruption of their exocrine glands and resulted in decreased production of sebum.[7]

MC5R
Identifiers
AliasesMC5R, MC2, Melanocortin 5 receptor
External IDsOMIM: 600042 MGI: 99420 HomoloGene: 4321 GeneCards: MC5R
Orthologs
SpeciesHumanMouse
Entrez

4161

17203

Ensembl

ENSG00000176136

ENSMUSG00000007480

UniProt

P33032

P41149

RefSeq (mRNA)

NM_005913

NM_013596

RefSeq (protein)

NP_005904

NP_038624

Location (UCSC)Chr 18: 13.82 – 13.83 MbChr 18: 68.47 – 68.48 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Physiology edit

MC5R is necessary for normal sebum production.[7][8][9] Stimulation of MC5R promotes fatty acid oxidation in skeletal muscle[10] and lypolysis in adipocytes.[11] MC5R is essential for erythrocyte differentiation.[12] MC5R is involved in inflammation.[13][14] MC5R helps maintain thermal homeostasis.[8][15]

MC5R is expressed in the brain at different levels depending on physical activity.[16]

Pheromones edit

MC5R is heavily expressed in the preputial gland in mice (a modified sebaceous gland involved in pheromone production). MC5R deficiency in male mice decreases aggressive behavior, promotes defensive behavior and encourages other male mice to attack MC5R-deficient males through pheromonal signals.[17][18][19]

MRAP edit

Melanocortin 2 receptor accessory protein (MRAP) traps MC5R protein inside cells.[20]

Evolution edit

Paralogues[21] edit

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000176136 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007480 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Chhajlani V, Muceniece R, Wikberg JE (September 1993). "Molecular cloning of a novel human melanocortin receptor". Biochemical and Biophysical Research Communications. 195 (2): 866–73. doi:10.1006/bbrc.1993.2125. PMID 8396929.
  6. ^ a b "Entrez Gene: MC5R melanocortin 5 receptor".
  7. ^ a b Thiboutot D, Sivarajah A, Gilliland K, Cong Z, Clawson G (October 2000). "The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells". The Journal of Investigative Dermatology. 115 (4): 614–9. doi:10.1046/j.1523-1747.2000.00094.x. PMID 10998132.
  8. ^ a b Chen W, Kelly MA, Opitz-Araya X, Thomas RE, Low MJ, Cone RD (December 1997). "Exocrine gland dysfunction in MC5-R-deficient mice: evidence for coordinated regulation of exocrine gland function by melanocortin peptides". Cell. 91 (6): 789–98. doi:10.1016/S0092-8674(00)80467-5. PMID 9413988. S2CID 6251691.
  9. ^ Zhang L, Li WH, Anthonavage M, Pappas A, Rossetti D, Cavender D, Seiberg M, Eisinger M (June 2011). "Melanocortin-5 receptor and sebogenesis". Eur J Pharmacol. 660 (1): 202–206. doi:10.1016/j.ejphar.2010.10.100. PMID 21215742.
  10. ^ An JJ, Rhee Y, Kim SH, Kim DM, Han DH, Hwang JH, Jin YJ, Cha BS, Baik JH, Lee WT, Lim SK (February 2007). "Peripheral effect of alpha-melanocyte-stimulating hormone on fatty acid oxidation in skeletal muscle". The Journal of Biological Chemistry. 282 (5): 2862–70. doi:10.1074/jbc.M603454200. PMID 17127674.
  11. ^ Møller CL, Raun K, Jacobsen ML, Pedersen TÅ, Holst B, Conde-Frieboes KW, Wulff BS (July 2011). "Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved" (PDF). Mol Cell Endocrinol. 341 (1–2): 9–17. doi:10.1016/j.mce.2011.03.010. PMID 21616121. S2CID 31837693.
  12. ^ Simamura E, Arikawa T, Ikeda T, Shimada H, Shoji H, Masuta H, Nakajima Y, Otani H, Yonekura H, Hatta T (April 2015). "Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1, 2 and 5". PLOS ONE. 10 (4): e0123232. Bibcode:2015PLoSO..1023232S. doi:10.1371/journal.pone.0123232. PMC 4393082. PMID 25860801.
  13. ^ Lee DJ, Taylor AW (October 2013). "Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice". J. Immunol. 191 (8): 4103–4111. doi:10.4049/jimmunol.1300182. PMC 3796047. PMID 24043903.
  14. ^ Jun DJ, Na KY, Kim W, Kwak D, Kwon EJ, Yoon JH, Yea K, Lee H, Kim J, Suh PG, Ryu SH, Kim KT (April 2010). "Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes". J Mol Endocrinol. 44 (4): 225–236. doi:10.1677/JME-09-0161. PMC 3058511. PMID 20089716.
  15. ^ Lute B, Jou W, Lateef DM, Goldgof M, Xiao C, Piñol RA, Kravitz AV, Miller NR, Huang YG, Girardet C, Butler AA, Gavrilova O, Reitman ML (August 2014). "Biphasic effect of melanocortin agonists on metabolic rate and body temperature". Cell Metab. 20 (2): 333–345. doi:10.1016/j.cmet.2014.05.021. PMC 4126889. PMID 24981835.
  16. ^ Shukla C, Britton SL, Koch LG, Novak CM (July 2012). "Region-specific differences in brain melanocortin receptors in rats of the lean phenotype". NeuroReport. 23 (10): 596–600. doi:10.1097/WNR.0b013e328354f5c1. PMC 3831884. PMID 22643233.
  17. ^ Morgan C, Thomas RE, Cone RD (January 2004). "Melanocortin-5 receptor deficiency promotes defensive behavior in male mice". Horm. Behav. 45 (1): 56–63. doi:10.1016/j.yhbeh.2003.08.004. PMID 14733892. S2CID 32531156.
  18. ^ Morgan C, Thomas RE, Ma W, Novotny MV, Cone RD (February 2004). "Melanocortin-5 receptor deficiency reduces a pheromonal signal for aggression in male mice". Chem Senses. 29 (2): 111–115. doi:10.1093/chemse/bjh011. PMID 14977807.
  19. ^ Morgan C, Cone RD (January 2006). "Melanocortin-5 receptor deficiency in mice blocks a novel pathway influencing pheromone-induced aggression". Behav. Genet. 36 (2): 291–300. doi:10.1007/s10519-005-9024-9. PMID 16408249. S2CID 9659300.
  20. ^ Sebag JA, Hinkle PM (August 2009). "Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking". J Biol Chem. 284 (34): 22641–22648. doi:10.1074/jbc.M109.022400. PMC 2755671. PMID 19535343.
  21. ^ "GeneCards®: The Human Gene Database".

Further reading edit

  • Fathi Z, Iben LG, Parker EM (January 1995). "Cloning, expression, and tissue distribution of a fifth melanocortin receptor subtype". Neurochemical Research. 20 (1): 107–13. doi:10.1007/BF00995160. PMID 7739752. S2CID 20792213.
  • Chowdhary BP, Gustavsson I, Wikberg JE, Chhajlani V (1994). "Localization of the human melanocortin-5 receptor gene (MC5R) to chromosome band 18p11.2 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 68 (1–2): 79–81. doi:10.1159/000133895. PMID 7956366.
  • Griffon N, Mignon V, Facchinetti P, Diaz J, Schwartz JC, Sokoloff P (April 1994). "Molecular cloning and characterization of the rat fifth melanocortin receptor". Biochemical and Biophysical Research Communications. 200 (2): 1007–14. doi:10.1006/bbrc.1994.1550. PMID 8179577.
  • Gantz I, Shimoto Y, Konda Y, Miwa H, Dickinson CJ, Yamada T (May 1994). "Molecular cloning, expression, and characterization of a fifth melanocortin receptor" (PDF). Biochemical and Biophysical Research Communications. 200 (3): 1214–20. doi:10.1006/bbrc.1994.1580. hdl:2027.42/31580. PMID 8185570.
  • Chhajlani V (February 1996). "Distribution of cDNA for melanocortin receptor subtypes in human tissues". Biochemistry and Molecular Biology International. 38 (1): 73–80. PMID 8932521.
  • Yang YK, Ollmann MM, Wilson BD, Dickinson C, Yamada T, Barsh GS, Gantz I (March 1997). "Effects of recombinant agouti-signaling protein on melanocortin action". Molecular Endocrinology. 11 (3): 274–80. doi:10.1210/mend.11.3.9898. PMID 9058374.
  • Frändberg PA, Xu X, Chhajlani V (July 1997). "Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH". Biochemical and Biophysical Research Communications. 236 (2): 489–92. doi:10.1006/bbrc.1997.6994. PMID 9240466.
  • Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I (January 1999). "Characterization of Agouti-related protein binding to melanocortin receptors". Molecular Endocrinology. 13 (1): 148–55. doi:10.1210/me.13.1.148. PMID 9892020.
  • Hatta N, Dixon C, Ray AJ, Phillips SR, Cunliffe WJ, Dale M, Todd C, Meggit S, Birch-MacHin MA, Rees JL (April 2001). "Expression, candidate gene, and population studies of the melanocortin 5 receptor". The Journal of Investigative Dermatology. 116 (4): 564–70. doi:10.1046/j.0022-202x.2001.01286.x. PMID 11286624.
  • Bednarek MA, MacNeil T, Kalyani RN, Tang R, Van der Ploeg LH, Weinberg DH (October 2001). "Selective, high affinity peptide antagonists of alpha-melanotropin action at human melanocortin receptor 4: their synthesis and biological evaluation in vitro". Journal of Medicinal Chemistry. 44 (22): 3665–72. doi:10.1021/jm010165y. PMID 11606131.
  • Lapinsh M, Veiksina S, Uhlén S, Petrovska R, Mutule I, Mutulis F, Yahorava S, Prusis P, Wikberg JE (January 2005). "Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes". Molecular Pharmacology. 67 (1): 50–9. doi:10.1124/mol.104.002857. PMID 15470082. S2CID 13536417.
  • Lohoff FW, Berrettini WH (December 2005). "Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder". Psychiatric Genetics. 15 (4): 255–8. doi:10.1097/00041444-200512000-00007. PMID 16314755. S2CID 21170090.
  • Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ (June 2007). "Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5". Peptides. 28 (6): 1191–6. doi:10.1016/j.peptides.2007.02.012. PMC 1955225. PMID 17482720.

External links edit

  • . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-07-14. Retrieved 2008-12-05.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

January 01, 1970
melanocortin, receptor, mc5r, protein, that, humans, encoded, mc5r, gene, located, chromosome, human, genome, when, mc5r, disrupted, transgenic, mice, induced, disruption, their, exocrine, glands, resulted, decreased, production, sebum, mc5ridentifiersaliasesm. Melanocortin 5 receptor MC5R is a protein that in humans is encoded by the MC5R gene 5 6 It is located on the chromosome 18 in the human genome 6 When the MC5R was disrupted in transgenic mice it induced disruption of their exocrine glands and resulted in decreased production of sebum 7 MC5RIdentifiersAliasesMC5R MC2 Melanocortin 5 receptorExternal IDsOMIM 600042 MGI 99420 HomoloGene 4321 GeneCards MC5RGene location Human Chr Chromosome 18 human 1 Band18p11 21Start13 824 149 bp 1 End13 827 323 bp 1 Gene location Mouse Chr Chromosome 18 mouse 2 Band18 E2 18 41 46 cMStart68 470 667 bp 2 End68 475 517 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inprefrontal cortexthymuscingulate gyrusskin of abdomenlymph nodeexocrine glandheadhypothalamusconnective tissueadipose tissueTop expressed inlacrimal glandliptriceps brachii muscleskin of abdomenankleentorhinal cortexextraocular muscletemporal muscledigastric muscleskin of backMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmelanocortin receptor activity protein binding G protein coupled receptor activity signal transducer activity hormone bindingCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membrane intracellular anatomical structureBiological processG protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger signal transduction G protein coupled receptor signaling pathway adenylate cyclase activating G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez416117203EnsemblENSG00000176136ENSMUSG00000007480UniProtP33032P41149RefSeq mRNA NM 005913NM 013596RefSeq protein NP 005904NP 038624Location UCSC Chr 18 13 82 13 83 MbChr 18 68 47 68 48 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Physiology 1 1 Pheromones 1 2 MRAP 2 Evolution 2 1 Paralogues 21 3 See also 4 References 5 Further reading 6 External linksPhysiology editMC5R is necessary for normal sebum production 7 8 9 Stimulation of MC5R promotes fatty acid oxidation in skeletal muscle 10 and lypolysis in adipocytes 11 MC5R is essential for erythrocyte differentiation 12 MC5R is involved in inflammation 13 14 MC5R helps maintain thermal homeostasis 8 15 MC5R is expressed in the brain at different levels depending on physical activity 16 Pheromones edit MC5R is heavily expressed in the preputial gland in mice a modified sebaceous gland involved in pheromone production MC5R deficiency in male mice decreases aggressive behavior promotes defensive behavior and encourages other male mice to attack MC5R deficient males through pheromonal signals 17 18 19 MRAP edit Melanocortin 2 receptor accessory protein MRAP traps MC5R protein inside cells 20 Evolution editParalogues 21 edit MC4R MC3R MC1R MC2R S1PR1 LPAR1 S1PR3 GPR12 LPAR2 GPR3 S1PR2 GPR6 GPR119 LPAR3 CNR1 S1PR5 S1PR4 CNR2See also editMelanocortin receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000176136 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000007480 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Chhajlani V Muceniece R Wikberg JE September 1993 Molecular cloning of a novel human melanocortin receptor Biochemical and Biophysical Research Communications 195 2 866 73 doi 10 1006 bbrc 1993 2125 PMID 8396929 a b Entrez Gene MC5R melanocortin 5 receptor a b Thiboutot D Sivarajah A Gilliland K Cong Z Clawson G October 2000 The melanocortin 5 receptor is expressed in human sebaceous glands and rat preputial cells The Journal of Investigative Dermatology 115 4 614 9 doi 10 1046 j 1523 1747 2000 00094 x PMID 10998132 a b Chen W Kelly MA Opitz Araya X Thomas RE Low MJ Cone RD December 1997 Exocrine gland dysfunction in MC5 R deficient mice evidence for coordinated regulation of exocrine gland function by melanocortin peptides Cell 91 6 789 98 doi 10 1016 S0092 8674 00 80467 5 PMID 9413988 S2CID 6251691 Zhang L Li WH Anthonavage M Pappas A Rossetti D Cavender D Seiberg M Eisinger M June 2011 Melanocortin 5 receptor and sebogenesis Eur J Pharmacol 660 1 202 206 doi 10 1016 j ejphar 2010 10 100 PMID 21215742 An JJ Rhee Y Kim SH Kim DM Han DH Hwang JH Jin YJ Cha BS Baik JH Lee WT Lim SK February 2007 Peripheral effect of alpha melanocyte stimulating hormone on fatty acid oxidation in skeletal muscle The Journal of Biological Chemistry 282 5 2862 70 doi 10 1074 jbc M603454200 PMID 17127674 Moller CL Raun K Jacobsen ML Pedersen TA Holst B Conde Frieboes KW Wulff BS July 2011 Characterization of murine melanocortin receptors mediating adipocyte lipolysis and examination of signalling pathways involved PDF Mol Cell Endocrinol 341 1 2 9 17 doi 10 1016 j mce 2011 03 010 PMID 21616121 S2CID 31837693 Simamura E Arikawa T Ikeda T Shimada H Shoji H Masuta H Nakajima Y Otani H Yonekura H Hatta T April 2015 Melanocortins contribute to sequential differentiation and enucleation of human erythroblasts via melanocortin receptors 1 2 and 5 PLOS ONE 10 4 e0123232 Bibcode 2015PLoSO 1023232S doi 10 1371 journal pone 0123232 PMC 4393082 PMID 25860801 Lee DJ Taylor AW October 2013 Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post experimental autoimmune uveitis in mice J Immunol 191 8 4103 4111 doi 10 4049 jimmunol 1300182 PMC 3796047 PMID 24043903 Jun DJ Na KY Kim W Kwak D Kwon EJ Yoon JH Yea K Lee H Kim J Suh PG Ryu SH Kim KT April 2010 Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3 L1 adipocytes J Mol Endocrinol 44 4 225 236 doi 10 1677 JME 09 0161 PMC 3058511 PMID 20089716 Lute B Jou W Lateef DM Goldgof M Xiao C Pinol RA Kravitz AV Miller NR Huang YG Girardet C Butler AA Gavrilova O Reitman ML August 2014 Biphasic effect of melanocortin agonists on metabolic rate and body temperature Cell Metab 20 2 333 345 doi 10 1016 j cmet 2014 05 021 PMC 4126889 PMID 24981835 Shukla C Britton SL Koch LG Novak CM July 2012 Region specific differences in brain melanocortin receptors in rats of the lean phenotype NeuroReport 23 10 596 600 doi 10 1097 WNR 0b013e328354f5c1 PMC 3831884 PMID 22643233 Morgan C Thomas RE Cone RD January 2004 Melanocortin 5 receptor deficiency promotes defensive behavior in male mice Horm Behav 45 1 56 63 doi 10 1016 j yhbeh 2003 08 004 PMID 14733892 S2CID 32531156 Morgan C Thomas RE Ma W Novotny MV Cone RD February 2004 Melanocortin 5 receptor deficiency reduces a pheromonal signal for aggression in male mice Chem Senses 29 2 111 115 doi 10 1093 chemse bjh011 PMID 14977807 Morgan C Cone RD January 2006 Melanocortin 5 receptor deficiency in mice blocks a novel pathway influencing pheromone induced aggression Behav Genet 36 2 291 300 doi 10 1007 s10519 005 9024 9 PMID 16408249 S2CID 9659300 Sebag JA Hinkle PM August 2009 Opposite effects of the melanocortin 2 MC2 receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking J Biol Chem 284 34 22641 22648 doi 10 1074 jbc M109 022400 PMC 2755671 PMID 19535343 GeneCards The Human Gene Database Further reading editFathi Z Iben LG Parker EM January 1995 Cloning expression and tissue distribution of a fifth melanocortin receptor subtype Neurochemical Research 20 1 107 13 doi 10 1007 BF00995160 PMID 7739752 S2CID 20792213 Chowdhary BP Gustavsson I Wikberg JE Chhajlani V 1994 Localization of the human melanocortin 5 receptor gene MC5R to chromosome band 18p11 2 by fluorescence in situ hybridization Cytogenetics and Cell Genetics 68 1 2 79 81 doi 10 1159 000133895 PMID 7956366 Griffon N Mignon V Facchinetti P Diaz J Schwartz JC Sokoloff P April 1994 Molecular cloning and characterization of the rat fifth melanocortin receptor Biochemical and Biophysical Research Communications 200 2 1007 14 doi 10 1006 bbrc 1994 1550 PMID 8179577 Gantz I Shimoto Y Konda Y Miwa H Dickinson CJ Yamada T May 1994 Molecular cloning expression and characterization of a fifth melanocortin receptor PDF Biochemical and Biophysical Research Communications 200 3 1214 20 doi 10 1006 bbrc 1994 1580 hdl 2027 42 31580 PMID 8185570 Chhajlani V February 1996 Distribution of cDNA for melanocortin receptor subtypes in human tissues Biochemistry and Molecular Biology International 38 1 73 80 PMID 8932521 Yang YK Ollmann MM Wilson BD Dickinson C Yamada T Barsh GS Gantz I March 1997 Effects of recombinant agouti signaling protein on melanocortin action Molecular Endocrinology 11 3 274 80 doi 10 1210 mend 11 3 9898 PMID 9058374 Frandberg PA Xu X Chhajlani V July 1997 Glutamine235 and arginine272 in human melanocortin 5 receptor determines its low affinity to MSH Biochemical and Biophysical Research Communications 236 2 489 92 doi 10 1006 bbrc 1997 6994 PMID 9240466 Yang YK Thompson DA Dickinson CJ Wilken J Barsh GS Kent SB Gantz I January 1999 Characterization of Agouti related protein binding to melanocortin receptors Molecular Endocrinology 13 1 148 55 doi 10 1210 me 13 1 148 PMID 9892020 Hatta N Dixon C Ray AJ Phillips SR Cunliffe WJ Dale M Todd C Meggit S Birch MacHin MA Rees JL April 2001 Expression candidate gene and population studies of the melanocortin 5 receptor The Journal of Investigative Dermatology 116 4 564 70 doi 10 1046 j 0022 202x 2001 01286 x PMID 11286624 Bednarek MA MacNeil T Kalyani RN Tang R Van der Ploeg LH Weinberg DH October 2001 Selective high affinity peptide antagonists of alpha melanotropin action at human melanocortin receptor 4 their synthesis and biological evaluation in vitro Journal of Medicinal Chemistry 44 22 3665 72 doi 10 1021 jm010165y PMID 11606131 Lapinsh M Veiksina S Uhlen S Petrovska R Mutule I Mutulis F Yahorava S Prusis P Wikberg JE January 2005 Proteochemometric mapping of the interaction of organic compounds with melanocortin receptor subtypes Molecular Pharmacology 67 1 50 9 doi 10 1124 mol 104 002857 PMID 15470082 S2CID 13536417 Lohoff FW Berrettini WH December 2005 Lack of association between variations in the melanocortin 5 receptor gene and bipolar disorder Psychiatric Genetics 15 4 255 8 doi 10 1097 00041444 200512000 00007 PMID 16314755 S2CID 21170090 Grieco P Cai M Han G Trivedi D Campiglia P Novellino E Hruby VJ June 2007 Further structure activity studies of lactam derivatives of MT II and SHU 9119 their activity and selectivity at human melanocortin receptors 3 4 and 5 Peptides 28 6 1191 6 doi 10 1016 j peptides 2007 02 012 PMC 1955225 PMID 17482720 External links edit Melanocortin Receptors MC5 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Archived from the original on 2014 07 14 Retrieved 2008 12 05 This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Melanocortin 5 receptor amp oldid 1191995944, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.