Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P3.[5]
This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function.[5]
Hla T, Lee MJ, Ancellin N, et al. (2000). "Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 16–24. Bibcode:2000NYASA.905...16H. doi:10.1111/j.1749-6632.2000.tb06534.x. PMID 10818438. S2CID 19435541.
Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905 (1): 54–60. Bibcode:2000NYASA.905...54S. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. S2CID 9257870.
Watsky MA, Griffith M, Wang DA, Tigyi GJ (2000). "Phospholipid growth factors and corneal wound healing". Ann. N. Y. Acad. Sci. 905 (1): 142–58. Bibcode:2000NYASA.905..142W. doi:10.1111/j.1749-6632.2000.tb06546.x. PMID 10818450. S2CID 9789496.
Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
Van Koppen CJ, Meyer Zu Heringdorf D, Zhang C, et al. (1996). "A distinct G(i) protein-coupled receptor for sphingosylphosphorylcholine in human leukemia HL-60 cells and human neutrophils". Mol. Pharmacol. 49 (6): 956–61. PMID 8649355.
Yamaguchi F, Tokuda M, Hatase O, Brenner S (1996). "Molecular cloning of the novel human G protein-coupled receptor (GPCR) gene mapped on chromosome 9". Biochem. Biophys. Res. Commun. 227 (2): 608–14. doi:10.1006/bbrc.1996.1553. PMID 8878560.
An S, Bleu T, Huang W, et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. doi:10.1016/S0014-5793(97)01301-X. PMID 9409733. S2CID 26300053.
Van Brocklyn JR, Tu Z, Edsall LC, et al. (1999). "Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218". J. Biol. Chem. 274 (8): 4626–32. doi:10.1074/jbc.274.8.4626. PMID 9988698.
Zhang Q, Peyruchaud O, French KJ, et al. (1999). "Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway". Blood. 93 (9): 2984–90. doi:10.1182/blood.V93.9.2984. PMID 10216094.
Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. doi:10.1074/jbc.274.27.18997. PMID 10383399.
Windh RT, Lee MJ, Hla T, et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. doi:10.1074/jbc.274.39.27351. PMID 10488065.
Goetzl EJ, Dolezalova H, Kong Y, et al. (1999). "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer". Cancer Res. 59 (20): 5370–5. PMID 10537322.
Lee MJ, Thangada S, Claffey KP, et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. doi:10.1016/S0092-8674(00)81661-X. PMID 10555146. S2CID 1126846.
An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5". J. Biol. Chem. 275 (1): 288–96. doi:10.1074/jbc.275.1.288. PMID 10617617.
Orlati S, Porcelli AM, Hrelia S, et al. (2000). "Sphingosine-1-phosphate activates phospholipase D in human airway epithelial cells via a G protein-coupled receptor". Arch. Biochem. Biophys. 375 (1): 69–77. doi:10.1006/abbi.1999.1589. PMID 10683250.
Lee H, Goetzl EJ, An S (2000). "Lysophosphatidic acid and sphingosine 1-phosphate stimulate endothelial cell wound healing". Am. J. Physiol., Cell Physiol. 278 (3): C612–8. doi:10.1152/ajpcell.2000.278.3.C612. PMID 10712250. S2CID 10976499.
Kimura T, Watanabe T, Sato K, et al. (2000). "Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3". Biochem. J. 348 (1): 71–6. doi:10.1042/0264-6021:3480071. PMC1221037. PMID 10794715.
External linksedit
"Lysophospholipid Receptors: S1P3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Lysophospholipid+receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
s1pr3, sphingosine, phosphate, receptor, also, known, human, gene, which, encodes, protein, coupled, receptor, which, binds, lipid, signaling, molecule, sphingosine, phosphate, hence, this, receptor, also, known, s1p3, identifiersaliases, edg3, lpb3, s1p3, sph. Sphingosine 1 phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein coupled receptor which binds the lipid signaling molecule sphingosine 1 phosphate S1P Hence this receptor is also known as S1P3 5 S1PR3IdentifiersAliasesS1PR3 EDG 3 EDG3 LPB3 S1P3 sphingosine 1 phosphate receptor 3External IDsOMIM 601965 MGI 1339365 HomoloGene 3829 GeneCards S1PR3Gene location Human Chr Chromosome 9 human 1 Band9q22 1Start88 990 863 bp 1 End89 005 155 bp 1 Gene location Mouse Chr Chromosome 13 mouse 2 Band13 13 A5Start51 562 675 bp 2 End51 576 833 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright ventricleright coronary arteryleft coronary arterysuperficial temporal arterystromal cell of endometriumascending aortapopliteal arterygastric mucosametanephrossynovial jointTop expressed ininternal carotid arterymolarleft lung lobeexternal carotid arterydermisfossabody of femurabdominal wallvas deferensmaxillary prominenceMore reference expression dataBioGPSn aGene ontologyMolecular functionsignal transducer activity lipid binding integrin binding sphingosine 1 phosphate receptor activity G protein coupled receptor activity protein bindingCellular componentintegral component of membrane integral component of plasma membrane membrane plasma membraneBiological processNotch signaling pathway signal transduction anatomical structure morphogenesis positive regulation of cytosolic calcium ion concentration G protein coupled receptor signaling pathway adenylate cyclase inhibiting G protein coupled receptor signaling pathway negative regulation of establishment of endothelial barrier positive regulation of cell population proliferation sphingosine 1 phosphate receptor signaling pathway regulation of interleukin 1 beta production cytokine production inflammatory responseSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez190313610EnsemblENSG00000213694ENSMUSG00000067586UniProtQ99500Q9Z0U9RefSeq mRNA NM 005226NM 010101RefSeq protein NP 005217NP 034231Location UCSC Chr 9 88 99 89 01 MbChr 13 51 56 51 58 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Evolution 2 1 Paralogues to S1PR3 Gene 6 3 See also 4 References 5 Further reading 6 External linksFunction editThis gene encodes a member of the EDG family of receptors which are G protein coupled receptors This protein has been identified as a functional receptor for sphingosine 1 phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function 5 Evolution editParalogues to S1PR3 Gene 6 edit S1PR1 S1PR5 S1PR2 S1PR4 LPAR1 LPAR3 LPAR2 CNR1 MC5R GPR6 GPR12 MC4R CNR2 GPR3 MC3R MC2R GPR119 MC1RSee also editLysophospholipid receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000213694 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000067586 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene S1PR3 sphingosine 1 phosphate receptor 3 GeneCards The Human Gene Database Further reading editHla T Lee MJ Ancellin N et al 2000 Sphingosine 1 phosphate signaling via the EDG 1 family of G protein coupled receptors Ann N Y Acad Sci 905 1 16 24 Bibcode 2000NYASA 905 16H doi 10 1111 j 1749 6632 2000 tb06534 x PMID 10818438 S2CID 19435541 Spiegel S 2000 Sphingosine 1 phosphate a ligand for the EDG 1 family of G protein coupled receptors Ann N Y Acad Sci 905 1 54 60 Bibcode 2000NYASA 905 54S doi 10 1111 j 1749 6632 2000 tb06537 x PMID 10818441 S2CID 9257870 Watsky MA Griffith M Wang DA Tigyi GJ 2000 Phospholipid growth factors and corneal wound healing Ann N Y Acad Sci 905 1 142 58 Bibcode 2000NYASA 905 142W doi 10 1111 j 1749 6632 2000 tb06546 x PMID 10818450 S2CID 9789496 Takuwa Y 2002 Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1 phosphate receptors Tanpakushitsu Kakusan Koso 47 4 Suppl 496 502 PMID 11915348 Van Koppen CJ Meyer Zu Heringdorf D Zhang C et al 1996 A distinct G i protein coupled receptor for sphingosylphosphorylcholine in human leukemia HL 60 cells and human neutrophils Mol Pharmacol 49 6 956 61 PMID 8649355 Yamaguchi F Tokuda M Hatase O Brenner S 1996 Molecular cloning of the novel human G protein coupled receptor GPCR gene mapped on chromosome 9 Biochem Biophys Res Commun 227 2 608 14 doi 10 1006 bbrc 1996 1553 PMID 8878560 An S Bleu T Huang W et al 1998 Identification of cDNAs encoding two G protein coupled receptors for lysosphingolipids FEBS Lett 417 3 279 82 doi 10 1016 S0014 5793 97 01301 X PMID 9409733 S2CID 26300053 Van Brocklyn JR Tu Z Edsall LC et al 1999 Sphingosine 1 phosphate induced cell rounding and neurite retraction are mediated by the G protein coupled receptor H218 J Biol Chem 274 8 4626 32 doi 10 1074 jbc 274 8 4626 PMID 9988698 Zhang Q Peyruchaud O French KJ et al 1999 Sphingosine 1 phosphate stimulates fibronectin matrix assembly through a Rho dependent signal pathway Blood 93 9 2984 90 doi 10 1182 blood V93 9 2984 PMID 10216094 Ancellin N Hla T 1999 Differential pharmacological properties and signal transduction of the sphingosine 1 phosphate receptors EDG 1 EDG 3 and EDG 5 J Biol Chem 274 27 18997 9002 doi 10 1074 jbc 274 27 18997 PMID 10383399 Windh RT Lee MJ Hla T et al 1999 Differential coupling of the sphingosine 1 phosphate receptors Edg 1 Edg 3 and H218 Edg 5 to the G i G q and G 12 families of heterotrimeric G proteins J Biol Chem 274 39 27351 8 doi 10 1074 jbc 274 39 27351 PMID 10488065 Goetzl EJ Dolezalova H Kong Y et al 1999 Distinctive expression and functions of the type 4 endothelial differentiation gene encoded G protein coupled receptor for lysophosphatidic acid in ovarian cancer Cancer Res 59 20 5370 5 PMID 10537322 Lee MJ Thangada S Claffey KP et al 1999 Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine 1 phosphate Cell 99 3 301 12 doi 10 1016 S0092 8674 00 81661 X PMID 10555146 S2CID 1126846 An S Zheng Y Bleu T 2000 Sphingosine 1 phosphate induced cell proliferation survival and related signaling events mediated by G protein coupled receptors Edg3 and Edg5 J Biol Chem 275 1 288 96 doi 10 1074 jbc 275 1 288 PMID 10617617 Orlati S Porcelli AM Hrelia S et al 2000 Sphingosine 1 phosphate activates phospholipase D in human airway epithelial cells via a G protein coupled receptor Arch Biochem Biophys 375 1 69 77 doi 10 1006 abbi 1999 1589 PMID 10683250 Lee H Goetzl EJ An S 2000 Lysophosphatidic acid and sphingosine 1 phosphate stimulate endothelial cell wound healing Am J Physiol Cell Physiol 278 3 C612 8 doi 10 1152 ajpcell 2000 278 3 C612 PMID 10712250 S2CID 10976499 Kimura T Watanabe T Sato K et al 2000 Sphingosine 1 phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors Edg 1 and Edg 3 Biochem J 348 1 71 6 doi 10 1042 0264 6021 3480071 PMC 1221037 PMID 10794715 External links edit Lysophospholipid Receptors S1P3 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Lysophospholipid receptors at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title S1PR3 amp oldid 1184821370, wikipedia, wiki, book, books, library,
