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Wikipedia

Meclofenoxate

January 01, 1970

Meclofenoxate (INN, BAN; brand name Lucidril, also known as centrophenoxine) is a cholinergic nootropic used as a dietary supplement.[2][3][4] It is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA).

Meclofenoxate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Legal status
Legal status
  • BR: Class C1 (Other controlled substances)[1]
  • US: Not FDA approved
  • In general: ℞ (Prescription only)
Identifiers
  • 2-Dimethylaminoethyl (4-chlorophenoxy)acetate
CAS Number
  • 51-68-3 Y
PubChem CID
  • 4039
ChemSpider
  • 3899 N
UNII
  • C76QQ2I0RG
KEGG
  • D00993 Y
CompTox Dashboard (EPA)
  • DTXSID9046940
ECHA InfoCard100.000.107
Chemical and physical data
FormulaC12H16ClNO3
Molar mass257.71 g·mol−1
3D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)OCC(=O)OCCN(C)C
  • InChI=1S/C12H16ClNO3/c1-14(2)7-8-16-12(15)9-17-11-5-3-10(13)4-6-11/h3-6H,7-9H2,1-2H3 N
  • Key:XZTYGFHCIAKPGJ-UHFFFAOYSA-N N
 NY (what is this?)  (verify)

In elderly patients, meclofenoxate has been shown to improve performance on certain memory tests.[5] Meclofenoxate also increases cellular membrane phospholipids.[citation needed] It is sold in Japan and some European countries, such as Germany, Hungary, and Austria, as a prescription drug.

Side effects edit

Meclofenoxate is considered to be safe and high in tolerability. However, possible side effects may include, rarely, insomnia, dizziness, restlessness, muscle tremor, depression, nausea, muscle tension, and headache; these side effects may be due to overdosage and may indicate the need for the dosage to be reduced.

Research edit

Meclofenoxate, as well as DMAE, have been found to increase the lifespans of mice by 26.5%.[6][7]

Brand names edit

In addition to Lucidril, meclofenoxate has also been marketed under the brand names Amipolen, Analux, Brenal, Cellative, Centrophenoxin, Cerebron, Cerutil, Closete, Helfergin, Lucidryl, Lutiaron, Marucotol, Proserout, Proseryl, and Ropoxyl.[8] In the US, meclofenoxate is sold as a dietary supplement, although it is an unapproved drug.[4]

See also edit

References edit

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 758–. ISBN 978-1-4757-2085-3.
  3. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 636–. ISBN 978-3-88763-075-1.
  4. ^ a b Cohen PA, Avula B, Khan I (October 2022). "The unapproved drug centrophenoxine (meclofenoxate) in cognitive enhancement dietary supplements". Clinical Toxicology. 60 (10): 1156–1158. doi:10.1080/15563650.2022.2109485. PMID 35959800. S2CID 251516603.
  5. ^ Marcer D, Hopkins SM (May 1977). "The differential effects of meclofenoxate on memory loss in the elderly". Age and Ageing. 6 (2): 123–31. doi:10.1093/ageing/6.2.123. PMID 329662.
  6. ^ Donaldson T (1 January 2003). "A Brief History of Anti-aging Drugs". In Klatz R, Goldman B (eds.). The Science of Anti-aging Medicine. American Academy of Anti-Aging Med. pp. 66–. ISBN 978-0-9668937-3-1.
  7. ^ Hothschild R (August 1973). "Effect of dimethylamnioethyl p-chlorophenoxyacetate on the life span of male Swiss Webster Albino mice". Experimental Gerontology. 8 (4): 177–183. doi:10.1016/0531-5565(73)90024-7. PMID 4147092.
  8. ^ Zhou Y (22 October 2013). Drugs in Psychiatric Practice. Elsevier. ISBN 978-1-4831-9193-5.

January 01, 1970
meclofenoxate, brand, name, lucidril, also, known, centrophenoxine, cholinergic, nootropic, used, dietary, supplement, ester, dimethylethanolamine, dmae, chlorophenoxyacetic, acid, pcpa, clinical, dataahfs, drugs, cominternational, drug, namesatc, coden06bx01,. Meclofenoxate INN BAN brand name Lucidril also known as centrophenoxine is a cholinergic nootropic used as a dietary supplement 2 3 4 It is an ester of dimethylethanolamine DMAE and 4 chlorophenoxyacetic acid pCPA MeclofenoxateClinical dataAHFS Drugs comInternational Drug NamesATC codeN06BX01 WHO Legal statusLegal statusBR Class C1 Other controlled substances 1 US Not FDA approved In general Prescription only IdentifiersIUPAC name 2 Dimethylaminoethyl 4 chlorophenoxy acetateCAS Number51 68 3 YPubChem CID4039ChemSpider3899 NUNIIC76QQ2I0RGKEGGD00993 YCompTox Dashboard EPA DTXSID9046940ECHA InfoCard100 000 107Chemical and physical dataFormulaC 12H 16Cl N O 3Molar mass257 71 g mol 13D model JSmol Interactive imageSMILES Clc1ccc cc1 OCC O OCCN C CInChI InChI 1S C12H16ClNO3 c1 14 2 7 8 16 12 15 9 17 11 5 3 10 13 4 6 11 h3 6H 7 9H2 1 2H3 NKey XZTYGFHCIAKPGJ UHFFFAOYSA N N N Y what is this verify In elderly patients meclofenoxate has been shown to improve performance on certain memory tests 5 Meclofenoxate also increases cellular membrane phospholipids citation needed It is sold in Japan and some European countries such as Germany Hungary and Austria as a prescription drug Contents 1 Side effects 2 Research 3 Brand names 4 See also 5 ReferencesSide effects editMeclofenoxate is considered to be safe and high in tolerability However possible side effects may include rarely insomnia dizziness restlessness muscle tremor depression nausea muscle tension and headache these side effects may be due to overdosage and may indicate the need for the dosage to be reduced Research editMeclofenoxate as well as DMAE have been found to increase the lifespans of mice by 26 5 6 7 Brand names editIn addition to Lucidril meclofenoxate has also been marketed under the brand names Amipolen Analux Brenal Cellative Centrophenoxin Cerebron Cerutil Closete Helfergin Lucidryl Lutiaron Marucotol Proserout Proseryl and Ropoxyl 8 In the US meclofenoxate is sold as a dietary supplement although it is an unapproved drug 4 See also edit nbsp Medicine portal Adafenoxate Cyprodenate ISRIBReferences edit Anvisa 2023 03 31 RDC Nº 784 Listas de Substancias Entorpecentes Psicotropicas Precursoras e Outras sob Controle Especial Collegiate Board Resolution No 784 Lists of Narcotic Psychotropic Precursor and Other Substances under Special Control in Brazilian Portuguese Diario Oficial da Uniao published 2023 04 04 Archived from the original on 2023 08 03 Retrieved 2023 08 16 Elks J 14 November 2014 The Dictionary of Drugs Chemical Data Chemical Data Structures and Bibliographies Springer pp 758 ISBN 978 1 4757 2085 3 Index Nominum 2000 International Drug Directory Taylor amp Francis January 2000 pp 636 ISBN 978 3 88763 075 1 a b Cohen PA Avula B Khan I October 2022 The unapproved drug centrophenoxine meclofenoxate in cognitive enhancement dietary supplements Clinical Toxicology 60 10 1156 1158 doi 10 1080 15563650 2022 2109485 PMID 35959800 S2CID 251516603 Marcer D Hopkins SM May 1977 The differential effects of meclofenoxate on memory loss in the elderly Age and Ageing 6 2 123 31 doi 10 1093 ageing 6 2 123 PMID 329662 Donaldson T 1 January 2003 A Brief History of Anti aging Drugs In Klatz R Goldman B eds The Science of Anti aging Medicine American Academy of Anti Aging Med pp 66 ISBN 978 0 9668937 3 1 Hothschild R August 1973 Effect of dimethylamnioethyl p chlorophenoxyacetate on the life span of male Swiss Webster Albino mice Experimental Gerontology 8 4 177 183 doi 10 1016 0531 5565 73 90024 7 PMID 4147092 Zhou Y 22 October 2013 Drugs in Psychiatric Practice Elsevier ISBN 978 1 4831 9193 5 Retrieved from https en wikipedia org w index php title Meclofenoxate amp oldid 1170637717, wikipedia, wiki, book, books, library,

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