Ptashne grew up in Chicago.[1] He earned his undergraduate degree at Reed College in Portland, Oregon in 1961 and his PhD from Harvard in 1968, after which he joined the faculty of Harvard. He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980. In 1993 he was awarded an endowed chair, and in 1997 he left Harvard for MSK.[2]
Ptashne was the first scientist to demonstrate specific binding between protein and DNA, and his lifelong work has been the elucidation of the molecular mechanisms of switch between lytic and lysogenic lifecyle of bacteriophage lambda, as well as how the yeast transcriptional activator Gal4 works. He was the originator of the "ball and stick" model of transcription factor function, demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors.
In 1980 he cofounded Genetics Institute, Inc. with Thomas Maniatis. The founding of a company by a Harvard scientist was something new at the time, and was very controversial.[1]
mark, ptashne, born, june, 1940, chicago, molecular, biologist, ludwig, chair, molecular, biology, memorial, sloan, kettering, cancer, center, york, city, born, 1940, june, 1940, chicagoalma, materreed, collegeharvard, universityawardsnas, award, molecular, bi. Mark Ptashne born June 5 1940 in Chicago is a molecular biologist He is the Ludwig Chair of Molecular Biology at Memorial Sloan Kettering Cancer Center in New York City Mark PtashneBorn 1940 06 05 June 5 1940 age 83 ChicagoAlma materReed CollegeHarvard UniversityAwardsNAS Award in Molecular Biology 1979 Louisa Gross Horwitz Prize 1985 Lasker Award 1997 Massry Prize 1998 Scientific careerFieldsMolecular BiologyInstitutionsMemorial Sloan Kettering Cancer CenterPtashne grew up in Chicago 1 He earned his undergraduate degree at Reed College in Portland Oregon in 1961 and his PhD from Harvard in 1968 after which he joined the faculty of Harvard He was made professor there in 1971 and became chair of the Department of Biochemistry and Molecular Biology in 1980 In 1993 he was awarded an endowed chair and in 1997 he left Harvard for MSK 2 The focus of his scientific career has been gene regulation 1 Ptashne was the first scientist to demonstrate specific binding between protein and DNA and his lifelong work has been the elucidation of the molecular mechanisms of switch between lytic and lysogenic lifecyle of bacteriophage lambda as well as how the yeast transcriptional activator Gal4 works He was the originator of the ball and stick model of transcription factor function demonstrating in bacteria and in yeast that they typically consist of separable regions that mediate DNA binding and interaction with transcriptional activators or repressors In 1980 he cofounded Genetics Institute Inc with Thomas Maniatis The founding of a company by a Harvard scientist was something new at the time and was very controversial 1 In 1985 he was awarded the Louisa Gross Horwitz Prize from Columbia University He won the Albert Lasker Award for Basic Medical Research in 1997 1 and the Massry Prize from the Keck School of Medicine University of Southern California in 1998 He has written popular books for a wider scientific audience including his book Genes and Signals Selected works BooksPtashne M Gann A 2002 Genes and Signals Cold Harbor Spring Laboratory Press ISBN 978 0 87969 633 7 Ptashne M 2004 A Genetic Switch Phage Lambda Revisited 3rd ed Cold Harbor Spring Laboratory Press ISBN 978 0 87969 716 7 PapersPtashne M 1967 Specific Binding of the l Phage Repressor to l DNA Nature 214 5085 232 234 Bibcode 1967Natur 214 232P doi 10 1038 214232a0 PMID 6034235 S2CID 4209094 Ptashne M et al 1980 How the l repressor and cro work Cell 19 1 1 11 doi 10 1016 0092 8674 80 90383 9 PMID 6444544 S2CID 54281357 Ptashne M 2011 Horace Judson 1931 2011 PLOS Biology 9 7 e1001104 doi 10 1371 journal pbio 1001104 PMC 3134443 References edit a b c d Hilts PJ 24 February 1998 Scientist at Work Mark Ptashne Virtuoso in Plucking Violin or Secrets of Genetic Switches The New York Times Mark Stephen Ptashne CV PDF MSK Retrieved 30 May 2018 External links editMark Ptashne information at Cooperstown Chamber Music Festival Site Mark Ptashne s page at Sloan Kettering Institute Site nbsp nbsp This article about a biologist from the United States is a stub You can help Wikipedia by expanding it vte nbsp This article about an American violinist or fiddler is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Mark Ptashne amp oldid 1193588633, wikipedia, wiki, book, books, library,
