The M6P-tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport.[1]Enzyme replacement therapy (ERT) for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate.[2] The pH in the late endosome can reach 6.0, which causes dissociation of M6P from its receptor.[1] Upon release, the enzymes are ferried to their final destination in the lysosomes.[1] The MPRs are packed into vesicles that bud off the late endosome and return to the trans-Golgi network.[1] In this way, the MPRs can be recycled.
^ abcdeAlberts, Bruce; et al. (2002). Molecular biology of the cell (4th ed.). New York: Garland Science. ISBN978-0-8153-3218-3.
^Coutinho, MF; Prata, MJ (2011-12-15). "Mannose-6-phosphate pathway: A review on its role in lysosomal function and dysfunction". Molecular Genetics and Metabolism. 105 (4). Elsevier: 542–550. doi:10.1016/j.ymgme.2011.12.012. PMID 22266136.
External linksedit
Mannose-6-Phosphate+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Role of M6P in protein modification(video)
April 12, 2024
mannose, phosphate, mannose, phosphate, molecule, bound, lectin, immune, system, converted, fructose, phosphate, mannose, phosphate, isomerase, namesiupac, name, phosphono, mannopyranoseidentifierscas, number, 3672, model, jsmol, interactive, imageinteractive,. Mannose 6 phosphate M6P is a molecule bound by lectin in the immune system M6P is converted to fructose 6 phosphate by mannose phosphate isomerase Mannose 6 phosphate NamesIUPAC name 6 O Phosphono D mannopyranoseIdentifiersCAS Number 3672 15 9 Y3D model JSmol Interactive imageInteractive imageChEBI CHEBI 48066 YChemSpider 58636 Unspecified anomers Y394282 alpha anomer Y388338 beta anomer YMeSH mannose 6 phosphatePubChem CID 65127UNII U2S53JF879 YCompTox Dashboard EPA DTXSID80957947InChI InChI 1S C6H13O9P c7 3 2 1 14 16 11 12 13 15 6 10 5 9 4 3 8 h2 10H 1H2 H2 11 12 13 t2 3 4 5 6 m1 s1 YKey NBSCHQHZLSJFNQ QTVWNMPRSA N YSMILES C C1C C C C O1 O O O O OP O O OO P O O OC C H 1OC O C H O C H O C H 1OPropertiesChemical formula C6H13O9PMolar mass 260 136 g molExcept where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa Y verify what is Y N Infobox references M6P is a key targeting signal for acid hydrolase precursor proteins that are destined for transport to lysosomes The M6P tag is added to such proteins in the cis Golgi apparatus Specifically in a reaction involving uridine diphosphate UDP and N acetylglucosamine the enzyme N acetylglucosamine 1 phosphate transferase catalyzes the N linked glycosylation of asparagine residues with M6P Once appropriately marked with the M6P targeting signal these proteins are moved to the trans Golgi network There the M6P moiety is recognized and bound by mannose 6 phosphate receptor MPR proteins at pH 6 5 6 7 1 The M6P tagged lysosomal enzymes are shipped to the late endosomes via vesicular transport 1 Enzyme replacement therapy ERT for several lysosomal storage diseases relies on this pathway to efficiently direct synthetic enzymes to the lysosome where each can metabolize its particular substrate 2 The pH in the late endosome can reach 6 0 which causes dissociation of M6P from its receptor 1 Upon release the enzymes are ferried to their final destination in the lysosomes 1 The MPRs are packed into vesicles that bud off the late endosome and return to the trans Golgi network 1 In this way the MPRs can be recycled See also editI cell disease Insulin like growth factor 2 receptor Mannose Mannose 1 phosphateReferences edit a b c d e Alberts Bruce et al 2002 Molecular biology of the cell 4th ed New York Garland Science ISBN 978 0 8153 3218 3 Coutinho MF Prata MJ 2011 12 15 Mannose 6 phosphate pathway A review on its role in lysosomal function and dysfunction Molecular Genetics and Metabolism 105 4 Elsevier 542 550 doi 10 1016 j ymgme 2011 12 012 PMID 22266136 External links editMannose 6 Phosphate Receptor at the U S National Library of Medicine Medical Subject Headings MeSH Role of M6P in protein modification video Retrieved from https en wikipedia org w index php title Mannose 6 phosphate amp oldid 1168628363, wikipedia, wiki, book, books, library,
