Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q.[6]
^ abcGRCm38: Ensembl release 89: ENSMUSG00000024436 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
^ ab"Entrez Gene: MRPS18B mitochondrial ribosomal protein S18B".
Further readingedit
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC1847948. PMID 17353931.
Shiina T, Ota M, Shimizu S, et al. (2006). "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity". Genetics. 173 (3): 1555–70. doi:10.1534/genetics.106.057034. PMC1526686. PMID 16702430.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Suzuki T, Terasaki M, Takemoto-Hori C, et al. (2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J. Biol. Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC310934. PMID 11042152.
This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.
mrps18b, ribosomal, protein, s18b, mitochondrial, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes3j9midentifiersaliases, c6orf14, hspc183, humans18a, mrps18, ptd017, s18amt, mitochondrial, ribosomal, protei. 28S ribosomal protein S18b mitochondrial is a protein that in humans is encoded by the MRPS18B gene 5 6 MRPS18BAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes3J9MIdentifiersAliasesMRPS18B C6orf14 HSPC183 HumanS18a MRP S18 2 MRPS18 2 PTD017 S18amt mitochondrial ribosomal protein S18BExternal IDsOMIM 611982 MGI 1914223 HomoloGene 32205 GeneCards MRPS18BGene location Human Chr Chromosome 6 human 1 Band6p21 33Start30 617 840 bp 1 End30 626 395 bp 1 Gene location Mouse Chr Chromosome 17 mouse 2 Band17 17 B1Start36 221 271 bp 2 End36 227 281 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleskeletal muscle tissueleft ventricleislet of Langerhanskidneyrectumright adrenal glandbody of pancreasright lobe of liverleft adrenal glandTop expressed inmorulablastocystproximal tubuleadrenal glandwhite adipose tissueplacentaquadriceps femoris musclemuscle tissueyolk sacliverMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionstructural constituent of ribosome protein bindingCellular componentcell junction ribosome nucleoplasm intracellular anatomical structure mitochondrial inner membrane mitochondrial small ribosomal subunit mitochondrionBiological processmitochondrial translational elongation protein biosynthesis mitochondrial translational termination mitochondrial translationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2897366973EnsemblENSG00000229861ENSG00000226111ENSG00000204568ENSG00000203624ENSG00000227420ENSG00000233813ENSG00000223775ENSMUSG00000024436UniProtQ9Y676Q99N84RefSeq mRNA NM 014046NM 025878NM 001347380NM 001361453NM 001361454NM 001361455RefSeq protein NP 054765NP 001334309NP 080154NP 001348382NP 001348383NP 001348384Location UCSC Chr 6 30 62 30 63 MbChr 17 36 22 36 23 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseMammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion Mitochondrial ribosomes mitoribosomes consist of a small 28S subunit and a large 39S subunit They have an estimated 75 protein to rRNA composition compared to prokaryotic ribosomes where this ratio is reversed Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA Among different species the proteins comprising the mitoribosome differ greatly in sequence and sometimes in biochemical properties which prevents easy recognition by sequence homology This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q 6 References edit a b c ENSG00000226111 ENSG00000204568 ENSG00000203624 ENSG00000227420 ENSG00000233813 ENSG00000223775 GRCh38 Ensembl release 89 ENSG00000229861 ENSG00000226111 ENSG00000204568 ENSG00000203624 ENSG00000227420 ENSG00000233813 ENSG00000223775 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000024436 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Cavdar Koc E Burkhart W Blackburn K Moseley A Spremulli LL May 2001 The small subunit of the mammalian mitochondrial ribosome Identification of the full complement of ribosomal proteins present J Biol Chem 276 22 19363 74 doi 10 1074 jbc M100727200 PMID 11279123 a b Entrez Gene MRPS18B mitochondrial ribosomal protein S18B Further reading editEwing RM Chu P Elisma F et al 2007 Large scale mapping of human protein protein interactions by mass spectrometry Mol Syst Biol 3 1 89 doi 10 1038 msb4100134 PMC 1847948 PMID 17353931 Shiina T Ota M Shimizu S et al 2006 Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity Genetics 173 3 1555 70 doi 10 1534 genetics 106 057034 PMC 1526686 PMID 16702430 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Zhang Z Gerstein M 2003 Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome Genomics 81 5 468 80 doi 10 1016 S0888 7543 03 00004 1 PMID 12706105 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Suzuki T Terasaki M Takemoto Hori C et al 2001 Proteomic analysis of the mammalian mitochondrial ribosome Identification of protein components in the 28 S small subunit J Biol Chem 276 35 33181 95 doi 10 1074 jbc M103236200 PMID 11402041 Zhang QH Ye M Wu XY et al 2001 Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34 hematopoietic stem progenitor cells Genome Res 10 10 1546 60 doi 10 1101 gr 140200 PMC 310934 PMID 11042152 nbsp This article on a gene on human chromosome 6 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title MRPS18B amp oldid 1142707862, wikipedia, wiki, book, books, library,
