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Wikipedia

MAP3K7IP2

January 01, 1970

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene.[5][6][7]

TAB2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTAB2, CHTD2, MAP3K7IP2, TAB-2, TGF-beta activated kinase 1/MAP3K7 binding protein 2, TGF-beta activated kinase 1 (MAP3K7) binding protein 2
External IDsOMIM: 605101; MGI: 1915902; HomoloGene: 9019; GeneCards: TAB2; OMA:TAB2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

23118

68652

Ensembl

ENSG00000055208

ENSMUSG00000015755

UniProt

Q9NYJ8

Q99K90

RefSeq (mRNA)

NM_001292034
NM_001292035
NM_015093
NM_145342
NM_001369506

NM_138667
NM_001359534

RefSeq (protein)

NP_001278963
NP_001278964
NP_055908
NP_001356435

NP_619608
NP_001346463

Location (UCSC)Chr 6: 149.22 – 149.41 MbChr 10: 7.91 – 7.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.[7] Mutations in MAP3K7IP2 have been associated with human congenital heart defects.[8]

Interactions edit

MAP3K7IP2 has been shown to interact with:

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000055208 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015755 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
  6. ^ a b c d e Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K (Jul 2000). "TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway". Mol Cell. 5 (4): 649–58. doi:10.1016/S1097-2765(00)80244-0. PMID 10882101.
  7. ^ a b "Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2".
  8. ^ Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA (2010). "Haploinsufficiency of TAB2 causes congenital heart defects in humans". Am J Hum Genet. 86 (6): 839–49. doi:10.1016/j.ajhg.2010.04.011. PMC 3032066. PMID 20493459.
  9. ^ a b c Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (Jul 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell. 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. PMID 12150997. S2CID 17679498.
  10. ^ Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  11. ^ a b Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
  12. ^ a b Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Dec 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
  13. ^ a b Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (Apr 2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Mol. Cell. Biol. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
  14. ^ a b Ma Q, Zhou L, Shi H, Huo K (Jun 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. 20 (6): 1044–51. doi:10.1016/j.cellsig.2008.01.015. PMID 18299187.
  15. ^ Li S, Wang L, Dorf ME (Jan 2009). "PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination". Mol. Cell. 33 (1): 30–42. doi:10.1016/j.molcel.2008.11.023. PMC 2643372. PMID 19150425.
  16. ^ Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y (2008). Unutmaz D (ed.). "TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL". PLOS ONE. 3 (12): e4064. Bibcode:2008PLoSO...3.4064W. doi:10.1371/journal.pone.0004064. PMC 2603309. PMID 19112497.
  17. ^ Windheim M, Stafford M, Peggie M, Cohen P (Mar 2008). "Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase". Mol. Cell. Biol. 28 (5): 1783–91. doi:10.1128/MCB.02380-06. PMC 2258775. PMID 18180283.

Further reading edit

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K (1996). "TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction". Science. 272 (5265): 1179–82. Bibcode:1996Sci...272.1179S. doi:10.1126/science.272.5265.1179. PMID 8638164. S2CID 84807994.
  • Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K (2001). "Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway". Mol. Cell. Biol. 21 (7): 2475–84. doi:10.1128/MCB.21.7.2475-2484.2001. PMC 86880. PMID 11259596.
  • Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X (2001). "IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B". J. Biol. Chem. 276 (45): 41661–7. doi:10.1074/jbc.M102262200. PMID 11518704.
  • Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N (2002). "Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6". Mol. Cell. Biol. 22 (4): 992–1000. doi:10.1128/MCB.22.4.992-1000.2002. PMC 134634. PMID 11809792.
  • Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ (2002). "ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis". J. Biol. Chem. 277 (34): 30454–62. doi:10.1074/jbc.M203312200. PMID 12048196.
  • Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell. 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. PMID 12150997. S2CID 17679498.
  • Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X (2002). "Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol". Mol. Cell. Biol. 22 (20): 7158–67. doi:10.1128/MCB.22.20.7158-7167.2002. PMC 139807. PMID 12242293.
  • Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X (2003). "Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR". J. Biol. Chem. 278 (19): 16713–9. doi:10.1074/jbc.M300562200. PMID 12609980.
  • Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501. S2CID 38880905.
  • Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (2004). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". EMBO J. 22 (23): 6277–88. doi:10.1093/emboj/cdg605. PMC 291846. PMID 14633987.
  • Cheung PC, Nebreda AR, Cohen P (2004). "TAB3, a new binding partner of the protein kinase TAK1". Biochem. J. 378 (Pt 1): 27–34. doi:10.1042/BJ20031794. PMC 1223947. PMID 14670075.
  • Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Owerbach D, Piña L, Gabbay KH (2004). "A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes". Diabetes. 53 (7): 1890–3. doi:10.2337/diabetes.53.7.1890. PMID 15220215.
  • Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ (2004). "TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains". Mol. Cell. 15 (4): 535–48. doi:10.1016/j.molcel.2004.08.008. PMID 15327770.

External links edit

  • Overview of all the structural information available in the PDB for UniProt: Q9NYJ8 (Human TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) at the PDBe-KB.
  • Overview of all the structural information available in the PDB for UniProt: Q99K90 (Mouse TGF-beta-activated kinase 1 and MAP3K7-binding protein 2) at the PDBe-KB.


January 01, 1970
map3k7ip2, mitogen, activated, protein, kinase, kinase, kinase, interacting, protein, enzyme, that, humans, encoded, gene, tab2available, structurespdbortholog, search, pdbe, rcsblist, codes2dae, 2wwz, 2wx0, 2wx1identifiersaliasestab2, chtd2, beta, activated, . Mitogen activated protein kinase kinase kinase 7 interacting protein 2 is an enzyme that in humans is encoded by the MAP3K7IP2 gene 5 6 7 TAB2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2DAE 2WWZ 2WX0 2WX1IdentifiersAliasesTAB2 CHTD2 MAP3K7IP2 TAB 2 TGF beta activated kinase 1 MAP3K7 binding protein 2 TGF beta activated kinase 1 MAP3K7 binding protein 2External IDsOMIM 605101 MGI 1915902 HomoloGene 9019 GeneCards TAB2 OMA TAB2 orthologsGene location Human Chr Chromosome 6 human 1 Band6q25 1Start149 218 641 bp 1 End149 411 613 bp 1 Gene location Mouse Chr Chromosome 10 mouse 2 Band10 10 A1Start7 905 653 bp 2 End7 956 230 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inparotid glandgastrocnemius musclehair follicleislet of Langerhansmonocytebiceps brachiioptic nerveperiodontal fiberganglionic eminencethoracic diaphragmTop expressed inplantaris muscleextensor digitorum longus muscleparotid glandleft lung lobesciatic nerveaortic valveabdominal wallbody of femurascending aortaPaneth cellMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionmetal ion binding K63 linked polyubiquitin modification dependent protein binding protein bindingCellular componentendosome membrane cytoplasm membrane plasma membrane cytosol nucleoplasmBiological processJNK cascade positive regulation of NF kappaB transcription factor activity positive regulation of protein kinase activity Fc epsilon receptor signaling pathway heart development nucleotide binding oligomerization domain containing signaling pathway MyD88 dependent toll like receptor signaling pathway stimulatory C type lectin receptor signaling pathway I kappaB kinase NF kappaB signaling negative regulation of autophagy positive regulation of I kappaB kinase NF kappaB signaling T cell receptor signaling pathway interleukin 1 mediated signaling pathway response to lipopolysaccharideSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2311868652EnsemblENSG00000055208ENSMUSG00000015755UniProtQ9NYJ8Q99K90RefSeq mRNA NM 001292034NM 001292035NM 015093NM 145342NM 001369506NM 138667NM 001359534RefSeq protein NP 001278963NP 001278964NP 055908NP 001356435NP 619608NP 001346463Location UCSC Chr 6 149 22 149 41 MbChr 10 7 91 7 96 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is an activator of MAP3K7 TAK1 which is required for the IL 1 induced activation of nuclear factor kappaB and MAPK8 JNK This protein forms a kinase complex with TRAF6 MAP3K7 and TAB1 thus serves as an adaptor linking MAP3K7 and TRAF6 This protein TAB1 and MAP3K7 also participate in the signal transduction induced by TNFSF11 RANKL through the activation of the receptor activator of NF kappB TNFRSF11A RANK which may regulate the development and function of osteoclasts 7 Mutations in MAP3K7IP2 have been associated with human congenital heart defects 8 Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editMAP3K7IP2 has been shown to interact with HDAC3 9 TAB1 6 10 11 MAP3K7IP3 12 MAP3K7 6 11 13 NFKB1 9 NUMBL 14 Nuclear receptor co repressor 1 9 TRAF2 6 15 and TRAF6 6 12 13 14 16 17 References edit a b c GRCh38 Ensembl release 89 ENSG00000055208 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000015755 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Nagase T Ishikawa K Suyama M Kikuno R Miyajima N Tanaka A Kotani H Nomura N Ohara O Apr 1999 Prediction of the coding sequences of unidentified human genes XI The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro DNA Res 5 5 277 86 doi 10 1093 dnares 5 5 277 PMID 9872452 a b c d e Takaesu G Kishida S Hiyama A Yamaguchi K Shibuya H Irie K Ninomiya Tsuji J Matsumoto K Jul 2000 TAB2 a novel adaptor protein mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL 1 signal transduction pathway Mol Cell 5 4 649 58 doi 10 1016 S1097 2765 00 80244 0 PMID 10882101 a b Entrez Gene MAP3K7IP2 mitogen activated protein kinase kinase kinase 7 interacting protein 2 Thienpont B Zhang L Postma AV Breckpot J Tranchevent LC Van Loo P Mollgard K Tommerup N Bache I Tumer Z van Engelen K Menten B Mortier G Waggoner D Gewillig M Moreau Y Devriendt K Larsen LA 2010 Haploinsufficiency of TAB2 causes congenital heart defects in humans Am J Hum Genet 86 6 839 49 doi 10 1016 j ajhg 2010 04 011 PMC 3032066 PMID 20493459 a b c Baek SH Ohgi KA Rose DW Koo EH Glass CK Rosenfeld MG Jul 2002 Exchange of N CoR corepressor and Tip60 coactivator complexes links gene expression by NF kappaB and beta amyloid precursor protein Cell 110 1 55 67 doi 10 1016 S0092 8674 02 00809 7 PMID 12150997 S2CID 17679498 Bouwmeester T Bauch A Ruffner H Angrand PO Bergamini G Croughton K Cruciat C Eberhard D Gagneur J Ghidelli S Hopf C Huhse B Mangano R Michon AM Schirle M Schlegl J Schwab M Stein MA Bauer A Casari G Drewes G Gavin AC Jackson DB Joberty G Neubauer G Rick J Kuster B Superti Furga G Feb 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 a b Cheung PC Nebreda AR Cohen P Feb 2004 TAB3 a new binding partner of the protein kinase TAK1 Biochem J 378 Pt 1 27 34 doi 10 1042 BJ20031794 PMC 1223947 PMID 14670075 a b Ishitani T Takaesu G Ninomiya Tsuji J Shibuya H Gaynor RB Matsumoto K Dec 2003 Role of the TAB2 related protein TAB3 in IL 1 and TNF signaling EMBO J 22 23 6277 88 doi 10 1093 emboj cdg605 PMC 291846 PMID 14633987 a b Takaesu G Ninomiya Tsuji J Kishida S Li X Stark GR Matsumoto K Apr 2001 Interleukin 1 IL 1 receptor associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL 1 signaling pathway Mol Cell Biol 21 7 2475 84 doi 10 1128 MCB 21 7 2475 2484 2001 PMC 86880 PMID 11259596 a b Ma Q Zhou L Shi H Huo K Jun 2008 NUMBL interacts with TAB2 and inhibits TNFalpha and IL 1beta induced NF kappaB activation Cell Signal 20 6 1044 51 doi 10 1016 j cellsig 2008 01 015 PMID 18299187 Li S Wang L Dorf ME Jan 2009 PKC phosphorylation of TRAF2 mediates IKKalpha beta recruitment and K63 linked polyubiquitination Mol Cell 33 1 30 42 doi 10 1016 j molcel 2008 11 023 PMC 2643372 PMID 19150425 Walsh MC Kim GK Maurizio PL Molnar EE Choi Y 2008 Unutmaz D ed TRAF6 autoubiquitination independent activation of the NFkappaB and MAPK pathways in response to IL 1 and RANKL PLOS ONE 3 12 e4064 Bibcode 2008PLoSO 3 4064W doi 10 1371 journal pone 0004064 PMC 2603309 PMID 19112497 Windheim M Stafford M Peggie M Cohen P Mar 2008 Interleukin 1 IL 1 induces the Lys63 linked polyubiquitination of IL 1 receptor associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase Mol Cell Biol 28 5 1783 91 doi 10 1128 MCB 02380 06 PMC 2258775 PMID 18180283 Further reading editNakajima D Okazaki N Yamakawa H Kikuno R Ohara O Nagase T 2003 Construction of expression ready cDNA clones for KIAA genes manual curation of 330 KIAA cDNA clones DNA Res 9 3 99 106 doi 10 1093 dnares 9 3 99 PMID 12168954 Shibuya H Yamaguchi K Shirakabe K Tonegawa A Gotoh Y Ueno N Irie K Nishida E Matsumoto K 1996 TAB1 an activator of the TAK1 MAPKKK in TGF beta signal transduction Science 272 5265 1179 82 Bibcode 1996Sci 272 1179S doi 10 1126 science 272 5265 1179 PMID 8638164 S2CID 84807994 Takaesu G Ninomiya Tsuji J Kishida S Li X Stark GR Matsumoto K 2001 Interleukin 1 IL 1 receptor associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL 1 signaling pathway Mol Cell Biol 21 7 2475 84 doi 10 1128 MCB 21 7 2475 2484 2001 PMC 86880 PMID 11259596 Qian Y Commane M Ninomiya Tsuji J Matsumoto K Li X 2001 IRAK mediated translocation of TRAF6 and TAB2 in the interleukin 1 induced activation of NFkappa B J Biol Chem 276 45 41661 7 doi 10 1074 jbc M102262200 PMID 11518704 Mizukami J Takaesu G Akatsuka H Sakurai H Ninomiya Tsuji J Matsumoto K Sakurai N 2002 Receptor activator of NF kappaB ligand RANKL activates TAK1 mitogen activated protein kinase kinase kinase through a signaling complex containing RANK TAB2 and TRAF6 Mol Cell Biol 22 4 992 1000 doi 10 1128 MCB 22 4 992 1000 2002 PMC 134634 PMID 11809792 Sanna MG da Silva Correia J Luo Y Chuang B Paulson LM Nguyen B Deveraux QL Ulevitch RJ 2002 ILPIP a novel anti apoptotic protein that enhances XIAP mediated activation of JNK1 and protection against apoptosis J Biol Chem 277 34 30454 62 doi 10 1074 jbc M203312200 PMID 12048196 Baek SH Ohgi KA Rose DW Koo EH Glass CK Rosenfeld MG 2002 Exchange of N CoR corepressor and Tip60 coactivator complexes links gene expression by NF kappaB and beta amyloid precursor protein Cell 110 1 55 67 doi 10 1016 S0092 8674 02 00809 7 PMID 12150997 S2CID 17679498 Jiang Z Ninomiya Tsuji J Qian Y Matsumoto K Li X 2002 Interleukin 1 IL 1 receptor associated kinase dependent IL 1 induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol Mol Cell Biol 22 20 7158 67 doi 10 1128 MCB 22 20 7158 7167 2002 PMC 139807 PMID 12242293 Jiang Z Zamanian Daryoush M Nie H Silva AM Williams BR Li X 2003 Poly I C induced Toll like receptor 3 TLR3 mediated activation of NFkappa B and MAP kinase is through an interleukin 1 receptor associated kinase IRAK independent pathway employing the signaling components TLR3 TRAF6 TAK1 TAB2 PKR J Biol Chem 278 19 16713 9 doi 10 1074 jbc M300562200 PMID 12609980 Matsuda A Suzuki Y Honda G Muramatsu S Matsuzaki O Nagano Y Doi T Shimotohno K Harada T Nishida E Hayashi H Sugano S 2003 Large scale identification and characterization of human genes that activate NF kappaB and MAPK signaling pathways Oncogene 22 21 3307 18 doi 10 1038 sj onc 1206406 PMID 12761501 S2CID 38880905 Ishitani T Takaesu G Ninomiya Tsuji J Shibuya H Gaynor RB Matsumoto K 2004 Role of the TAB2 related protein TAB3 in IL 1 and TNF signaling EMBO J 22 23 6277 88 doi 10 1093 emboj cdg605 PMC 291846 PMID 14633987 Cheung PC Nebreda AR Cohen P 2004 TAB3 a new binding partner of the protein kinase TAK1 Biochem J 378 Pt 1 27 34 doi 10 1042 BJ20031794 PMC 1223947 PMID 14670075 Bouwmeester T Bauch A Ruffner H Angrand PO Bergamini G Croughton K Cruciat C Eberhard D Gagneur J Ghidelli S Hopf C Huhse B Mangano R Michon AM Schirle M Schlegl J Schwab M Stein MA Bauer A Casari G Drewes G Gavin AC Jackson DB Joberty G Neubauer G Rick J Kuster B Superti Furga G 2004 A physical and functional map of the human TNF alpha NF kappa B signal transduction pathway Nat Cell Biol 6 2 97 105 doi 10 1038 ncb1086 PMID 14743216 S2CID 11683986 Owerbach D Pina L Gabbay KH 2004 A 212 kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes Diabetes 53 7 1890 3 doi 10 2337 diabetes 53 7 1890 PMID 15220215 Kanayama A Seth RB Sun L Ea CK Hong M Shaito A Chiu YH Deng L Chen ZJ 2004 TAB2 and TAB3 activate the NF kappaB pathway through binding to polyubiquitin chains Mol Cell 15 4 535 48 doi 10 1016 j molcel 2004 08 008 PMID 15327770 External links editOverview of all the structural information available in the PDB for UniProt Q9NYJ8 Human TGF beta activated kinase 1 and MAP3K7 binding protein 2 at the PDBe KB Overview of all the structural information available in the PDB for UniProt Q99K90 Mouse TGF beta activated kinase 1 and MAP3K7 binding protein 2 at the PDBe KB Retrieved from https en wikipedia org w index php title MAP3K7IP2 amp oldid 1191514839, wikipedia, wiki, book, books, library,

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