Luis Agote (September 22, 1868 – November 12, 1954) was an Argentinephysician and researcher. He was the first to perform a non-direct blood transfusion using sodium citrate as an anticoagulant.[1] The procedure took place in Rawson hospital in the city of Buenos Aires on November 9, 1914. Agote was the first to perform this procedure in the Americas. Agote worked independently and separately from the Belgian surgeon Albert Hustin, who discovered that sodium citrate in tolerable quantities could anticoagulate blood for transfusion on March 27, 1914.
Agote was the son of a politician. He studied first in the Colegio Nacional de Buenos Aires, and then at the University of Buenos AiresFaculty of Medicine, where he was also a teacher. He graduated as a doctor in 1893 with a thesis about suppurative hepatitis. He became Secretary of the National Department of Hygiene in 1894 and became head of the leper hospital in 1895 on the island of Martin Garcia. He was elected Congressman in 1910 and Senator in 1916 of the legislature in Argentina.
First recorded transfusionsedit
The first recorded blood transfusion was made between dogs by the English doctor Richard Lower around 1666. In 1667, French scientist Juan Bautista Denys transfused a human with animal blood. In 1900, Karl Landsteiner identified some of the blood substances responsible for the agglutination of red blood cells, identifying blood groups for the first time and some of their incompatibilities.
Dr. Luis Agote (2nd from right) overseeing one of the first safe and effective blood transfusion in 1914
Direct transfusions were still not practiced at the beginning of the 20th century because it was impossible to keep unaltered blood outside the body for later use. After 6–12 minutes, coagulation begins manifested initially by a gradual increase of viscosity that terminates with almost complete solidification. Coagulation is the defense of an organism to staunch wounds and minimize hemorrhages. Now we know that clotting is almost totally formed by platelets fastened by a network of filaments of fibrin.
Fibrin does not normally exist in blood and is created from protein plasma by the action of the thrombin enzyme. Similarly, thrombin is not naturally present in blood and is created by the precursor substance prothombrin, in a process that involves platelets, some exiting from calcium and substances produced by lesioned materials. Since clots are not created if there is a lack of some of these elements, the addition of sodium citrate (which eliminates calcium ions from blood) prevents its formation.
Referencesedit
^. IBMS. Archived from the original on June 24, 2016. Retrieved June 14, 2016.
External linksedit
(Spanish)
(Spanish)
Genealogia Familiar
January 19, 2024
luis, agote, september, 1868, november, 1954, argentine, physician, researcher, first, perform, direct, blood, transfusion, using, sodium, citrate, anticoagulant, procedure, took, place, rawson, hospital, city, buenos, aires, november, 1914, agote, first, perf. Luis Agote September 22 1868 November 12 1954 was an Argentine physician and researcher He was the first to perform a non direct blood transfusion using sodium citrate as an anticoagulant 1 The procedure took place in Rawson hospital in the city of Buenos Aires on November 9 1914 Agote was the first to perform this procedure in the Americas Agote worked independently and separately from the Belgian surgeon Albert Hustin who discovered that sodium citrate in tolerable quantities could anticoagulate blood for transfusion on March 27 1914 Dr Luis Agote Contents 1 Biography 2 First recorded transfusions 3 References 4 External linksBiography editAgote was the son of a politician He studied first in the Colegio Nacional de Buenos Aires and then at the University of Buenos Aires Faculty of Medicine where he was also a teacher He graduated as a doctor in 1893 with a thesis about suppurative hepatitis He became Secretary of the National Department of Hygiene in 1894 and became head of the leper hospital in 1895 on the island of Martin Garcia He was elected Congressman in 1910 and Senator in 1916 of the legislature in Argentina First recorded transfusions editThe first recorded blood transfusion was made between dogs by the English doctor Richard Lower around 1666 In 1667 French scientist Juan Bautista Denys transfused a human with animal blood In 1900 Karl Landsteiner identified some of the blood substances responsible for the agglutination of red blood cells identifying blood groups for the first time and some of their incompatibilities nbsp Dr Luis Agote 2nd from right overseeing one of the first safe and effective blood transfusion in 1914Direct transfusions were still not practiced at the beginning of the 20th century because it was impossible to keep unaltered blood outside the body for later use After 6 12 minutes coagulation begins manifested initially by a gradual increase of viscosity that terminates with almost complete solidification Coagulation is the defense of an organism to staunch wounds and minimize hemorrhages Now we know that clotting is almost totally formed by platelets fastened by a network of filaments of fibrin Fibrin does not normally exist in blood and is created from protein plasma by the action of the thrombin enzyme Similarly thrombin is not naturally present in blood and is created by the precursor substance prothombrin in a process that involves platelets some exiting from calcium and substances produced by lesioned materials Since clots are not created if there is a lack of some of these elements the addition of sodium citrate which eliminates calcium ions from blood prevents its formation References edit History of blood transfusion The Institute of Biomedical Science IBMS Archived from the original on June 24 2016 Retrieved June 14 2016 External links editAgote s short biography Spanish Biography Spanish Genealogia Familiar Retrieved from https en wikipedia org w index php title Luis Agote amp oldid 1129103858, wikipedia, wiki, book, books, library,
