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Lubert Stryer

April 26, 2024

Lubert Stryer (2 March 1938 - April 2024[1]) was the Emeritus Mrs. George A. Winzer Professor of Cell Biology, at Stanford University School of Medicine.[2][3] His research over more than four decades has been centered on the interplay of light and life. In 2007 he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision, pioneering the development of high density microarrays for genetic analysis, and authoring the standard undergraduate biochemistry textbook, Biochemistry.[4] It is now in its tenth edition and also edited by Jeremy Berg, Justin Hines, John L. Tymoczko and Gregory J. Gatto, Jr.[5]

Lubert Stryer
Born (1938-03-02) March 2, 1938 (age 86)
Tianjin, China
Died
Stanford,California
CitizenshipUnited States
EducationUniversity of Chicago (B.S. 1957)
Harvard Medical School (M.D.)
Known forTextbook Biochemistry (ten editions)
AwardsNational Academy of Sciences, European Inventor of the Year (2006), Eli Lilly Award in Biological Chemistry
Scientific career
FieldsBiochemistry, fluorescence spectroscopy
InstitutionsDepartment of physics at Harvard; MRC Laboratory of Molecular Biology at Cambridge, UK; department of biochemistry at Stanford University; Yale University
Notable studentsRichard P. Haugland, Jeremy M. Berg

Stryer received his B.S. degree from the University of Chicago in 1957 and his M.D. degree from Harvard Medical School. He was a Helen Hay Whitney Research Fellow[6] in the department of physics at Harvard and then at the MRC Laboratory of Molecular Biology[7] in Cambridge, England, before joining the faculty of the department of biochemistry at Stanford in 1963. In 1969 he moved to Yale to become Professor of Molecular Biophysics and Biochemistry, and in 1976, he returned to Stanford to head a new Department of Structural Biology.[3][8]

Research profile edit

Stryer and coworkers pioneered the use of fluorescence spectroscopy, particularly Förster resonance energy transfer (FRET), to monitor the structure and dynamics of biological macromolecules.[9][10] In 1967, Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor,[11][12] as predicted by Förster's theory. They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules.

A second contribution was Stryer's discovery of the primary stage of amplification in visual excitation.[13][14] Stryer, together with Fung and Hurley, showed that a single photoexcited rhodopsin molecule activates many molecules of transducin, which in turn activate many molecules of a cyclic GMP phosphodiesterase. Stryer's laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation.[15][16][17]

Stryer participated in developing light-directed, spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides.[18][19][20] Light-directed combinatorial synthesis has been used by Stephen Fodor and coworkers at Affymetrix to make DNA arrays containing millions of different sequences for genetic analyses.

Since 1975, Stryer has authored ten editions of the textbook Biochemistry.[21]

Stryer also chaired a National Research Council committee that produced a report entitled Bio2010: Transforming Undergraduate Education for Future Research Biologists.[22][23]

Honors edit

Notable students edit

References edit

  1. ^ https://www.genomeweb.com/people-news/lubert-stryer/622341
  2. ^ "Lubert Stryer".
  3. ^ a b c "Our Apologies | American Philosophical Society". Archived from the original on 2012-07-20. Retrieved 2012-03-10.
  4. ^ "President to Award 2005-2006 National Medals of Science and National Medals of Technology Honoring Nation's Leading Researchers, Inventors and Innovators - NSF - National Science Foundation".
  5. ^ Stryer; et al. (2023). Biochemistry (10 ed.). Palgrave Macmillan. ISBN 978-1319498504.
  6. ^ . Archived from the original on 2012-11-14. Retrieved 2012-04-01.{{cite web}}: CS1 maint: archived copy as title (link)
  7. ^ "Alumni - MRC Laboratory of Molecular Biology". MRC Laboratory of Molecular Biology.
  8. ^ McCarthy, Pumtiwitt. "Everything is illuminated: 'Reflections' on light and life by Lubert Stryer". American Society for Biochemistry and Molecular Biology. Retrieved 19 June 2016.
  9. ^ Stryer, L (1968). "Fluorescence spectroscopy of proteins". Science. 1632 (3853): 526–533. Bibcode:1968Sci...162..526S. doi:10.1126/science.162.3853.526. PMID 5706935.
  10. ^ . Archived from the original on 2011-06-14. Retrieved 2010-10-18.
  11. ^ Stryer, L.; Haugland, R.P. (1967). "Energy transfer: a spectroscopic ruler". Proc. Natl. Acad. Sci. USA. 58 (2): 719–725. Bibcode:1967PNAS...58..719S. doi:10.1073/pnas.58.2.719. PMC 335693. PMID 5233469.
  12. ^ Lakowicz, J.R., 2006. Principles of Fluorescence Spectroscopy (Springer, 3rd ed., p. 449)
  13. ^ Fung, B.; Hurley, J.B.; Stryer, L. (1981). "Flow of information in the light-triggered cyclic nucleotide cascade of vision". Proc. Natl. Acad. Sci. USA. 78 (1): 152–156. Bibcode:1981PNAS...78..152F. doi:10.1073/pnas.78.1.152. PMC 319009. PMID 6264430.
  14. ^ "Chemical & Engineering News - Serving the chemical, life sciences and laboratory worlds".
  15. ^ Koch, K.-W.; Stryer, L. (1988). "Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion". Nature. 334 (6177): 64–66. Bibcode:1988Natur.334...64K. doi:10.1038/334064a0. PMID 2455233. S2CID 4253998.
  16. ^ <Ames, J.B., Ishima, R., Tanaka, T., Gordon, J.I., Stryer, L., Ikura, M., 1997. Molecular mechanics of calcium-myristoyl switches. Nature 389:198-202
  17. ^ Burgoyne, R.D.; Weiss, J.L. (2001). "The neuronal calcium sensor family of Ca2+-binding proteins". Biochem. J. 353 (Pt 1): 1–12. doi:10.1042/bj3530001. PMC 1221537. PMID 11115393.
  18. ^ Fodor, S.P.A.; Read, J.L.; Pirrung, M.C.; Stryer, L.; Lu, A.T.; Solas, D. (1991). "Light-directed, spatially addressable parallel chemical synthesis". Science. 251 (4995): 767–773. Bibcode:1991Sci...251..767F. doi:10.1126/science.1990438. PMID 1990438.
  19. ^ Fodor, S.P.A., Pirrung, M.C., Read, J.L., and Stryer, L., Array of oligonucleotides on a solid substrate. U.S. Patent No. 5,445,934. Issued August 29, 1995
  20. ^ "2007 Newcomb Cleveland Prize Recipients". AAAS - The World's Largest General Scientific Society.
  21. ^ Latchman,D.S. (1995) Trends Biochem. Sci. 20:488.
  22. ^ Council, National Research; Studies, Division on Earth Life; Sciences, Board on Life; Century, Committee on Undergraduate Biology Education to Prepare Research Scientists for the 21st (2003). BIO2010: Transforming Undergraduate Education for Future Research Biologists - The National Academies Press. doi:10.17226/10497. ISBN 978-0-309-08535-9. PMID 20669482.{{cite book}}: CS1 maint: numeric names: authors list (link)
  23. ^ Kennedy, D (2003). "Points of View: Is Bio2010 the Right Blueprint for the Biology of the Future?". Cell Biol Educ. 2 (4): 224–7. doi:10.1187/cbe.03-10-0039. PMC 256982. PMID 14673487.
  24. ^ "Recipients - ACS Division of Biological Chemistry Website".
  25. ^ "American Academy of Arts & Sciences".
  26. ^ "National Academy of Sciences".
  27. ^ "AAAS Awards and Honors". archives.aaas.org. Retrieved 2019-10-23.
  28. ^ 1992 http://convocation.uchicago.edu/page/1990 2019-02-16 at the Wayback Machine
  29. ^ "Roche Life Science | Welcome". lifescience.roche.com. Retrieved 2019-10-24.
  30. ^ "Lubert Stryer".
  31. ^ European Patent Office. "EPO - Stephen P.A. Fodor, Michael C. Pirrung, J. Leighton Read and Lubert Stryer (Affymax Research Institute, Palo Alto, USA)".
  32. ^ "Faculty & Research".
  33. ^ . Archived from the original on 2009-04-11. Retrieved 2012-04-01.
  34. ^ "Tobias Meyer - Mrs. George A. Winzer Professor in Cell Biology and Professor of Chemical & Systems Biology | Welcome to Bio-X".

April 26, 2024
lubert, stryer, march, 1938, april, 2024, emeritus, george, winzer, professor, cell, biology, stanford, university, school, medicine, research, over, more, than, four, decades, been, centered, interplay, light, life, 2007, received, national, medal, science, f. Lubert Stryer 2 March 1938 April 2024 1 was the Emeritus Mrs George A Winzer Professor of Cell Biology at Stanford University School of Medicine 2 3 His research over more than four decades has been centered on the interplay of light and life In 2007 he received the National Medal of Science from President Bush at a ceremony at the White House for elucidating the biochemical basis of signal amplification in vision pioneering the development of high density microarrays for genetic analysis and authoring the standard undergraduate biochemistry textbook Biochemistry 4 It is now in its tenth edition and also edited by Jeremy Berg Justin Hines John L Tymoczko and Gregory J Gatto Jr 5 Lubert StryerBorn 1938 03 02 March 2 1938 age 86 Tianjin ChinaDiedStanford CaliforniaCitizenshipUnited StatesEducationUniversity of Chicago B S 1957 Harvard Medical School M D Known forTextbook Biochemistry ten editions AwardsNational Academy of Sciences European Inventor of the Year 2006 Eli Lilly Award in Biological ChemistryScientific careerFieldsBiochemistry fluorescence spectroscopyInstitutionsDepartment of physics at Harvard MRC Laboratory of Molecular Biology at Cambridge UK department of biochemistry at Stanford University Yale UniversityNotable studentsRichard P Haugland Jeremy M Berg Stryer received his B S degree from the University of Chicago in 1957 and his M D degree from Harvard Medical School He was a Helen Hay Whitney Research Fellow 6 in the department of physics at Harvard and then at the MRC Laboratory of Molecular Biology 7 in Cambridge England before joining the faculty of the department of biochemistry at Stanford in 1963 In 1969 he moved to Yale to become Professor of Molecular Biophysics and Biochemistry and in 1976 he returned to Stanford to head a new Department of Structural Biology 3 8 Contents 1 Research profile 2 Honors 3 Notable students 4 ReferencesResearch profile editStryer and coworkers pioneered the use of fluorescence spectroscopy particularly Forster resonance energy transfer FRET to monitor the structure and dynamics of biological macromolecules 9 10 In 1967 Stryer and Haugland showed that the efficiency of energy transfer depends on the inverse sixth power of the distance between the donor and acceptor 11 12 as predicted by Forster s theory They proposed that energy transfer can serve as a spectroscopic ruler to reveal proximity relationships in biological macromolecules A second contribution was Stryer s discovery of the primary stage of amplification in visual excitation 13 14 Stryer together with Fung and Hurley showed that a single photoexcited rhodopsin molecule activates many molecules of transducin which in turn activate many molecules of a cyclic GMP phosphodiesterase Stryer s laboratory has also contributed to our understanding of the role of calcium in visual recovery and adaptation 15 16 17 Stryer participated in developing light directed spatially addressable parallel chemical synthesis for the synthesis of peptides and polynucleotides 18 19 20 Light directed combinatorial synthesis has been used by Stephen Fodor and coworkers at Affymetrix to make DNA arrays containing millions of different sequences for genetic analyses Since 1975 Stryer has authored ten editions of the textbook Biochemistry 21 Stryer also chaired a National Research Council committee that produced a report entitled Bio2010 Transforming Undergraduate Education for Future Research Biologists 22 23 Honors editAmerican Chemical Society Award in Biological Chemistry Eli Lilly Award in Biological Chemistry 1970 24 American Academy of Arts and Sciences elected 1975 25 National Academy of Sciences elected 1984 26 American Association for the Advancement of Science Newcomb Cleveland Prize 1992 27 Honorary Doctor of Science degree University of Chicago 1992 28 Molecular Bioanalytics Award German Society for Biochemistry and Molecular Biology 2002 29 American Philosophical Society 2006 3 National Medal of Science 2006 30 European Inventor of the Year 2006 in the category Small and medium sized enterprises 31 Notable students editRichard P Haugland Ph D 1970 founder of Molecular Probes Inc Richard A Mathies postdoc dean of the college of chemistry University of California Berkeley 32 Tobias Meyer postdoc now professor department of chemical and systems biology Stanford University 33 34 Cheng Wen Wu postdoc former founding president of the Taiwan National Health Research Institutes 1996 2005 now professor at the Taiwan Medical College Jeremy M Berg co author of widely used Biochemistry textbookReferences edit https www genomeweb com people news lubert stryer 622341 Lubert Stryer a b c Our Apologies American Philosophical Society Archived from the original on 2012 07 20 Retrieved 2012 03 10 President to Award 2005 2006 National Medals of Science and National Medals of Technology Honoring Nation s Leading Researchers Inventors and Innovators NSF National Science Foundation Stryer et al 2023 Biochemistry 10 ed Palgrave Macmillan ISBN 978 1319498504 Archived copy Archived from the original on 2012 11 14 Retrieved 2012 04 01 a href Template Cite web html title Template Cite web cite web a CS1 maint archived copy as title link Alumni MRC Laboratory of Molecular Biology MRC Laboratory of Molecular Biology McCarthy Pumtiwitt Everything is illuminated Reflections on light and life by Lubert Stryer American Society for Biochemistry and Molecular Biology Retrieved 19 June 2016 Stryer L 1968 Fluorescence spectroscopy of proteins Science 1632 3853 526 533 Bibcode 1968Sci 162 526S doi 10 1126 science 162 3853 526 PMID 5706935 Invitrogen Molecular Probes Press Release Archived from the original on 2011 06 14 Retrieved 2010 10 18 Stryer L Haugland R P 1967 Energy transfer a spectroscopic ruler Proc Natl Acad Sci USA 58 2 719 725 Bibcode 1967PNAS 58 719S doi 10 1073 pnas 58 2 719 PMC 335693 PMID 5233469 Lakowicz J R 2006 Principles of Fluorescence Spectroscopy Springer 3rd ed p 449 Fung B Hurley J B Stryer L 1981 Flow of information in the light triggered cyclic nucleotide cascade of vision Proc Natl Acad Sci USA 78 1 152 156 Bibcode 1981PNAS 78 152F doi 10 1073 pnas 78 1 152 PMC 319009 PMID 6264430 Chemical amp Engineering News Serving the chemical life sciences and laboratory worlds Koch K W Stryer L 1988 Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ion Nature 334 6177 64 66 Bibcode 1988Natur 334 64K doi 10 1038 334064a0 PMID 2455233 S2CID 4253998 lt Ames J B Ishima R Tanaka T Gordon J I Stryer L Ikura M 1997 Molecular mechanics of calcium myristoyl switches Nature 389 198 202 Burgoyne R D Weiss J L 2001 The neuronal calcium sensor family of Ca2 binding proteins Biochem J 353 Pt 1 1 12 doi 10 1042 bj3530001 PMC 1221537 PMID 11115393 Fodor S P A Read J L Pirrung M C Stryer L Lu A T Solas D 1991 Light directed spatially addressable parallel chemical synthesis Science 251 4995 767 773 Bibcode 1991Sci 251 767F doi 10 1126 science 1990438 PMID 1990438 Fodor S P A Pirrung M C Read J L and Stryer L Array of oligonucleotides on a solid substrate U S Patent No 5 445 934 Issued August 29 1995 2007 Newcomb Cleveland Prize Recipients AAAS The World s Largest General Scientific Society Latchman D S 1995 Trends Biochem Sci 20 488 Council National Research Studies Division on Earth Life Sciences Board on Life Century Committee on Undergraduate Biology Education to Prepare Research Scientists for the 21st 2003 BIO2010 Transforming Undergraduate Education for Future Research Biologists The National Academies Press doi 10 17226 10497 ISBN 978 0 309 08535 9 PMID 20669482 a href Template Cite book html title Template Cite book cite book a CS1 maint numeric names authors list link Kennedy D 2003 Points of View Is Bio2010 the Right Blueprint for the Biology of the Future Cell Biol Educ 2 4 224 7 doi 10 1187 cbe 03 10 0039 PMC 256982 PMID 14673487 Recipients ACS Division of Biological Chemistry Website American Academy of Arts amp Sciences National Academy of Sciences AAAS Awards and Honors archives aaas org Retrieved 2019 10 23 1992 http convocation uchicago edu page 1990 Archived 2019 02 16 at the Wayback Machine Roche Life Science Welcome lifescience roche com Retrieved 2019 10 24 Lubert Stryer European Patent Office EPO Stephen P A Fodor Michael C Pirrung J Leighton Read and Lubert Stryer Affymax Research Institute Palo Alto USA Faculty amp Research Meyer Lab Archived from the original on 2009 04 11 Retrieved 2012 04 01 Tobias Meyer Mrs George A Winzer Professor in Cell Biology and Professor of Chemical amp Systems Biology Welcome to Bio X Retrieved from https en wikipedia org w index php title Lubert Stryer amp oldid 1219437321, wikipedia, wiki, book, books, library,

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