List of polysubstance combinations

See also: Mixed drink § Polysubstance

Not to be confused with Lacing (drugs) § Commonly laced substances.

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.

A drug combination chart designed for harm reduction by TripSit.me^[1]

To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

Drug 1	Drug 2	Drug 3	Drug 4	Polysubstance slang,^[2]^[3]^[4] or brand name	Intoxication name	Comment
Any dissociative	Any dissociative			Void flip	Void flipping
Any dissociative	DMT			Dime bar, angel flip	Dimension flipping, angel flipping
Any depressant	Any stimulant			Speedball, powerball, over and under	Powerballing, speedballing^[5]
Any pharmaceutical	Any pharmaceutical			Polypharmacy	Pharming ^[citation needed]	Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.^[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.^[6]
Any drug	Cannabis			Amp joint^[7]
Any drug	Nicotine			Cooler^[5]
Any β-Carboline containing plant (e.g. Banisteriopsis caapi or Peganum harmala)	DMT			Ayahuasca, Changa		Ayahuasca is drunk. Changa is smoked or vaped.
Any antiretroviral drug	Black tar heroin			Whoonga, Nyaope ^[8]		Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
Any deliriant or diphenhydramine	MDMA			Nightmare flip	Nightmare flipping
2C-B or the closely related 2C-x	LSD or any of the Lysergamides	MDMA or any Empathogen-entactogen		Ali flip^[9]^[10]	Ali flipping^[9]^[10]	This combination start as a classic Candyflip and end in a Nexus flip. The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA ( so 6 hours after the LSD ). MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY. This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.
2C-B	MDMA			Nexus flip^[9]^[10]	Nexus flipping^[9]^[10]	The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½). The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.
2C-B	DXM			Nexuswalk^[11]	Nexuswalk	Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-B	LSD			Gnome flip	Gnome flipping
2C-E	LSD	MDMA		Haychmaich flip^[5]	Haychmaich flipping
2C-P	2C-E			Meskini Trip	Meskini Tripping
2C-E	MDMA or any Empathogen-entactogen	2C-B or the closely related 2C-x		Elias flip^[5]	Elias flipping	The Elias Flipping inspired by the Ali Flip with the use of 2C-E instead of LSD.
Alcohol	Benzodiazepine			Time flip	Time flipping
Alcohol	Caffeine			Caffeinated alcoholic drink
Alcohol	Cannabis			Tincture of cannabis. Herb and Al. Judgement Day	Cross fading, twisting, getting twisted^[12]	Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol	Cocaine			Snow-cone	Snow-coning	Ethanol is metabolized into cocaethylene^[13]
Alcohol	MDMA			Tipsy flip	Tipsy flipping	It may be dangerous
Alcohol	Nicotine			Nicotini		A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine	Barbiturates			Inbetweens^[14]
Amphetamine	Cannabis	LSD		Hippie heart attack ^[citation needed]
Amphetamine	Cocaine			Snow seals
Amphetamine	Heroin			Bombido^[14]
Amphetamine	Xanax			Orange Dream Blossom	Cloud Rush	The combination is crushed together and insufflated
Belladonna	Hashish			Alamout black hash^[5]		Mixed
Caffeine	Cannabis			Hippie-speedball ^[citation needed]	Hippie-speedballing
Caffeine	Diphenhydramine			Sleep walk	Sleepwalking
Caffeine	Methamphetamine			Ya ba, biker's coffee, kamikaze
Cacao bean	Magic mushroom					Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD	THC					Low to moderate doses of CBD might reduce some of the paranoia, anxiety,^[15] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.^[16]^[17]^[18] Low doses of Kanna might also help counteract the anxiety.^[19]^[20]
Cannabis	Cocoa solids			Cannabis-infused brownie		Cannabis edible
Cannabis	Crack cocaine			Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)^[21]	Cocoa puffs, splitting
Cannabis	Crack cocaine	Heroin		Major Pronin, El Diablo
Cannabis	Crack cocaine	PCP		Jim Jones
Cannabis	Damiana					Damiana and other herbs can be used as a tobacco alternative for rolling joints.^[22]
Cannabis	DXM	Nicotine		Candy blunt
Cannabis	Heroin or opium			A-bomb, Atom bomb, stuff^[5]
Cannabis	MDMA			Stoner flip	Stoner flipping
Cannabis	Ketamine			Stoner Kitty
Cannabis	Ketamine	Cocaine		Simmered	Getting Simmered
Cannabis	Nicotine			Blunt, joint, spliff		A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis	Opium			Demetra
Cannabis	PCP			Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom)	Illing	Wet is cannabis dipped in PCP ^[23]
Cannabis	PCP	Nicotine		Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt	Illing
Cocaine	Heroin			Snowball. Other names: Belushi, bombita, murder one, whiz bang	Snowballing
Cocaine	Heroin	LSD		Frisco special^[5]
Cocaine	Heroin	Nicotine		Flamethrower, primos		Cigarette laced with cocaine and heroin
Cocaine	Ketamine			CK1, Calvin Klein, Cable, Party bag		While CK1, Calvin Klein and Cable are all names for using both substances; a Party bag is in specific reference to when the substances are mixed in a single bag prior to use.
Cocaine	Ketamine	MDMA		Ketamollicaine
Cocaine	LSD	MDMA		Candy-flip on a string	Candy-flipping on a string	High risk on health
Cocaine	MDMA			Sugar flip	Sugar flipping
Cocaine	Morphine			C & M
Cocaine	PCP			Space, whack
Cocaine	Wine			Coca wine		Ethanol is metabolized into cocaethylene
Cocaine	Quetiapine			Q-ball
Codeine	Glutethimide			Pancakes and syrups		Combination of glutethimide and codeine cough syrup
Codeine	Promethazine			Lean, purple drank, oil
Crack cocaine	Fentanyl			Dirty fentanyl, takeover ^[citation needed]
Crack cocaine	Heroin			Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine	LSD			Cracid, outerlimits		Cracid is a portmanteau of crack cocaine and acid ^[citation needed]
Crack cocaine	Methamphetamine			Fire, twisters
Crack cocaine	Nicotine			Coolie, crimmie, woolas		A cigarette laced with crack ^[citation needed]
Crack cocaine	Nicotine	PCP		Ozone		PCP and crack cigarette ^[citation needed]
Crack cocaine	PCP			Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic	Missile basing, space basing
Diphenhydramine	DXM			OTC flip, counterflipping	OTC flipping, robowalking on a string
DMT	LSD			Cosmo flip, Meadow flip	Cosmo flipping, meadow flipping
DMT	LSD	Psilocybin or psilocybin mushroom		Super flip	Super flipping	Take LSD and shrooms then at the come up smoke DMT
DMT	MAOIs			Pharmahuasca
DMT	Psilocybin or psilocybin mushroom			Terence flip	Terence flipping
DMT	Alcohol			Spyder, Spyder spin	Spyder spinning
DXM	LSD			LSDXM
DXM	MDMA			Robo flip	Robo flipping
DXM	Psilocybin or psilocybin mushroom			Cherry-bomb	Cherry-bombing
Fentanyl	Heroin			Birria, chiva loca, Facebook		Facebook is mixed in a pill form ^[citation needed]
Fentanyl (and/or heroin)	Xylazine			Tranq, Tranq dope		"Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or fentanyl
GHB	MDMA			Gamma flip	Gamma flipping
GHB	Methamphetamine			Cherry meth
Hashish	Crack cocaine			Double zero
Hashish	LSD			Royal temple ball		The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
Hashish	Opium			Black hash, black Russian
Heroin	Methamphetamine			Goofball
Heroin	Morphine			New Jack swing
Heroin	PCP			Alien sex fiend^[5]
Ketamine	LSD			Dolphin flip	Dolphin flipping
Ketamine	MDMA			Kitty flip,^[24] MK-ultra	Kitty flipping
Ketamine	Psilocybin or Psilocybin mushrooms			Funky flip	Funky flipping	Fungus and K: one confirmed option is to ingest a low (0.75g) dose of psilocybin, wait 45 minutes, snort half a moderate dose of powdered ketamine, wait 10 minutes, snort the other half
LSD	Ketamine	MDMA		Holy Trident, Martin Luther King flip, Galaxy flip	Holy Tridenting, Martin Luther King flipping, Galaxy Flipping
LSD	MDMA			Candy flip^[9]^[10]	Candy flipping^[9]^[10]	Generally, the MDMA is taken approximatly 4 hours after the LSD ingestion.
LSD	MDMA	Psilocybin or psilocybin mushroom		Jedi flip,^[24] twilight flip	Jedi flipping, twilight flipping
LSD	MDMA	Mushrooms	Ketamine	Quantum Flip	Quantum Flipping	Similar to Jedi flipping, but with a heavy dissociative effect induced by ketamine. The substances are taken in the order of LSD, Mushrooms, MDMA, then ketamine. Each substance should be taken at the peak of the previous substance to maximize the synergistic effects. Ketamine can be re-dosed as needed to extend the trip. The end result is a highly visual and euphoric experience with periods of deep dissociation.
LSD	Mescaline			Stella trip
LSD	Nitrous oxide			Gasid
LSD	PCP			Black acid
LSD	MDMA	Ketamine		Swalap Flip	Swalaped
LSD	Psilocybin or psilocybin mushroom			God's flesh, Soul Bomb, Alice,^[5] Wizard flip	Wizard flipping
LSD	MDMA	Any dissociative	(Optional) DMT	Pixie flip, portal flip	Pixie flipping, portal flipping
MDMA	Mescaline or psychoactive cactus			Love flip, love trip	Love flipping
MDMA	Methadone			Chocolate flip	Chocolate flipping
MDMA	Methamphetamine			Trailer flip	Trailer flipping
MDMA	DMT			Shaman flip, time flip	Shaman flipping, time flipping
MDMA	Nitrous oxide			Nox
MDMA	Opiates			Poppy flip	Poppy flipping
MDMA	PCP			Domex, elephant flip	Elephant flipping
MDMA	Psilocybin or psilocybin mushroom			Hippie flip	Hippie flipping
MDMA	Methaqualone			Disco flipping, Jelly flipping	Troll Roll, Hippy flip^[24]	Hippy flipping^[25]
MDMA	Viagra (or other PDE5 inhibitors such as Cialis or Levitra)			Sextacy
MDMA	Xanax			Zen flip	Zen flipping
MDMA	Ketamine	Mushrooms		Obama Flip	Obama Flipping
Methamphetamine	Secobarbital, or other barbiturates			Poor man's speedball
Methamphetamine	Alpha-PVP			Cartel meth		So-called "cartel meth" is primarily composed of cutting agents such as isopropylbenzylamine and/or dimethylsulfone with a small proportion of methamphetamine plus the potent stimulant Alpha-PVP
Nicotine	PCP			Chipping, fry cigarette
Pentazocine	Tripelannamine			T's and blues
Venlafaxine	Mirtazepine			California rocket fuel		None of the drugs are illegal and the combination is used for medical purposes.

See also

• ACE mixture
• Brompton cocktail
• D-IX
• Desbutal
• Dexamyl
• Gray death
• Neuroleptanalgesic
• Rodent cocktail
• Tuinal
• Twilight sleep
• Whoonga
• List of plants used for smoking

References

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External links