The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, glycoprotein 130 (IL6ST, gp130). Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.[5]
Interactionsedit
Leukemia inhibitory factor receptor has been shown to interact with glycoprotein 130.[6][7]
LIFR has also been identified as a breast cancer metastasis suppressor that functions through the Hippo-YAP pathway. LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool.
^Timmermann A, Küster A, Kurth I, Heinrich PC, Müller-Newen G (June 2002). "A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor". European Journal of Biochemistry. 269 (11): 2716–26. doi:10.1046/j.1432-1033.2002.02941.x. PMID 12047380.
^Mosley B, De Imus C, Friend D, Boiani N, Thoma B, Park LS, Cosman D (December 1996). "Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation". The Journal of Biological Chemistry. 271 (51): 32635–43. doi:10.1074/jbc.271.51.32635. PMID 8999038.
Further readingedit
Tomida M (May 2000). "Structural and functional studies on the leukemia inhibitory factor receptor (LIF-R): gene and soluble form of LIF-R, and cytoplasmic domain of LIF-R required for differentiation and growth arrest of myeloid leukemic cells". Leukemia & Lymphoma. 37 (5–6): 517–25. doi:10.3109/10428190009058503. PMID 11042511. S2CID 22834354.
Lass A, Weiser W, Munafo A, Loumaye E (December 2001). "Leukemia inhibitory factor in human reproduction". Fertility and Sterility. 76 (6): 1091–6. doi:10.1016/S0015-0282(01)02878-3. PMID 11730732.
Gearing DP, Bruce AG (January 1992). "Oncostatin M binds the high-affinity leukemia inhibitory factor receptor". The New Biologist. 4 (1): 61–5. PMID 1536831.
Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B (March 1992). "The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor". Science. 255 (5050): 1434–7. Bibcode:1992Sci...255.1434G. doi:10.1126/science.1542794. PMID 1542794.
Gearing DP, Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D, Beckmann MP (October 1991). "Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130". The EMBO Journal. 10 (10): 2839–48. doi:10.1002/j.1460-2075.1991.tb07833.x. PMC452994. PMID 1915266.
Boulton TG, Stahl N, Yancopoulos GD (April 1994). "Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors". The Journal of Biological Chemistry. 269 (15): 11648–55. doi:10.1016/S0021-9258(19)78174-5. PMID 7512571.
Schiemann WP, Graves LM, Baumann H, Morella KK, Gearing DP, Nielsen MD, Krebs EG, Nathanson NM (June 1995). "Phosphorylation of the human leukemia inhibitory factor (LIF) receptor by mitogen-activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation". Proceedings of the National Academy of Sciences of the United States of America. 92 (12): 5361–5. Bibcode:1995PNAS...92.5361S. doi:10.1073/pnas.92.12.5361. PMC41694. PMID 7777512.
Gearing DP, Druck T, Huebner K, Overhauser J, Gilbert DJ, Copeland NG, Jenkins NA (October 1993). "The leukemia inhibitory factor receptor (LIFR) gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12-p13". Genomics. 18 (1): 148–50. doi:10.1006/geno.1993.1441. PMID 8276403.
Sharkey AM, Dellow K, Blayney M, Macnamee M, Charnock-Jones S, Smith SK (October 1995). "Stage-specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos". Biology of Reproduction. 53 (4): 974–81. doi:10.1095/biolreprod53.4.974. PMID 8547494.
Kojima K, Kanzaki H, Iwai M, Hatayama H, Fujimoto M, Narukawa S, Higuchi T, Kaneko Y, Mori T, Fujita J (July 1995). "Expression of leukaemia inhibitory factor (LIF) receptor in human placenta: a possible role for LIF in the growth and differentiation of trophoblasts". Human Reproduction. 10 (7): 1907–11. doi:10.1093/oxfordjournals.humrep.a136205. PMID 8583009.
Tomida M, Gotoh O (July 1996). "Structure of the gene encoding the human differentiation-stimulating factor/leukemia inhibitory factor receptor". Journal of Biochemistry. 120 (1): 201–5. doi:10.1093/oxfordjournals.jbchem.a021386. PMID 8864865.
Wang Z, Melmed S (October 1997). "Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage". The Journal of Biological Chemistry. 272 (44): 27957–65. doi:10.1074/jbc.272.44.27957. PMID 9346946.
Tanaka M, Hara T, Copeland NG, Gilbert DJ, Jenkins NA, Miyajima A (February 1999). "Reconstitution of the functional mouse oncostatin M (OSM) receptor: molecular cloning of the mouse OSM receptor beta subunit". Blood. 93 (3): 804–15. doi:10.1182/blood.V93.3.804. PMID 9920829. S2CID 39078004.
Knight DA, Lydell CP, Zhou D, Weir TD, Robert Schellenberg R, Bai TR (April 1999). "Leukemia inhibitory factor (LIF) and LIF receptor in human lung. Distribution and regulation of LIF release". American Journal of Respiratory Cell and Molecular Biology. 20 (4): 834–41. doi:10.1165/ajrcmb.20.4.3429. PMID 10101017.
Kakizawa T, Miyamoto T, Ichikawa K, Kaneko A, Suzuki S, Hara M, Nagasawa T, Takeda T, Mori JI, Kumagai M, Hashizume K (July 1999). "Functional interaction between Oct-1 and retinoid X receptor". The Journal of Biological Chemistry. 274 (27): 19103–8. doi:10.1074/jbc.274.27.19103. PMID 10383413.
Bartoe JL, Nathanson NM (May 2000). "Differential regulation of leukemia inhibitory factor-stimulated neuronal gene expression by protein phosphatases SHP-1 and SHP-2 through mitogen-activated protein kinase-dependent and -independent pathways". Journal of Neurochemistry. 74 (5): 2021–32. doi:10.1046/j.1471-4159.2000.0742021.x. PMID 10800945. S2CID 23296203.
Bamberger AM, Schulte HM, Wullbrand A, Jung R, Beil FU, Bamberger CM (April 2000). "Expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF-R) in the human adrenal cortex: implications for steroidogenesis". Molecular and Cellular Endocrinology. 162 (1–2): 145–9. doi:10.1016/S0303-7207(00)00200-8. PMID 10854707. S2CID 24089439.
Blanchard F, Duplomb L, Wang Y, Robledo O, Kinzie E, Pitard V, Godard A, Jacques Y, Baumann H (September 2000). "Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal-regulated kinase". The Journal of Biological Chemistry. 275 (37): 28793–801. doi:10.1074/jbc.M003986200. PMID 10858440.
Plun-Favreau H, Elson G, Chabbert M, Froger J, deLapeyrière O, Lelièvre E, Guillet C, Hermann J, Gauchat JF, Gascan H, Chevalier S (April 2001). "The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin-like cytokine". The EMBO Journal. 20 (7): 1692–703. doi:10.1093/emboj/20.7.1692. PMC145510. PMID 11285233.
External linksedit
LIF+Receptor+alpha+Subunit at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
leukemia, inhibitory, factor, receptor, lifr, redirects, here, confused, with, instrument, flight, rules, lifr, also, known, cd118, cluster, differentiation, subunit, receptor, leukemia, inhibitory, factor, lifravailable, structurespdbortholog, search, pdbe, r. LIFR redirects here Not to be confused with Low instrument flight rules LIFR also known as CD118 Cluster of Differentiation 118 is a subunit of a receptor for leukemia inhibitory factor LIFRAvailable structuresPDBOrtholog search PDBe RCSBList of PDB id codes3E0GIdentifiersAliasesLIFR CD118 LIF R SJS2 STWS SWS leukemia inhibitory factor receptor alpha LIF receptor alpha LIF receptor subunit alphaExternal IDsOMIM 151443 MGI 96788 HomoloGene 1735 GeneCards LIFR OMA LIFR orthologsGene location Human Chr Chromosome 5 human 1 Band5p13 1Start38 474 668 bp 1 End38 608 354 bp 1 Gene location Mouse Chr Chromosome 15 mouse 2 Band15 A1 15 3 46 cMStart7 120 095 bp 2 End7 226 970 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ininternal globus pallidusexternal globus pallidustibiaAchilles tendonsubthalamic nucleusponscardialower lobe of lungsuperficial temporal arteryinferior ganglion of vagus nerveTop expressed inbody of femursternocleidomastoid muscleparotid glandfacial motor nucleustriceps brachii muscletemporal muscletrigeminal ganglionseminal vesiculavastus lateralis musclepontine nucleiMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionciliary neurotrophic factor receptor activity growth factor binding oncostatin M receptor activity protein binding cytokine receptor activity ciliary neurotrophic factor receptor binding leukemia inhibitory factor receptor activity cytokine bindingCellular componentintegral component of membrane membrane plasma membrane receptor complex integral component of plasma membrane extracellular region extracellular exosome extracellular space external side of plasma membraneBiological processresponse to cytokine leukemia inhibitory factor signaling pathway oncostatin M mediated signaling pathway cytokine mediated signaling pathway ciliary neurotrophic factor mediated signaling pathway cell surface receptor signaling pathway positive regulation of cell population proliferation regulation of cytokine mediated signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez397716880EnsemblENSG00000113594ENSMUSG00000054263UniProtP42702P42703RefSeq mRNA NM 001127671NM 002310NM 001364297NM 001364298NM 001113386NM 013584NM 001358593RefSeq protein NP 001121143NP 002301NP 001351226NP 001351227NP 001106857NP 038612NP 001345522Location UCSC Chr 5 38 47 38 61 MbChr 15 7 12 7 23 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 See also 4 References 5 Further reading 6 External linksFunction editThe leukemia inhibitory factor LIF is a polyfunctional cytokine that affects the differentiation survival and proliferation of a wide variety of cells in the adult and the embryo LIF action appears to be mediated through a high affinity receptor complex composed of a low affinity LIF binding chain LIF receptor and a high affinity converter subunit glycoprotein 130 IL6ST gp130 Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems including the ciliary neurotrophic factor growth hormone and prolactin 5 Interactions editLeukemia inhibitory factor receptor has been shown to interact with glycoprotein 130 6 7 LIFR has also been identified as a breast cancer metastasis suppressor that functions through the Hippo YAP pathway LIFR is down regulated in a number of breast carcinomas and may serve a prognostic tool See also editCluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000113594 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000054263 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene LIFR leukemia inhibitory factor receptor alpha Timmermann A Kuster A Kurth I Heinrich PC Muller Newen G June 2002 A functional role of the membrane proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor European Journal of Biochemistry 269 11 2716 26 doi 10 1046 j 1432 1033 2002 02941 x PMID 12047380 Mosley B De Imus C Friend D Boiani N Thoma B Park LS Cosman D December 1996 Dual oncostatin M OSM receptors Cloning and characterization of an alternative signaling subunit conferring OSM specific receptor activation The Journal of Biological Chemistry 271 51 32635 43 doi 10 1074 jbc 271 51 32635 PMID 8999038 Further reading editTomida M May 2000 Structural and functional studies on the leukemia inhibitory factor receptor LIF R gene and soluble form of LIF R and cytoplasmic domain of LIF R required for differentiation and growth arrest of myeloid leukemic cells Leukemia amp Lymphoma 37 5 6 517 25 doi 10 3109 10428190009058503 PMID 11042511 S2CID 22834354 Lass A Weiser W Munafo A Loumaye E December 2001 Leukemia inhibitory factor in human reproduction Fertility and Sterility 76 6 1091 6 doi 10 1016 S0015 0282 01 02878 3 PMID 11730732 Gearing DP Bruce AG January 1992 Oncostatin M binds the high affinity leukemia inhibitory factor receptor The New Biologist 4 1 61 5 PMID 1536831 Gearing DP Comeau MR Friend DJ Gimpel SD Thut CJ McGourty J Brasher KK King JA Gillis S Mosley B March 1992 The IL 6 signal transducer gp130 an oncostatin M receptor and affinity converter for the LIF receptor Science 255 5050 1434 7 Bibcode 1992Sci 255 1434G doi 10 1126 science 1542794 PMID 1542794 Gearing DP Thut CJ VandeBos T Gimpel SD Delaney PB King J Price V Cosman D Beckmann MP October 1991 Leukemia inhibitory factor receptor is structurally related to the IL 6 signal transducer gp130 The EMBO Journal 10 10 2839 48 doi 10 1002 j 1460 2075 1991 tb07833 x PMC 452994 PMID 1915266 Boulton TG Stahl N Yancopoulos GD April 1994 Ciliary neurotrophic factor leukemia inhibitory factor interleukin 6 oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors The Journal of Biological Chemistry 269 15 11648 55 doi 10 1016 S0021 9258 19 78174 5 PMID 7512571 Schiemann WP Graves LM Baumann H Morella KK Gearing DP Nielsen MD Krebs EG Nathanson NM June 1995 Phosphorylation of the human leukemia inhibitory factor LIF receptor by mitogen activated protein kinase and the regulation of LIF receptor function by heterologous receptor activation Proceedings of the National Academy of Sciences of the United States of America 92 12 5361 5 Bibcode 1995PNAS 92 5361S doi 10 1073 pnas 92 12 5361 PMC 41694 PMID 7777512 Gearing DP Druck T Huebner K Overhauser J Gilbert DJ Copeland NG Jenkins NA October 1993 The leukemia inhibitory factor receptor LIFR gene is located within a cluster of cytokine receptor loci on mouse chromosome 15 and human chromosome 5p12 p13 Genomics 18 1 148 50 doi 10 1006 geno 1993 1441 PMID 8276403 Sharkey AM Dellow K Blayney M Macnamee M Charnock Jones S Smith SK October 1995 Stage specific expression of cytokine and receptor messenger ribonucleic acids in human preimplantation embryos Biology of Reproduction 53 4 974 81 doi 10 1095 biolreprod53 4 974 PMID 8547494 Kojima K Kanzaki H Iwai M Hatayama H Fujimoto M Narukawa S Higuchi T Kaneko Y Mori T Fujita J July 1995 Expression of leukaemia inhibitory factor LIF receptor in human placenta a possible role for LIF in the growth and differentiation of trophoblasts Human Reproduction 10 7 1907 11 doi 10 1093 oxfordjournals humrep a136205 PMID 8583009 Tomida M Gotoh O July 1996 Structure of the gene encoding the human differentiation stimulating factor leukemia inhibitory factor receptor Journal of Biochemistry 120 1 201 5 doi 10 1093 oxfordjournals jbchem a021386 PMID 8864865 Wang Z Melmed S October 1997 Identification of an upstream enhancer within a functional promoter of the human leukemia inhibitory factor receptor gene and its alternative promoter usage The Journal of Biological Chemistry 272 44 27957 65 doi 10 1074 jbc 272 44 27957 PMID 9346946 Tanaka M Hara T Copeland NG Gilbert DJ Jenkins NA Miyajima A February 1999 Reconstitution of the functional mouse oncostatin M OSM receptor molecular cloning of the mouse OSM receptor beta subunit Blood 93 3 804 15 doi 10 1182 blood V93 3 804 PMID 9920829 S2CID 39078004 Knight DA Lydell CP Zhou D Weir TD Robert Schellenberg R Bai TR April 1999 Leukemia inhibitory factor LIF and LIF receptor in human lung Distribution and regulation of LIF release American Journal of Respiratory Cell and Molecular Biology 20 4 834 41 doi 10 1165 ajrcmb 20 4 3429 PMID 10101017 Kakizawa T Miyamoto T Ichikawa K Kaneko A Suzuki S Hara M Nagasawa T Takeda T Mori JI Kumagai M Hashizume K July 1999 Functional interaction between Oct 1 and retinoid X receptor The Journal of Biological Chemistry 274 27 19103 8 doi 10 1074 jbc 274 27 19103 PMID 10383413 Bartoe JL Nathanson NM May 2000 Differential regulation of leukemia inhibitory factor stimulated neuronal gene expression by protein phosphatases SHP 1 and SHP 2 through mitogen activated protein kinase dependent and independent pathways Journal of Neurochemistry 74 5 2021 32 doi 10 1046 j 1471 4159 2000 0742021 x PMID 10800945 S2CID 23296203 Bamberger AM Schulte HM Wullbrand A Jung R Beil FU Bamberger CM April 2000 Expression of leukemia inhibitory factor LIF and LIF receptor LIF R in the human adrenal cortex implications for steroidogenesis Molecular and Cellular Endocrinology 162 1 2 145 9 doi 10 1016 S0303 7207 00 00200 8 PMID 10854707 S2CID 24089439 Blanchard F Duplomb L Wang Y Robledo O Kinzie E Pitard V Godard A Jacques Y Baumann H September 2000 Stimulation of leukemia inhibitory factor receptor degradation by extracellular signal regulated kinase The Journal of Biological Chemistry 275 37 28793 801 doi 10 1074 jbc M003986200 PMID 10858440 Plun Favreau H Elson G Chabbert M Froger J deLapeyriere O Lelievre E Guillet C Hermann J Gauchat JF Gascan H Chevalier S April 2001 The ciliary neurotrophic factor receptor alpha component induces the secretion of and is required for functional responses to cardiotrophin like cytokine The EMBO Journal 20 7 1692 703 doi 10 1093 emboj 20 7 1692 PMC 145510 PMID 11285233 External links editLIF Receptor alpha Subunit at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Leukemia inhibitory factor receptor amp oldid 1217570385, wikipedia, wiki, book, books, library,
