Jerzy Jurka
Jerzy Władysław Jurka (June 4, 1950 – July 19, 2014) was a Polish-American computational and molecular biologist. He served as the assistant director of research at the Linus Pauling Institute prior to founding the Genetic Information Research Institute. He collaborated with several notable scientists including Linus Pauling, George Irving Bell, Roy Britten, Temple Smith, and Emile Zuckerkandl.[2] His Erdős number is 3, using the path through Temple Smith and Stanislaw Ulam.[3]
Jerzy Władysław Jurka | |
|---|---|
| Born | 4 June 1950 |
| Died | 19 July 2014 (aged 64)[1] |
| Nationality | American |
| Alma mater | Jagiellonian University (M.Sc. Chemistry) University of Warsaw (D.Sc. Molecular Biology) Harvard University (Post-doc) |
| Known for | Contributions to understanding of transposable elements |
| Spouse | Dr. Elzbieta Jurka |
| Children | Michael Jurka Matthew Jurka Timothy Jurka |
| Scientific career | |
| Fields | Chemistry Molecular Biology |
Research edit
Dr. Jurka is best known for his work on eukaryotic transposable elements (TEs), including the discovery of the major families of Alu elements.[4] He also proposed the mechanism of Alu proliferation and discovered their paternal transmission.[5][6] The majority of known types of class II TEs, or DNA transposons, were discovered or co-discovered by his team at the Genetic Information Research Institute, based on DNA sequence analysis. The first one, reported in 2001 with Vladimir Kapitonov, became known as Helitron, which is playing a major role in genomic evolution.[7] In 2006 they reported a study of a new, self-synthesizing transposable element called Polinton or Maverick, which is present in many diverse eukaryotes.[8][9] More recently, Jurka and his co-workers presented a hypothesis that links the origin of repetitive families (TE families), to population subdivision and speciation based on classical concepts of population genetics.[10]
Jerzy Jurka is the founder of Repbase [1], which he developed since 1990 with his team and other contributors. Repbase is the primary reference database of TEs used in DNA annotation and analysis.
References edit
- ^ "Jerzy Jurka". MercuryNews.com.
- ^ "An Oral History of the Linus Pauling Institute". Oregon State University.
- ^ The Erdős Project, "Paths to Erdős"
- ^ Jurka J, Smith T (July 1988). "A fundamental division in the Alu family of repeated sequences". Proceedings of the National Academy of Sciences. 85 (July): 279–90. Bibcode:1988PNAS...85.4775J. doi:10.1073/pnas.85.13.4775. PMC 280518. PMID 3387438.
- ^ Jurka J (March 1997). "Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposons". Proceedings of the National Academy of Sciences. 94 (5): 1872–1877. Bibcode:1997PNAS...94.1872J. doi:10.1073/pnas.94.5.1872. PMC 20010. PMID 9050872.
- ^ Jurka J, et al. (June 2002). "Active Alu elements are passed primarily through paternal germlines". Theoretical Population Biology. 61 (4): 519–530. doi:10.1006/tpbi.2002.1602. PMID 12167372.
- ^ Vladimir V. Kapitonov; Jerzy Jurka (October 2007). "Helitrons on a roll: eukaryotic rolling-circle transposons". Trends in Genetics. 23 (10): 521–9. doi:10.1016/j.tig.2007.08.004. PMID 17850916.
- ^ Vladimir V. Kapitonov; Jerzy Jurka (March 21, 2006). "Self-synthesizing DNA transposons in eukaryotes". PNAS. 103 (12). National Academy of Sciences: 4540–4545. Bibcode:2006PNAS..103.4540K. doi:10.1073/pnas.0600833103. PMC 1450207. PMID 16537396.
- ^ Pritham EJ, Putivala T, Feschotte C (April 2007). "Mavericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses". Gene. 390 (April): 3–17. doi:10.1016/j.gene.2006.08.008. PMID 17034960.
- ^ Jurka J, Bao W, Kojima K (June 2011). "Families of transposable elements, population structure and the origin of species". Biology Direct. 6 (1): 44. doi:10.1186/1745-6150-6-44. PMC 3183009. PMID 21929767.