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JacSue Kehoe

January 01, 1970

JacSue Kehoe (October 23, 1935 – June 25, 2019) was an American neuroscientist and neuroscience researcher. She spent decades working with the neurons of Aplysia californica, studying post-synaptic nerve response.[2] She discovered that one neurotransmitter can have multiple types of receptors, which could vary in level and type of response.[3] Kehoe worked for the Centre national de la recherche scientifique,[2] where she made many other discoveries in neuroscience.

JacSue Kehoe
Born(1935-10-23)October 23, 1935
Cleveland, Ohio, U.S.
DiedJune 25, 2019(2019-06-25) (aged 83)[1]
EducationNorthwestern University (BA, 1957)
Brown University (PhD, 1961)
Occupation(s)Instructor at Brown University, researcher at CRNS
AwardsForbes Lectureship, 1977

Early life edit

JacSue Kehoe was born on October 23, 1935, in Cleveland, Ohio.[2] Her mother was a former doctoral candidate turned English teacher. Her father was an employee of the Chrysler Corporation. The youngest of three, Kehoe and her family moved to Evansville, Indiana, for the duration of World War II for her father’s work.[2] After the war they migrated back to the city, where Kehoe discovered her interest in the performing arts. She became assistant to the dramatic arts teacher at her high school: this position inspired her to become a theater director.[2] She attended Northwestern University to pursue a degree in theater.[2]

After two years pursuing her theater degree,[2] she switched her major to experimental psychology. Human behavior was a major interest of the field. Kehoe performed experiments testing memory for her honor’s thesis. After two years she graduated Northwestern with a bachelor's degree in experimental psychology.[2]

Kehoe continued her education at Brown University.[2] She focused on the function of the nervous system and its relation to psychology, furthering her understanding of human memory.[2] She performed experiments concerning the proactive and retroactive inhibition of memory retention on pigeons,[4] earning her Ph.D. in 1961.

Career edit

Kehoe joined the psychology faculty of Brown University, before moving to Washington, D.C., to continue her research. As a postdoctoral fellow at the Walter Reed Army Institute of Research she furthered her study of discrimination learning in pigeons, rats and squirrels and became increasingly focused on the physiological basis of behavior.[2] In a nearby lab Felix Strumwasser was using neurons from Aplysia californica, a species of sea slug, to study circadian rhythms. These cells were ideal for studying the effects of neurotransmitters on neuron behavior: using discarded Aplysia ganglia and equipment provided by Strumwasser’s lab, Kehoe began her study of synaptic physiology.[2]

In 1964 Kehoe moved to Paris to continue her work on Aplysia[5][6] at the Institut Marey. She began experimenting to identify the neurotransmitter that brought about postsynaptic potentials (PSP).[2] Attempting to use curare, a Cholinergic antagonist, to this end, she observed instead a change in the cells' spontaneous synaptic activity.[2] This activity was unusual, so she refocused her research on this hyperpolarizing response for several years. After many tests using a setup of her own design Kehoe discovered that methyl-xylocholine, an Adrenergic neuron blocker, inhibited the K-dependent response she had found in the cells.[2] This was unusual, as the Aplysia response she was researching was cholinergic and was not expected to change with the addition of an adrenergic inhibitor. From this data Kehoe determined that both the adrenergic and cholinergic responses she observed involved the same receptor.[2] She determined that multiple receptors for a particular neurotransmitter could be found on a neuron,[3] each receptor could change the conductance of the neurotransmitter in a different and independent manner, and that the postsynaptic response could vary from cell to cell.[2]

Kehoe then took a position as a full-time researcher at the Centre national de la recherche scientifique (C.N.R.S.).[2][7] In 1968 she and Philippe traveled to Cambridge[8] on sabbatical, where they continued their research. Kehoe worked under Gabriel Horn in the anatomy department, who arranged for her to be admitted to High Table at King's College. At the time High Table was all male—Kehoe was the first visiting female academic to be granted access.[2]

In the same year her husband Philippe accepted a teaching position in Paris, so that they could operate their own lab. Upon their return from Cambridge they were given space for their lab at École Normale Supérieure.[2] Over the following summers Kehoe also acted as an instructor at a research program in the United States. At Cold Spring Harbor Laboratory, she taught summer courses to students with an interest in neuroscience research from 1971 to the mid-1980s.[2][5][9] Kehoe continued to travel the world, giving seminars and conferences on her discoveries, as well as performing her own experiments.[2][10] She continued her research to identify the neurotransmitters used in Aplysia, turning her attention towards glutamate[2][11] receptors in the late 20th century. In 2002 she and Philippe gave up their lab to other researchers, and moved their research to the lab of their colleagues, Alain Marty and Isabel Llano, in another part of Paris.[2] As of 2017 Kehoe continued researching neurotransmitters and their effects.

Personal life edit

In 1967 Kehoe married fellow researcher and French native Philippe Ascher. In the fall of 1968 she had her first son David. Her second son Ivan was born after she began working at Cold Spring. Until her death, she has spent most of her life in Paris with her husband and their two children.

Works edit

  • Kehoe, Jacsue (1963-06-01). "Effects of prior and interpolated learning on retention in pigeons". Journal of Experimental Psychology. 65 (6): 537–545. doi:10.1037/h0041864. PMID 14031682.
  • Kehoe, J. (1967-09-30). "Pharmacological characteristics and ionic bases of a 2 component postsynaptic inhibition". Nature. 215 (5109): 1503–1505. Bibcode:1967Natur.215.1503K. doi:10.1038/2151503b0. PMID 4293852. S2CID 4186621.
  • Kehoe, J. (1969-03-01). "Single presynaptic neurone mediates a two component postsynaptic inhibition". Nature. 221 (5183): 866–868. Bibcode:1969Natur.221..866K. doi:10.1038/221866a0. PMID 4387868. S2CID 4176193.
  • Kehoe, J. S.; Ascher, P. (1970-02-28). "Re-evaluation of the synaptic activation of an electrogenic sodium pump". Nature. 225 (5235): 820–823. Bibcode:1970Natur.225..820K. doi:10.1038/225820a0. PMID 5415112. S2CID 4256264.
  • Kehoe, J. (1972-08-01). "Three acetylcholine receptors in Aplysia neurones". The Journal of Physiology. 225 (1): 115–146. doi:10.1113/jphysiol.1972.sp009931. PMC 1331096. PMID 4679741.
  • Kehoe, J. (1978-08-31). "Transformation by concanavalin A of the response of molluscan neurones to L-glutamate". Nature. 274 (5674): 866–869. Bibcode:1978Natur.274..866K. doi:10.1038/274866a0. PMID 210395. S2CID 4294451.
  • Kehoe, J. (1990-10-01). "Cyclic AMP-induced slow inward current: its synaptic manifestation in Aplysia neurons". The Journal of Neuroscience. 10 (10): 3208–3218. doi:10.1523/JNEUROSCI.10-10-03208.1990. PMC 6570174. PMID 1698941.
  • Kehoe, J.; McIntosh, J. M. (1998-10-15). "Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons". The Journal of Neuroscience. 18 (20): 8198–8213. doi:10.1523/JNEUROSCI.18-20-08198.1998. PMC 6792842. PMID 9763466.
  • Kehoe, JacSue; Vulfius, Catherine (2000-12-01). "Independence of and Interactions between GABA-, Glutamate-, and Acetylcholine-Activated Cl Conductances in AplysiaNeurons". Journal of Neuroscience. 20 (23): 8585–8596. doi:10.1523/JNEUROSCI.20-23-08585.2000. PMC 6773048. PMID 11102462.
  • Tieman, T. L.; Steel, D. J.; Gor, Y.; Kehoe, J.; Schwartz, J. H.; Feinmark, S. J. (2001-05-01). "A pertussis toxin-sensitive 8-lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons". Journal of Neurophysiology. 85 (5): 2150–2158. doi:10.1152/jn.2001.85.5.2150. PMID 11353029.
  • Kehoe, JacSue; Buldakova, Svetlana; Acher, Francine; Dent, Joseph; Bregestovski, Piotr; Bradley, Jonathan (2009-06-25). "Aplysia cys-loop Glutamate-Gated Chloride Channels Reveal Convergent Evolution of Ligand Specificity". Journal of Molecular Evolution. 69 (2): 125–141. Bibcode:2009JMolE..69..125K. doi:10.1007/s00239-009-9256-z. PMID 19554247. S2CID 31988613.
  • Blarre, Thomas; Bertrand, Hugues-Olivier; Acher, Francine C.; Kehoe, JacSue (2014-09-26). "Molecular Determinants of Agonist Selectivity in Glutamate-Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABAA-ρ Receptors". PLOS ONE. 9 (9): e108458. Bibcode:2014PLoSO...9j8458B. doi:10.1371/journal.pone.0108458. PMC 4178172. PMID 25259865.

References edit

  1. ^ "JacSue Kehoe (in memoriam)". www.sppin.fr. Retrieved 2020-01-07.
  2. ^ a b c d e f g h i j k l m n o p q r s t u v w x Kehoe, JacSue (2004). The History of Neuroscience in Autobiography, Volume 4: JacSue Kehoe. San Diego, California: Elsevier. pp. 320–345. ISBN 978-0-12-660246-3.
  3. ^ a b Kehoe 1972.
  4. ^ Kehoe 1963.
  5. ^ a b Kandel, Eric R. (2008-05-20). Psychiatry, Psychoanalysis, and the New Biology of Mind. American Psychiatric Pub. ISBN 9781585626847.
  6. ^ DPhil, Gordon M. Shepherd MD (2009-10-28). Creating Modern Neuroscience: The Revolutionary 1950s. Oxford University Press. ISBN 9780199741472.
  7. ^ "JacSue Kehoe". wormbase.org. National Human Genome Research Institute.
  8. ^ Horn, Gabriel; Hinde, Robert A. (1970-11-01). Short-Term Changes in Neural Activity and Behaviour: A Conference Sponsored by King's College Research Centre Cambridge. CUP Archive. ISBN 9780521079426.
  9. ^ "Jones Building before and after Renovation - The Memory Board at Cold Spring Harbor Laboratory". libfe.cshl.edu. Retrieved 2016-11-29.
  10. ^ Marder, Eve (2008). "The roads not taken". Current Biology. 18 (17): R725–R726. doi:10.1016/j.cub.2008.07.044. PMID 18786366.
  11. ^ Kehoe & Vulfius 2000.

January 01, 1970
jacsue, kehoe, october, 1935, june, 2019, american, neuroscientist, neuroscience, researcher, spent, decades, working, with, neurons, aplysia, californica, studying, post, synaptic, nerve, response, discovered, that, neurotransmitter, have, multiple, types, re. JacSue Kehoe October 23 1935 June 25 2019 was an American neuroscientist and neuroscience researcher She spent decades working with the neurons of Aplysia californica studying post synaptic nerve response 2 She discovered that one neurotransmitter can have multiple types of receptors which could vary in level and type of response 3 Kehoe worked for the Centre national de la recherche scientifique 2 where she made many other discoveries in neuroscience JacSue KehoeBorn 1935 10 23 October 23 1935Cleveland Ohio U S DiedJune 25 2019 2019 06 25 aged 83 1 EducationNorthwestern University BA 1957 Brown University PhD 1961 Occupation s Instructor at Brown University researcher at CRNSAwardsForbes Lectureship 1977 Contents 1 Early life 2 Career 3 Personal life 4 Works 5 ReferencesEarly life editJacSue Kehoe was born on October 23 1935 in Cleveland Ohio 2 Her mother was a former doctoral candidate turned English teacher Her father was an employee of the Chrysler Corporation The youngest of three Kehoe and her family moved to Evansville Indiana for the duration of World War II for her father s work 2 After the war they migrated back to the city where Kehoe discovered her interest in the performing arts She became assistant to the dramatic arts teacher at her high school this position inspired her to become a theater director 2 She attended Northwestern University to pursue a degree in theater 2 After two years pursuing her theater degree 2 she switched her major to experimental psychology Human behavior was a major interest of the field Kehoe performed experiments testing memory for her honor s thesis After two years she graduated Northwestern with a bachelor s degree in experimental psychology 2 Kehoe continued her education at Brown University 2 She focused on the function of the nervous system and its relation to psychology furthering her understanding of human memory 2 She performed experiments concerning the proactive and retroactive inhibition of memory retention on pigeons 4 earning her Ph D in 1961 Career editKehoe joined the psychology faculty of Brown University before moving to Washington D C to continue her research As a postdoctoral fellow at the Walter Reed Army Institute of Research she furthered her study of discrimination learning in pigeons rats and squirrels and became increasingly focused on the physiological basis of behavior 2 In a nearby lab Felix Strumwasser was using neurons from Aplysia californica a species of sea slug to study circadian rhythms These cells were ideal for studying the effects of neurotransmitters on neuron behavior using discarded Aplysia ganglia and equipment provided by Strumwasser s lab Kehoe began her study of synaptic physiology 2 In 1964 Kehoe moved to Paris to continue her work on Aplysia 5 6 at the Institut Marey She began experimenting to identify the neurotransmitter that brought about postsynaptic potentials PSP 2 Attempting to use curare a Cholinergic antagonist to this end she observed instead a change in the cells spontaneous synaptic activity 2 This activity was unusual so she refocused her research on this hyperpolarizing response for several years After many tests using a setup of her own design Kehoe discovered that methyl xylocholine an Adrenergic neuron blocker inhibited the K dependent response she had found in the cells 2 This was unusual as the Aplysia response she was researching was cholinergic and was not expected to change with the addition of an adrenergic inhibitor From this data Kehoe determined that both the adrenergic and cholinergic responses she observed involved the same receptor 2 She determined that multiple receptors for a particular neurotransmitter could be found on a neuron 3 each receptor could change the conductance of the neurotransmitter in a different and independent manner and that the postsynaptic response could vary from cell to cell 2 Kehoe then took a position as a full time researcher at the Centre national de la recherche scientifique C N R S 2 7 In 1968 she and Philippe traveled to Cambridge 8 on sabbatical where they continued their research Kehoe worked under Gabriel Horn in the anatomy department who arranged for her to be admitted to High Table at King s College At the time High Table was all male Kehoe was the first visiting female academic to be granted access 2 In the same year her husband Philippe accepted a teaching position in Paris so that they could operate their own lab Upon their return from Cambridge they were given space for their lab at Ecole Normale Superieure 2 Over the following summers Kehoe also acted as an instructor at a research program in the United States At Cold Spring Harbor Laboratory she taught summer courses to students with an interest in neuroscience research from 1971 to the mid 1980s 2 5 9 Kehoe continued to travel the world giving seminars and conferences on her discoveries as well as performing her own experiments 2 10 She continued her research to identify the neurotransmitters used in Aplysia turning her attention towards glutamate 2 11 receptors in the late 20th century In 2002 she and Philippe gave up their lab to other researchers and moved their research to the lab of their colleagues Alain Marty and Isabel Llano in another part of Paris 2 As of 2017 Kehoe continued researching neurotransmitters and their effects Personal life editIn 1967 Kehoe married fellow researcher and French native Philippe Ascher In the fall of 1968 she had her first son David Her second son Ivan was born after she began working at Cold Spring Until her death she has spent most of her life in Paris with her husband and their two children Works editKehoe Jacsue 1963 06 01 Effects of prior and interpolated learning on retention in pigeons Journal of Experimental Psychology 65 6 537 545 doi 10 1037 h0041864 PMID 14031682 Kehoe J 1967 09 30 Pharmacological characteristics and ionic bases of a 2 component postsynaptic inhibition Nature 215 5109 1503 1505 Bibcode 1967Natur 215 1503K doi 10 1038 2151503b0 PMID 4293852 S2CID 4186621 Kehoe J 1969 03 01 Single presynaptic neurone mediates a two component postsynaptic inhibition Nature 221 5183 866 868 Bibcode 1969Natur 221 866K doi 10 1038 221866a0 PMID 4387868 S2CID 4176193 Kehoe J S Ascher P 1970 02 28 Re evaluation of the synaptic activation of an electrogenic sodium pump Nature 225 5235 820 823 Bibcode 1970Natur 225 820K doi 10 1038 225820a0 PMID 5415112 S2CID 4256264 Kehoe J 1972 08 01 Three acetylcholine receptors in Aplysia neurones The Journal of Physiology 225 1 115 146 doi 10 1113 jphysiol 1972 sp009931 PMC 1331096 PMID 4679741 Kehoe J 1978 08 31 Transformation by concanavalin A of the response of molluscan neurones to L glutamate Nature 274 5674 866 869 Bibcode 1978Natur 274 866K doi 10 1038 274866a0 PMID 210395 S2CID 4294451 Kehoe J 1990 10 01 Cyclic AMP induced slow inward current its synaptic manifestation in Aplysia neurons The Journal of Neuroscience 10 10 3208 3218 doi 10 1523 JNEUROSCI 10 10 03208 1990 PMC 6570174 PMID 1698941 Kehoe J McIntosh J M 1998 10 15 Two distinct nicotinic receptors one pharmacologically similar to the vertebrate alpha7 containing receptor mediate Cl currents in aplysia neurons The Journal of Neuroscience 18 20 8198 8213 doi 10 1523 JNEUROSCI 18 20 08198 1998 PMC 6792842 PMID 9763466 Kehoe JacSue Vulfius Catherine 2000 12 01 Independence of and Interactions between GABA Glutamate and Acetylcholine Activated Cl Conductances in AplysiaNeurons Journal of Neuroscience 20 23 8585 8596 doi 10 1523 JNEUROSCI 20 23 08585 2000 PMC 6773048 PMID 11102462 Tieman T L Steel D J Gor Y Kehoe J Schwartz J H Feinmark S J 2001 05 01 A pertussis toxin sensitive 8 lipoxygenase pathway is activated by a nicotinic acetylcholine receptor in aplysia neurons Journal of Neurophysiology 85 5 2150 2158 doi 10 1152 jn 2001 85 5 2150 PMID 11353029 Kehoe JacSue Buldakova Svetlana Acher Francine Dent Joseph Bregestovski Piotr Bradley Jonathan 2009 06 25 Aplysia cys loop Glutamate Gated Chloride Channels Reveal Convergent Evolution of Ligand Specificity Journal of Molecular Evolution 69 2 125 141 Bibcode 2009JMolE 69 125K doi 10 1007 s00239 009 9256 z PMID 19554247 S2CID 31988613 Blarre Thomas Bertrand Hugues Olivier Acher Francine C Kehoe JacSue 2014 09 26 Molecular Determinants of Agonist Selectivity in Glutamate Gated Chloride Channels Which Likely Explain the Agonist Selectivity of the Vertebrate Glycine and GABAA r Receptors PLOS ONE 9 9 e108458 Bibcode 2014PLoSO 9j8458B doi 10 1371 journal pone 0108458 PMC 4178172 PMID 25259865 References edit JacSue Kehoe in memoriam www sppin fr Retrieved 2020 01 07 a b c d e f g h i j k l m n o p q r s t u v w x Kehoe JacSue 2004 The History of Neuroscience in Autobiography Volume 4 JacSue Kehoe San Diego California Elsevier pp 320 345 ISBN 978 0 12 660246 3 a b Kehoe 1972 Kehoe 1963 a b Kandel Eric R 2008 05 20 Psychiatry Psychoanalysis and the New Biology of Mind American Psychiatric Pub ISBN 9781585626847 DPhil Gordon M Shepherd MD 2009 10 28 Creating Modern Neuroscience The Revolutionary 1950s Oxford University Press ISBN 9780199741472 JacSue Kehoe wormbase org National Human Genome Research Institute Horn Gabriel Hinde Robert A 1970 11 01 Short Term Changes in Neural Activity and Behaviour A Conference Sponsored by King s College Research Centre Cambridge CUP Archive ISBN 9780521079426 Jones Building before and after Renovation The Memory Board at Cold Spring Harbor Laboratory libfe cshl edu Retrieved 2016 11 29 Marder Eve 2008 The roads not taken Current Biology 18 17 R725 R726 doi 10 1016 j cub 2008 07 044 PMID 18786366 Kehoe amp Vulfius 2000 Retrieved from https en wikipedia org w index php title JacSue Kehoe amp oldid 1181670809, wikipedia, wiki, book, books, library,

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