fbpx
Wikipedia

Iohexol

April 11, 2024

Iohexol, sold under the trade name Omnipaque among others, is a contrast agent used for X-ray imaging.[4] This includes when visualizing arteries, veins, ventricles of the brain, the urinary system, and joints, as well as during computed tomography (CT scan).[4] It is given by mouth, injection into a vein, or into a body cavity.[5]

Iohexol
Clinical data
Trade namesOmnipaque, Hexopaque, Oraltag, others
Other names5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N'-bis(2,3-dihydroxypropyl)isophthalamide
AHFS/Drugs.comMicromedex Detailed Consumer Information
License data
Routes of
administration		Intrathecal, intravascular, by mouth, intracavital, rectal
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein bindingLow
MetabolismNil
Elimination half-lifeVariable
ExcretionKidney, unchanged
Identifiers
  • 1-N,3-N-Bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide
CAS Number
  • 66108-95-0 Y
PubChem CID
  • 3730
DrugBank
  • DB01362 Y
ChemSpider
  • 3599 Y
UNII
  • 4419T9MX03
KEGG
  • D01817 Y
ChEBI
  • CHEBI:31709 Y
ChEMBL
  • ChEMBL1200455 N
CompTox Dashboard (EPA)
  • DTXSID6023157
ECHA InfoCard100.060.130
Chemical and physical data
FormulaC19H26I3N3O9
Molar mass821.142 g·mol−1
3D model (JSmol)
  • Interactive image
Melting point174 to 180 °C (345 to 356 °F)
  • O=C(N(c1c(I)c(c(I)c(c1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)CC(O)CO)C
  • InChI=1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34) Y
  • Key:NTHXOOBQLCIOLC-UHFFFAOYSA-N Y
 NY (what is this?)  (verify)

Side effects include vomiting, skin flushing, headache, itchiness, kidney problems, and low blood pressure.[4] Less commonly allergic reactions or seizures may occur.[4] Allergies to povidone-iodine or shellfish do not affect the risk of side effects more than other allergies.[6] Use in the later part of pregnancy may cause hypothyroidism in the baby.[7] Iohexol is an iodinated non-ionic radiocontrast agent.[4] It is in the low osmolar family.[8]

Iohexol was approved for medical use in 1985.[9] It is on the World Health Organization's List of Essential Medicines.[10][5]

Chemistry edit

The osmolality of iohexol ranges from 322 mOsm/kg—approximately 1.1 times that of blood plasma—to 844 mOsm/kg, almost three times that of blood.[11] Despite this difference, iohexol is still considered a low-osmolality contrast agent; the osmolality of older agents, such as diatrizoate, may be more than twice as high.[12]

Adverse effects edit

The most common side effects after intravenous injections are: pain at the site of injection (3%), blurring of vision (2%), nausea (2%), arrhythmia (2%), taste perversion (1%), hypotension (0.7%), and vomiting (0.7%).[13]

Society and culture edit

Naming edit

It is sold under the brand names Omnipaque.[14] It is also sold as a density gradient medium under the names Accudenz, Histodenz, and Nycodenz.[15][16]

Available forms edit

It is available in various concentrations, from 140[13] to 350[17] milligrams of iodine per milliliter.[13] Iohexol can given as intrathecal, intravascular, oral, rectal, intraarticular, or into the body cavity.[13]

References edit

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.
  2. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  3. ^ "Regulatory Decision Summary for Omnipaque". Drug and Health Products Portal. 29 December 2023. Retrieved 2 April 2024.
  4. ^ a b c d e World Health Organization (2009). Stuart MC, Kouimtzi M, Hill SR (eds.). WHO Model Formulary 2008. World Health Organization. pp. 317–8. hdl:10665/44053. ISBN 9789241547659.
  5. ^ a b Hamilton R (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 171. ISBN 9781284057560.
  6. ^ ACR Manual on Contrast Media v10.3. 2017 (PDF). American College of Radiology. 2017. p. 6. ISBN 9781559030120. (PDF) from the original on 1 January 2018. Retrieved 1 January 2018.
  7. ^ Briggs GG, Freeman RK, Yaffe SJ (2011). Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Lippincott Williams & Wilkins. p. 761. ISBN 9781608317080. from the original on 1 January 2017.
  8. ^ Sutton D, Young JW (2012). A Short Textbook of Clinical Imaging. Springer Science & Business Media. p. 235. ISBN 9781447117551. from the original on 1 January 2017.
  9. ^ Broe ME, Porter GA, Bennett WM, Verpooten GA (2013). Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals. Springer Science & Business Media. p. 325. ISBN 9789401590884. from the original on 1 January 2017.
  10. ^ World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  11. ^ GE Healthcare (May 2006). "Omnipaque (Iohexol) injection. Product label". DailyMed. U.S. National Library of Medicine. Retrieved 28 March 2007.
  12. ^ Amersham Health (April 2006). "Hypaque (Diatrizoate Meglumine and Diatrizoate Sodium) injection, solution. Product label". DailyMed. U.S. National Library of Medicine. from the original on 23 May 2011. Retrieved 29 March 2007.
  13. ^ a b c d (PDF). US Food and Drug Administration. Archived from the original (PDF) on 11 July 2022. Retrieved 13 December 2022.
  14. ^ "Omnipaque" (PDF). Ireland: Health Products Regulatory Authority. January 2018. Retrieved 31 July 2020.
  15. ^ (PDF). Product information sheet. Sigma-Aldrich. D2158. Archived from the original (PDF) on 20 November 2015. Retrieved 19 November 2015.
  16. ^ (PDF). Axis-Shield Density Gradient Media. Archived from the original (PDF) on 26 February 2015. Retrieved 19 November 2015.
  17. ^ Haberfeld H, ed. (2020). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Omnipaque 350 mg J/ml Infusionsflasche.

April 11, 2024
iohexol, sold, under, trade, name, omnipaque, among, others, contrast, agent, used, imaging, this, includes, when, visualizing, arteries, veins, ventricles, brain, urinary, system, joints, well, during, computed, tomography, scan, given, mouth, injection, into. Iohexol sold under the trade name Omnipaque among others is a contrast agent used for X ray imaging 4 This includes when visualizing arteries veins ventricles of the brain the urinary system and joints as well as during computed tomography CT scan 4 It is given by mouth injection into a vein or into a body cavity 5 IohexolClinical dataTrade namesOmnipaque Hexopaque Oraltag othersOther names5 N 2 3 Dihydroxypropyl acetamido 2 4 6 triiodo N N bis 2 3 dihydroxypropyl isophthalamideAHFS Drugs comMicromedex Detailed Consumer InformationLicense dataUS DailyMed IohexolRoutes ofadministrationIntrathecal intravascular by mouth intracavital rectalATC codeV08AB02 WHO Legal statusLegal statusCA only 2 3 US WARNING 1 Rx only In general Prescription only Pharmacokinetic dataProtein bindingLowMetabolismNilElimination half lifeVariableExcretionKidney unchangedIdentifiersIUPAC name 1 N 3 N Bis 2 3 dihydroxypropyl 5 N 2 3 dihydroxypropyl acetamido 2 4 6 triiodobenzene 1 3 dicarboxamideCAS Number66108 95 0 YPubChem CID3730DrugBankDB01362 YChemSpider3599 YUNII4419T9MX03KEGGD01817 YChEBICHEBI 31709 YChEMBLChEMBL1200455 NCompTox Dashboard EPA DTXSID6023157ECHA InfoCard100 060 130Chemical and physical dataFormulaC 19H 26I 3N 3O 9Molar mass821 142 g mol 13D model JSmol Interactive imageMelting point174 to 180 C 345 to 356 F SMILES O C N c1c I c c I c c1I C O NCC O CO C O NCC O CO CC O CO CInChI InChI 1S C19H26I3N3O9 c1 8 29 25 4 11 32 7 28 17 15 21 12 18 33 23 2 9 30 5 26 14 20 13 16 17 22 19 34 24 3 10 31 6 27 h9 11 26 28 30 32H 2 7H2 1H3 H 23 33 H 24 34 YKey NTHXOOBQLCIOLC UHFFFAOYSA N Y N Y what is this verify Side effects include vomiting skin flushing headache itchiness kidney problems and low blood pressure 4 Less commonly allergic reactions or seizures may occur 4 Allergies to povidone iodine or shellfish do not affect the risk of side effects more than other allergies 6 Use in the later part of pregnancy may cause hypothyroidism in the baby 7 Iohexol is an iodinated non ionic radiocontrast agent 4 It is in the low osmolar family 8 Iohexol was approved for medical use in 1985 9 It is on the World Health Organization s List of Essential Medicines 10 5 Contents 1 Chemistry 2 Adverse effects 3 Society and culture 3 1 Naming 3 2 Available forms 4 ReferencesChemistry editThe osmolality of iohexol ranges from 322 mOsm kg approximately 1 1 times that of blood plasma to 844 mOsm kg almost three times that of blood 11 Despite this difference iohexol is still considered a low osmolality contrast agent the osmolality of older agents such as diatrizoate may be more than twice as high 12 Adverse effects editThe most common side effects after intravenous injections are pain at the site of injection 3 blurring of vision 2 nausea 2 arrhythmia 2 taste perversion 1 hypotension 0 7 and vomiting 0 7 13 Society and culture editNaming edit It is sold under the brand names Omnipaque 14 It is also sold as a density gradient medium under the names Accudenz Histodenz and Nycodenz 15 16 Available forms edit It is available in various concentrations from 140 13 to 350 17 milligrams of iodine per milliliter 13 Iohexol can given as intrathecal intravascular oral rectal intraarticular or into the body cavity 13 References edit FDA sourced list of all drugs with black box warnings Use Download Full Results and View Query links nctr crs fda gov FDA Retrieved 22 October 2023 Product monograph brand safety updates Health Canada February 2024 Retrieved 24 March 2024 Regulatory Decision Summary for Omnipaque Drug and Health Products Portal 29 December 2023 Retrieved 2 April 2024 a b c d e World Health Organization 2009 Stuart MC Kouimtzi M Hill SR eds WHO Model Formulary 2008 World Health Organization pp 317 8 hdl 10665 44053 ISBN 9789241547659 a b Hamilton R 2015 Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab Coat Edition Jones amp Bartlett Learning p 171 ISBN 9781284057560 ACR Manual on Contrast Media v10 3 2017 PDF American College of Radiology 2017 p 6 ISBN 9781559030120 Archived PDF from the original on 1 January 2018 Retrieved 1 January 2018 Briggs GG Freeman RK Yaffe SJ 2011 Drugs in Pregnancy and Lactation A Reference Guide to Fetal and Neonatal Risk Lippincott Williams amp Wilkins p 761 ISBN 9781608317080 Archived from the original on 1 January 2017 Sutton D Young JW 2012 A Short Textbook of Clinical Imaging Springer Science amp Business Media p 235 ISBN 9781447117551 Archived from the original on 1 January 2017 Broe ME Porter GA Bennett WM Verpooten GA 2013 Clinical Nephrotoxins Renal Injury from Drugs and Chemicals Springer Science amp Business Media p 325 ISBN 9789401590884 Archived from the original on 1 January 2017 World Health Organization 2019 World Health Organization model list of essential medicines 21st list 2019 Geneva World Health Organization hdl 10665 325771 WHO MVP EMP IAU 2019 06 License CC BY NC SA 3 0 IGO GE Healthcare May 2006 Omnipaque Iohexol injection Product label DailyMed U S National Library of Medicine Retrieved 28 March 2007 Amersham Health April 2006 Hypaque Diatrizoate Meglumine and Diatrizoate Sodium injection solution Product label DailyMed U S National Library of Medicine Archived from the original on 23 May 2011 Retrieved 29 March 2007 a b c d Highlights of prescribing information for Omnipaque PDF US Food and Drug Administration Archived from the original PDF on 11 July 2022 Retrieved 13 December 2022 Omnipaque PDF Ireland Health Products Regulatory Authority January 2018 Retrieved 31 July 2020 HistoDenz PDF Product information sheet Sigma Aldrich D2158 Archived from the original PDF on 20 November 2015 Retrieved 19 November 2015 Nycodenz A universal density gradient medium PDF Axis Shield Density Gradient Media Archived from the original PDF on 26 February 2015 Retrieved 19 November 2015 Haberfeld H ed 2020 Austria Codex in German Vienna Osterreichischer Apothekerverlag Omnipaque 350 mg J ml Infusionsflasche Portal nbsp Medicine Retrieved from https en wikipedia org w index php title Iohexol amp oldid 1216827088, wikipedia, wiki, book, books, library,

article

, read, download, free, free download, mp3, video, mp4, 3gp, jpg, jpeg, gif, png, picture, music, song, movie, book, game, games.