The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[5]
^Sliva, D; Gu M; Zhu Y X; Chen J; Tsai S; Du X; Yang Y C (February 2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. 345 (3): 741–7. doi:10.1042/0264-6021:3450741. ISSN 0264-6021. PMC1220812. PMID 10642536.
Further readingedit
Knoops L, Renauld JC (2005). "IL-9 and its receptor: from signal transduction to tumorigenesis". Growth Factors. 22 (4): 207–15. doi:10.1080/08977190410001720879. PMID 15621723. S2CID 40523692.
Renauld JC, Druez C, Kermouni A, et al. (1992). "Expression cloning of the murine and human interleukin 9 receptor cDNAs". Proc. Natl. Acad. Sci. U.S.A. 89 (12): 5690–4. Bibcode:1992PNAS...89.5690R. doi:10.1073/pnas.89.12.5690. PMC49358. PMID 1376929.
Kimura Y, Takeshita T, Kondo M, et al. (1995). "Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex". Int. Immunol. 7 (1): 115–20. doi:10.1093/intimm/7.1.115. PMID 7718508.
Chang MS, Engel G, Benedict C, et al. (1994). "Isolation and characterization of the human interleukin-9 receptor gene". Blood. 83 (11): 3199–205. doi:10.1182/blood.V83.11.3199.3199. PMID 8193355.
Kermouni A, Van Roost E, Arden KC, et al. (1996). "The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter". Genomics. 29 (2): 371–82. doi:10.1006/geno.1995.9992. PMID 8666384.
Demoulin JB, Uyttenhove C, Van Roost E, et al. (1996). "A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9". Mol. Cell. Biol. 16 (9): 4710–6. doi:10.1128/MCB.16.9.4710. PMC231471. PMID 8756628.
Vermeesch JR, Petit P, Kermouni A, et al. (1997). "The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y". Hum. Mol. Genet. 6 (1): 1–8. doi:10.1093/hmg/6.1.1. PMID 9002663.
Bauer JH, Liu KD, You Y, et al. (1998). "Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis". J. Biol. Chem. 273 (15): 9255–60. doi:10.1074/jbc.273.15.9255. PMID 9535918.
Levitt RC, McLane MP, MacDonald D, et al. (1999). "IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders". J. Allergy Clin. Immunol. 103 (5 Pt 2): S485–91. doi:10.1016/S0091-6749(99)70165-X. PMID 10329852.
Sliva D, Zhu YX, Tsai S, et al. (1999). "Tip60 interacts with human interleukin-9 receptor alpha-chain". Biochem. Biophys. Res. Commun. 263 (1): 149–55. doi:10.1006/bbrc.1999.1083. PMID 10486269.
Sliva D, Gu M, Zhu YX, et al. (2000). "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor". Biochem. J. 345 (3): 741–7. doi:10.1042/0264-6021:3450741. PMC1220812. PMID 10642536.
Ciccodicola A, D'Esposito M, Esposito T, et al. (2000). "Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region". Hum. Mol. Genet. 9 (3): 395–401. doi:10.1093/hmg/9.3.395. PMID 10655549.
De Smedt M, Verhasselt B, Kerre T, et al. (2000). "Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development". J. Immunol. 164 (4): 1761–7. doi:10.4049/jimmunol.164.4.1761. PMID 10657622.
Kauppi P, Laitinen T, Ollikainen V, et al. (2001). "The IL9R region contribution in asthma is supported by genetic association in an isolated population". Eur. J. Hum. Genet. 8 (10): 788–92. doi:10.1038/sj.ejhg.5200541. PMID 11039580.
Abdelilah S, Latifa K, Esra N, et al. (2001). "Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release". J. Immunol. 166 (4): 2768–74. doi:10.4049/jimmunol.166.4.2768. PMID 11160343.
Asao H, Okuyama C, Kumaki S, et al. (2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623.
Little FF, Cruikshank WW, Center DM (2001). "Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells". Am. J. Respir. Cell Mol. Biol. 25 (3): 347–52. doi:10.1165/ajrcmb.25.3.4349. PMID 11588013.
Tsukadaira A, Okubo Y, Koyama S, et al. (2002). "Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor". Exp. Lung Res. 28 (2): 123–39. doi:10.1080/019021402753462040. PMID 11868823. S2CID 26893804.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Melén E, Gullstén H, Zucchelli M, et al. (2005). "Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation". J. Med. Genet. 41 (12): e123. doi:10.1136/jmg.2004.023135. PMC1735647. PMID 15591265.
interleukin, receptor, interleukin, receptor, il9r, also, known, cd129, cluster, differentiation, type, cytokine, receptor, il9r, also, denotes, human, gene, il9ridentifiersaliasesil9r, cd129, interleukin, receptorexternal, idsomim, 300007, 96564, homologene, . Interleukin 9 receptor IL9R also known as CD129 Cluster of Differentiation 129 is a type I cytokine receptor IL9R also denotes its human gene 5 IL9RIdentifiersAliasesIL9R CD129 IL 9R interleukin 9 receptorExternal IDsOMIM 300007 MGI 96564 HomoloGene 37591 GeneCards IL9RGene location Human Chr X chromosome human 1 BandXq28 and Yq12Start155 997 696 bp 1 End156 010 817 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 A4Start32 137 541 bp 2 End32 150 279 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inlymph nodeappendixspleenright uterine tuberectumurinary bladderbloodgallbladderthymusupper lobe of left lungTop expressed inspermatocytethymusspermatidspleenembryolipadrenal glandmuscleheartmuscle tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytokine receptor activity interleukin 9 receptor activity protein bindingCellular componentintegral component of membrane integral component of plasma membrane membrane extracellular region extracellular space plasma membraneBiological processcell population proliferation signal transduction interleukin 9 mediated signaling pathway regulation of cell population proliferationSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez358116199EnsemblENSG00000124334ENSMUSG00000020279UniProtQ01113Q01114RefSeq mRNA NM 002186NM 176786NM 001134458NM 008374RefSeq protein NP 002177NP 789743NP 001127930NP 032400Location UCSC Chr X 156 156 01 MbChr 11 32 14 32 15 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 IL9 The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor gamma IL2RG a common gamma subunit shared by the receptors of many different cytokines The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins which connect to different biologic responses This gene is located at the pseudoautosomal regions of X and Y chromosomes Genetic studies suggested an association of this gene with the development of asthma Multiple pseudogenes on chromosome 9 10 16 and 18 have been described Alternatively spliced transcript variants encoding distinct isoforms have been reported 5 Contents 1 Interactions 2 See also 3 References 4 Further reading 5 External linksInteractions editInterleukin 9 receptor has been shown to interact with YWHAZ 6 See also editCluster of differentiationReferences edit a b c GRCh38 Ensembl release 89 ENSG00000124334 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020279 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b Entrez Gene IL9R interleukin 9 receptor Sliva D Gu M Zhu Y X Chen J Tsai S Du X Yang Y C February 2000 14 3 3zeta interacts with the alpha chain of human interleukin 9 receptor Biochem J 345 3 741 7 doi 10 1042 0264 6021 3450741 ISSN 0264 6021 PMC 1220812 PMID 10642536 Further reading editKnoops L Renauld JC 2005 IL 9 and its receptor from signal transduction to tumorigenesis Growth Factors 22 4 207 15 doi 10 1080 08977190410001720879 PMID 15621723 S2CID 40523692 Renauld JC Druez C Kermouni A et al 1992 Expression cloning of the murine and human interleukin 9 receptor cDNAs Proc Natl Acad Sci U S A 89 12 5690 4 Bibcode 1992PNAS 89 5690R doi 10 1073 pnas 89 12 5690 PMC 49358 PMID 1376929 Kimura Y Takeshita T Kondo M et al 1995 Sharing of the IL 2 receptor gamma chain with the functional IL 9 receptor complex Int Immunol 7 1 115 20 doi 10 1093 intimm 7 1 115 PMID 7718508 Chang MS Engel G Benedict C et al 1994 Isolation and characterization of the human interleukin 9 receptor gene Blood 83 11 3199 205 doi 10 1182 blood V83 11 3199 3199 PMID 8193355 Kermouni A Van Roost E Arden KC et al 1996 The IL 9 receptor gene IL9R genomic structure chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes and identification of IL9R pseudogenes at 9qter 10pter 16pter and 18pter Genomics 29 2 371 82 doi 10 1006 geno 1995 9992 PMID 8666384 Demoulin JB Uyttenhove C Van Roost E et al 1996 A single tyrosine of the interleukin 9 IL 9 receptor is required for STAT activation antiapoptotic activity and growth regulation by IL 9 Mol Cell Biol 16 9 4710 6 doi 10 1128 MCB 16 9 4710 PMC 231471 PMID 8756628 Vermeesch JR Petit P Kermouni A et al 1997 The IL 9 receptor gene located in the Xq Yq pseudoautosomal region has an autosomal origin escapes X inactivation and is expressed from the Y Hum Mol Genet 6 1 1 8 doi 10 1093 hmg 6 1 1 PMID 9002663 Bauer JH Liu KD You Y et al 1998 Heteromerization of the gammac chain with the interleukin 9 receptor alpha subunit leads to STAT activation and prevention of apoptosis J Biol Chem 273 15 9255 60 doi 10 1074 jbc 273 15 9255 PMID 9535918 Levitt RC McLane MP MacDonald D et al 1999 IL 9 pathway in asthma new therapeutic targets for allergic inflammatory disorders J Allergy Clin Immunol 103 5 Pt 2 S485 91 doi 10 1016 S0091 6749 99 70165 X PMID 10329852 Sliva D Zhu YX Tsai S et al 1999 Tip60 interacts with human interleukin 9 receptor alpha chain Biochem Biophys Res Commun 263 1 149 55 doi 10 1006 bbrc 1999 1083 PMID 10486269 Sliva D Gu M Zhu YX et al 2000 14 3 3zeta interacts with the alpha chain of human interleukin 9 receptor Biochem J 345 3 741 7 doi 10 1042 0264 6021 3450741 PMC 1220812 PMID 10642536 Ciccodicola A D Esposito M Esposito T et al 2000 Differentially regulated and evolved genes in the fully sequenced Xq Yq pseudoautosomal region Hum Mol Genet 9 3 395 401 doi 10 1093 hmg 9 3 395 PMID 10655549 De Smedt M Verhasselt B Kerre T et al 2000 Signals from the IL 9 receptor are critical for the early stages of human intrathymic T cell development J Immunol 164 4 1761 7 doi 10 4049 jimmunol 164 4 1761 PMID 10657622 Kauppi P Laitinen T Ollikainen V et al 2001 The IL9R region contribution in asthma is supported by genetic association in an isolated population Eur J Hum Genet 8 10 788 92 doi 10 1038 sj ejhg 5200541 PMID 11039580 Abdelilah S Latifa K Esra N et al 2001 Functional expression of IL 9 receptor by human neutrophils from asthmatic donors role in IL 8 release J Immunol 166 4 2768 74 doi 10 4049 jimmunol 166 4 2768 PMID 11160343 Asao H Okuyama C Kumaki S et al 2001 Cutting edge the common gamma chain is an indispensable subunit of the IL 21 receptor complex J Immunol 167 1 1 5 doi 10 4049 jimmunol 167 1 1 PMID 11418623 Little FF Cruikshank WW Center DM 2001 Il 9 stimulates release of chemotactic factors from human bronchial epithelial cells Am J Respir Cell Mol Biol 25 3 347 52 doi 10 1165 ajrcmb 25 3 4349 PMID 11588013 Tsukadaira A Okubo Y Koyama S et al 2002 Human bronchial epithelium expresses interleukin 9 receptors and releases neutrophil chemotactic factor Exp Lung Res 28 2 123 39 doi 10 1080 019021402753462040 PMID 11868823 S2CID 26893804 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Melen E Gullsten H Zucchelli M et al 2005 Sex specific protective effects of interleukin 9 receptor haplotypes on childhood wheezing and sensitisation J Med Genet 41 12 e123 doi 10 1136 jmg 2004 023135 PMC 1735647 PMID 15591265 External links editIL9R protein human at the U S National Library of Medicine Medical Subject Headings MeSH This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This membrane protein related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Interleukin 9 receptor amp oldid 1079538457, wikipedia, wiki, book, books, library,
