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Arcuate nucleus

April 07, 2024

This article is about the hypothalamic structure. For the structure in the medulla oblongata, see Arcuate nucleus (medulla).

The arcuate nucleus of the hypothalamus (also known as ARH,[1] ARC,[2] or infundibular nucleus[2][3]) is an aggregation of neurons in the mediobasal hypothalamus, adjacent to the third ventricle and the median eminence. The arcuate nucleus includes several important and diverse populations of neurons that help mediate different neuroendocrine and physiological functions, including neuroendocrine neurons, centrally projecting neurons, and astrocytes. The populations of neurons found in the arcuate nucleus are based on the hormones they secrete or interact with and are responsible for hypothalamic function, such as regulating hormones released from the pituitary gland or secreting their own hormones. Neurons in this region are also responsible for integrating information and providing inputs to other nuclei in the hypothalamus or inputs to areas outside this region of the brain. These neurons, generated from the ventral part of the periventricular epithelium during embryonic development, locate dorsally in the hypothalamus, becoming part of the ventromedial hypothalamic region.[1][2][4] The function of the arcuate nucleus relies on its diversity of neurons, but its central role is involved in homeostasis. The arcuate nucleus provides many physiological roles involved in feeding, metabolism, fertility, and cardiovascular regulation.[1][2][4][5]

Arcuate nucleus
Arcuate nucleus is 'AR', at bottom center, in green.
Details
Part ofHypothalamus
Identifiers
Latinnucleus arcuatus hypothalami
MeSHD001111
NeuroNames395
NeuroLex IDbirnlex_1638
TA98A14.1.08.923
TA25726
FMA62329
Anatomical terms of neuroanatomy
[edit on Wikidata]

Cell populations edit

Neuroendocrine neurons edit

Different groups of arcuate nucleus neuroendocrine neurons secrete various types or combinations of neurotransmitters and neuropeptides, such as neuropeptide Y (NPY), gonadotropin-releasing hormone (GnRH), agouti-related peptide (AgRP), cocaine- and amphetamine-regulated transcript (CART), kisspeptin, dopamine, substance P, growth hormone–releasing hormone (GHRH), neurokinin B (NKB), β-endorphin, melanocyte-stimulating hormone (MSH), and somatostatin. Proopiomelanocortin (POMC) is a precursor polypeptide that is cleaved into MSH, ACTH, and β-endorphin and expressed in the arcuate nucleus.[1]

Groups of neuroendocrine neurons include:

  • TIDA neurons, or tuberoinfundibular dopamine neurons, are neurons that regulate the secretion of prolactin from the pituitary gland and release the neurotransmitter dopamine. TIDA neurons have nerve endings in the median eminence that release dopamine into the hypophysial portal blood.[6] In lactating females, TIDA neurons are inhibited by the stimulus of suckling. Dopamine released from their nerve endings at the median eminence is transported to the anterior pituitary gland, where it regulates the secretion of prolactin. Dopamine inhibits prolactin secretion, so when the TIDA neurons are inhibited, there is increased secretion of prolactin, which stimulates lactogenesis (milk production). Prolactin acts in a short-loop negative feedback manner to decrease its levels by stimulating the release of dopamine. Dopaminergic neurons of the arcuate also inhibit the release of gonadotropin-releasing hormone, explaining in part why lactating (or otherwise hyperprolactinemic) women experience oligomenorrhea or amenorrhea (infrequency or absence of menses).[6]
  • Kisspeptin/NKB neurons within the arcuate nucleus form synaptic inputs with TIDA neurons. These neurons express estrogen receptors and also coexpress neurokinin B in female rats.[7]
  • GHRH neurons help to control growth hormone (GH) secretion in conjunction with somatostatin and NPY.[8]
  • NPY/AgRP neurons and POMC/CART neurons make up two groups of neurons in the arcuate nucleus that are centrally involved in the neuroendocrine function of feeding. Medial neurons utilize NPY peptides as neurotransmitters to stimulate appetite, and lateral neurons utilize POMC/CART to inhibit appetite.[2] NPY and POMC/CART neurons are sensitive to peripheral hormones such as leptin and insulin.[4] POMC/CART neurons also secrete melanocyte-stimulating hormone, which suppresses appetite.[9][10]: 419 
  • GnRH neurons have also been found.[1][2] These neurons secrete GnRH and histamine.[2]
  • There are also groups of neurons expressing NKB and dynorphin that help to control reproduction.[2]

Centrally-projecting neurons edit

Other types of neurons have projection pathways from the arcuate nucleus to mediate different regions of the hypothalamus or to other regions outside of the hypothalamus.[2][4] Projections of these neurons extend a long distance from the arcuate nucleus to the median eminence to influence the release of hormones from the pituitary gland.[1][2] Neurons of the arcuate nucleus have intrahypothalamic projections for neuroendocrine circuitry.[1] such as neural projections that influence feeding behavior project to the paraventricular nucleus of the hypothalamus (PVH), the dorsomedial hypothalamic nucleus (DMH), and the lateral hypothalamic area (LHA).[1] Populations of neurons connect to the intermediate lobes of the pituitary gland, from the lateral division of the ARH to the neural and intermediate parts of the pituitary gland, and the caudal division of ARH to the median eminence.[2]

Groups of neurons that project elsewhere within the central nervous system include:

  • Centrally projecting neurons that contain neuropeptide Y (NPY), agouti-related protein (AGRP), and the inhibitory neurotransmitter GABA. These neurons, in the most ventromedial part of the nucleus, project strongly to the lateral hypothalamus and to the paraventricular nucleus of the hypothalamus, and are important in the regulation of appetite. When activated, these neurons can produce ravenous eating. These neurons are inhibited by leptin, insulin, and peptide YY and activated by ghrelin.
  • Centrally projecting neurons that contain peptide products of pro-opiomelanocortin (POMC), and cocaine- and amphetamine-regulated transcript (CART). These neurons have widespread projections to many brain areas, including to all nuclei in the hypothalamus. These cells are important in the regulation of appetite, and, when activated, they inhibit feeding. These neurons are activated by circulating concentrations of leptin and insulin, and they are directly innervated and inhibited by the NPY neurons.[11] POMC neurons that project to the medial preoptic nucleus are also involved in the regulation of sexual behavior in both males and females. The expression of POMC is regulated by gonadal steroids. The release of a POMC product, beta-endorphin is regulated by NPY.
  • Centrally projecting neurons that make somatostatin; the neurosecretory somatostatin neurons that regulate growth hormone secretion are a different population, located in the periventricular nucleus.
  • Feeding regulatory neurons also activate oxytocin-containing neurons of the periventricular nucleus (PVN), which projects to nucleus of tractus solitarius in the medulla oblongata.[2]
  • Others receive direct synaptic inputs from extra hypothalamic sites projecting into the amygdala, the hippocampus, and the entorhinal cortex.[2]

Other neurons edit

Other cell populations include:

  • A small population of neurons that sensitive to ghrelin. The role of this population is not known; many neurons in the arcuate nucleus express receptors for ghrelin, but these are thought to respond mainly to blood-borne ghrelin.[12][13]
  • The arcuate nucleus also contains a population of specialized ependymal cells, called tanycytes.
  • Astrocytes in the arcuate nucleus hold high capacity glucose transporters that function as nutrient sensors for appetite controlling neurons[2]
  • The diverse and specialized collections of neurons reside within a special compartment with glial cells and have their own network of capillaries and a membrane of tanycytes that help create a blood brain barrier.[2] Circulating or molecules such as hormones travel in the blood and can directly affect these neurons and their plasticity as evidence by adult neurogenesis.[2]

References edit

  1. ^ a b c d e f g h Bouret SG, Draper SJ, Simerly RB (March 2004). "Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice". The Journal of Neuroscience. 24 (11): 2797–805. doi:10.1523/JNEUROSCI.5369-03.2004. PMC 6729527. PMID 15028773.
  2. ^ a b c d e f g h i j k l m n o p Dudas B (2013). The Human Hypothalamus: Anatomy, Functions and Disorders. New York: Nova Science Publishers. ISBN 978-1-62081-806-0.
  3. ^ . Archived from the original on 2008-05-22. Retrieved 2007-11-03.
  4. ^ a b c d Sapru HN (April 2013). "Role of the hypothalamic arcuate nucleus in cardiovascular regulation". Autonomic Neuroscience. 175 (1–2): 38–50. doi:10.1016/j.autneu.2012.10.016. PMC 3625681. PMID 23260431.
  5. ^ Coppari R, Ichinose M, Lee CE, Pullen AE, Kenny CD, McGovern RA, Tang V, Liu SM, Ludwig T, Chua SC, Lowell BB, Elmquist JK (January 2005). "The hypothalamic arcuate nucleus: a key site for mediating leptin's effects on glucose homeostasis and locomotor activity". Cell Metabolism. 1 (1): 63–72. doi:10.1016/j.cmet.2004.12.004. PMID 16054045.
  6. ^ a b Voogt JL, Lee Y, Yang S, Arbogast L (2001-01-01). "Chapter 12 Regulation of prolactin secretion during pregnancy and lactation". The Maternal Brain. Progress in Brain Research. Vol. 133. pp. 173–85. doi:10.1016/S0079-6123(01)33013-3. ISBN 9780444505484. PMID 11589129.
  7. ^ Sawai N, Iijima N, Takumi K, Matsumoto K, Ozawa H (September 2012). "Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin/neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats". Neuroscience Research. 74 (1): 10–6. doi:10.1016/j.neures.2012.05.011. PMID 22691459. S2CID 38679755.
  8. ^ Mano-Otagiri A, Nemoto T, Sekino A, Yamauchi N, Shuto Y, Sugihara H, Oikawa S, Shibasaki T (September 2006). "Growth hormone-releasing hormone (GHRH) neurons in the arcuate nucleus (Arc) of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated: Evidence that ghrelin receptor is involved in the up-regulation of GHRH expression in the arc". Endocrinology. 147 (9): 4093–103. doi:10.1210/en.2005-1619. PMID 16728494.
  9. ^ Baltatzi M, Hatzitolios A, Tziomalos K, Iliadis F, Zamboulis C (September 2008). "Neuropeptide Y and alpha-melanocyte-stimulating hormone: interaction in obesity and possible role in the development of hypertension". International Journal of Clinical Practice. 62 (9): 1432–40. doi:10.1111/j.1742-1241.2008.01823.x. PMID 18793378. S2CID 33693505.
  10. ^ Carlson NR (2012). Physiology of Behavior Books a La Carte Edition (11th ed.). Boston: Pearson College Div. ISBN 978-0-205-23981-8.
  11. ^ Arora S, Anubhuti (December 2006). "Role of neuropeptides in appetite regulation and obesity--a review". Neuropeptides. 40 (6): 375–401. doi:10.1016/j.npep.2006.07.001. PMID 16935329. S2CID 35190198.
  12. ^ Riediger T, Traebert M, Schmid HA, Scheel C, Lutz TA, Scharrer E (May 2003). "Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus". Neuroscience Letters. 341 (2): 151–5. doi:10.1016/S0304-3940(02)01381-2. PMID 12686388. S2CID 34697353.
  13. ^ Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P (January 2013). "Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons". Proceedings of the National Academy of Sciences of the United States of America. 110 (4): 1512–7. Bibcode:2013PNAS..110.1512S. doi:10.1073/pnas.1212137110. PMC 3557016. PMID 23297228.

Footnotes edit

  • Kawano H, Daikoku S (May 1988). "Somatostatin-containing neuron systems in the rat hypothalamus: retrograde tracing and immunohistochemical studies". The Journal of Comparative Neurology. 271 (2): 293–9. doi:10.1002/cne.902710209. PMID 2897982. S2CID 23815658.
  • Cone RD (May 2005). "Anatomy and regulation of the central melanocortin system" (PDF). Nature Neuroscience. 8 (5): 571–8. doi:10.1038/nn1455. PMID 15856065. S2CID 13400886.
  • Abizaid A, Horvath TL (August 2008). "Brain circuits regulating energy homeostasis". Regulatory Peptides. 149 (1–3): 3–10. doi:10.1016/j.regpep.2007.10.006. PMC 2605273. PMID 18514925.

April 07, 2024
arcuate, nucleus, this, article, about, hypothalamic, structure, structure, medulla, oblongata, medulla, arcuate, nucleus, hypothalamus, also, known, infundibular, nucleus, aggregation, neurons, mediobasal, hypothalamus, adjacent, third, ventricle, median, emi. This article is about the hypothalamic structure For the structure in the medulla oblongata see Arcuate nucleus medulla The arcuate nucleus of the hypothalamus also known as ARH 1 ARC 2 or infundibular nucleus 2 3 is an aggregation of neurons in the mediobasal hypothalamus adjacent to the third ventricle and the median eminence The arcuate nucleus includes several important and diverse populations of neurons that help mediate different neuroendocrine and physiological functions including neuroendocrine neurons centrally projecting neurons and astrocytes The populations of neurons found in the arcuate nucleus are based on the hormones they secrete or interact with and are responsible for hypothalamic function such as regulating hormones released from the pituitary gland or secreting their own hormones Neurons in this region are also responsible for integrating information and providing inputs to other nuclei in the hypothalamus or inputs to areas outside this region of the brain These neurons generated from the ventral part of the periventricular epithelium during embryonic development locate dorsally in the hypothalamus becoming part of the ventromedial hypothalamic region 1 2 4 The function of the arcuate nucleus relies on its diversity of neurons but its central role is involved in homeostasis The arcuate nucleus provides many physiological roles involved in feeding metabolism fertility and cardiovascular regulation 1 2 4 5 Arcuate nucleusArcuate nucleus is AR at bottom center in green DetailsPart ofHypothalamusIdentifiersLatinnucleus arcuatus hypothalamiMeSHD001111NeuroNames395NeuroLex IDbirnlex 1638TA98A14 1 08 923TA25726FMA62329Anatomical terms of neuroanatomy edit on Wikidata Contents 1 Cell populations 1 1 Neuroendocrine neurons 1 2 Centrally projecting neurons 1 3 Other neurons 2 References 3 FootnotesCell populations editNeuroendocrine neurons edit Different groups of arcuate nucleus neuroendocrine neurons secrete various types or combinations of neurotransmitters and neuropeptides such as neuropeptide Y NPY gonadotropin releasing hormone GnRH agouti related peptide AgRP cocaine and amphetamine regulated transcript CART kisspeptin dopamine substance P growth hormone releasing hormone GHRH neurokinin B NKB b endorphin melanocyte stimulating hormone MSH and somatostatin Proopiomelanocortin POMC is a precursor polypeptide that is cleaved into MSH ACTH and b endorphin and expressed in the arcuate nucleus 1 Groups of neuroendocrine neurons include TIDA neurons or tuberoinfundibular dopamine neurons are neurons that regulate the secretion of prolactin from the pituitary gland and release the neurotransmitter dopamine TIDA neurons have nerve endings in the median eminence that release dopamine into the hypophysial portal blood 6 In lactating females TIDA neurons are inhibited by the stimulus of suckling Dopamine released from their nerve endings at the median eminence is transported to the anterior pituitary gland where it regulates the secretion of prolactin Dopamine inhibits prolactin secretion so when the TIDA neurons are inhibited there is increased secretion of prolactin which stimulates lactogenesis milk production Prolactin acts in a short loop negative feedback manner to decrease its levels by stimulating the release of dopamine Dopaminergic neurons of the arcuate also inhibit the release of gonadotropin releasing hormone explaining in part why lactating or otherwise hyperprolactinemic women experience oligomenorrhea or amenorrhea infrequency or absence of menses 6 Kisspeptin NKB neurons within the arcuate nucleus form synaptic inputs with TIDA neurons These neurons express estrogen receptors and also coexpress neurokinin B in female rats 7 GHRH neurons help to control growth hormone GH secretion in conjunction with somatostatin and NPY 8 NPY AgRP neurons and POMC CART neurons make up two groups of neurons in the arcuate nucleus that are centrally involved in the neuroendocrine function of feeding Medial neurons utilize NPY peptides as neurotransmitters to stimulate appetite and lateral neurons utilize POMC CART to inhibit appetite 2 NPY and POMC CART neurons are sensitive to peripheral hormones such as leptin and insulin 4 POMC CART neurons also secrete melanocyte stimulating hormone which suppresses appetite 9 10 419 GnRH neurons have also been found 1 2 These neurons secrete GnRH and histamine 2 There are also groups of neurons expressing NKB and dynorphin that help to control reproduction 2 Centrally projecting neurons edit Other types of neurons have projection pathways from the arcuate nucleus to mediate different regions of the hypothalamus or to other regions outside of the hypothalamus 2 4 Projections of these neurons extend a long distance from the arcuate nucleus to the median eminence to influence the release of hormones from the pituitary gland 1 2 Neurons of the arcuate nucleus have intrahypothalamic projections for neuroendocrine circuitry 1 such as neural projections that influence feeding behavior project to the paraventricular nucleus of the hypothalamus PVH the dorsomedial hypothalamic nucleus DMH and the lateral hypothalamic area LHA 1 Populations of neurons connect to the intermediate lobes of the pituitary gland from the lateral division of the ARH to the neural and intermediate parts of the pituitary gland and the caudal division of ARH to the median eminence 2 Groups of neurons that project elsewhere within the central nervous system include Centrally projecting neurons that contain neuropeptide Y NPY agouti related protein AGRP and the inhibitory neurotransmitter GABA These neurons in the most ventromedial part of the nucleus project strongly to the lateral hypothalamus and to the paraventricular nucleus of the hypothalamus and are important in the regulation of appetite When activated these neurons can produce ravenous eating These neurons are inhibited by leptin insulin and peptide YY and activated by ghrelin Centrally projecting neurons that contain peptide products of pro opiomelanocortin POMC and cocaine and amphetamine regulated transcript CART These neurons have widespread projections to many brain areas including to all nuclei in the hypothalamus These cells are important in the regulation of appetite and when activated they inhibit feeding These neurons are activated by circulating concentrations of leptin and insulin and they are directly innervated and inhibited by the NPY neurons 11 POMC neurons that project to the medial preoptic nucleus are also involved in the regulation of sexual behavior in both males and females The expression of POMC is regulated by gonadal steroids The release of a POMC product beta endorphin is regulated by NPY Centrally projecting neurons that make somatostatin the neurosecretory somatostatin neurons that regulate growth hormone secretion are a different population located in the periventricular nucleus Feeding regulatory neurons also activate oxytocin containing neurons of the periventricular nucleus PVN which projects to nucleus of tractus solitarius in the medulla oblongata 2 Others receive direct synaptic inputs from extra hypothalamic sites projecting into the amygdala the hippocampus and the entorhinal cortex 2 Other neurons edit Other cell populations include A small population of neurons that sensitive to ghrelin The role of this population is not known many neurons in the arcuate nucleus express receptors for ghrelin but these are thought to respond mainly to blood borne ghrelin 12 13 The arcuate nucleus also contains a population of specialized ependymal cells called tanycytes Astrocytes in the arcuate nucleus hold high capacity glucose transporters that function as nutrient sensors for appetite controlling neurons 2 The diverse and specialized collections of neurons reside within a special compartment with glial cells and have their own network of capillaries and a membrane of tanycytes that help create a blood brain barrier 2 Circulating or molecules such as hormones travel in the blood and can directly affect these neurons and their plasticity as evidence by adult neurogenesis 2 References edit a b c d e f g h Bouret SG Draper SJ Simerly RB March 2004 Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice The Journal of Neuroscience 24 11 2797 805 doi 10 1523 JNEUROSCI 5369 03 2004 PMC 6729527 PMID 15028773 a b c d e f g h i j k l m n o p Dudas B 2013 The Human Hypothalamus Anatomy Functions and Disorders New York Nova Science Publishers ISBN 978 1 62081 806 0 onderzoekinformatie nl Project Does activation of neurons in the infundibular nucleus in menopause prevent the occurrence of Alzheimer changes Archived from the original on 2008 05 22 Retrieved 2007 11 03 a b c d Sapru HN April 2013 Role of the hypothalamic arcuate nucleus in cardiovascular regulation Autonomic Neuroscience 175 1 2 38 50 doi 10 1016 j autneu 2012 10 016 PMC 3625681 PMID 23260431 Coppari R Ichinose M Lee CE Pullen AE Kenny CD McGovern RA Tang V Liu SM Ludwig T Chua SC Lowell BB Elmquist JK January 2005 The hypothalamic arcuate nucleus a key site for mediating leptin s effects on glucose homeostasis and locomotor activity Cell Metabolism 1 1 63 72 doi 10 1016 j cmet 2004 12 004 PMID 16054045 a b Voogt JL Lee Y Yang S Arbogast L 2001 01 01 Chapter 12 Regulation of prolactin secretion during pregnancy and lactation The Maternal Brain Progress in Brain Research Vol 133 pp 173 85 doi 10 1016 S0079 6123 01 33013 3 ISBN 9780444505484 PMID 11589129 Sawai N Iijima N Takumi K Matsumoto K Ozawa H September 2012 Immunofluorescent histochemical and ultrastructural studies on the innervation of kisspeptin neurokinin B neurons to tuberoinfundibular dopaminergic neurons in the arcuate nucleus of rats Neuroscience Research 74 1 10 6 doi 10 1016 j neures 2012 05 011 PMID 22691459 S2CID 38679755 Mano Otagiri A Nemoto T Sekino A Yamauchi N Shuto Y Sugihara H Oikawa S Shibasaki T September 2006 Growth hormone releasing hormone GHRH neurons in the arcuate nucleus Arc of the hypothalamus are decreased in transgenic rats whose expression of ghrelin receptor is attenuated Evidence that ghrelin receptor is involved in the up regulation of GHRH expression in the arc Endocrinology 147 9 4093 103 doi 10 1210 en 2005 1619 PMID 16728494 Baltatzi M Hatzitolios A Tziomalos K Iliadis F Zamboulis C September 2008 Neuropeptide Y and alpha melanocyte stimulating hormone interaction in obesity and possible role in the development of hypertension International Journal of Clinical Practice 62 9 1432 40 doi 10 1111 j 1742 1241 2008 01823 x PMID 18793378 S2CID 33693505 Carlson NR 2012 Physiology of Behavior Books a La Carte Edition 11th ed Boston Pearson College Div ISBN 978 0 205 23981 8 Arora S Anubhuti December 2006 Role of neuropeptides in appetite regulation and obesity a review Neuropeptides 40 6 375 401 doi 10 1016 j npep 2006 07 001 PMID 16935329 S2CID 35190198 Riediger T Traebert M Schmid HA Scheel C Lutz TA Scharrer E May 2003 Site specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus Neuroscience Letters 341 2 151 5 doi 10 1016 S0304 3940 02 01381 2 PMID 12686388 S2CID 34697353 Schaeffer M Langlet F Lafont C Molino F Hodson DJ Roux T Lamarque L Verdie P Bourrier E Dehouck B Baneres JL Martinez J Mery PF Marie J Trinquet E Fehrentz JA Prevot V Mollard P January 2013 Rapid sensing of circulating ghrelin by hypothalamic appetite modifying neurons Proceedings of the National Academy of Sciences of the United States of America 110 4 1512 7 Bibcode 2013PNAS 110 1512S doi 10 1073 pnas 1212137110 PMC 3557016 PMID 23297228 Footnotes editKawano H Daikoku S May 1988 Somatostatin containing neuron systems in the rat hypothalamus retrograde tracing and immunohistochemical studies The Journal of Comparative Neurology 271 2 293 9 doi 10 1002 cne 902710209 PMID 2897982 S2CID 23815658 Cone RD May 2005 Anatomy and regulation of the central melanocortin system PDF Nature Neuroscience 8 5 571 8 doi 10 1038 nn1455 PMID 15856065 S2CID 13400886 Abizaid A Horvath TL August 2008 Brain circuits regulating energy homeostasis Regulatory Peptides 149 1 3 3 10 doi 10 1016 j regpep 2007 10 006 PMC 2605273 PMID 18514925 Retrieved from https en wikipedia org w index php title Arcuate nucleus amp oldid 1216463920, wikipedia, wiki, book, books, library,

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