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Hydrogenosome

January 31, 2023

A hydrogenosome is a membrane-enclosed organelle found in some anaerobic ciliates, flagellates, and fungi. Hydrogenosomes are highly variable organelles that have presumably evolved from protomitochondria to produce molecular hydrogen and ATP in anaerobic conditions.[1]

Diagram of activity in an S. salmonicida hydrogenosome for producing ATP, molecular hydrogen, acetate, and carbon dioxide

Hydrogenosomes were discovered in 1973 by D. G. Lindmark and M. Müller. Because hydrogenosomes hold evolutionary lineage significance for organisms living in anaerobic or oxygen-stressed environments, many research institutions have since documented their findings on how the organelle differs in various sources.[2]

History

Hydrogenosomes were isolated, purified, biochemically characterized and named in the early 1970s by Lindmark and Müller at Rockefeller University. In addition to this seminal study on hydrogenosomes, they also demonstrated for the first time the presence of pyruvate:ferredoxin oxido-reductase and hydrogenase in eukaryotes.[2] Further studies were subsequently conducted on the biochemical cytology and subcellular organization of several anaerobic protozoan parasites (ex:Trichomonas vaginalis, Tritrichomonas foetus, Giardia lamblia, and Entamoeba sp.).[1]

Using information obtained from hydrogenosomal and biochemical cytology studies these researchers determined the mode of action of metronidazole (Flagyl) . Today, metronidazole is recognized as a standard chemotherapeutic agent for the treatment of anaerobic infections.[3][4]

Since their discovery, hydrogenosomes have been found in a variety of anaerobic unicellular ciliates, flagellates, and fungi. The most notable amongst these is the parasitic Trichomonas vaginalis.[5]

Description

Hydrogenosomes are organelles that are speculated to have evolved from mitochondria to provide a different mechanism for anaerobic ATP synthesis utilizing pyruvate. The reaction results in the production of molecular hydrogen, from which the organelle receives its name.[2]

Hydrogenosomes range from 0.5-2 micrometers and are bound by a double membrane. They are most often dumb-bell-shaped and found in large complexes of stacked hydrogenosomes. These stacks range from 4 or 5 (called juvenile complexes) to 20 or more hydrogenosomes.[1]

In most cases, hydrogenosomes are genomeless, as a majority of the mitochondrial genome was transferred to the nucleus; because of this, all hydrogenosomal proteins are imported to the organelle.[6][7] However, a hydrogenosomal genome has been detected in the cockroach ciliate Nyctotherus ovalis, and the stramenopile Blastocystis.[8]

Due to the fact that many organisms have evolved to fit their anaerobic environments, a multitude of organisms have independently evolved hydrogenosomes or structures with similar functions. The similarity between Nyctotherus and Blastocystis, which are only distantly related, is believed to be the result of convergent evolution, and calls into question whether there is a clear-cut distinction between mitochondria, hydrogenosomes, and mitosomes (another kind of degenerate mitochondria).[1][8]

Source organisms

A non-exhaustive list of organisms containing hydrogenosomes includes:

The vast variety of source organisms can be accredited to the theorized convergent evolution of hydrogenosomes from mitochondria to fit an anaerobic environment.[1][6][8]

In 2010, scientists have also reported their discovery of the first known anaerobic metazoans with hydrogenosome-like organelles. Three multicellular species of Loricifera — Spinoloricus nov. sp., Rugiloricus nov. sp. and Pliciloricus nov. sp. — have been found deep in Mediterranean sediments, and use hydrogenosomes in their anaerobic metabolism cycle.[9]

ATP Synthesis

 
Abb.1: Model of ATP-synthesis in hydrogenosomes.

The hydrogenosomes of trichomonads (the most studied of the hydrogenosome-containing microorganisms) produce molecular hydrogen, acetate, carbon dioxide and ATP by the combined actions of pyruvate:ferredoxin oxido-reductase, hydrogenase, acetate:succinate CoA transferase and succinate thiokinase. Superoxide dismutase, malate dehydrogenase (decarboxylating), ferredoxin, adenylate kinase and NADH:ferredoxin oxido-reductase are also localized in the hydrogenosome.[10]

See also

References

  1. ^ a b c d e de Graaf RM, Duarte I, van Alen TA, Kuiper JW, Schotanus K, Rosenberg J, et al. (December 2009). "The hydrogenosomes of Psalteriomonas lanterna". BMC Evolutionary Biology. 9 (1): 287. doi:10.1186/1471-2148-9-287. PMC 2796672. PMID 20003182.
  2. ^ a b c Lindmark, Donald G.; Müller, Miklós (1973-11-25). "Hydrogenosome, a Cytoplasmic Organelle of the Anaerobic Flagellate Tritrichomonas foetus, and Its Role in Pyruvate Metabolism". Journal of Biological Chemistry. 248 (22): 7724–7728. doi:10.1016/S0021-9258(19)43249-3. ISSN 0021-9258. PMID 4750424.
  3. ^ "Flagyl, Flagyl ER (metronidazole) dosing, indications, interactions, adverse effects, and more". reference.medscape.com. Retrieved 2021-04-11.
  4. ^ Hrdý I, Cammack R, Stopka P, Kulda J, Tachezy J (December 2005). "Alternative pathway of metronidazole activation in Trichomonas vaginalis hydrogenosomes". Antimicrobial Agents and Chemotherapy. 49 (12): 5033–6. doi:10.1128/AAC.49.12.5033-5036.2005. PMC 1315937. PMID 16304169.
  5. ^ Schneider RE, Brown MT, Shiflett AM, Dyall SD, Hayes RD, Xie Y, et al. (November 2011). "The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes". International Journal for Parasitology. 41 (13–14): 1421–34. doi:10.1016/j.ijpara.2011.10.001. PMC 4437511. PMID 22079833.
  6. ^ a b Rada P, Doležal P, Jedelský PL, Bursac D, Perry AJ, Šedinová M, et al. (2011-09-15). "The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis". PLOS ONE. 6 (9): e24428. Bibcode:2011PLoSO...624428R. doi:10.1371/journal.pone.0024428. PMC 3174187. PMID 21935410.
  7. ^ Mai Z, Ghosh S, Frisardi M, Rosenthal B, Rogers R, Samuelson J (March 1999). "Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica". Molecular and Cellular Biology. 19 (3): 2198–205. doi:10.1128/MCB.19.3.2198. PMC 84012. PMID 10022906.
  8. ^ a b c Stechmann A, Hamblin K, Pérez-Brocal V, Gaston D, Richmond GS, van der Giezen M, et al. (April 2008). "Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes". Current Biology. 18 (8): 580–5. doi:10.1016/j.cub.2008.03.037. PMC 2428068. PMID 18403202.
  9. ^ Danovaro R, Dell'Anno A, Pusceddu A, Gambi C, Heiner I, Kristensen RM (April 2010). "The first metazoa living in permanently anoxic conditions". BMC Biology. 8: 30. doi:10.1186/1741-7007-8-30. PMC 2907586. PMID 20370908.
  10. ^ Hjort K, Goldberg AV, Tsaousis AD, Hirt RP, Embley TM (March 2010). "Diversity and reductive evolution of mitochondria among microbial eukaryotes". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 365 (1541): 713–27. doi:10.1098/rstb.2009.0224. PMC 2817227. PMID 20124340.

January 31, 2023
hydrogenosome, hydrogenosome, membrane, enclosed, organelle, found, some, anaerobic, ciliates, flagellates, fungi, highly, variable, organelles, that, have, presumably, evolved, from, protomitochondria, produce, molecular, hydrogen, anaerobic, conditions, diag. A hydrogenosome is a membrane enclosed organelle found in some anaerobic ciliates flagellates and fungi Hydrogenosomes are highly variable organelles that have presumably evolved from protomitochondria to produce molecular hydrogen and ATP in anaerobic conditions 1 Diagram of activity in an S salmonicida hydrogenosome for producing ATP molecular hydrogen acetate and carbon dioxide Hydrogenosomes were discovered in 1973 by D G Lindmark and M Muller Because hydrogenosomes hold evolutionary lineage significance for organisms living in anaerobic or oxygen stressed environments many research institutions have since documented their findings on how the organelle differs in various sources 2 Contents 1 History 2 Description 3 Source organisms 4 ATP Synthesis 5 See also 6 ReferencesHistory EditHydrogenosomes were isolated purified biochemically characterized and named in the early 1970s by Lindmark and Muller at Rockefeller University In addition to this seminal study on hydrogenosomes they also demonstrated for the first time the presence of pyruvate ferredoxin oxido reductase and hydrogenase in eukaryotes 2 Further studies were subsequently conducted on the biochemical cytology and subcellular organization of several anaerobic protozoan parasites ex Trichomonas vaginalis Tritrichomonas foetus Giardia lamblia and Entamoeba sp 1 Using information obtained from hydrogenosomal and biochemical cytology studies these researchers determined the mode of action of metronidazole Flagyl Today metronidazole is recognized as a standard chemotherapeutic agent for the treatment of anaerobic infections 3 4 Since their discovery hydrogenosomes have been found in a variety of anaerobic unicellular ciliates flagellates and fungi The most notable amongst these is the parasitic Trichomonas vaginalis 5 Description EditHydrogenosomes are organelles that are speculated to have evolved from mitochondria to provide a different mechanism for anaerobic ATP synthesis utilizing pyruvate The reaction results in the production of molecular hydrogen from which the organelle receives its name 2 Hydrogenosomes range from 0 5 2 micrometers and are bound by a double membrane They are most often dumb bell shaped and found in large complexes of stacked hydrogenosomes These stacks range from 4 or 5 called juvenile complexes to 20 or more hydrogenosomes 1 In most cases hydrogenosomes are genomeless as a majority of the mitochondrial genome was transferred to the nucleus because of this all hydrogenosomal proteins are imported to the organelle 6 7 However a hydrogenosomal genome has been detected in the cockroach ciliate Nyctotherus ovalis and the stramenopile Blastocystis 8 Due to the fact that many organisms have evolved to fit their anaerobic environments a multitude of organisms have independently evolved hydrogenosomes or structures with similar functions The similarity between Nyctotherus and Blastocystis which are only distantly related is believed to be the result of convergent evolution and calls into question whether there is a clear cut distinction between mitochondria hydrogenosomes and mitosomes another kind of degenerate mitochondria 1 8 Source organisms EditA non exhaustive list of organisms containing hydrogenosomes includes parabasalid flagellates e g Trichomonas vaginalis Tritrichomonas foetus Histomonas meleagridis preaxostylid flagellates e g Trimastix pyriformis heterolobosean amoeboflagellates e g Psalteriomonas lanterna anaerobic ciliates e g Nyctotherus ovalis Metopus palaeformis Trimyema compressum Caenomorpha uniserialis Dasytricha ruminantium anaerobic chytridiomycete fungi e g Neocallimastix spp Piromyces spp The vast variety of source organisms can be accredited to the theorized convergent evolution of hydrogenosomes from mitochondria to fit an anaerobic environment 1 6 8 In 2010 scientists have also reported their discovery of the first known anaerobic metazoans with hydrogenosome like organelles Three multicellular species of Loricifera Spinoloricus nov sp Rugiloricus nov sp and Pliciloricus nov sp have been found deep in Mediterranean sediments and use hydrogenosomes in their anaerobic metabolism cycle 9 ATP Synthesis Edit Abb 1 Model of ATP synthesis in hydrogenosomes The hydrogenosomes of trichomonads the most studied of the hydrogenosome containing microorganisms produce molecular hydrogen acetate carbon dioxide and ATP by the combined actions of pyruvate ferredoxin oxido reductase hydrogenase acetate succinate CoA transferase and succinate thiokinase Superoxide dismutase malate dehydrogenase decarboxylating ferredoxin adenylate kinase and NADH ferredoxin oxido reductase are also localized in the hydrogenosome 10 See also EditMitochondria Mitosome PlastidReferences Edit a b c d e de Graaf RM Duarte I van Alen TA Kuiper JW Schotanus K Rosenberg J et al December 2009 The hydrogenosomes of Psalteriomonas lanterna BMC Evolutionary Biology 9 1 287 doi 10 1186 1471 2148 9 287 PMC 2796672 PMID 20003182 a b c Lindmark Donald G Muller Miklos 1973 11 25 Hydrogenosome a Cytoplasmic Organelle of the Anaerobic Flagellate Tritrichomonas foetus and Its Role in Pyruvate Metabolism Journal of Biological Chemistry 248 22 7724 7728 doi 10 1016 S0021 9258 19 43249 3 ISSN 0021 9258 PMID 4750424 Flagyl Flagyl ER metronidazole dosing indications interactions adverse effects and more reference medscape com Retrieved 2021 04 11 Hrdy I Cammack R Stopka P Kulda J Tachezy J December 2005 Alternative pathway of metronidazole activation in Trichomonas vaginalis hydrogenosomes Antimicrobial Agents and Chemotherapy 49 12 5033 6 doi 10 1128 AAC 49 12 5033 5036 2005 PMC 1315937 PMID 16304169 Schneider RE Brown MT Shiflett AM Dyall SD Hayes RD Xie Y et al November 2011 The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria yet complex compared with mitosomes International Journal for Parasitology 41 13 14 1421 34 doi 10 1016 j ijpara 2011 10 001 PMC 4437511 PMID 22079833 a b Rada P Dolezal P Jedelsky PL Bursac D Perry AJ Sedinova M et al 2011 09 15 The core components of organelle biogenesis and membrane transport in the hydrogenosomes of Trichomonas vaginalis PLOS ONE 6 9 e24428 Bibcode 2011PLoSO 624428R doi 10 1371 journal pone 0024428 PMC 3174187 PMID 21935410 Mai Z Ghosh S Frisardi M Rosenthal B Rogers R Samuelson J March 1999 Hsp60 is targeted to a cryptic mitochondrion derived organelle crypton in the microaerophilic protozoan parasite Entamoeba histolytica Molecular and Cellular Biology 19 3 2198 205 doi 10 1128 MCB 19 3 2198 PMC 84012 PMID 10022906 a b c Stechmann A Hamblin K Perez Brocal V Gaston D Richmond GS van der Giezen M et al April 2008 Organelles in Blastocystis that blur the distinction between mitochondria and hydrogenosomes Current Biology 18 8 580 5 doi 10 1016 j cub 2008 03 037 PMC 2428068 PMID 18403202 Danovaro R Dell Anno A Pusceddu A Gambi C Heiner I Kristensen RM April 2010 The first metazoa living in permanently anoxic conditions BMC Biology 8 30 doi 10 1186 1741 7007 8 30 PMC 2907586 PMID 20370908 Hjort K Goldberg AV Tsaousis AD Hirt RP Embley TM March 2010 Diversity and reductive evolution of mitochondria among microbial eukaryotes Philosophical Transactions of the Royal Society of London Series B Biological Sciences 365 1541 713 27 doi 10 1098 rstb 2009 0224 PMC 2817227 PMID 20124340 Portals Biology Science Retrieved from https en wikipedia org w index php title Hydrogenosome amp oldid 1112552149, wikipedia, wiki, book, books, library,

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