^Chackalamannil S, Davies RJ, Wang Y, et al. (March 1999). "Total Synthesis of (+)-Himbacine and (+)-Himbeline". J. Org. Chem. 64 (6): 1932–1940. doi:10.1021/jo981983+. PMID 11674285.
^Malaska MJ, Fauq AH, Kozikowski AP, Aagaard PJ, McKinney M (1995). "Chemical Modification of Ring C of Himbacine: Discovery of a Pharmacophoric Element for M2-Selectivity". Bioorganic & Medicinal Chemistry Letters. 5 (1): 61–66. doi:10.1016/0960-894X(94)00459-S.
^Chackalamannil S, Doller D, McQuade R, Ruperto V (2004). "Himbacine analogs as muscarinic receptor antagonists-effects of tether and heterocyclic variations". Bioorganic & Medicinal Chemistry Letters. 14 (15): 3967–3970. doi:10.1016/j.bmcl.2004.05.047. PMID 15225708.
^Chackalamannil S, Wang Y, Greenlee WJ, et al. (2008). "Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity". J. Med. Chem. 51 (11): 3061–3064. doi:10.1021/jm800180e. PMID 18447380.
^"Blog entry about Himbacine and its history in drug development". 13 May 2008. Retrieved 2016-08-11.
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himbacine, alkaloid, isolated, from, bark, australian, magnolias, been, synthesized, using, diels, alder, reaction, step, activity, muscarinic, receptor, antagonist, with, specificity, muscarinic, acetylcholine, receptor, made, promising, starting, point, alzh. Himbacine is an alkaloid isolated from the bark of Australian magnolias Himbacine has been synthesized using a Diels Alder reaction as a key step 1 Himbacine s activity as a muscarinic receptor antagonist with specificity for the muscarinic acetylcholine receptor M2 made it a promising starting point in Alzheimer s disease research 2 3 The development of a muscarinic antagonist based on himbacine failed but an analog vorapaxar has been approved by the FDA as a thrombin receptor antagonist 4 5 HimbacineClinical dataATC codenoneIdentifiersIUPAC name 3aR 4R 4aS 8aR 9aS 4 E 2R 6S 1 6 dimethylpiperidin 2 yl vinyl 3 methyldecahydronaphtho 2 3 c furan 1 3H oneCAS Number6879 74 9 YPubChem CID6436265IUPHAR BPS324ChemSpider4940913 YUNIIM17C7V122DChEBICHEBI 5720 YChEMBLChEMBL277642 YChemical and physical dataFormulaC 22H 35N O 2Molar mass345 527 g mol 13D model JSmol Interactive imageSMILES O C3O C H C H 4 C H C C C H 1N C C H C CCC1 C H 2 C H CCCC2 C C H 34 CInChI InChI 1S C22H35NO2 c1 14 7 6 9 17 23 14 3 11 12 19 18 10 5 4 8 16 18 13 20 21 19 15 2 25 22 20 24 h11 12 14 21H 4 10 13H2 1 3H3 b12 11 t14 15 16 17 18 19 20 21 m0 s1 YKey FMPNFDSPHNUFOS LPJDIUFZSA N Y verify References edit Chackalamannil S Davies RJ Wang Y et al March 1999 Total Synthesis of Himbacine and Himbeline J Org Chem 64 6 1932 1940 doi 10 1021 jo981983 PMID 11674285 Malaska MJ Fauq AH Kozikowski AP Aagaard PJ McKinney M 1995 Chemical Modification of Ring C of Himbacine Discovery of a Pharmacophoric Element for M2 Selectivity Bioorganic amp Medicinal Chemistry Letters 5 1 61 66 doi 10 1016 0960 894X 94 00459 S Chackalamannil S Doller D McQuade R Ruperto V 2004 Himbacine analogs as muscarinic receptor antagonists effects of tether and heterocyclic variations Bioorganic amp Medicinal Chemistry Letters 14 15 3967 3970 doi 10 1016 j bmcl 2004 05 047 PMID 15225708 Chackalamannil S Wang Y Greenlee WJ et al 2008 Discovery of a Novel Orally Active Himbacine Based Thrombin Receptor Antagonist SCH 530348 with Potent Antiplatelet Activity J Med Chem 51 11 3061 3064 doi 10 1021 jm800180e PMID 18447380 Blog entry about Himbacine and its history in drug development 13 May 2008 Retrieved 2016 08 11 nbsp This pharmacology related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Himbacine amp oldid 1136159302, wikipedia, wiki, book, books, library,
