Harry Rubin (born June 23, 1926, in New York City)[1] – February 2, 2020)[2] was an American cell biologist and virologist. He is known for his experimental research on oncoviruses and how cellular microenvironment and cellular aging affect the regulation of cancerous tumors.[2][3]
Biographyedit
His parents were Jewish immigrants and his father had a grocery store and delicatessen in Manhattan. Harry Rubin graduated in 1947 as a Doctor of Veterinary Medicine (D.V.M.) from the New York State College of Veterinary Medicine at Cornell University. From 1947 to 1948 he served in the joint U.S.-Mexican Aftosa Commission dealing with an outbreak of hoof-and-mouth disease (fiebre aftosa in Spanish) among cattle in Mexico.[4][5] From 1948 to 1952 he was stationed in Montgomery, Alabama as a commissioned officer of the United States Public Health Service. In January 1952 he married Dorothy Margaret Shuster, who was being trained as a flight evacuation nurse in the U.S. Air Force when he met her.[4]
In 1952 he was briefly enrolled as a graduate student at New York University, but Wendell Stanley recruited him to work at UC Berkeley's Virus Laboratory. From 1952 to 1953 Rubin was a research fellow at UC Berkeley. From 1953 to 1958 he was a research fellow at Caltech. There he worked in Renato Dulbecco's laboratory and discovered in 1955 that, in a tumor infected with Rous sarcoma virus (RSV), every cell in the tumor is capable of releasing RSV. In 1958 Temin and Rubin published an important paper Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture on their breakthrough in developing a tissue culture assay for RSV. At UC Berkeley, Rubin was an associate professor from 1958 to 1960 and a full professor from 1960 to 2001, when he retired as professor emeritus.[4]
He was "a singer and guitar player much in demand at parties."[6] During the 1960s he was active in Berkeley's anti-Vietnam war movement. In the 1970s he became interested in Jewish ethics and the ideas of some Jewish philosophers such as Emmanuel Levinas, Franz Rosenzweig, Joseph B. Soloveitchik, and Eliezer Berkovits. Rubin and his wife joined the Congregation Beth Israel in Berkeley, and he met regularly with a philosophy discussion group of congregation members.[4]
Harry and Dorothy Rubin had two sons and two daughters. He died on February 2, 2020.[4] His grave is in Gan Shalom Cemetery, Contra Costa County, California.[8]
Selected publicationsedit
Rubin, Harry (1955). "Quantitative relations between causative virus and cell in the Rous No. 1 chicken sarcoma". Virology. 1 (5): 445–473. doi:10.1016/0042-6822(55)90037-4. PMID 13274745.
Temin, Howard M.; Rubin, Harry (1958). "Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture". Virology. 6 (3): 669–688. doi:10.1016/0042-6822(58)90114-4. PMID 13616179.
Rubin, H.; Temin, H.M. (1959). "A radiological study of cell-virus interaction in the rous sarcoma". Virology. 7 (1): 75–91. doi:10.1016/0042-6822(59)90178-3. PMID 13636057.
Rubin, H.; Fanshier, L.; Cornelius, A.; Hughes, W.F. (1962). "Tolerance and immunity in chickens after congenital and contact infection with an avian leukosis virus". Virology. 17: 143–156. doi:10.1016/0042-6822(62)90091-0. PMID 14494904.
Rubin, H. (1965). "Genetic control of cellular susceptibility to pseudotypes of rous sarcoma virus". Virology. 26 (2): 270–276. doi:10.1016/0042-6822(65)90274-6. PMID 14323995.
Chow, Ming; Rubin, Harry (1999). "Clonal dynamics of progressive neoplastic transformation". Proceedings of the National Academy of Sciences. 96 (12): 6976–6981. Bibcode:1999PNAS...96.6976C. doi:10.1073/pnas.96.12.6976. PMC22027. PMID 10359824.
Rubin, Harry (2003). "Cancer cachexia: Its correlations and causes". Proceedings of the National Academy of Sciences. 100 (9): 5384–5389. Bibcode:2003PNAS..100.5384R. doi:10.1073/pnas.0931260100. PMC154354. PMID 12702753.
Rubin, Harry (2008). "Cell–cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype". Proceedings of the National Academy of Sciences. 105 (17): 6215–6221. Bibcode:2008PNAS..105.6215R. doi:10.1073/pnas.0800747105. PMC2359782. PMID 18434545.
Rubin, Harry (2011). "The early history of tumor virology: Rous, RIF, and RAV". Proceedings of the National Academy of Sciences. 108 (35): 14389–14396. Bibcode:2011PNAS..10814389R. doi:10.1073/pnas.1108655108. PMC3167550. PMID 21813762.
Rubin, Harry (2017). "Dynamics of cell transformation in culture and its significance for tumor development in animals". Proceedings of the National Academy of Sciences. 114 (46): 12237–12242. doi:10.1073/pnas.1715236114. PMC5699091. PMID 29087347.
Referencesedit
^biographical information from American Men and Women of Science, Thomson Gale, 2005
^ abSanders, Robert (February 7, 2020). "Virus expert and cancer biologist Harry Rubin dies at 93". Berkeley News. UC Berkeley.
^. Department of Cellular & Molecular Biology, UC Berkeley. Archived from the original on 2009-01-04.
^ abcdefgMartin, G. Steven (2021). "In Memoriam. Harry Rubin". Academic Senate, University of California.
^McCulloch, A. E. (December 1949). "We're Winning the Battle of Aftosa". The Rotarian. LXXV (6): 26–28.
^Crow, James Franklin; Dove, William F., eds. (2000). Perspectives on Genetics: Anecdotal, Historical, and Critical Commentaries, 1987-1998. Univ of Wisconsin Press. p. 540. ISBN9780299166045.
^"Harry Rubin, D.V.M." Cell Biology Tree (academictree.org).
^"Harry Rubin (search)". Gan Shalom Cemetery, Contra Costa County.
January 01, 1970
harry, rubin, virologist, harry, rubin, born, june, 1926, york, city, february, 2020, american, cell, biologist, virologist, known, experimental, research, oncoviruses, cellular, microenvironment, cellular, aging, affect, regulation, cancerous, tumors, biograp. Harry Rubin born June 23 1926 in New York City 1 February 2 2020 2 was an American cell biologist and virologist He is known for his experimental research on oncoviruses and how cellular microenvironment and cellular aging affect the regulation of cancerous tumors 2 3 Biography editHis parents were Jewish immigrants and his father had a grocery store and delicatessen in Manhattan Harry Rubin graduated in 1947 as a Doctor of Veterinary Medicine D V M from the New York State College of Veterinary Medicine at Cornell University From 1947 to 1948 he served in the joint U S Mexican Aftosa Commission dealing with an outbreak of hoof and mouth disease fiebre aftosa in Spanish among cattle in Mexico 4 5 From 1948 to 1952 he was stationed in Montgomery Alabama as a commissioned officer of the United States Public Health Service In January 1952 he married Dorothy Margaret Shuster who was being trained as a flight evacuation nurse in the U S Air Force when he met her 4 In 1952 he was briefly enrolled as a graduate student at New York University but Wendell Stanley recruited him to work at UC Berkeley s Virus Laboratory From 1952 to 1953 Rubin was a research fellow at UC Berkeley From 1953 to 1958 he was a research fellow at Caltech There he worked in Renato Dulbecco s laboratory and discovered in 1955 that in a tumor infected with Rous sarcoma virus RSV every cell in the tumor is capable of releasing RSV In 1958 Temin and Rubin published an important paper Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture on their breakthrough in developing a tissue culture assay for RSV At UC Berkeley Rubin was an associate professor from 1958 to 1960 and a full professor from 1960 to 2001 when he retired as professor emeritus 4 At UC Berkeley s Virus Laboratory Rubin working with postdoctoral fellows Peter K Vogt and Hidesaburo Hanafusa demonstrated that avian sarcoma leukosis virus ASLV can act as a helper virus for RSV This research earned Rubin the 1964 Albert Lasker Award for Basic Medical Research shared with Renato Dulbecco 4 Rubin received in 1961 the Eli Lilly Award in Bacteriology and Immunology and in 1963 the Merck Research Award He was elected in 1978 a member of the United States National Academy of Sciences 4 He was a singer and guitar player much in demand at parties 6 During the 1960s he was active in Berkeley s anti Vietnam war movement In the 1970s he became interested in Jewish ethics and the ideas of some Jewish philosophers such as Emmanuel Levinas Franz Rosenzweig Joseph B Soloveitchik and Eliezer Berkovits Rubin and his wife joined the Congregation Beth Israel in Berkeley and he met regularly with a philosophy discussion group of congregation members 4 His doctoral students include Howard M Temin and Gail R Martin 7 Harry and Dorothy Rubin had two sons and two daughters He died on February 2 2020 4 His grave is in Gan Shalom Cemetery Contra Costa County California 8 Selected publications editRubin Harry 1955 Quantitative relations between causative virus and cell in the Rous No 1 chicken sarcoma Virology 1 5 445 473 doi 10 1016 0042 6822 55 90037 4 PMID 13274745 Temin Howard M Rubin Harry 1958 Characteristics of an assay for Rous sarcoma virus and Rous sarcoma cells in tissue culture Virology 6 3 669 688 doi 10 1016 0042 6822 58 90114 4 PMID 13616179 Rubin H Temin H M 1959 A radiological study of cell virus interaction in the rous sarcoma Virology 7 1 75 91 doi 10 1016 0042 6822 59 90178 3 PMID 13636057 Rubin H Fanshier L Cornelius A Hughes W F 1962 Tolerance and immunity in chickens after congenital and contact infection with an avian leukosis virus Virology 17 143 156 doi 10 1016 0042 6822 62 90091 0 PMID 14494904 Rubin H 1965 Genetic control of cellular susceptibility to pseudotypes of rous sarcoma virus Virology 26 2 270 276 doi 10 1016 0042 6822 65 90274 6 PMID 14323995 Chow Ming Rubin Harry 1999 Clonal dynamics of progressive neoplastic transformation Proceedings of the National Academy of Sciences 96 12 6976 6981 Bibcode 1999PNAS 96 6976C doi 10 1073 pnas 96 12 6976 PMC 22027 PMID 10359824 Rubin Harry 2003 Cancer cachexia Its correlations and causes Proceedings of the National Academy of Sciences 100 9 5384 5389 Bibcode 2003PNAS 100 5384R doi 10 1073 pnas 0931260100 PMC 154354 PMID 12702753 Rubin Harry 2008 Cell cell contact interactions conditionally determine suppression and selection of the neoplastic phenotype Proceedings of the National Academy of Sciences 105 17 6215 6221 Bibcode 2008PNAS 105 6215R doi 10 1073 pnas 0800747105 PMC 2359782 PMID 18434545 Rubin Harry 2011 The early history of tumor virology Rous RIF and RAV Proceedings of the National Academy of Sciences 108 35 14389 14396 Bibcode 2011PNAS 10814389R doi 10 1073 pnas 1108655108 PMC 3167550 PMID 21813762 Rubin Harry 2017 Dynamics of cell transformation in culture and its significance for tumor development in animals Proceedings of the National Academy of Sciences 114 46 12237 12242 doi 10 1073 pnas 1715236114 PMC 5699091 PMID 29087347 References edit biographical information from American Men and Women of Science Thomson Gale 2005 a b Sanders Robert February 7 2020 Virus expert and cancer biologist Harry Rubin dies at 93 Berkeley News UC Berkeley Harry Rubin Department of Cellular amp Molecular Biology UC Berkeley Archived from the original on 2009 01 04 a b c d e f g Martin G Steven 2021 In Memoriam Harry Rubin Academic Senate University of California McCulloch A E December 1949 We re Winning the Battle of Aftosa The Rotarian LXXV 6 26 28 Crow James Franklin Dove William F eds 2000 Perspectives on Genetics Anecdotal Historical and Critical Commentaries 1987 1998 Univ of Wisconsin Press p 540 ISBN 9780299166045 Harry Rubin D V M Cell Biology Tree academictree org Harry Rubin search Gan Shalom Cemetery Contra Costa County Retrieved from https en wikipedia org w index php title Harry Rubin virologist amp oldid 1222232913, wikipedia, wiki, book, books, library,
