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Harden M. McConnell

April 12, 2024

Harden M. McConnell (July 18, 1927 – October 8, 2014) was an American physical chemist. His many awards included the National Medal of Science and the Wolf Prize, and he was elected to the National Academy of Science."[1][2]

Harden M. McConnell
Born(1927-07-18)July 18, 1927
Richmond, Virginia[1]
DiedOctober 8, 2014(2014-10-08) (aged 87)
EducationGeorge Washington University (B.S 1947), California Institute of Technology (Ph.D., 1951)
Known forspin-labeling
AwardsWolf Prize in Chemistry, National Academy of Science
Scientific career
FieldsPhysical chemistry
InstitutionsShell Development Company, California Institute of Technology, Stanford University
Doctoral advisorNorman Davidson, John D. Roberts, Linus Pauling
Doctoral studentsRoger D. Kornberg

Education and career edit

Harden earned a B.S. degree in chemistry from George Washington University in 1947, and his Ph.D. in chemistry from the California Institute of Technology in 1951 with Norman Davidson. After serving for two years as a National Research Fellow in physics at the University of Chicago with Robert S. Mulliken and John Platt, he held a position as research chemist at Shell Development Company. He was recruited by Norman Davidson, John D. Roberts, and Linus Pauling at the California Institute of Technology in 1956 as assistant professor of chemistry, he was promoted to professor of chemistry and physics in 1963, and in 1964 he moved to Stanford University as a professor. In 1979 he was named Robert Eckles Swain Professor of Chemistry at Stanford University. From September 1989 to September 1992, he was head of the department of chemistry at Stanford. On September 1, 2000, Harden was granted emeritus status.[3][4][5]

Research edit

McConnell did important research to the understanding of the relation between molecular electronic structure and electron and nuclear magnetic resonance spectra during the period of 1955 through 1965. After that, he developed the technique of spin-labels, whereby electron and nuclear magnetic resonance spectra can be used to study the structure and kinetics of proteins and membranes.[3]

He recognized that the discovery of nuclear hyperfine interactions in aromatic free radicals represented a major breakthrough in the study of the electronic structure of unsaturated hydrocarbons. His theoretical and experimental studies of nuclear hyperfine interactions in such compounds showed conclusively that this interaction gave a measure of the unpaired electron spin densities on the carbon atoms (see McConnell equation for details). His theoretical and experimental investigations of the anisotropic nuclear hyperfine interactions laid a firm foundation for the analysis of the paramagnetic resonance spectra of organic free radicals in. molecular crystals. His work also provided the first experimental demonstration of a negative spin density at a proton. He also realized that certain nitric oxide free radicals had the potential of providing labels for studying molecular motions. His introduction of 'spin labels' has led to a deep understanding of such motions, and to extensive applications in many biological systems of great interest. These motions include the rates of translational diffusion of lipids in bilayer membranes as well as the rates of trans membrane phospholipid "flip-flop". In fact nitric oxide free radical "spin labels" provided some of the earliest evidence for the fluidity of biological membranes.[3][6]

His later research was concerned with the physical chemistry of biological membranes. These studies range all the way from lipid monolayers at the air-water interface to the regions of membrane-membrane contact that are important in immunology. An important contribution was the introduction of supported lipid bilayers to mimic cell surfaces. For example, this system was used to mimic antigen presentation whereby a specific molecule of the major histocompatibility complex is incorporated into the bilayer, a specific antigenic peptide is added, and the combined system used to stimulate a specific T - helper cell.[7]

In 1983 McConnell founded Molecular Devices Corporation along with three former graduate students and post docs (Gillian Humphries, j. Wallace Parce and Dean Hafeman) together with a talented engineer, Calvin Chow. The company produced instrumentation for biochemical analysis and drug discovery. The company had over 1,000 employees when it was acquired in 2007. McConnell served on the board of directors between 1983 and 2007.[8]

"The majority of the 150 scientists who worked with Harden as graduate students, postdocs, and senior colleagues, attended a symposium on April 4, 1992, at Stanford University, in celebration of Harden's 65th birthday. As an outgrowth of that symposium, these scientists organized special issues of the Biophysical Journal[9] and The Journal of Physical Chemistry[10] to present current aspects of their work and his. Several other scientists whose work has been influenced by McConnell's contributed articles also. The symposium and these papers provide powerful testimony to the profound impact that Harden McConnell has had in the fields of chemical physics, molecular biophysics, and cellular biophysics. McConnell's influence comes not only from his own impressive publication list, but also from the scores of scientists whose careers he has inspired, by his example of intellectual brilliance, and personal integrity."[6] "The McConnell Book: Biographical Sketches and Memoirs of Students and Lab Associates in Celebration of Harden M. McConnell's 65th Birthday," was also published.[11] An updated and expanded version of Harden's research and publications is available as a website.[12]

Awards and honours edit

He was awarded the Wolf Prize in Chemistry in 1983/84 for "his studies of the electronic structure of molecules through paramagnetic resonance spectroscopy and for the introduction and biological applications of spin label techniques".[13]

He has also received several awards and honours. Following are the awards and honours received by Dr. McConnell.

Personal life edit

Harden M. McConnell was born on July 18, 1927, in Richmond, Virginia, and his interest in science, particularly chemistry, began when he discovered a box of copper sulfate crystals in the basement of his home at the approximate age of 12. He died on Wednesday, October 8, 2014.

References edit

  1. ^ a b "Harden Marsden McConnell".
  2. ^ Keith Hodgson, Chair of the Stanford Chemistry Department, in a Departmental email message announcing Harden's death, October 10, 2014.
  3. ^ a b c d Hayes Griffith; Betty J. Gaffney; Alvin L. Kwiram (1993). "Harden M. McConnell: A Celebration of His Scientific Achievements". Journal of Physical Chemistry. 97 (12): 2805–2822. doi:10.1021/j100114a001.
  4. ^ "Report of the President to the Board of Trustees". news.stanford.edu. 23 January 2023.
  5. ^ "Harden M. McConnell, Professor Emeritus," Stanford Chemistry Department 2013-10-21 at the Wayback Machine (accessed October 10, 2014).
  6. ^ a b David D. Thomas; Betty J. Gaffney; O.Hayes Griffith (March 1993). "Harden M. McConnell: The Science Speaks for Itself". Biophysical Journal. 64 (3): 573–960. Bibcode:1993BpJ....64..573T. doi:10.1016/S0006-3495(93)81415-2. PMC 1262368. PMID 19431875.
  7. ^ Harden McConnell (2010). "Adventures in Physical Chemistry". Annual Review of Biophysics. 39: 1–21. doi:10.1146/annurev.biophys.093008.131315. PMID 20462374.
  8. ^ hardenmcconnell.org > Addendum I: Molecular Devices Corporation (accessed October 11, 2014)
  9. ^ Biophysical Journal Volume 64, Issue 3, Pages 573-960 (March 1993) (This issue is made freely available as part of this journal's Open Archive.) (accessed October 11, 2014).
  10. ^ The Journal of Physical Chemistry, Volume 97, Issue 12, Pages 2805-3075, March 1, 1993 (accessed October 11, 2014)
  11. ^ McConnell, Harden M., ed. (May 21, 1992). The McConnell book: biographical sketches and memoirs of students and lab associates in celebration of Harden M. McConnell's 65th birthday, 1992. s.n.] – via Library Catalog (Blacklight).
  12. ^ hardenmcconnell.org (accessed October 11, 2014)
  13. ^ . Archived from the original on 2007-05-17. Retrieved 2007-08-26.
  14. ^ "ACS Award in Pure Chemistry". American Chemical Society.
  15. ^ . Archived from the original on August 14, 2014.
  16. ^ "PEOPLE". Chemical & Engineering News. 46 (38): 36–39. 1968. doi:10.1021/cen-v046n038.p036.
  17. ^ "Irving Langmuir Award in Chemical Physics". American Chemical Society.
  18. ^ ""Harden M. McConnell Winner of Wolf Prize in Chemistry - 1983/1984" Wolf Foundation(accessed October, 10, 2014)".
  19. ^ "Harden McConnell wins Pauling Award". Chemical and Engineering News. 65 (51): 45. 1987. doi:10.1021/cen-v065n051.p045.
  20. ^ . Archived from the original on October 17, 2014.
  21. ^ Stanford School of Humanities and Sciences > Honors and Awards > National Medal of Science 2014-10-18 at the Wayback Machine (accessed October 11, 2014)
  22. ^ "Peter Debye Award in Physical Chemistry". American Chemical Society.
  23. ^ "McConnell named to the first class of Society Fellows of the Biophysical Society". news.stanford.edu. 23 January 2023.
  24. ^ "Harden McConnell named winner of 2002 Welch Award in Chemistry: 06/02". news.stanford.edu. 23 January 2023.

External links edit

  • Research Studies of Harden M. McConnell (Autobiographical)
  • Harden M. McConnell's Citation Profile on Google Scholar
  • Student Theses (Harden M. McConnell as Primary Advisor)
  • The Wolf Prize in Chemistry in 1984/85
  • Harden M. McConnell at the International Academy of Quantum Molecular Science

April 12, 2024
harden, mcconnell, july, 1927, october, 2014, american, physical, chemist, many, awards, included, national, medal, science, wolf, prize, elected, national, academy, science, born, 1927, july, 1927richmond, virginia, diedoctober, 2014, 2014, aged, educationgeo. Harden M McConnell July 18 1927 October 8 2014 was an American physical chemist His many awards included the National Medal of Science and the Wolf Prize and he was elected to the National Academy of Science 1 2 Harden M McConnellBorn 1927 07 18 July 18 1927Richmond Virginia 1 DiedOctober 8 2014 2014 10 08 aged 87 EducationGeorge Washington University B S 1947 California Institute of Technology Ph D 1951 Known forspin labelingAwardsWolf Prize in Chemistry National Academy of ScienceScientific careerFieldsPhysical chemistryInstitutionsShell Development Company California Institute of Technology Stanford UniversityDoctoral advisorNorman Davidson John D Roberts Linus PaulingDoctoral studentsRoger D Kornberg Contents 1 Education and career 2 Research 3 Awards and honours 4 Personal life 5 References 6 External linksEducation and career editHarden earned a B S degree in chemistry from George Washington University in 1947 and his Ph D in chemistry from the California Institute of Technology in 1951 with Norman Davidson After serving for two years as a National Research Fellow in physics at the University of Chicago with Robert S Mulliken and John Platt he held a position as research chemist at Shell Development Company He was recruited by Norman Davidson John D Roberts and Linus Pauling at the California Institute of Technology in 1956 as assistant professor of chemistry he was promoted to professor of chemistry and physics in 1963 and in 1964 he moved to Stanford University as a professor In 1979 he was named Robert Eckles Swain Professor of Chemistry at Stanford University From September 1989 to September 1992 he was head of the department of chemistry at Stanford On September 1 2000 Harden was granted emeritus status 3 4 5 Research editMcConnell did important research to the understanding of the relation between molecular electronic structure and electron and nuclear magnetic resonance spectra during the period of 1955 through 1965 After that he developed the technique of spin labels whereby electron and nuclear magnetic resonance spectra can be used to study the structure and kinetics of proteins and membranes 3 He recognized that the discovery of nuclear hyperfine interactions in aromatic free radicals represented a major breakthrough in the study of the electronic structure of unsaturated hydrocarbons His theoretical and experimental studies of nuclear hyperfine interactions in such compounds showed conclusively that this interaction gave a measure of the unpaired electron spin densities on the carbon atoms see McConnell equation for details His theoretical and experimental investigations of the anisotropic nuclear hyperfine interactions laid a firm foundation for the analysis of the paramagnetic resonance spectra of organic free radicals in molecular crystals His work also provided the first experimental demonstration of a negative spin density at a proton He also realized that certain nitric oxide free radicals had the potential of providing labels for studying molecular motions His introduction of spin labels has led to a deep understanding of such motions and to extensive applications in many biological systems of great interest These motions include the rates of translational diffusion of lipids in bilayer membranes as well as the rates of trans membrane phospholipid flip flop In fact nitric oxide free radical spin labels provided some of the earliest evidence for the fluidity of biological membranes 3 6 His later research was concerned with the physical chemistry of biological membranes These studies range all the way from lipid monolayers at the air water interface to the regions of membrane membrane contact that are important in immunology An important contribution was the introduction of supported lipid bilayers to mimic cell surfaces For example this system was used to mimic antigen presentation whereby a specific molecule of the major histocompatibility complex is incorporated into the bilayer a specific antigenic peptide is added and the combined system used to stimulate a specific T helper cell 7 In 1983 McConnell founded Molecular Devices Corporation along with three former graduate students and post docs Gillian Humphries j Wallace Parce and Dean Hafeman together with a talented engineer Calvin Chow The company produced instrumentation for biochemical analysis and drug discovery The company had over 1 000 employees when it was acquired in 2007 McConnell served on the board of directors between 1983 and 2007 8 The majority of the 150 scientists who worked with Harden as graduate students postdocs and senior colleagues attended a symposium on April 4 1992 at Stanford University in celebration of Harden s 65th birthday As an outgrowth of that symposium these scientists organized special issues of the Biophysical Journal 9 and The Journal of Physical Chemistry 10 to present current aspects of their work and his Several other scientists whose work has been influenced by McConnell s contributed articles also The symposium and these papers provide powerful testimony to the profound impact that Harden McConnell has had in the fields of chemical physics molecular biophysics and cellular biophysics McConnell s influence comes not only from his own impressive publication list but also from the scores of scientists whose careers he has inspired by his example of intellectual brilliance and personal integrity 6 The McConnell Book Biographical Sketches and Memoirs of Students and Lab Associates in Celebration of Harden M McConnell s 65th Birthday was also published 11 An updated and expanded version of Harden s research and publications is available as a website 12 Awards and honours editHe was awarded the Wolf Prize in Chemistry in 1983 84 for his studies of the electronic structure of molecules through paramagnetic resonance spectroscopy and for the introduction and biological applications of spin label techniques 13 He has also received several awards and honours Following are the awards and honours received by Dr McConnell California Section Award of the ACS 1961 3 National ACS Award in Pure Chemistry 1962 14 Election to the National Academy of Sciences 1965 15 Harrison Howe Award ACS 1968 16 Irving Langmuir Award in Chemical Physics American Chemical Society 1972 17 International Academy of Quantum Molecular Sciences 1974 Elected Fellow of the American Association for the Advancement of Science 1982 Dickson Prize for Science Carnegie Mellon University 1982 ISCO Award 1984 Wolf Prize shared with Herbert S Gutowsky and John S Waugh 1984 18 Pauling Medal Puget Sound and Oregon ACS Sections 1987 19 Wheland Medal University of Chicago 1988 U S National Academy of Sciences Award in Chemical Sciences 1988 20 National Medal of Science Chemistry 1989 21 Peter Debye Award in Physical Chemistry ACS 1990 22 Doctor of Science University of Chicago Honorary 1991 Bruker Prize Royal Society of Chemistry 1995 ACS Award in Surface Chemistry 1997 Serbian Academy of Sciences and Arts 1997 Biophysical Society Fellow 1999 23 Zavoisky Award 2000 Welch Award in Chemistry 2002 24 Fellow Royal Society of Chemistry 2008 Fellow International ESR EPR Society 2014 Personal life editHarden M McConnell was born on July 18 1927 in Richmond Virginia and his interest in science particularly chemistry began when he discovered a box of copper sulfate crystals in the basement of his home at the approximate age of 12 He died on Wednesday October 8 2014 References edit a b Harden Marsden McConnell Keith Hodgson Chair of the Stanford Chemistry Department in a Departmental email message announcing Harden s death October 10 2014 a b c d Hayes Griffith Betty J Gaffney Alvin L Kwiram 1993 Harden M McConnell A Celebration of His Scientific Achievements Journal of Physical Chemistry 97 12 2805 2822 doi 10 1021 j100114a001 Report of the President to the Board of Trustees news stanford edu 23 January 2023 Harden M McConnell Professor Emeritus Stanford Chemistry Department Archived 2013 10 21 at the Wayback Machine accessed October 10 2014 a b David D Thomas Betty J Gaffney O Hayes Griffith March 1993 Harden M McConnell The Science Speaks for Itself Biophysical Journal 64 3 573 960 Bibcode 1993BpJ 64 573T doi 10 1016 S0006 3495 93 81415 2 PMC 1262368 PMID 19431875 Harden McConnell 2010 Adventures in Physical Chemistry Annual Review of Biophysics 39 1 21 doi 10 1146 annurev biophys 093008 131315 PMID 20462374 hardenmcconnell org gt Addendum I Molecular Devices Corporation accessed October 11 2014 Biophysical Journal Volume 64 Issue 3 Pages 573 960 March 1993 This issue is made freely available as part of this journal s Open Archive accessed October 11 2014 The Journal of Physical Chemistry Volume 97 Issue 12 Pages 2805 3075 March 1 1993 accessed October 11 2014 McConnell Harden M ed May 21 1992 The McConnell book biographical sketches and memoirs of students and lab associates in celebration of Harden M McConnell s 65th birthday 1992 s n via Library Catalog Blacklight hardenmcconnell org accessed October 11 2014 The Wolf Prize in Chemistry Archived from the original on 2007 05 17 Retrieved 2007 08 26 ACS Award in Pure Chemistry American Chemical Society Harden McConnell National Academy of Sciences gt Member Directory accessed October 10 2014 Archived from the original on August 14 2014 PEOPLE Chemical amp Engineering News 46 38 36 39 1968 doi 10 1021 cen v046n038 p036 Irving Langmuir Award in Chemical Physics American Chemical Society Harden M McConnell Winner of Wolf Prize in Chemistry 1983 1984 Wolf Foundation accessed October 10 2014 Harden McConnell wins Pauling Award Chemical and Engineering News 65 51 45 1987 doi 10 1021 cen v065n051 p045 NAS Award in Chemical Sciences National Academy of Sciences gt Awards accessed October 10 2014 Archived from the original on October 17 2014 Stanford School of Humanities and Sciences gt Honors and Awards gt National Medal of Science Archived 2014 10 18 at the Wayback Machine accessed October 11 2014 Peter Debye Award in Physical Chemistry American Chemical Society McConnell named to the first class of Society Fellows of the Biophysical Society news stanford edu 23 January 2023 Harden McConnell named winner of 2002 Welch Award in Chemistry 06 02 news stanford edu 23 January 2023 External links editResearch Studies of Harden M McConnell Autobiographical Harden M McConnell s Citation Profile on Google Scholar Student Theses Harden M McConnell as Primary Advisor The Wolf Prize in Chemistry in 1984 85 Harden M McConnell at the International Academy of Quantum Molecular Science Retrieved from https en wikipedia org w index php title Harden M McConnell amp oldid 1180813138, wikipedia, wiki, book, books, library,

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