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Hailan Hu

April 25, 2024

In this Chinese name, the family name is Hu.

Hu Hailan (Chinese: 胡海岚; pinyin: Hú Hǎilán; born 1973)[1] is a Chinese neuroscientist, professor, and executive director of the Center for Neuroscience at Zhejiang University School of Medicine in Hangzhou, China.[2] Hu explores neural mechanisms underlying social behaviors and psychiatric diseases. She specifically explores the neural substrates of social rank and the role of neuron-glia interactions in driving depressive behaviors. Hu discovered the anatomical and molecular targets of ketamine's fast-acting antidepressant effects to be localized to the lateral habenular circuits in rodents. Hu was also the first scientist outside of Europe and America to be awarded the IBRO-Kemali Prize in over 20 years. She is also a member of the Jiusan Society.[3]

Hu Hailan
胡海岚
Born1973 (age 50–51)
Dongyang, Zhejiang, China
Alma materPeking University
University of California, Berkeley
Cold Spring Harbor Laboratory
Known forNeural circuits underlying social dominance, habenular neural circuits in depression
Awards2019 IBRO-Kemali International Prize
2016 Tan Jia Zhen Life Science Award
2015 Chinese Young Female scientist Award
2015 Changjiang Scholar Award
2015 L'Oréal-UNESCO For Women in Science
Scientific career
FieldsNeuroscience
InstitutionsZhejiang University School of Medicine

Early life and education edit

Hu was born in Dongyang, Jinhua, Zhejiang province in 1973. Hu pursued her undergraduate degree at Peking University in Beijing, China.[4] In 1996, she received her Bachelors of Science in biochemistry and molecular biology.[5]

Hu then moved to the United States to work as a research technician for one year at the University of California, San Francisco.[5] She then pursued her graduate studies at the University of California, Berkeley.[4] Under the mentorship of Corey S. Goodman, Hu explored the role of the plexin receptor and the Rho family GTPases in central nervous system development in Drosophila.[6] Plexins are receptors involved in axon guidance, and Hu discovered a seven amino acid sequence in plexin, PlexB, which is necessary for Rac-GTP binding and subsequently axon guidance.[7] Interestingly, PlexB inhibits Rac from binding downstream interactors while at the same time enhancing RhoA activity, altogether driving axon guidance.[7] In further work, Hu found that CrossGAP, a GTPase-activating protein, is responsible for regulating Rac dependent-cytoskeletal changes during axon guidance in Drosophila.[8] Hu completed her PhD in 2002.[6]

Following her PhD, Hu pursued her postdoctoral work under the mentorship of Julius Zhu and Roberto Malinow at the University of Virginia.[6] In 2004, Hu moved to the Cold Spring Harbor Laboratory and then to the University of California, San Diego in 2006, to continue working under the mentorship of Malinow.[4] During her postdoc, Hu explored the role of AMPA receptor trafficking in emotional enhancement of memory formation as well as the role of Ras GTPase signalling in fragile X syndrome.[9]

Career and research edit

In 2008, Hu returned to China and joined the Chinese Academy of Sciences Institute of Neuroscience in Shanghai and became the principal investigator of the Hu Lab.[4] Her lab has been focusing on the neural mechanisms of social dominance in mice as well as the neural mechanisms of depression and the antidepressant effects of ketamine.[4] Her lab has pioneered techniques with which to probe the neural correlates of social rank.[4] In 2015, Hu was recruited to become a professor and senior investigator at the QuiShi Academy for Advanced Studies within the Medical School of Zhejiang University in Hangzhou, China. Hu also became the executive director at the Center for Neuroscience at Zhejiang University School of Medicine.[1]

Neural circuit mechanisms of social dominance edit

Hu and her lab pioneered the study of neural circuit mechanisms governing social rank. In 2011, they showed that neurons in the medial prefrontal cortex of mice encode rank-specific information.[10] Mice with higher social rank had increased strength of excitatory inputs in the layer IV pyramidal neurons of the mPFC compared to more subordinate mice.[10] Further, manipulating the synaptic strength in the mPFC led to upward or downward movement in the social hierarchy, suggesting that these neurons are fundamental in the neural processes governing social rank.[10]

Hu and her team subsequently explored the effects of winning a social competition on social neural circuits across dominance rank.[11] They found that activating the dorsomedial prefrontal cortex (dmPFC) induces winning in social competitions.[11] Specifically, the medial dorsal thalamic (MDT) inputs to the dmPFC, when stimulated, led to increased dominance behavior through increased initiations of competitions and more effortful behaviors.[11] They propose that mPFC neural computations are fundamental in guiding dominance based behaviors, such as competition.[11]

An important contribution that Hu and her team made to the field was the establishment of reliable tests to assess dominance rank in a hierarchy.[12] They use a behavioral assay called the "tube test" to obtain information about a mouse's rank.[12] This test involves two mice from a cage meeting head to head in a small tube.[12] Since both mice cannot fit to pass each other in the tube, one mouse is pushed by the other. The winner of this social encounter is the mouse that pushes the other mouse out.[12] The tube test is performed in a round-robin type fashion such that the mouse that wins the mouse encounters across several days and continues to win in a stable way is deemed the dominant mouse.[12] The correlation between tube test wins and dominance allows a researcher to then probe the neural correlates of dominance or other biological phenomena in relation to dominance.[12]

Neural and glial mechanisms of depression edit

Hu and her team study the neural circuit mechanisms driving depression in rodent models.[13] They found in 2013 that the lateral habenula (LHb) circuits play a role in depression through neuronal adaptations associated with the enzyme BCamKII upregulation.[13] Increases in BCamKII lead to increased excitatory synaptic transmission and action potential firing through increased expression of a specific subtype of glutamate receptors.[13] Overall habenular hyperactivity was associated with depressive phenotypes.[13]

In a following study, Hu and her team further explored the mechanisms of habenular hyperactivity.[14] Using a proteomic analysis, they found evidence of upregulation of an astrocytic potassium channel, Kir4.1, in rat models of depression and the expression profiles of this channel seem to be localized to the synaptic junctions between astrocytes and neuronal somas.[14] Hu found that these channels tightly regulate neuronal bursting and excitability of neurons in the LHb.[14] By manipulating the expression levels of Kir4.1, Hu and her team showed that astrocytic Kir4.1 bidirectionally regulates the hyperexcitability of neurons as well as depressive behavioral symptoms highlighting the role of glia-neuron interactions in psychiatric illnesses such as depression.[14]

Hu and her colleagues then explored the potential of using ketamine to target the burst firing/hyperactivity in lateral habenula neurons that was leading to depressive phenotypes.[15] Ketamine has been previously shown to be effective as a rapid antidepressant, yet the mechanisms of action have not yet been completely elucidated.[15] They showed that blocking the NMDAR-dependent burst firing in the LHb, through ketamine administration, is able to alleviate symptoms of depression in rodent models.[15] The blocking of LHb hyperactivity appears to disinhibit downstream monoaminergic reward centers thereby exerting antidepressant effects on habenular circuitry.[15]

Awards and honors edit

  • 2019 Prize for Scientific and Technological Progress Ho Leung Ho Lee Foundation[16]
  • 2019 IBRO-Kemali International Prize for research in basic and clinical neurosciences[1]
  • 2016 Tan Jia Zhen Life Science Award[17]
  • 2015 Chinese Young Female scientist Award[18]
  • 2015 Chang Jiang Scholar Award[17]
  • 2015 L'Oréal-UNESCO For Women in Science[19]
  • 2013 Meiji Life Science Outstanding Award[20]
  • 2012 Chinese Outstanding Youth Award[20]
  • 2012 and 2014 Excellent Mentorship Award of Chinese Academy of Sciences[20]
  • 2010-2012 Shanghai Pujiang Talent Award[20]
  • 2009-2012 Chinese Hundred Talent Plan Award[20]
  • 2003-2006 Damon Runyon Foundation Postdoctoral Fellowship[20]
  • 2002 HHMI and IBRO fellowships for MBL Neurobiology Course [20]
  • 1998-2003 Howard Hughes Medical Institute Predoctoral Fellowship[20]

Select publications edit

  • Hu H, Cui Y, Yang Y. Circuits and functions of the lateral habenula in health and in disease. Nature Reviews. Neuroscience. 2020 PMID 32269316 DOI: 10.1038/s41583-020-0292-4[9]
  • Gao Z, Hu H. Star-like cells spark behavioural hyperactivity in mice. Nature. 2019 571: 43–44. PMID 31263260 DOI: 10.1038/d41586-019-01949-2 [9]
  • Cui Y, Hu S, Hu H. Lateral Habenular Burst Firing as a Target of the Rapid Antidepressant Effects of Ketamine. Trends in Neurosciences. 2019 42: 179–191. PMID 30823984 DOI: 10.1016/j.tins.2018.12.002 [9]
  • Fan Z, Zhu H, Zhou T, Wang S, Wu Y, Hu H. Using the tube test to measure social hierarchy in mice. Nature Protocols. 2019 PMID 30770887 DOI: 10.1038/s41596-018-0116-4 [9]
  • Cui Y, Yang Y, Dong Y, Hu H. Decoding Depression: Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula. Cold Spring Harbor Symposia On Quantitative Biology. PMID 30718267 DOI: 10.1101/sqb.2018.83.036871 [9]
  • Yang Y, Cui Y, Sang K, Dong Y, Ni Z, Ma S, Hu H. Ketamine blocks bursting in the lateral habenula to rapidly relieve depression. Nature. 2018 554: 317–322. PMID 29446381 DOI: 10.1038/nature25509 [9]
  • Cui Y, Yang Y, Ni Z, Dong Y, Cai G, Foncelle A, Ma S, Sang K, Tang S, Li Y, Shen Y, Berry H, Wu S, Hu H. Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression. Nature. 2018  554: 323–327. PMID 29446379 DOI: 10.1038/nature25752 [9]
  • Zhou T, Zhu H, Fan Z, Wang F, Chen Y, Liang H, Yang Z, Zhang L, Lin L, Zhan Y, Wang Z, Hu H. History of winning remodels thalamo-PFC circuit to reinforce social dominance. Science 2017 (New York, N.Y.). 357: 162–168. PMID 28706064 DOI: 10.1126/science.aak9726 [9]
  • Wang F, Zhu J, Zhu H, Zhang Q, Lin Z, Hu H. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science 2011 (New York, N.Y.). 334: 693–7. PMID 21960531 DOI: 10.1126/science.1209951 [9]
  • Hu H, Qin Y, Bochorishvili G, Zhu Y, van Aelst L, Zhu JJ. Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 2008 28: 7847–62. PMID 18667617 DOI: 10.1523/JNEUROSCI.1496-08.2008 [9]
  • Hu H, Real E, Takamiya K, Kang MG, Ledoux J, Huganir RL, Malinow R. Emotion enhances learning via norepinephrine regulation of AMPA-receptor trafficking. Cell. 2007 131: 160–73. PMID 17923095 DOI: 10.1016/j.cell.2007.09.017 [9]
  • Hu H, Marton TF, Goodman CS. Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling. Neuron. 2001 32: 39–51. PMID 11604137 DOI: 10.1016/S0896-6273(01)00453-6[9]

References edit

  1. ^ a b c "Female Chinese Scholar Is First Asian to Win IBRO-Kemali International Prize for Neuroscience". www.yicaiglobal.com. Retrieved 2020-05-19.
  2. ^ Peng Dingning (彭叮咛) (2022). 胡海岚：解开抑郁症的秘密 [Hu Hailan: Unlocking the Secret of Depression]. Culture and History Vision (in Chinese). 638. Yuhua District, Changsha, Hunan: Integrated Media Center of the Hunan Provincial Committee of the Chinese People's Political Consultative Conference: 54–55. ISSN 1672-8653.
  3. ^ "胡海岚：2022年世界杰出女科学家成就奖". 93.gov.cn. Retrieved 16 September 2022.
  4. ^ a b c d e f O’Meara, Sarah (2018-05-30). "The zest of Zhejiang". Nature. 557 (7707): S53. Bibcode:2018Natur.557S..53O. doi:10.1038/d41586-018-05266-y. PMID 29844557.
  5. ^ a b "Hailan Hu Lab" (PDF). Retrieved May 18, 2020.
  6. ^ a b c "Neurotree - Hailan Hu". neurotree.org. Retrieved 2020-05-19.
  7. ^ a b Hu, Hailan; Marton, Tobias F.; Goodman, Corey S. (2001-10-11). "Plexin B Mediates Axon Guidance in Drosophila by Simultaneously Inhibiting Active Rac and Enhancing RhoA Signaling". Neuron. 32 (1): 39–51. doi:10.1016/S0896-6273(01)00453-6. ISSN 0896-6273. PMID 11604137. S2CID 18847228.
  8. ^ Hu, Hailan; Li, Ming; Labrador, Juan-Pablo; McEwen, Jason; Lai, Eric C.; Goodman, Corey S.; Bashaw, Greg J. (2005-03-22). "Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion". Proceedings of the National Academy of Sciences. 102 (12): 4613–4618. Bibcode:2005PNAS..102.4613H. doi:10.1073/pnas.0409325102. ISSN 0027-8424. PMC 555501. PMID 15755809.
  9. ^ a b c d e f g h i j k l m "Hailan Hu Publications". Retrieved May 18, 2020.
  10. ^ a b c Wang, Fei; Zhu, Jun; Zhu, Hong; Zhang, Qi; Lin, Zhanmin; Hu, Hailan (2011-11-04). "Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex". Science. 334 (6056): 693–697. Bibcode:2011Sci...334..693W. doi:10.1126/science.1209951. ISSN 0036-8075. PMID 21960531. S2CID 15173160.
  11. ^ a b c d Zhou, Tingting; Zhu, Hong; Fan, Zhengxiao; Wang, Fei; Chen, Yang; Liang, Hexing; Yang, Zhongfei; Zhang, Lu; Lin, Longnian; Zhan, Yang; Wang, Zheng (2017-07-14). "History of winning remodels thalamo-PFC circuit to reinforce social dominance". Science. 357 (6347): 162–168. Bibcode:2017Sci...357..162Z. doi:10.1126/science.aak9726. ISSN 0036-8075. PMID 28706064.
  12. ^ a b c d e f Fan, Zhengxiao; Zhu, Hong; Zhou, Tingting; Wang, Sheng; Wu, Yan; Hu, Hailan (March 2019). "Using the tube test to measure social hierarchy in mice". Nature Protocols. 14 (3): 819–831. doi:10.1038/s41596-018-0116-4. ISSN 1750-2799. PMID 30770887. S2CID 62880228.
  13. ^ a b c d Li, Kun; Zhou, Tao; Liao, Lujian; Yang, Zhongfei; Wong, Catherine; Henn, Fritz; Malinow, Roberto; Yates, John R.; Hu, Hailan (2013-08-30). "βCaMKII in Lateral Habenula Mediates Core Symptoms of Depression". Science. 341 (6149): 1016–1020. Bibcode:2013Sci...341.1016L. doi:10.1126/science.1240729. ISSN 0036-8075. PMC 3932364. PMID 23990563.
  14. ^ a b c d Cui, Yihui; Yang, Yan; Ni, Zheyi; Dong, Yiyan; Cai, Guohong; Foncelle, Alexandre; Ma, Shuangshuang; Sang, Kangning; Tang, Siyang; Li, Yuezhou; Shen, Ying (February 2018). "Astroglial Kir4.1 in the lateral habenula drives neuronal bursts in depression". Nature. 554 (7692): 323–327. Bibcode:2018Natur.554..323C. doi:10.1038/nature25752. ISSN 1476-4687. PMID 29446379. S2CID 205264212.
  15. ^ a b c d Yang, Yan; Cui, Yihui; Sang, Kangning; Dong, Yiyan; Ni, Zheyi; Ma, Shuangshuang; Hu, Hailan (February 2018). "Ketamine blocks bursting in the lateral habenula to rapidly relieve depression". Nature. 554 (7692): 317–322. Bibcode:2018Natur.554..317Y. doi:10.1038/nature25509. ISSN 1476-4687. PMID 29446381. S2CID 3334820.
  16. ^ "Prof. HU Hailan honored with the 2019 Prize by the Ho Leung Ho Lee Foundation". www.zju.edu.cn. Retrieved 2020-05-19.
  17. ^ a b "IBRO2019". ibro.cjint.kr. Retrieved 2020-05-19.
  18. ^ "9位女科学家获2015年"中国青年女科学家奖"". Retrieved May 18, 2020.
  19. ^ "Prof. Hu Hailan Wins 12th L'Oréal-UNESCO For Women in Science China Fellowships-Archives-Zhejiang University". www.zju.edu.cn. Retrieved 2020-05-19.
  20. ^ a b c d e f g h "Hailan Hu-Zhejiang University Personal homepage". person.zju.edu.cn. Retrieved 2020-05-19.

April 25, 2024
hailan, this, chinese, name, family, name, hailan, chinese, 胡海岚, pinyin, hǎilán, born, 1973, chinese, neuroscientist, professor, executive, director, center, neuroscience, zhejiang, university, school, medicine, hangzhou, china, explores, neural, mechanisms, u. In this Chinese name the family name is Hu Hu Hailan Chinese 胡海岚 pinyin Hu Hǎilan born 1973 1 is a Chinese neuroscientist professor and executive director of the Center for Neuroscience at Zhejiang University School of Medicine in Hangzhou China 2 Hu explores neural mechanisms underlying social behaviors and psychiatric diseases She specifically explores the neural substrates of social rank and the role of neuron glia interactions in driving depressive behaviors Hu discovered the anatomical and molecular targets of ketamine s fast acting antidepressant effects to be localized to the lateral habenular circuits in rodents Hu was also the first scientist outside of Europe and America to be awarded the IBRO Kemali Prize in over 20 years She is also a member of the Jiusan Society 3 Hu Hailan胡海岚Born1973 age 50 51 Dongyang Zhejiang ChinaAlma materPeking UniversityUniversity of California BerkeleyCold Spring Harbor LaboratoryKnown forNeural circuits underlying social dominance habenular neural circuits in depressionAwards2019 IBRO Kemali International Prize2016 Tan Jia Zhen Life Science Award2015 Chinese Young Female scientist Award2015 Changjiang Scholar Award2015 L Oreal UNESCO For Women in ScienceScientific careerFieldsNeuroscienceInstitutionsZhejiang University School of Medicine Contents 1 Early life and education 2 Career and research 2 1 Neural circuit mechanisms of social dominance 2 2 Neural and glial mechanisms of depression 3 Awards and honors 4 Select publications 5 ReferencesEarly life and education editHu was born in Dongyang Jinhua Zhejiang province in 1973 Hu pursued her undergraduate degree at Peking University in Beijing China 4 In 1996 she received her Bachelors of Science in biochemistry and molecular biology 5 Hu then moved to the United States to work as a research technician for one year at the University of California San Francisco 5 She then pursued her graduate studies at the University of California Berkeley 4 Under the mentorship of Corey S Goodman Hu explored the role of the plexin receptor and the Rho family GTPases in central nervous system development in Drosophila 6 Plexins are receptors involved in axon guidance and Hu discovered a seven amino acid sequence in plexin PlexB which is necessary for Rac GTP binding and subsequently axon guidance 7 Interestingly PlexB inhibits Rac from binding downstream interactors while at the same time enhancing RhoA activity altogether driving axon guidance 7 In further work Hu found that CrossGAP a GTPase activating protein is responsible for regulating Rac dependent cytoskeletal changes during axon guidance in Drosophila 8 Hu completed her PhD in 2002 6 Following her PhD Hu pursued her postdoctoral work under the mentorship of Julius Zhu and Roberto Malinow at the University of Virginia 6 In 2004 Hu moved to the Cold Spring Harbor Laboratory and then to the University of California San Diego in 2006 to continue working under the mentorship of Malinow 4 During her postdoc Hu explored the role of AMPA receptor trafficking in emotional enhancement of memory formation as well as the role of Ras GTPase signalling in fragile X syndrome 9 Career and research editIn 2008 Hu returned to China and joined the Chinese Academy of Sciences Institute of Neuroscience in Shanghai and became the principal investigator of the Hu Lab 4 Her lab has been focusing on the neural mechanisms of social dominance in mice as well as the neural mechanisms of depression and the antidepressant effects of ketamine 4 Her lab has pioneered techniques with which to probe the neural correlates of social rank 4 In 2015 Hu was recruited to become a professor and senior investigator at the QuiShi Academy for Advanced Studies within the Medical School of Zhejiang University in Hangzhou China Hu also became the executive director at the Center for Neuroscience at Zhejiang University School of Medicine 1 Neural circuit mechanisms of social dominance edit Hu and her lab pioneered the study of neural circuit mechanisms governing social rank In 2011 they showed that neurons in the medial prefrontal cortex of mice encode rank specific information 10 Mice with higher social rank had increased strength of excitatory inputs in the layer IV pyramidal neurons of the mPFC compared to more subordinate mice 10 Further manipulating the synaptic strength in the mPFC led to upward or downward movement in the social hierarchy suggesting that these neurons are fundamental in the neural processes governing social rank 10 Hu and her team subsequently explored the effects of winning a social competition on social neural circuits across dominance rank 11 They found that activating the dorsomedial prefrontal cortex dmPFC induces winning in social competitions 11 Specifically the medial dorsal thalamic MDT inputs to the dmPFC when stimulated led to increased dominance behavior through increased initiations of competitions and more effortful behaviors 11 They propose that mPFC neural computations are fundamental in guiding dominance based behaviors such as competition 11 An important contribution that Hu and her team made to the field was the establishment of reliable tests to assess dominance rank in a hierarchy 12 They use a behavioral assay called the tube test to obtain information about a mouse s rank 12 This test involves two mice from a cage meeting head to head in a small tube 12 Since both mice cannot fit to pass each other in the tube one mouse is pushed by the other The winner of this social encounter is the mouse that pushes the other mouse out 12 The tube test is performed in a round robin type fashion such that the mouse that wins the mouse encounters across several days and continues to win in a stable way is deemed the dominant mouse 12 The correlation between tube test wins and dominance allows a researcher to then probe the neural correlates of dominance or other biological phenomena in relation to dominance 12 Neural and glial mechanisms of depression edit Hu and her team study the neural circuit mechanisms driving depression in rodent models 13 They found in 2013 that the lateral habenula LHb circuits play a role in depression through neuronal adaptations associated with the enzyme BCamKII upregulation 13 Increases in BCamKII lead to increased excitatory synaptic transmission and action potential firing through increased expression of a specific subtype of glutamate receptors 13 Overall habenular hyperactivity was associated with depressive phenotypes 13 In a following study Hu and her team further explored the mechanisms of habenular hyperactivity 14 Using a proteomic analysis they found evidence of upregulation of an astrocytic potassium channel Kir4 1 in rat models of depression and the expression profiles of this channel seem to be localized to the synaptic junctions between astrocytes and neuronal somas 14 Hu found that these channels tightly regulate neuronal bursting and excitability of neurons in the LHb 14 By manipulating the expression levels of Kir4 1 Hu and her team showed that astrocytic Kir4 1 bidirectionally regulates the hyperexcitability of neurons as well as depressive behavioral symptoms highlighting the role of glia neuron interactions in psychiatric illnesses such as depression 14 Hu and her colleagues then explored the potential of using ketamine to target the burst firing hyperactivity in lateral habenula neurons that was leading to depressive phenotypes 15 Ketamine has been previously shown to be effective as a rapid antidepressant yet the mechanisms of action have not yet been completely elucidated 15 They showed that blocking the NMDAR dependent burst firing in the LHb through ketamine administration is able to alleviate symptoms of depression in rodent models 15 The blocking of LHb hyperactivity appears to disinhibit downstream monoaminergic reward centers thereby exerting antidepressant effects on habenular circuitry 15 Awards and honors edit2019 Prize for Scientific and Technological Progress Ho Leung Ho Lee Foundation 16 2019 IBRO Kemali International Prize for research in basic and clinical neurosciences 1 2016 Tan Jia Zhen Life Science Award 17 2015 Chinese Young Female scientist Award 18 2015 Chang Jiang Scholar Award 17 2015 L Oreal UNESCO For Women in Science 19 2013 Meiji Life Science Outstanding Award 20 2012 Chinese Outstanding Youth Award 20 2012 and 2014 Excellent Mentorship Award of Chinese Academy of Sciences 20 2010 2012 Shanghai Pujiang Talent Award 20 2009 2012 Chinese Hundred Talent Plan Award 20 2003 2006 Damon Runyon Foundation Postdoctoral Fellowship 20 2002 HHMI and IBRO fellowships for MBL Neurobiology Course 20 1998 2003 Howard Hughes Medical Institute Predoctoral Fellowship 20 Select publications editHu H Cui Y Yang Y Circuits and functions of the lateral habenula in health and in disease Nature Reviews Neuroscience 2020 PMID 32269316 DOI 10 1038 s41583 020 0292 4 9 Gao Z Hu H Star like cells spark behavioural hyperactivity in mice Nature 2019 571 43 44 PMID 31263260 DOI 10 1038 d41586 019 01949 2 9 Cui Y Hu S Hu H Lateral Habenular Burst Firing as a Target of the Rapid Antidepressant Effects of Ketamine Trends in Neurosciences 2019 42 179 191 PMID 30823984 DOI 10 1016 j tins 2018 12 002 9 Fan Z Zhu H Zhou T Wang S Wu Y Hu H Using the tube test to measure social hierarchy in mice Nature Protocols 2019 PMID 30770887 DOI 10 1038 s41596 018 0116 4 9 Cui Y Yang Y Dong Y Hu H Decoding Depression Insights from Glial and Ketamine Regulation of Neuronal Burst Firing in Lateral Habenula Cold Spring Harbor Symposia On Quantitative Biology PMID 30718267 DOI 10 1101 sqb 2018 83 036871 9 Yang Y Cui Y Sang K Dong Y Ni Z Ma S Hu H Ketamine blocks bursting in the lateral habenula to rapidly relieve depression Nature 2018 554 317 322 PMID 29446381 DOI 10 1038 nature25509 9 Cui Y Yang Y Ni Z Dong Y Cai G Foncelle A Ma S Sang K Tang S Li Y Shen Y Berry H Wu S Hu H Astroglial Kir4 1 in the lateral habenula drives neuronal bursts in depression Nature 2018 554 323 327 PMID 29446379 DOI 10 1038 nature25752 9 Zhou T Zhu H Fan Z Wang F Chen Y Liang H Yang Z Zhang L Lin L Zhan Y Wang Z Hu H History of winning remodels thalamo PFC circuit to reinforce social dominance Science 2017 New York N Y 357 162 168 PMID 28706064 DOI 10 1126 science aak9726 9 Wang F Zhu J Zhu H Zhang Q Lin Z Hu H Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex Science 2011 New York N Y 334 693 7 PMID 21960531 DOI 10 1126 science 1209951 9 Hu H Qin Y Bochorishvili G Zhu Y van Aelst L Zhu JJ Ras signaling mechanisms underlying impaired GluR1 dependent plasticity associated with fragile X syndrome The Journal of Neuroscience the Official Journal of the Society For Neuroscience 2008 28 7847 62 PMID 18667617 DOI 10 1523 JNEUROSCI 1496 08 2008 9 Hu H Real E Takamiya K Kang MG Ledoux J Huganir RL Malinow R Emotion enhances learning via norepinephrine regulation of AMPA receptor trafficking Cell 2007 131 160 73 PMID 17923095 DOI 10 1016 j cell 2007 09 017 9 Hu H Marton TF Goodman CS Plexin B mediates axon guidance in Drosophila by simultaneously inhibiting active Rac and enhancing RhoA signaling Neuron 2001 32 39 51 PMID 11604137 DOI 10 1016 S0896 6273 01 00453 6 9 References edit a b c Female Chinese Scholar Is First Asian to Win IBRO Kemali International Prize for Neuroscience www yicaiglobal com Retrieved 2020 05 19 Peng Dingning 彭叮咛 2022 胡海岚 解开抑郁症的秘密 Hu Hailan Unlocking the Secret of Depression Culture and History Vision in Chinese 638 Yuhua District Changsha Hunan Integrated Media Center of the Hunan Provincial Committee of the Chinese People s Political Consultative Conference 54 55 ISSN 1672 8653 胡海岚 2022年世界杰出女科学家成就奖 93 gov cn Retrieved 16 September 2022 a b c d e f O Meara Sarah 2018 05 30 The zest of Zhejiang Nature 557 7707 S53 Bibcode 2018Natur 557S 53O doi 10 1038 d41586 018 05266 y PMID 29844557 a b Hailan Hu Lab PDF Retrieved May 18 2020 a b c Neurotree Hailan Hu neurotree org Retrieved 2020 05 19 a b Hu Hailan Marton Tobias F Goodman Corey S 2001 10 11 Plexin B Mediates Axon Guidance in Drosophila by Simultaneously Inhibiting Active Rac and Enhancing RhoA Signaling Neuron 32 1 39 51 doi 10 1016 S0896 6273 01 00453 6 ISSN 0896 6273 PMID 11604137 S2CID 18847228 Hu Hailan Li Ming Labrador Juan Pablo McEwen Jason Lai Eric C Goodman Corey S Bashaw Greg J 2005 03 22 Cross GTPase activating protein CrossGAP Vilse links the Roundabout receptor to Rac to regulate midline repulsion Proceedings of the National Academy of Sciences 102 12 4613 4618 Bibcode 2005PNAS 102 4613H doi 10 1073 pnas 0409325102 ISSN 0027 8424 PMC 555501 PMID 15755809 a b c d e f g h i j k l m Hailan Hu Publications Retrieved May 18 2020 a b c Wang Fei Zhu Jun Zhu Hong Zhang Qi Lin Zhanmin Hu Hailan 2011 11 04 Bidirectional Control of Social Hierarchy by Synaptic Efficacy in Medial Prefrontal Cortex Science 334 6056 693 697 Bibcode 2011Sci 334 693W doi 10 1126 science 1209951 ISSN 0036 8075 PMID 21960531 S2CID 15173160 a b c d Zhou Tingting Zhu Hong Fan Zhengxiao Wang Fei Chen Yang Liang Hexing Yang Zhongfei Zhang Lu Lin Longnian Zhan Yang Wang Zheng 2017 07 14 History of winning remodels thalamo PFC circuit to reinforce social dominance Science 357 6347 162 168 Bibcode 2017Sci 357 162Z doi 10 1126 science aak9726 ISSN 0036 8075 PMID 28706064 a b c d e f Fan Zhengxiao Zhu Hong Zhou Tingting Wang Sheng Wu Yan Hu Hailan March 2019 Using the tube test to measure social hierarchy in mice Nature Protocols 14 3 819 831 doi 10 1038 s41596 018 0116 4 ISSN 1750 2799 PMID 30770887 S2CID 62880228 a b c d Li Kun Zhou Tao Liao Lujian Yang Zhongfei Wong Catherine Henn Fritz Malinow Roberto Yates John R Hu Hailan 2013 08 30 bCaMKII in Lateral Habenula Mediates Core Symptoms of Depression Science 341 6149 1016 1020 Bibcode 2013Sci 341 1016L doi 10 1126 science 1240729 ISSN 0036 8075 PMC 3932364 PMID 23990563 a b c d Cui Yihui Yang Yan Ni Zheyi Dong Yiyan Cai Guohong Foncelle Alexandre Ma Shuangshuang Sang Kangning Tang Siyang Li Yuezhou Shen Ying February 2018 Astroglial Kir4 1 in the lateral habenula drives neuronal bursts in depression Nature 554 7692 323 327 Bibcode 2018Natur 554 323C doi 10 1038 nature25752 ISSN 1476 4687 PMID 29446379 S2CID 205264212 a b c d Yang Yan Cui Yihui Sang Kangning Dong Yiyan Ni Zheyi Ma Shuangshuang Hu Hailan February 2018 Ketamine blocks bursting in the lateral habenula to rapidly relieve depression Nature 554 7692 317 322 Bibcode 2018Natur 554 317Y doi 10 1038 nature25509 ISSN 1476 4687 PMID 29446381 S2CID 3334820 Prof HU Hailan honored with the 2019 Prize by the Ho Leung Ho Lee Foundation www zju edu cn Retrieved 2020 05 19 a b IBRO2019 ibro cjint kr Retrieved 2020 05 19 9位女科学家获2015年 中国青年女科学家奖 Retrieved May 18 2020 Prof Hu Hailan Wins 12th L Oreal UNESCO For Women in Science China Fellowships Archives Zhejiang University www zju edu cn Retrieved 2020 05 19 a b c d e f g h Hailan Hu Zhejiang University Personal homepage person zju edu cn Retrieved 2020 05 19 Retrieved from https en wikipedia org w index php title Hailan Hu amp oldid 1153999533, wikipedia, wiki, book, books, library,

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