The enzyme 17-beta hydroxysteroid dehydrogenase-12 (HSD17B12) uses NADPH to reduce 3-ketoacyl-CoA to 3-hydroxyacyl-CoA during the second step of fatty acid elongation.[supplied by OMIM][7]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000149084 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000027195 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Moon YA, Horton JD (Feb 2003). "Identification of two mammalian reductases involved in the two-carbon fatty acyl elongation cascade". J Biol Chem. 278 (9): 7335–43. doi:10.1074/jbc.M211684200. PMID 12482854.
^Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC2896744. PMID 19027726.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Luu-The V, Tremblay P, Labrie F (2006). "Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women". Mol. Endocrinol. 20 (2): 437–43. doi:10.1210/me.2005-0058. PMID 16166196.
Sakurai N, Miki Y, Suzuki T, et al. (2006). "Systemic distribution and tissue localizations of human 17beta-hydroxysteroid dehydrogenase type 12". J. Steroid Biochem. Mol. Biol. 99 (4–5): 174–81. doi:10.1016/j.jsbmb.2006.01.010. PMID 16621523. S2CID 22249124.
This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
hsd17b12, estradiol, beta, dehydrogenase, enzyme, that, humans, encoded, gene, identifiersaliases, sdr12c1, hydroxysteroid, beta, dehydrogenase, hydroxysteroid, beta, dehydrogenase, 12external, idsomim, 609574, 1926967, homologene, 95094, genecards, orthologsg. Estradiol 17 beta dehydrogenase 12 is an enzyme that in humans is encoded by the HSD17B12 gene 5 6 7 HSD17B12IdentifiersAliasesHSD17B12 KAR SDR12C1 hydroxysteroid 17 beta dehydrogenase 12 hydroxysteroid 17 beta dehydrogenase 12External IDsOMIM 609574 MGI 1926967 HomoloGene 95094 GeneCards HSD17B12 OMA HSD17B12 orthologsGene location Human Chr Chromosome 11 human 1 Band11p11 2Start43 680 680 bp 1 End43 856 617 bp 1 Gene location Mouse Chr Chromosome 2 mouse 2 Band2 2 E1Start93 863 034 bp 2 End93 988 309 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendothelial cellretinal pigment epitheliumpancreatic ductal celloptic nerveinferior ganglion of vagus nervecardiarenal medullaspinal gangliapericardiumpylorusTop expressed inbrown adipose tissuecumulus cellleft lobe of liverciliary bodyirissciatic nervelipmammary glandretinal pigment epitheliumsubcutaneous adipose tissueMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionheparin binding estradiol 17 beta dehydrogenase activity oxidoreductase activity collagen binding fibronectin binding protein binding 3 oxo lignoceroyl CoA reductase activity 3 oxo behenoyl CoA reductase activity long chain 3 hydroxyacyl CoA dehydrogenase activity 3 oxo arachidoyl CoA reductase activity 3 oxo cerotoyl CoA reductase activityCellular componentintegral component of membrane membrane endoplasmic reticulum endoplasmic reticulum membrane extracellular matrixBiological processlipid metabolism extracellular matrix organization long chain fatty acyl CoA biosynthetic process positive regulation of cell substrate adhesion fatty acid biosynthetic process estrogen biosynthetic process steroid biosynthetic processSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez5114456348EnsemblENSG00000149084ENSMUSG00000027195UniProtQ53GQ0O70503RefSeq mRNA NM 016142NM 019657RefSeq protein NP 057226NP 062631Location UCSC Chr 11 43 68 43 86 MbChr 2 93 86 93 99 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse The enzyme 17 beta hydroxysteroid dehydrogenase 12 HSD17B12 uses NADPH to reduce 3 ketoacyl CoA to 3 hydroxyacyl CoA during the second step of fatty acid elongation supplied by OMIM 7 References edit a b c GRCh38 Ensembl release 89 ENSG00000149084 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000027195 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Moon YA Horton JD Feb 2003 Identification of two mammalian reductases involved in the two carbon fatty acyl elongation cascade J Biol Chem 278 9 7335 43 doi 10 1074 jbc M211684200 PMID 12482854 Persson B Kallberg Y Bray JE Bruford E Dellaporta SL Favia AD Duarte RG Jornvall H Kavanagh KL Kedishvili N Kisiela M Maser E Mindnich R Orchard S Penning TM Thornton JM Adamski J Oppermann U Feb 2009 The SDR short chain dehydrogenase reductase and related enzymes nomenclature initiative Chem Biol Interact 178 1 3 94 8 Bibcode 2009CBI 178 94P doi 10 1016 j cbi 2008 10 040 PMC 2896744 PMID 19027726 a b Entrez Gene HSD17B12 hydroxysteroid 17 beta dehydrogenase 12 Further reading editMaruyama K Sugano S 1994 Oligo capping a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides Gene 138 1 2 171 4 doi 10 1016 0378 1119 94 90802 8 PMID 8125298 Suzuki Y Yoshitomo Nakagawa K Maruyama K et al 1997 Construction and characterization of a full length enriched and a 5 end enriched cDNA library Gene 200 1 2 149 56 doi 10 1016 S0378 1119 97 00411 3 PMID 9373149 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Suzuki Y Yamashita R Shirota M et al 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions Genome Res 14 9 1711 8 doi 10 1101 gr 2435604 PMC 515316 PMID 15342556 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Gnatenko DV Cupit LD Huang EC et al 2005 Platelets express steroidogenic 17beta hydroxysteroid dehydrogenases Distinct profiles predict the essential thrombocythemic phenotype Thromb Haemost 94 2 412 21 doi 10 1160 TH05 01 0037 PMID 16113833 S2CID 257259321 Luu The V Tremblay P Labrie F 2006 Characterization of type 12 17beta hydroxysteroid dehydrogenase an isoform of type 3 17beta hydroxysteroid dehydrogenase responsible for estradiol formation in women Mol Endocrinol 20 2 437 43 doi 10 1210 me 2005 0058 PMID 16166196 Sakurai N Miki Y Suzuki T et al 2006 Systemic distribution and tissue localizations of human 17beta hydroxysteroid dehydrogenase type 12 J Steroid Biochem Mol Biol 99 4 5 174 81 doi 10 1016 j jsbmb 2006 01 010 PMID 16621523 S2CID 22249124 nbsp This article on a gene on human chromosome 11 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title HSD17B12 amp oldid 1216742015, wikipedia, wiki, book, books, library,
