Caetano-Anolles obtained his doctorate in biochemistry at the National University of La Plata in Argentina in 1986. During his early career at Ohio State University and the University of Tennessee he studied the symbiosis between nitrogen-fixing root nodule-forming bacteria and legumes from different angles, exploring the role of bacterial attachment and chemotaxis and plant systemic signals that control nodule number. While in Tennessee he co-invented the technique of DNA amplification with arbitrary primers [see DNA amplification fingerprinting (DAF) and randomly amplified polymorphic DNA (RAPD)]. This technique generates fingerprints of nucleic acids and molecular markers useful for genome mapping and molecular ecology and evolution. He also developed widely used methods for the silver staining of DNA that are commercially available. He holds several US patents in molecular biology. He joined the faculty of the Department of Biology at the University of Oslo in 1998 and directed the laboratory of molecular ecology and evolution.
Since 2003, he has been at the University of Illinois and is an affiliate of the Carl R. Woese Institute for Genomic Biology. He received the Emile Zuckerkandl Prize in molecular evolution in 2002 and became University Scholar of the University of Illinois in 2010. His current research integrates structural biology, genomics and molecular evolution. He is particularly interested in evolution of macromolecular structure. His research group has recently reconstructed the history of the protein world using information in entire genomes, revealed the existence of a 'big bang' of protein domain combinations late in evolution,[1] traced evolution of proteins in biological networks (see the MANET database), uncovered the origin of modern biological networks in pathways of nucleotide metabolism,[2] and revealed important evolutionary reductive tendencies in the structural make up of proteins.[3]
A new virus theory
Recently, his group used genomic information to propose that viruses are derived from ancient cells and were the first lineage to arise from the last universal ancestor of life (LUCA).[4] The group also found Archaea was the first cellular lineage to arise in evolution[5][6] from a universal ancestor that was complex at the molecular[7] and cellular level.[8] His team is currently exploring the role of structure and organization in the coevolution of proteins and functional RNA (e.g., ribosomal and transfer RNA), including the origin and history of translation and the genetic code. Phylogenomic analysis of RNA and protein molecules that make up the massive ribosomal ensemble shows that the most ancient ribosomal RNA structure interacted with the most ancient ribosomal protein and that this triggered a coordinated accretion process that ultimately resulted in a functional ribosomal core, half-way in evolution of life and prior to cellular diversification.[9] These coevolutionary patterns challenge the ancient ‘RNA world’ hypothesis and place the rise of genetics late in evolution.[10]
Family
Caetano-Anollés and his wife Gloria have two children, both of whom have been part of his research team. Gloria is a surgical nurse and worked in the thoracic surgery team of René Favaloro in Argentina and in the surgical department of the Baptist Hospital of East Tennessee.
Selected publicationsedit
Nasir A, Kim KM, Caetano-Anollés G (2012) Viral evolution. Primordial cellular origins and late adaptation to parasitism. Mobile Genetic Elements 2(5): 1-6.[11]
Kim KM, Win T, Jiang YY, Chen LL, Xiong M, Caetano-Anollés D, Zhang HY, Caetano-Anollés G (2012) Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen. Structure 20(1): 67-76.[12]
Kim KM, Caetano-Anollés G (2010) Emergence and evolution of modern molecular functions inferred from phylogenomic analysis of ontological data" Molecular Biology and Evolution 27(7) 1710-1733.
Caetano-Anollés G, Wang M, Mittenthal JE (2009) The origin, evolution and structure of the protein world. Biochemical Journal 417(3): 621-637.[13]
Sun FJ, Caetano-Anollés G (2008) Evolutionary patterns in the sequence and structure of transfer RNA: early origins of Archaea and viruses. PLoS Computational Biology 4(3): e1000018.[14]
Sun FJ, Caetano-Anollés G (2008) The origin and evolution of tRNA inferred from phylogenetic analysis of structure" Journal of Molecular Evolution 66(1) 21-35.
Wang M, Yafremava LS, Caetano-Anollés D, Mittenthal JS, Caetano-Anollés G (2007) Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world" Genome Research 17(11) 1572-1585.
Wang M, Caetano-Anollés G (2006) Global phylogeny determined by the combination of protein domains in proteomes" Molecular Biology and Evolution 23(12) 2444-54.
Mathesius U, Mulders S, Gao M, Teplitski M, Caetano-Anollés G, Rolfe BG, Bauer WD (2003) Extensive and specific responses of a eukaryote to bacterial-sensing signals. Proceedings of the National Academy of Sciences USA 100(3) 1444-1449.
Caetano-Anollés G, Caetano-Anollés D (2003) An evolutionarily structured universe of protein architecture" Genome Research 13(7) 1563-1571.
Caetano-Anollés G (2002) Tracing the evolution of RNA structure in ribosomes" Nucleic Acids Research 30(11) 2575-2587.
Caetano-Anollés G (2002) Evolved RNA secondary structure and the rooting of the universal tree" Journal of Molecular Evolution 54(3) 333-345.
Caetano-Anollés G (1996) Scanning of nucleic acids by in vitro amplification: new developments and applications. Nature Biotechnology 14(13) 1668-1674.
Caetano-Anollés G, Gresshoff PM (1991) Plant genetic control of nodulation. Annual Review in Microbiology 45:345-382.
Referencesedit
^Wang M, Caetano-Anollés G (2009). "The evolutionary mechanics of domain organization in proteomes and the rise of modularity in the protein world". Structure. 17 (1): 66–78. doi:10.1016/j.str.2008.11.008. PMID 19141283.
^Caetano-Anollés G, Kim HS, Mittenthal JE (2007). "The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture". Proc Natl Acad Sci USA. 104 (22): 9358–63. Bibcode:2007PNAS..104.9358C. doi:10.1073/pnas.0701214104. PMC1890499. PMID 17517598.
^Wang M, Kurland CG, Caetano-Anollés G (2011). "Reductive evolution of proteomes and protein structure". Proc Natl Acad Sci USA. 108 (29): 11954–58. Bibcode:2011PNAS..10811954W. doi:10.1073/pnas.1017361108. PMC3141956. PMID 21730144.
^Nasir A, Kim KM, Caetano-Anollés G (2012). "Giant viruses coexisted with the cellular ancestors and represent a distinct supergroup along with superkingdoms Archaea, Bacteria and Eukarya". BMC Evol Biol. 12 (1): 156. doi:10.1186/1471-2148-12-156. PMC3570343. PMID 22920653.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^Kim KM, Caetano-Anollés G (2012). "The evolutionary history of protein fold families and proteomes confirms that the archaeal ancestor is more ancient than the ancestors of other superkingdoms". BMC Evol Biol. 12 (1): 13. doi:10.1186/1471-2148-12-13. PMC3306197. PMID 22284070.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^Sun FJ, Caetano-Anollés G (2010). "The ancient history of the structure of ribonuclease P and the early origins of Archaea". BMC Bioinformatics. 11: 153. doi:10.1186/1471-2105-11-153. PMC2858038. PMID 20334683.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^Kim KM, Caetano-Anollés G (2011). "The proteomic complexity and rise of the primordial ancestor of diversified life". BMC Evol Biol. 11 (1): 140. doi:10.1186/1471-2148-11-140. PMC3123224. PMID 21612591.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^"Life began with a planetary mega-organism". newscientist.com. November 25, 2011. Retrieved 8 December 2012.
^Harish A, Caetano-Anollés G (2012). "Ribosomal history reveals origins of modern protein synthesis". PLOS ONE. 7 (3): e32776. Bibcode:2012PLoSO...732776H. doi:10.1371/journal.pone.0032776. PMC3299690. PMID 22427882.
^"Your grandmother was a molecule". blogs.scientificamerican.com. March 14, 2012. Retrieved 8 December 2012.
^"Study of giant viruses shakes up tree of life". nsf.gov. September 13, 2012. Retrieved 11 July 2012.
^Saito MA (2012). "The rise of oxygen and aerobic biochemistry". Structure. 20 (1): 1–2. doi:10.1016/j.str.2011.12.006. PMID 22244750.
^"Study of protein structures reveals key events in evolutionary history". Phys.org. March 10, 2009. Retrieved 11 July 2012.
^"Transfer RNA transforms tree of life". the-scientist.com. March 7, 2008. Retrieved 8 December 2012.
gustavo, caetano, anolles, gustavo, caetano, anollés, professor, bioinformatics, department, crop, sciences, university, illinois, urbana, champaign, expert, field, evolutionary, comparative, genomics, gustavo, caetano, anollésalma, maternational, university, . Gustavo Caetano Anolles is Professor of Bioinformatics in the Department of Crop Sciences University of Illinois at Urbana Champaign He is an expert in the field of evolutionary and comparative genomics Gustavo Caetano AnollesAlma materNational University of La PlataKnown forRoot nodule research genetic marker silver stain molecular evolution phylogenomicsAwardsZuckerkandl PrizeScientific careerFieldsComputational Biology Astrobiology GenomicsInstitutionsUniversity of Illinois at Urbana ChampaignWebsitehttp gca cropsci illinois edu gca html Contents 1 Biography 2 Selected publications 3 References 4 External linksBiography editStudies and early researchesCaetano Anolles obtained his doctorate in biochemistry at the National University of La Plata in Argentina in 1986 During his early career at Ohio State University and the University of Tennessee he studied the symbiosis between nitrogen fixing root nodule forming bacteria and legumes from different angles exploring the role of bacterial attachment and chemotaxis and plant systemic signals that control nodule number While in Tennessee he co invented the technique of DNA amplification with arbitrary primers see DNA amplification fingerprinting DAF and randomly amplified polymorphic DNA RAPD This technique generates fingerprints of nucleic acids and molecular markers useful for genome mapping and molecular ecology and evolution He also developed widely used methods for the silver staining of DNA that are commercially available He holds several US patents in molecular biology He joined the faculty of the Department of Biology at the University of Oslo in 1998 and directed the laboratory of molecular ecology and evolution Since 2003 he has been at the University of Illinois and is an affiliate of the Carl R Woese Institute for Genomic Biology He received the Emile Zuckerkandl Prize in molecular evolution in 2002 and became University Scholar of the University of Illinois in 2010 His current research integrates structural biology genomics and molecular evolution He is particularly interested in evolution of macromolecular structure His research group has recently reconstructed the history of the protein world using information in entire genomes revealed the existence of a big bang of protein domain combinations late in evolution 1 traced evolution of proteins in biological networks see the MANET database uncovered the origin of modern biological networks in pathways of nucleotide metabolism 2 and revealed important evolutionary reductive tendencies in the structural make up of proteins 3 A new virus theoryRecently his group used genomic information to propose that viruses are derived from ancient cells and were the first lineage to arise from the last universal ancestor of life LUCA 4 The group also found Archaea was the first cellular lineage to arise in evolution 5 6 from a universal ancestor that was complex at the molecular 7 and cellular level 8 His team is currently exploring the role of structure and organization in the coevolution of proteins and functional RNA e g ribosomal and transfer RNA including the origin and history of translation and the genetic code Phylogenomic analysis of RNA and protein molecules that make up the massive ribosomal ensemble shows that the most ancient ribosomal RNA structure interacted with the most ancient ribosomal protein and that this triggered a coordinated accretion process that ultimately resulted in a functional ribosomal core half way in evolution of life and prior to cellular diversification 9 These coevolutionary patterns challenge the ancient RNA world hypothesis and place the rise of genetics late in evolution 10 FamilyCaetano Anolles and his wife Gloria have two children both of whom have been part of his research team Gloria is a surgical nurse and worked in the thoracic surgery team of Rene Favaloro in Argentina and in the surgical department of the Baptist Hospital of East Tennessee Selected publications editNasir A Kim KM Caetano Anolles G 2012 Viral evolution Primordial cellular origins and late adaptation to parasitism Mobile Genetic Elements 2 5 1 6 11 Kim KM Win T Jiang YY Chen LL Xiong M Caetano Anolles D Zhang HY Caetano Anolles G 2012 Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen Structure 20 1 67 76 12 Kim KM Caetano Anolles G 2010 Emergence and evolution of modern molecular functions inferred from phylogenomic analysis of ontological data Molecular Biology and Evolution 27 7 1710 1733 Caetano Anolles G Wang M Mittenthal JE 2009 The origin evolution and structure of the protein world Biochemical Journal 417 3 621 637 13 Sun FJ Caetano Anolles G 2008 Evolutionary patterns in the sequence and structure of transfer RNA early origins of Archaea and viruses PLoS Computational Biology 4 3 e1000018 14 Sun FJ Caetano Anolles G 2008 The origin and evolution of tRNA inferred from phylogenetic analysis of structure Journal of Molecular Evolution 66 1 21 35 Wang M Yafremava LS Caetano Anolles D Mittenthal JS Caetano Anolles G 2007 Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world Genome Research 17 11 1572 1585 Wang M Caetano Anolles G 2006 Global phylogeny determined by the combination of protein domains in proteomes Molecular Biology and Evolution 23 12 2444 54 Mathesius U Mulders S Gao M Teplitski M Caetano Anolles G Rolfe BG Bauer WD 2003 Extensive and specific responses of a eukaryote to bacterial sensing signals Proceedings of the National Academy of Sciences USA 100 3 1444 1449 Caetano Anolles G Caetano Anolles D 2003 An evolutionarily structured universe of protein architecture Genome Research 13 7 1563 1571 Caetano Anolles G 2002 Tracing the evolution of RNA structure in ribosomes Nucleic Acids Research 30 11 2575 2587 Caetano Anolles G 2002 Evolved RNA secondary structure and the rooting of the universal tree Journal of Molecular Evolution 54 3 333 345 Caetano Anolles G 1996 Scanning of nucleic acids by in vitro amplification new developments and applications Nature Biotechnology 14 13 1668 1674 Caetano Anolles G Gresshoff PM 1991 Plant genetic control of nodulation Annual Review in Microbiology 45 345 382 References edit Wang M Caetano Anolles G 2009 The evolutionary mechanics of domain organization in proteomes and the rise of modularity in the protein world Structure 17 1 66 78 doi 10 1016 j str 2008 11 008 PMID 19141283 Caetano Anolles G Kim HS Mittenthal JE 2007 The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture Proc Natl Acad Sci USA 104 22 9358 63 Bibcode 2007PNAS 104 9358C doi 10 1073 pnas 0701214104 PMC 1890499 PMID 17517598 Wang M Kurland CG Caetano Anolles G 2011 Reductive evolution of proteomes and protein structure Proc Natl Acad Sci USA 108 29 11954 58 Bibcode 2011PNAS 10811954W doi 10 1073 pnas 1017361108 PMC 3141956 PMID 21730144 Nasir A Kim KM Caetano Anolles G 2012 Giant viruses coexisted with the cellular ancestors and represent a distinct supergroup along with superkingdoms Archaea Bacteria and Eukarya BMC Evol Biol 12 1 156 doi 10 1186 1471 2148 12 156 PMC 3570343 PMID 22920653 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint unflagged free DOI link Kim KM Caetano Anolles G 2012 The evolutionary history of protein fold families and proteomes confirms that the archaeal ancestor is more ancient than the ancestors of other superkingdoms BMC Evol Biol 12 1 13 doi 10 1186 1471 2148 12 13 PMC 3306197 PMID 22284070 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint unflagged free DOI link Sun FJ Caetano Anolles G 2010 The ancient history of the structure of ribonuclease P and the early origins of Archaea BMC Bioinformatics 11 153 doi 10 1186 1471 2105 11 153 PMC 2858038 PMID 20334683 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint unflagged free DOI link Kim KM Caetano Anolles G 2011 The proteomic complexity and rise of the primordial ancestor of diversified life BMC Evol Biol 11 1 140 doi 10 1186 1471 2148 11 140 PMC 3123224 PMID 21612591 a href Template Cite journal html title Template Cite journal cite journal a CS1 maint unflagged free DOI link Life began with a planetary mega organism newscientist com November 25 2011 Retrieved 8 December 2012 Harish A Caetano Anolles G 2012 Ribosomal history reveals origins of modern protein synthesis PLOS ONE 7 3 e32776 Bibcode 2012PLoSO 732776H doi 10 1371 journal pone 0032776 PMC 3299690 PMID 22427882 Your grandmother was a molecule blogs scientificamerican com March 14 2012 Retrieved 8 December 2012 Study of giant viruses shakes up tree of life nsf gov September 13 2012 Retrieved 11 July 2012 Saito MA 2012 The rise of oxygen and aerobic biochemistry Structure 20 1 1 2 doi 10 1016 j str 2011 12 006 PMID 22244750 Study of protein structures reveals key events in evolutionary history Phys org March 10 2009 Retrieved 11 July 2012 Transfer RNA transforms tree of life the scientist com March 7 2008 Retrieved 8 December 2012 External links edit nbsp Scholia has a profile for Gustavo Caetano Anolles Q5621363 Gustavo Caetano Anolles page at the Department of Crop Sciences 1 Evolutionary Bioinformatics laboratory 2 Evolutionary Bioinformatics blog 3 Molecular Ancestry Networks MANET 4 Retrieved from https en wikipedia org w index php title Gustavo Caetano Anolles amp oldid 1113075865, wikipedia, wiki, book, books, library,
