MANET traces for example the ancestry of individual metabolic enzymes in metabolism with bioinformatic, phylogenetic, and statistical methods. MANET currently links information in the Structural Classification of Proteins (SCOP) database, the metabolic pathways database of the Kyoto Encyclopedia of Genes and Genomes (KEGG), and phylogenetic reconstructions describing the evolution of protein fold architecture at a universal level.[3] The database has been updated to reflect evolution of metabolism at the level of protein fold families.[4] MANET literally "paints" the ancestries of enzymes derived from rooted phylogenetic trees directly onto over one hundred metabolic pathways representations, paying homage to one of the fathers of impressionism. It also provides numerous functionalities that enable searching specific protein folds with defined ancestry values, displaying the distribution of enzymes that are painted, and exploring quantitative details describing individual protein folds. This permits the study of global and local metabolic network architectures, and the extraction of evolutionary patterns at global and local levels.
A statistical analysis of the data in MANET showed for example a patchy distribution of ancestry values assigned to protein folds in each subnetwork, indicating that evolution of metabolism occurred globally by widespread recruitment of enzymes.[2] MANET was used recently to sort out enzymatic recruitment processes in metabolic networks and propose that modern metabolism originated in the purine nucleotide metabolic subnetwork.[5] The database is useful for the study of metabolic evolution.
External linksedit
Referencesedit
^. www.manet.uiuc.edu. Archived from the original on 9 July 2017. Retrieved 14 January 2022.
^ abKim HS, Mittenthal JE, Caetano-Anolles G (2006). "MANET:tracing evolution of protein architecture in metabolic networks". BMC Bioinformatics. 7: 351. doi:10.1186/1471-2105-7-351. PMC1559654. PMID 16854231.
^Caetano-Anolles G, Caetano-Anolles D (2003). "An evolutionarily structured universe of protein architecture". Genome Res. 13 (7): 1563–71. doi:10.1101/gr.1161903. PMC403752. PMID 12840035.
^Mughal F, Caetano-Anolles G (2019). "MANET 3.0: Hierarchy and modularity in evolving metabolic networks". PLOS ONE. 14 (10): e0224201. Bibcode:2019PLoSO..1424201M. doi:10.1371/journal.pone.0224201. PMC6812854. PMID 31648227.
^Caetano-Anolles G, Kim HS, Mittenthal JE (2007). "The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture". Proc Natl Acad Sci USA. 104 (22): 9358–63. Bibcode:2007PNAS..104.9358C. doi:10.1073/pnas.0701214104. PMC1890499. PMID 17517598.
February 16, 2024
manet, database, molecular, ancestry, network, manet, database, bioinformatics, database, that, maps, evolutionary, relationships, protein, architectures, directly, onto, biological, networks, originally, developed, shin, mittenthal, gustavo, caetano, anolles,. The Molecular Ancestry Network MANET database is a bioinformatics database that maps evolutionary relationships of protein architectures directly onto biological networks 1 It was originally developed by Hee Shin Kim Jay E Mittenthal and Gustavo Caetano Anolles in the Department of Crop Sciences of the University of Illinois at Urbana Champaign 2 MANET traces for example the ancestry of individual metabolic enzymes in metabolism with bioinformatic phylogenetic and statistical methods MANET currently links information in the Structural Classification of Proteins SCOP database the metabolic pathways database of the Kyoto Encyclopedia of Genes and Genomes KEGG and phylogenetic reconstructions describing the evolution of protein fold architecture at a universal level 3 The database has been updated to reflect evolution of metabolism at the level of protein fold families 4 MANET literally paints the ancestries of enzymes derived from rooted phylogenetic trees directly onto over one hundred metabolic pathways representations paying homage to one of the fathers of impressionism It also provides numerous functionalities that enable searching specific protein folds with defined ancestry values displaying the distribution of enzymes that are painted and exploring quantitative details describing individual protein folds This permits the study of global and local metabolic network architectures and the extraction of evolutionary patterns at global and local levels A statistical analysis of the data in MANET showed for example a patchy distribution of ancestry values assigned to protein folds in each subnetwork indicating that evolution of metabolism occurred globally by widespread recruitment of enzymes 2 MANET was used recently to sort out enzymatic recruitment processes in metabolic networks and propose that modern metabolism originated in the purine nucleotide metabolic subnetwork 5 The database is useful for the study of metabolic evolution External links editMolecular Ancestry Network MANET databaseReferences edit Molecular Ancestry Network University of Illinois www manet uiuc edu Archived from the original on 9 July 2017 Retrieved 14 January 2022 a b Kim HS Mittenthal JE Caetano Anolles G 2006 MANET tracing evolution of protein architecture in metabolic networks BMC Bioinformatics 7 351 doi 10 1186 1471 2105 7 351 PMC 1559654 PMID 16854231 Caetano Anolles G Caetano Anolles D 2003 An evolutionarily structured universe of protein architecture Genome Res 13 7 1563 71 doi 10 1101 gr 1161903 PMC 403752 PMID 12840035 Mughal F Caetano Anolles G 2019 MANET 3 0 Hierarchy and modularity in evolving metabolic networks PLOS ONE 14 10 e0224201 Bibcode 2019PLoSO 1424201M doi 10 1371 journal pone 0224201 PMC 6812854 PMID 31648227 Caetano Anolles G Kim HS Mittenthal JE 2007 The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture Proc Natl Acad Sci USA 104 22 9358 63 Bibcode 2007PNAS 104 9358C doi 10 1073 pnas 0701214104 PMC 1890499 PMID 17517598 Retrieved from https en wikipedia org w index php title MANET database amp oldid 1197202589, wikipedia, wiki, book, books, library,
