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Wikipedia

Gem-associated protein 5

March 16, 2024

Gem-associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene.[5][6]

GEMIN5
Identifiers
AliasesGEMIN5, GEMIN-5, gem nuclear organelle associated protein 5, NEDCAM
External IDsOMIM: 607005 MGI: 2449311 HomoloGene: 9155 GeneCards: GEMIN5
Orthologs
SpeciesHumanMouse
Entrez

25929

216766

Ensembl

ENSG00000082516

ENSMUSG00000037275

UniProt

Q8TEQ6

Q8BX17

RefSeq (mRNA)

NM_015465
NM_001252156

NM_001166669
NM_001166670
NM_001166671
NM_172558
NM_001374702

RefSeq (protein)

NP_001239085
NP_056280

NP_001160141
NP_001160142
NP_001160143
NP_766146
NP_001361631

Location (UCSC)Chr 5: 154.89 – 154.94 MbChr 11: 58.01 – 58.06 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

Gem-associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), gem-associated protein 2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), and GEMIN4 (MIM 606969).[6]

Interactions edit

GEMIN5 has been shown to interact with DDX20[5][7] and SMN1.[5]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000082516 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037275 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (Feb 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J Biol Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
  6. ^ a b "Entrez Gene: GEMIN5 gem (nuclear organelle) associated protein 5".
  7. ^ Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. 16 (6): 720–8. doi:10.1101/gad.974702. PMC 155365. PMID 11914277.

Further reading edit

  • Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Battle DJ, Lau CK, Wan L, Deng H, Lotti F, Dreyfuss G (2006). "The Gemin5 protein of the SMN complex identifies snRNAs". Mol. Cell. 23 (2): 273–9. doi:10.1016/j.molcel.2006.05.036. PMID 16857593.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Kim EK, Noh KT, Yoon JH, Cho JH, Yoon KW, Dreyfuss G, Choi EJ (2007). "Positive regulation of ASK1-mediated c-Jun NH(2)-terminal kinase signaling pathway by the WD-repeat protein Gemin5". Cell Death Differ. 14 (8): 1518–28. doi:10.1038/sj.cdd.4402157. PMID 17541429.
  • Hao le T, Fuller HR, Lam le T, Le TT, Burghes AH, Morris GE (2007). "Absence of gemin5 from SMN complexes in nuclear Cajal bodies". BMC Cell Biol. 8: 28. doi:10.1186/1471-2121-8-28. PMC 1939999. PMID 17640370.
  • Battle DJ, Kasim M, Wang J, Dreyfuss G (2007). "SMN-independent subunits of the SMN complex. Identification of a small nuclear ribonucleoprotein assembly intermediate". J. Biol. Chem. 282 (38): 27953–9. doi:10.1074/jbc.M702317200. PMID 17640873.


 

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

March 16, 2024
associated, protein, protein, that, humans, encoded, gemin5, gene, gemin5identifiersaliasesgemin5, gemin, nuclear, organelle, associated, protein, nedcamexternal, idsomim, 607005, 2449311, homologene, 9155, genecards, gemin5gene, location, human, chromosome, h. Gem associated protein 5 is a protein that in humans is encoded by the GEMIN5 gene 5 6 GEMIN5IdentifiersAliasesGEMIN5 GEMIN 5 gem nuclear organelle associated protein 5 NEDCAMExternal IDsOMIM 607005 MGI 2449311 HomoloGene 9155 GeneCards GEMIN5Gene location Human Chr Chromosome 5 human 1 Band5q33 2Start154 887 411 bp 1 End154 938 211 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 B1 3Start58 010 828 bp 2 End58 059 365 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inoocytesecondary oocytetibialis anterior muscledeltoid musclebiceps brachiigastrocnemius musclequadriceps femoris muscleAchilles tendonvastus lateralis muscleislet of LangerhansTop expressed inspermatocytespermatidseminiferous tubuleinternal carotid arterymorulaintestinal villusexternal carotid arteryprimitive streakmaxillary prominenceabdominal wallMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionsnRNA binding protein binding RNA 7 methylguanosine cap binding mRNA 3 UTR binding U1 snRNA binding U4 snRNA binding U4atac snRNA binding ribosome binding RNA bindingCellular componentcytoplasm SMN complex SMN Sm protein complex cytosol nuclear body membrane Gemini of coiled bodies nucleoplasm nucleus cytosolic large ribosomal subunit SMN Gemin2 complexBiological processmRNA splicing via spliceosome mRNA processing RNA splicing spliceosomal snRNP assembly import into nucleus protein biosynthesis regulation of translation protein containing complex assemblySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez25929216766EnsemblENSG00000082516ENSMUSG00000037275UniProtQ8TEQ6Q8BX17RefSeq mRNA NM 015465NM 001252156NM 001166669NM 001166670NM 001166671NM 172558NM 001374702RefSeq protein NP 001239085NP 056280NP 001160141NP 001160142NP 001160143NP 766146NP 001361631Location UCSC Chr 5 154 89 154 94 MbChr 11 58 01 58 06 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Function 2 Interactions 3 References 4 Further readingFunction editGem associated protein 5 is part of the SMN a large protein complex localized to both the cytoplasm and the nucleus that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins snRNPs Other members of this complex include SMN MIM 600354 gem associated protein 2 SIP1 MIM 602595 GEMIN3 DDX20 MIM 606168 and GEMIN4 MIM 606969 6 Interactions editGEMIN5 has been shown to interact with DDX20 5 7 and SMN1 5 References edit a b c GRCh38 Ensembl release 89 ENSG00000082516 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000037275 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine a b c Gubitz AK Mourelatos Z Abel L Rappsilber J Mann M Dreyfuss G Feb 2002 Gemin5 a novel WD repeat protein component of the SMN complex that binds Sm proteins J Biol Chem 277 7 5631 6 doi 10 1074 jbc M109448200 PMID 11714716 a b Entrez Gene GEMIN5 gem nuclear organelle associated protein 5 Mourelatos Z Dostie J Paushkin S Sharma A Charroux B Abel L Rappsilber J Mann M Dreyfuss G Mar 2002 miRNPs a novel class of ribonucleoproteins containing numerous microRNAs Genes Dev 16 6 720 8 doi 10 1101 gad 974702 PMC 155365 PMID 11914277 Further reading editBaccon J Pellizzoni L Rappsilber J Mann M Dreyfuss G 2002 Identification and characterization of Gemin7 a novel component of the survival of motor neuron complex J Biol Chem 277 35 31957 62 doi 10 1074 jbc M203478200 PMID 12065586 Beausoleil SA Jedrychowski M Schwartz D Elias JE Villen J Li J Cohn MA Cantley LC Gygi SP 2004 Large scale characterization of HeLa cell nuclear phosphoproteins Proc Natl Acad Sci U S A 101 33 12130 5 Bibcode 2004PNAS 10112130B doi 10 1073 pnas 0404720101 PMC 514446 PMID 15302935 Kimura K Wakamatsu A Suzuki Y Ota T Nishikawa T Yamashita R Yamamoto J Sekine M Tsuritani K Wakaguri H Ishii S Sugiyama T Saito K Isono Y Irie R Kushida N Yoneyama T Otsuka R Kanda K Yokoi T Kondo H Wagatsuma M Murakawa K Ishida S Ishibashi T Takahashi Fujii A Tanase T Nagai K Kikuchi H Nakai K Isogai T Sugano S 2006 Diversification of transcriptional modulation Large scale identification and characterization of putative alternative promoters of human genes Genome Res 16 1 55 65 doi 10 1101 gr 4039406 PMC 1356129 PMID 16344560 Battle DJ Lau CK Wan L Deng H Lotti F Dreyfuss G 2006 The Gemin5 protein of the SMN complex identifies snRNAs Mol Cell 23 2 273 9 doi 10 1016 j molcel 2006 05 036 PMID 16857593 Beausoleil SA Villen J Gerber SA Rush J Gygi SP 2006 A probability based approach for high throughput protein phosphorylation analysis and site localization Nat Biotechnol 24 10 1285 92 doi 10 1038 nbt1240 PMID 16964243 S2CID 14294292 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Kim EK Noh KT Yoon JH Cho JH Yoon KW Dreyfuss G Choi EJ 2007 Positive regulation of ASK1 mediated c Jun NH 2 terminal kinase signaling pathway by the WD repeat protein Gemin5 Cell Death Differ 14 8 1518 28 doi 10 1038 sj cdd 4402157 PMID 17541429 Hao le T Fuller HR Lam le T Le TT Burghes AH Morris GE 2007 Absence of gemin5 from SMN complexes in nuclear Cajal bodies BMC Cell Biol 8 28 doi 10 1186 1471 2121 8 28 PMC 1939999 PMID 17640370 Battle DJ Kasim M Wang J Dreyfuss G 2007 SMN independent subunits of the SMN complex Identification of a small nuclear ribonucleoprotein assembly intermediate J Biol Chem 282 38 27953 9 doi 10 1074 jbc M702317200 PMID 17640873 nbsp This article on a gene on human chromosome 5 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Gem associated protein 5 amp oldid 1188024225, wikipedia, wiki, book, books, library,

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