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Wikipedia

GTF3C2

January 01, 1970

General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene.[5][6]

GTF3C2
Identifiers
AliasesGTF3C2, TFIIIC-BETA, TFIIIC110, general transcription factor IIIC subunit 2
External IDsOMIM: 604883; MGI: 1919002; HomoloGene: 37490; GeneCards: GTF3C2; OMA:GTF3C2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

2976

71752

Ensembl

ENSG00000115207

ENSMUSG00000106864

UniProt

Q8WUA4

Q8BL74

RefSeq (mRNA)

NM_001035521
NM_001521
NM_001318909
NM_001388380

NM_027901

RefSeq (protein)

NP_001030598
NP_001305838
NP_001512

NP_082177

Location (UCSC)Chr 2: 27.33 – 27.36 MbChr 5: 31.31 – 31.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

GTF3C2 has been shown to interact with GTF3C4[7] and GTF3C5.[8]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115207 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000106864 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sinn E, Wang Z, Kovelman R, Roeder RG (Jun 1995). "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors". Genes Dev. 9 (6): 675–85. doi:10.1101/gad.9.6.675. PMID 7729686.
  6. ^ "Entrez Gene: GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa".
  7. ^ Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  8. ^ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.

Further reading edit

  • Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  • Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
  • Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Chu WM, Wang Z, Roeder RG, Schmid CW (1997). "RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2". J. Biol. Chem. 272 (23): 14755–61. doi:10.1074/jbc.272.23.14755. PMID 9169441.
  • Oettel S, Härtel F, Kober I, Iben S, Seifart KH (1997). "Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes". Nucleic Acids Res. 25 (12): 2440–7. doi:10.1093/nar/25.12.2440. PMC 146769. PMID 9171097.
  • Wang Z, Roeder RG (1998). "DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III". Mol. Cell. 1 (5): 749–57. doi:10.1016/S1097-2765(00)80074-X. PMID 9660958.
  • Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. doi:10.1128/mcb.19.7.4944. PMC 84305. PMID 10373544.
  • Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. PMC 84812. PMID 10523658.
  • Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Innes F, Ramsbottom B, White RJ (2006). "A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC". Nucleic Acids Res. 34 (11): 3399–407. doi:10.1093/nar/gkl432. PMC 1488882. PMID 16822860.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.

External links edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


 

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
gtf3c2, general, transcription, factor, polypeptide, protein, that, humans, encoded, gene, identifiersaliases, tfiiic, beta, tfiiic110, general, transcription, factor, iiic, subunit, 2external, idsomim, 604883, 1919002, homologene, 37490, genecards, orthologsg. General transcription factor 3C polypeptide 2 is a protein that in humans is encoded by the GTF3C2 gene 5 6 GTF3C2IdentifiersAliasesGTF3C2 TFIIIC BETA TFIIIC110 general transcription factor IIIC subunit 2External IDsOMIM 604883 MGI 1919002 HomoloGene 37490 GeneCards GTF3C2 OMA GTF3C2 orthologsGene location Human Chr Chromosome 2 human 1 Band2p23 3Start27 325 849 bp 1 End27 357 034 bp 1 Gene location Mouse Chr Chromosome 5 mouse 2 Band5 5 B1Start31 313 349 bp 2 End31 337 488 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inright lobe of thyroid glandright uterine tubeskin of abdomenleft lobe of thyroid glandminor salivary glandsbody of pancreasgastric mucosatibial nerverectumanterior pituitaryTop expressed inyolk sacinternal carotid arteryexternal carotid arterysecondary oocyteciliary bodyhair folliclemaxillary prominencethymusparotid glandcerebellar cortexMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding protein binding RNA polymerase III general transcription initiation factor activityCellular componenttranscription factor TFIIIC complex nucleus nucleoplasmBiological processtRNA transcription by RNA polymerase III 5S class rRNA transcription by RNA polymerase III transcription DNA templated transcription by RNA polymerase IIISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez297671752EnsemblENSG00000115207ENSMUSG00000106864UniProtQ8WUA4Q8BL74RefSeq mRNA NM 001035521NM 001521NM 001318909NM 001388380NM 027901RefSeq protein NP 001030598NP 001305838NP 001512NP 082177Location UCSC Chr 2 27 33 27 36 MbChr 5 31 31 31 34 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editGTF3C2 has been shown to interact with GTF3C4 7 and GTF3C5 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000115207 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000106864 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Sinn E Wang Z Kovelman R Roeder RG Jun 1995 Cloning and characterization of a TFIIIC2 subunit TFIIIC beta whose presence correlates with activation of RNA polymerase III mediated transcription by adenovirus E1A expression and serum factors Genes Dev 9 6 675 85 doi 10 1101 gad 9 6 675 PMID 7729686 Entrez Gene GTF3C2 general transcription factor IIIC polypeptide 2 beta 110kDa Hsieh YJ Kundu TK Wang Z Kovelman R Roeder RG Nov 1999 The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone specific acetyltransferase activity Mol Cell Biol 19 11 7697 704 doi 10 1128 mcb 19 11 7697 PMC 84812 PMID 10523658 Hsieh YJ Wang Z Kovelman R Roeder RG Jul 1999 Cloning and characterization of two evolutionarily conserved subunits TFIIIC102 and TFIIIC63 of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III Mol Cell Biol 19 7 4944 52 doi 10 1128 mcb 19 7 4944 PMC 84305 PMID 10373544 Further reading editJang KL Collins MK Latchman DS 1992 The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC J Acquir Immune Defic Syndr 5 11 1142 7 PMID 1403646 Nomura N Miyajima N Sazuka T Tanaka A Kawarabayasi Y Sato S Nagase T Seki N Ishikawa K Tabata S 1994 Prediction of the coding sequences of unidentified human genes I The coding sequences of 40 new genes KIAA0001 KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG 1 DNA Res 1 1 27 35 doi 10 1093 dnares 1 1 27 PMID 7584026 Nomura N Miyajima N Sazuka T Tanaka A Kawarabayasi Y Sato S Nagase T Seki N Ishikawa K Tabata S 1994 Prediction of the coding sequences of unidentified human genes I The coding sequences of 40 new genes KIAA0001 KIAA0040 deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG 1 supplement DNA Res 1 1 47 56 doi 10 1093 dnares 1 1 47 PMID 7584028 Andersson B Wentland MA Ricafrente JY Liu W Gibbs RA 1996 A double adaptor method for improved shotgun library construction Anal Biochem 236 1 107 13 doi 10 1006 abio 1996 0138 PMID 8619474 Yu W Andersson B Worley KC Muzny DM Ding Y Liu W Ricafrente JY Wentland MA Lennon G Gibbs RA 1997 Large scale concatenation cDNA sequencing Genome Res 7 4 353 8 doi 10 1101 gr 7 4 353 PMC 139146 PMID 9110174 Chu WM Wang Z Roeder RG Schmid CW 1997 RNA polymerase III transcription repressed by Rb through its interactions with TFIIIB and TFIIIC2 J Biol Chem 272 23 14755 61 doi 10 1074 jbc 272 23 14755 PMID 9169441 Oettel S Hartel F Kober I Iben S Seifart KH 1997 Human transcription factors IIIC2 IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes Nucleic Acids Res 25 12 2440 7 doi 10 1093 nar 25 12 2440 PMC 146769 PMID 9171097 Wang Z Roeder RG 1998 DNA topoisomerase I and PC4 can interact with human TFIIIC to promote both accurate termination and transcription reinitiation by RNA polymerase III Mol Cell 1 5 749 57 doi 10 1016 S1097 2765 00 80074 X PMID 9660958 Hsieh YJ Wang Z Kovelman R Roeder RG 1999 Cloning and characterization of two evolutionarily conserved subunits TFIIIC102 and TFIIIC63 of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III Mol Cell Biol 19 7 4944 52 doi 10 1128 mcb 19 7 4944 PMC 84305 PMID 10373544 Hsieh YJ Kundu TK Wang Z Kovelman R Roeder RG 1999 The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone specific acetyltransferase activity Mol Cell Biol 19 11 7697 704 doi 10 1128 mcb 19 11 7697 PMC 84812 PMID 10523658 Suzuki Y Yamashita R Shirota M Sakakibara Y Chiba J Mizushima Sugano J Nakai K Sugano S 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions Genome Res 14 9 1711 8 doi 10 1101 gr 2435604 PMC 515316 PMID 15342556 Rual JF Venkatesan K Hao T Hirozane Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette Stamm L Cusick ME Hill DE Roth FP Vidal M 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 Innes F Ramsbottom B White RJ 2006 A test of the model that RNA polymerase III transcription is regulated by selective induction of the 110 kDa subunit of TFIIIC Nucleic Acids Res 34 11 3399 407 doi 10 1093 nar gkl432 PMC 1488882 PMID 16822860 Beausoleil SA Villen J Gerber SA Rush J Gygi SP 2006 A probability based approach for high throughput protein phosphorylation analysis and site localization Nat Biotechnol 24 10 1285 92 doi 10 1038 nbt1240 PMID 16964243 S2CID 14294292 Olsen JV Blagoev B Gnad F Macek B Kumar C Mortensen P Mann M 2006 Global in vivo and site specific phosphorylation dynamics in signaling networks Cell 127 3 635 48 doi 10 1016 j cell 2006 09 026 PMID 17081983 S2CID 7827573 Dumay Odelot H Marck C Durrieu Gaillard S Lefebvre O Jourdain S Prochazkova M Pflieger A Teichmann M 2007 Identification molecular cloning and characterization of the sixth subunit of human transcription factor TFIIIC J Biol Chem 282 23 17179 89 doi 10 1074 jbc M611542200 PMID 17409385 External links editGTF3C2 protein human at the U S National Library of Medicine Medical Subject Headings MeSH FactorBook TFIIIC 110 This article incorporates text from the United States National Library of Medicine which is in the public domain nbsp This article on a gene on human chromosome 2 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GTF3C2 amp oldid 1118750172, wikipedia, wiki, book, books, library,

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