GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand. In one study, the chemokine CCL5 (RANTES) has been shown to stimulate calcium mobilization and inositol triphosphate formation in GPR75-transfected cells.[7]
A 2021 study reported that people with protein-truncating variants of GPR75 were associated with 5.3kg lower body weight and 54% lower odds for obesity. GPR75 knock-out mice showed resistance to weight gain under high-fat diet.[8]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000119737 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000043999 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Tarttelin EE, Kirschner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K, Csaky K, Stratakis CA, Gregory-Evans CY (June 1999). "Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16". Biochemical and Biophysical Research Communications. 260 (1): 174–80. doi:10.1006/bbrc.1999.0753. PMID 10381362.
^ ab"Entrez Gene: GPR75 G protein-coupled receptor 75".
^Ignatov A, Robert J, Gregory-Evans C, Schaller HC (November 2006). "RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75". British Journal of Pharmacology. 149 (5): 490–7. doi:10.1038/sj.bjp.0706909. PMC2014681. PMID 17001303.
^Akbari P, Gilani A, Sosina O, et al. (2 July 2021). "Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity". Science. 373 (6550). doi:10.1126/science.abf8683. PMC10275396. PMID 34210852. S2CID 235699731.
gpr75, probable, protein, coupled, receptor, protein, that, humans, encoded, gene, identifiersaliases, gprchr2, wi31133, protein, coupled, receptor, 75external, idsomim, 606704, 2441843, homologene, 4945, genecards, orthologsgene, location, human, chromosome, . Probable G protein coupled receptor 75 is a protein that in humans is encoded by the GPR75 gene 5 6 GPR75IdentifiersAliasesGPR75 GPRchr2 WI31133 G protein coupled receptor 75External IDsOMIM 606704 MGI 2441843 HomoloGene 4945 GeneCards GPR75 OMA GPR75 orthologsGene location Human Chr Chromosome 2 human 1 Band2p16 2Start53 852 912 bp 1 End53 859 967 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 A4Start30 835 358 bp 2 End30 843 729 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inislet of Langerhansprefrontal cortexinternal globus palliduscaudate nucleusnucleus accumbensamygdalaputamencingulate gyruscorpus callosumganglionic eminenceTop expressed invisual cortexcerebellar cortexsuperior frontal gyruscerebellar vermishippocampus properfacial motor nucleusneural tubedorsomedial hypothalamic nucleusolfactory bulbnucleus accumbensMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionC C chemokine receptor activity signal transducer activity G protein coupled receptor activityCellular componentintegral component of membrane plasma membrane integral component of plasma membrane membraneBiological processchemokine mediated signaling pathway regulation of neuron death signal transduction G protein coupled receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez10936237716EnsemblENSG00000119737ENSMUSG00000043999UniProtO95800Q6X632RefSeq mRNA NM 006794NM 175490RefSeq protein NP 006785NP 780699Location UCSC Chr 2 53 85 53 86 MbChr 11 30 84 30 84 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editGPR75 is a member of the G protein coupled receptor family GPRs are cell surface receptors that activate guanine nucleotide binding proteins upon the binding of a ligand 6 GPR75 is currently classified as an orphan GPCR and several studies are underway to identify its ligand In one study the chemokine CCL5 RANTES has been shown to stimulate calcium mobilization and inositol triphosphate formation in GPR75 transfected cells 7 A 2021 study reported that people with protein truncating variants of GPR75 were associated with 5 3kg lower body weight and 54 lower odds for obesity GPR75 knock out mice showed resistance to weight gain under high fat diet 8 References edit a b c GRCh38 Ensembl release 89 ENSG00000119737 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000043999 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Tarttelin EE Kirschner LS Bellingham J Baffi J Taymans SE Gregory Evans K Csaky K Stratakis CA Gregory Evans CY June 1999 Cloning and characterization of a novel orphan G protein coupled receptor localized to human chromosome 2p16 Biochemical and Biophysical Research Communications 260 1 174 80 doi 10 1006 bbrc 1999 0753 PMID 10381362 a b Entrez Gene GPR75 G protein coupled receptor 75 Ignatov A Robert J Gregory Evans C Schaller HC November 2006 RANTES stimulates Ca2 mobilization and inositol trisphosphate IP3 formation in cells transfected with G protein coupled receptor 75 British Journal of Pharmacology 149 5 490 7 doi 10 1038 sj bjp 0706909 PMC 2014681 PMID 17001303 Akbari P Gilani A Sosina O et al 2 July 2021 Sequencing of 640 000 exomes identifies GPR75 variants associated with protection from obesity Science 373 6550 doi 10 1126 science abf8683 PMC 10275396 PMID 34210852 S2CID 235699731 nbsp This transmembrane receptor related article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title GPR75 amp oldid 1170018577, wikipedia, wiki, book, books, library,
