This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells. Alternate transcriptional splice variants which encode the same protein have been characterized.[6] FAM3C functions and expression also were studied in mammalian brains[7][8] which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer's disease (AD), which highlighted FAM3C as a promising therapeutic target for Alzheimer's disease. Moreover, level of FAM3C was claimed to be a biomarker for AD together with saposin D.[9]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000196937 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029672 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Zhu Y, Xu G, Patel A, McLaughlin MM, Silverman C, Knecht K, Sweitzer S, Li X, McDonnell P, Mirabile R, Zimmerman D, Boyce R, Tierney LA, Hu E, Livi GP, Wolf B, Abdel-Meguid SS, Rose GD, Aurora R, Hensley P, Briggs M, Young PR (August 2002). "Cloning, expression, and initial characterization of a novel cytokine-like gene family". Genomics. 80 (2): 144–50. doi:10.1006/geno.2002.6816. PMID 12160727.
^ ab"Entrez Gene: FAM3C family with sequence similarity 3, member C".
^Hasegawa H, Liu L, Tooyama I, Murayama S, Nishimura M (June 2014). "The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor". Nature Communications. 5: 3917. Bibcode:2014NatCo...5.3917H. doi:10.1038/ncomms4917. PMID 24894631.
^Liu L, Watanabe N, Akatsu H, Nishimura M (August 2016). "Neuronal expression of ILEI/FAM3C and its reduction in Alzheimer's disease". Neuroscience. 330: 236–46. doi:10.1016/j.neuroscience.2016.05.050. PMID 27256505. S2CID 24057333.
^US 7993868, Davies, Huw Alun; Blennow, Kaj & McGuire, James Norton, "Saposin D and FAM3C are biomarkers for alzheimer's disease", published 9 Aug 2011
Further readingedit
Sanger Centre, The; Washington University Genome Sequencing Cente, The (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM (July 2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLOS Biology. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC449870. PMID 15252450.
Mauri P, Scarpa A, Nascimbeni AC, Benazzi L, Parmagnani E, Mafficini A, Della Peruta M, Bassi C, Miyazaki K, Sorio C (July 2005). "Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology: a strategy for identification of novel cancer markers". FASEB Journal. 19 (9): 1125–7. doi:10.1096/fj.04-3000fje. PMID 15985535. S2CID 33940827.
Grønborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A (January 2006). "Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach". Molecular & Cellular Proteomics. 5 (1): 157–71. doi:10.1074/mcp.M500178-MCP200. PMID 16215274.
Guo J, Cheng H, Zhao S, Yu L (January 2006). "GG: a domain involved in phage LTF apparatus and implicated in human MEB and non-syndromic hearing loss diseases". FEBS Letters. 580 (2): 581–4. doi:10.1016/j.febslet.2005.12.076. PMID 16406369. S2CID 1013478.
Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, Schreiber M, Jechlinger M, Beug H (September 2006). "ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells". Cancer Cell. 10 (3): 227–39. doi:10.1016/j.ccr.2006.07.020. PMID 16959614.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
fam3c, protein, protein, that, humans, encoded, gene, identifiersaliases, ilei, gs3786, family, with, sequence, similarity, member, fam3, metabolism, regulating, signaling, molecule, cexternal, idsomim, 608618, 107892, homologene, 8926, genecards, orthologsgen. Protein FAM3C is a protein that in humans is encoded by the FAM3C gene 5 6 FAM3CIdentifiersAliasesFAM3C ILEI GS3786 family with sequence similarity 3 member C FAM3 metabolism regulating signaling molecule CExternal IDsOMIM 608618 MGI 107892 HomoloGene 8926 GeneCards FAM3C OMA FAM3C orthologsGene location Human Chr Chromosome 7 human 1 Band7q31 31Start121 348 878 bp 1 End121 396 364 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 A3 1 6 9 24 cMStart22 306 519 bp 2 End22 356 242 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed injejunal mucosaAchilles tendonponsduodenumgerminal epitheliumpericardiumvulvaendometriumparietal pleuraorbitofrontal cortexTop expressed inmolarsemi lunar valvecumulus cellaortic valveepithelium of stomachascending aortaurotheliummucous cell of stomachcalvariaretinal pigment epitheliumMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytokine activity protein bindingCellular componentextracellular exosome cytoplasmic vesicle platelet dense granule lumen extracellular region extracellular space Golgi apparatusBiological processmulticellular organism development platelet degranulation regulation of signaling receptor activity biological process negative regulation of gluconeogenesis signal transductionSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez1044727999EnsemblENSG00000196937ENSMUSG00000029672UniProtQ92520Q91VU0RefSeq mRNA NM 001040020NM 014888NM 138587RefSeq protein NP 001035109NP 055703NP 613053Location UCSC Chr 7 121 35 121 4 MbChr 6 22 31 22 36 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseFunction editThis gene is a member of the family with sequence similarity 3 FAM3 family and encodes a secreted protein with a GG domain A change in expression of this protein has been noted in pancreatic cancer derived cells Alternate transcriptional splice variants which encode the same protein have been characterized 6 FAM3C functions and expression also were studied in mammalian brains 7 8 which shown that a reduced FAM3C level associated to the onset of sporadic Alzheimer s disease AD which highlighted FAM3C as a promising therapeutic target for Alzheimer s disease Moreover level of FAM3C was claimed to be a biomarker for AD together with saposin D 9 References edit a b c GRCh38 Ensembl release 89 ENSG00000196937 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029672 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Zhu Y Xu G Patel A McLaughlin MM Silverman C Knecht K Sweitzer S Li X McDonnell P Mirabile R Zimmerman D Boyce R Tierney LA Hu E Livi GP Wolf B Abdel Meguid SS Rose GD Aurora R Hensley P Briggs M Young PR August 2002 Cloning expression and initial characterization of a novel cytokine like gene family Genomics 80 2 144 50 doi 10 1006 geno 2002 6816 PMID 12160727 a b Entrez Gene FAM3C family with sequence similarity 3 member C Hasegawa H Liu L Tooyama I Murayama S Nishimura M June 2014 The FAM3 superfamily member ILEI ameliorates Alzheimer s disease like pathology by destabilizing the penultimate amyloid b precursor Nature Communications 5 3917 Bibcode 2014NatCo 5 3917H doi 10 1038 ncomms4917 PMID 24894631 Liu L Watanabe N Akatsu H Nishimura M August 2016 Neuronal expression of ILEI FAM3C and its reduction in Alzheimer s disease Neuroscience 330 236 46 doi 10 1016 j neuroscience 2016 05 050 PMID 27256505 S2CID 24057333 US 7993868 Davies Huw Alun Blennow Kaj amp McGuire James Norton Saposin D and FAM3C are biomarkers for alzheimer s disease published 9 Aug 2011 Further reading editSanger Centre The Washington University Genome Sequencing Cente The November 1998 Toward a complete human genome sequence Genome Research 8 11 1097 108 doi 10 1101 gr 8 11 1097 PMID 9847074 Fortna A Kim Y MacLaren E Marshall K Hahn G Meltesen L Brenton M Hink R Burgers S Hernandez Boussard T Karimpour Fard A Glueck D McGavran L Berry R Pollack J Sikela JM July 2004 Lineage specific gene duplication and loss in human and great ape evolution PLOS Biology 2 7 E207 doi 10 1371 journal pbio 0020207 PMC 449870 PMID 15252450 Mauri P Scarpa A Nascimbeni AC Benazzi L Parmagnani E Mafficini A Della Peruta M Bassi C Miyazaki K Sorio C July 2005 Identification of proteins released by pancreatic cancer cells by multidimensional protein identification technology a strategy for identification of novel cancer markers FASEB Journal 19 9 1125 7 doi 10 1096 fj 04 3000fje PMID 15985535 S2CID 33940827 Gronborg M Kristiansen TZ Iwahori A Chang R Reddy R Sato N Molina H Jensen ON Hruban RH Goggins MG Maitra A Pandey A January 2006 Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach Molecular amp Cellular Proteomics 5 1 157 71 doi 10 1074 mcp M500178 MCP200 PMID 16215274 Guo J Cheng H Zhao S Yu L January 2006 GG a domain involved in phage LTF apparatus and implicated in human MEB and non syndromic hearing loss diseases FEBS Letters 580 2 581 4 doi 10 1016 j febslet 2005 12 076 PMID 16406369 S2CID 1013478 Waerner T Alacakaptan M Tamir I Oberauer R Gal A Brabletz T Schreiber M Jechlinger M Beug H September 2006 ILEI a cytokine essential for EMT tumor formation and late events in metastasis in epithelial cells Cancer Cell 10 3 227 39 doi 10 1016 j ccr 2006 07 020 PMID 16959614 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title FAM3C amp oldid 1215939807, wikipedia, wiki, book, books, library,
