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Estrogen-related receptor alpha

Estrogen-related receptor alpha (ERRα), also known as NR3B1 (nuclear receptor subfamily 3, group B, member 1), is a nuclear receptor that in humans is encoded by the ESRRA (Estrogen Related Receptor Alpha) gene.[3][4] ERRα was originally cloned by DNA sequence homology to the estrogen receptor alpha (ERα, NR3A1),[4] but subsequent ligand binding and reporter-gene transfection experiments demonstrated that estrogens did not regulate ERRα.[5] Currently, ERRα is considered an orphan nuclear receptor.[4][5]

ESRRA
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1, estrogen related receptor alpha
External IDsOMIM: 601998 HomoloGene: 136738 GeneCards: ESRRA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282450
NM_001282451
NM_004451

n/a

RefSeq (protein)

NP_001269379
NP_001269380
NP_004442

n/a

Location (UCSC)Chr 11: 64.31 – 64.32 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Tissue distribution edit

ERRα has wide tissue distribution but it is most highly expressed in tissues that preferentially use fatty acids as energy sources such as kidney, heart, brown adipose tissue, cerebellum, intestine, and skeletal muscle.[6] Recently, ERRα has been detected in normal adrenal cortex tissues, in which its expression is possibly related to adrenal development, with a possible role in fetal adrenal function, in DHEAS production in adrenarche, and also in steroid production of post-adrenarche/adult life.[7]

Function edit

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. Results of both in vitro and in vivo studies suggest that ERRα is required for the activation of mitochondrial genes as well as increased mitochondrial biogenesis.[8][9] This protein acts as a site-specific (consensus TNAAGGTCA) transcription regulator and has been also shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. It was reported that ERRα can activate reporters containing steroidogenesis factor 1 (SF-1) response elements as a result of transient transfection assays,[10] and a possible role of ERRα in steroidogenesis with relation to SF-1 was subsequently demonstrated in adrenocortical cells.[11] The transcriptional activation of CYP17A1 and SULT2A1 in the adrenal has been proposed as the mechanism of action possibly accounting for the increment in DHEAS serum levels by ERRα.[11] ERRα has been suggested to act as a transcriptional activator of CYP11B1 and CYP11B2, which indicates that this nuclear receptor may be required for the production of cortisol and aldosterone in the adrenal gland.[12]

Metabolism edit

ERRα regulates genes involved in mitochondrial biogenesis,[13] gluconeogenesis,[14] oxidative phosphorylation,[15] and fatty acid metabolism,[16] and brown adipose tissue thermogenesis.[17][18] It was recently identified as an important regulator of the mammalian circadian clock, and its output pathways at both transcriptional and physiological levels regulated the expression of transcription factors involved in metabolic homeostasis.[19] It has been demonstrated that ERRα is required for the maintenance of diurnal cholesterol, glucose, insulin, bile acid, and trygliceride levels as well as locomotor rhythms in mice.[19] ERRα is related to mitochondrial function but studies involving ERRα knockout mice suggested that this receptor, while dispensable for basal cellular function, is definitely necessary to provide the levels of energy necessary to respond to physiological and pathological insults in diverse tissues,[5] the lack of that nuclear receptor leading to impaired fat metabolism and absorption.[20]

Estrogen signaling edit

Estrogen receptor alpha (ERα) and estrogen-related receptor alpha (ERRα) have been found to regulate many of the same genes.[21][22] Furthermore, ERRα appears to modulate the activity of ERα in various tissues including breast, uterus, and bone.[23]

Ligands edit

No endogenous ligands of ERRα have been identified to date, hence ERRα is classified as an orphan receptor. In addition both biochemical and structural studies indicate that ERRα is constitutively active in the absence of ligand.[24] ERRα does, however, interact with the metabolic-inducible coactivator PGC1-α in its AF2 region which is sometimes referred to as the "protein ligand" of ERRα.

The isoflavone phytoestrogens genistein and daidzein are non-selective ERR agonists,[25] while XCT790 has been identified as a potent and selective inverse agonist of ERRα.[26] SLU-PP-332 is a potent agonist of ERRα.[27]

Cholesterol has recently been found to bind to and activate the ERRα, and may be the endogenous ligand for the receptor.[28] Moreover, the effects of cholesterol, statins, and bisphosphonates on osteoclastogenesis in bone tissue require ERRα; in accordance, cholesterol-induced bone loss or bisphosphonate osteoprotection is absent in ERRα knockout mice.[28] Furthermore, statin-associated myopathy and suppression of cholesterol-induced cytokine secretion by macrophages are reduced by absence or inhibition of ERRα.[28] As such, modulation of ERRα signaling is a key mediator in the actions of statins (by changes in cholesterol levels) and bisphosphonates.[28]

See also edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173153 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Entrez Gene: ESRRA estrogen-related receptor alpha".
  4. ^ a b c Giguère V, Yang N, Segui P, Evans RM (January 1988). "Identification of a new class of steroid hormone receptors". Nature. 331 (6151): 91–4. Bibcode:1988Natur.331...91G. doi:10.1038/331091a0. PMID 3267207. S2CID 4275394.
  5. ^ a b c Deblois G, Giguère V (August 2011). "Functional and physiological genomics of estrogen-related receptors (ERRs) in health and disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1812 (8): 1032–40. doi:10.1016/j.bbadis.2010.12.009. PMID 21172432.
  6. ^ Bookout AL, Jeong Y, Downes M, Yu RT, Evans RM, Mangelsdorf DJ (August 2006). "Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network". Cell. 126 (4): 789–99. doi:10.1016/j.cell.2006.06.049. PMC 6211849. PMID 16923397.
  7. ^ Felizola SJ, Nakamura Y, Hui XG, Satoh F, Morimoto R, M McNamara K, et al. (January 2013). "Estrogen-related receptor α in normal adrenal cortex and adrenocortical tumors: involvement in development and oncogenesis". Molecular and Cellular Endocrinology. 365 (2): 207–11. doi:10.1016/j.mce.2012.10.020. PMC 4097865. PMID 23123734.
  8. ^ Schreiber SN, Emter R, Hock MB, Knutti D, Cardenas J, Podvinec M, et al. (April 2004). "The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6472–7. Bibcode:2004PNAS..101.6472S. doi:10.1073/pnas.0308686101. PMC 404069. PMID 15087503.
  9. ^ Villena JA, Hock MB, Chang WY, Barcas JE, Giguère V, Kralli A (January 2007). "Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1418–23. Bibcode:2007PNAS..104.1418V. doi:10.1073/pnas.0607696104. PMC 1783094. PMID 17229846.
  10. ^ Bonnelye E, Vanacker JM, Dittmar T, Begue A, Desbiens X, Denhardt DT, et al. (June 1997). "The ERR-1 orphan receptor is a transcriptional activator expressed during bone development". Molecular Endocrinology. 11 (7): 905–16. doi:10.1210/mend.11.7.9948. PMID 9178750.
  11. ^ a b Seely J, Amigh KS, Suzuki T, Mayhew B, Sasano H, Giguere V, et al. (August 2005). "Transcriptional regulation of dehydroepiandrosterone sulfotransferase (SULT2A1) by estrogen-related receptor alpha". Endocrinology. 146 (8): 3605–13. doi:10.1210/en.2004-1619. PMID 15878968.
  12. ^ Cheng LC, Pai TW, Li LA (January 2012). "Regulation of human CYP11B1 and CYP11B2 promoters by transposable elements and conserved cis elements". Steroids. 77 (1–2): 100–9. doi:10.1016/j.steroids.2011.10.010. PMID 22079243. S2CID 140208125.
  13. ^ Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, et al. (July 1999). "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1". Cell. 98 (1): 115–24. doi:10.1016/S0092-8674(00)80611-X. PMID 10412986. S2CID 16143809.
  14. ^ Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, et al. (September 2001). "Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1". Nature. 413 (6852): 131–8. Bibcode:2001Natur.413..131Y. doi:10.1038/35093050. PMID 11557972. S2CID 11184579.
  15. ^ Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, et al. (April 2004). "Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle". Proceedings of the National Academy of Sciences of the United States of America. 101 (17): 6570–5. Bibcode:2004PNAS..101.6570M. doi:10.1073/pnas.0401401101. PMC 404086. PMID 15100410.
  16. ^ Huss JM, Torra IP, Staels B, Giguère V, Kelly DP (October 2004). "Estrogen-related receptor alpha directs peroxisome proliferator-activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle". Molecular and Cellular Biology. 24 (20): 9079–91. doi:10.1128/MCB.24.20.9079-9091.2004. PMC 517878. PMID 15456881.
  17. ^ Villena JA, Hock MB, Chang WY, Barcas JE, Giguère V, Kralli A (January 2007). "Orphan nuclear receptor estrogen-related receptor alpha is essential for adaptive thermogenesis". Proceedings of the National Academy of Sciences of the United States of America. 104 (4): 1418–23. Bibcode:2007PNAS..104.1418V. doi:10.1073/pnas.0607696104. PMC 1783094. PMID 17229846.
  18. ^ Emmett MJ, Lim HW, Jager J, Richter HJ, Adlanmerini M, Peed LC, et al. (June 2017). "Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge". Nature. 546 (7659): 544–548. Bibcode:2017Natur.546..544E. doi:10.1038/nature22819. PMC 5826652. PMID 28614293.
  19. ^ a b Dufour CR, Levasseur MP, Pham NH, Eichner LJ, Wilson BJ, Charest-Marcotte A, et al. (June 2011). Mangelsdorf DJ (ed.). "Genomic convergence among ERRα, PROX1, and BMAL1 in the control of metabolic clock outputs". PLOS Genetics. 7 (6): e1002143. doi:10.1371/journal.pgen.1002143. PMC 3121748. PMID 21731503.
  20. ^ Luo J, Sladek R, Carrier J, Bader JA, Richard D, Giguère V (November 2003). "Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha". Molecular and Cellular Biology. 23 (22): 7947–56. doi:10.1128/MCB.23.22.7947-7956.2003. PMC 262360. PMID 14585956.
  21. ^ Vanacker JM, Bonnelye E, Chopin-Delannoy S, Delmarre C, Cavaillès V, Laudet V (May 1999). "Transcriptional activities of the orphan nuclear receptor ERR alpha (estrogen receptor-related receptor-alpha)". Molecular Endocrinology. 13 (5): 764–73. CiteSeerX 10.1.1.321.1698. doi:10.1210/mend.13.5.0281. PMID 10319326.
  22. ^ Vanacker JM, Pettersson K, Gustafsson JA, Laudet V (August 1999). "Transcriptional targets shared by estrogen receptor- related receptors (ERRs) and estrogen receptor (ER) alpha, but not by ERbeta". The EMBO Journal. 18 (15): 4270–9. doi:10.1093/emboj/18.15.4270. PMC 1171503. PMID 10428965.
  23. ^ Stein RA, McDonnell DP (December 2006). "Estrogen-related receptor alpha as a therapeutic target in cancer". Endocrine-Related Cancer. 13 (Suppl 1): S25–32. doi:10.1677/erc.1.01292. PMID 17259555.
  24. ^ Kallen J, Schlaeppi JM, Bitsch F, Filipuzzi I, Schilb A, Riou V, et al. (November 2004). "Evidence for ligand-independent transcriptional activation of the human estrogen-related receptor alpha (ERRalpha): crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator-activated receptor coactivator-1alpha". The Journal of Biological Chemistry. 279 (47): 49330–7. doi:10.1074/jbc.M407999200. PMID 15337744.
  25. ^ Suetsugi M, Su L, Karlsberg K, Yuan YC, Chen S (November 2003). "Flavone and isoflavone phytoestrogens are agonists of estrogen-related receptors". Molecular Cancer Research. 1 (13): 981–91. PMID 14638870.
  26. ^ Busch BB, Stevens WC, Martin R, Ordentlich P, Zhou S, Sapp DW, et al. (November 2004). "Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor alpha". Journal of Medicinal Chemistry. 47 (23): 5593–6. doi:10.1021/jm049334f. PMID 15509154.
  27. ^ Billon C, Schoepke E, Avdagic A, Chatterjee A, Butler AA, Elgendy B, et al. (September 2023). "A Synthetic ERR Agonist Alleviates Metabolic Syndrome". The Journal of Pharmacology and Experimental Therapeutics. 388 (2): 232–240. doi:10.1124/jpet.123.001733. PMC 10801787. PMID 37739806.
  28. ^ a b c d Wei W, Schwaid AG, Wang X, Wang X, Chen S, Chu Q, et al. (March 2016). "Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects". Cell Metabolism. 23 (3): 479–91. doi:10.1016/j.cmet.2015.12.010. PMC 4785078. PMID 26777690.

External links edit

  • FactorBook ERRA
  • Overview of all the structural information available in the PDB for UniProt: P11474 (Steroid hormone receptor ERR1) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

estrogen, related, receptor, alpha, errα, also, known, nr3b1, nuclear, receptor, subfamily, group, member, nuclear, receptor, that, humans, encoded, esrra, estrogen, related, receptor, alpha, gene, errα, originally, cloned, sequence, homology, estrogen, recept. Estrogen related receptor alpha ERRa also known as NR3B1 nuclear receptor subfamily 3 group B member 1 is a nuclear receptor that in humans is encoded by the ESRRA Estrogen Related Receptor Alpha gene 3 4 ERRa was originally cloned by DNA sequence homology to the estrogen receptor alpha ERa NR3A1 4 but subsequent ligand binding and reporter gene transfection experiments demonstrated that estrogens did not regulate ERRa 5 Currently ERRa is considered an orphan nuclear receptor 4 5 ESRRAAvailable structuresPDBHuman UniProt search PDBe RCSBList of PDB id codes1XB7 2PJL 3D24 3K6PIdentifiersAliasesESRRA ERR1 ERRa ERRalpha ESRL1 NR3B1 estrogen related receptor alphaExternal IDsOMIM 601998 HomoloGene 136738 GeneCards ESRRAGene location Human Chr Chromosome 11 human 1 Band11q13 1Start64 305 497 bp 1 End64 316 743 bp 1 RNA expression patternBgeeHumanMouse ortholog Top expressed ingastrocnemius muscleleft ventricleright lobe of liverpancreatic ductal cellbody of stomachminor salivary glandbody of pancreasvena cavamonocytetriceps brachii musclen aMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding sequence specific DNA binding protein domain specific binding DNA binding transcription factor activity zinc ion binding DNA binding transcription activator activity RNA polymerase II specific metal ion binding RNA polymerase II cis regulatory region sequence specific DNA binding steroid hormone receptor activity DNA binding transcription repressor activity RNA polymerase II specific nuclear receptor activity steroid binding protein binding DNA binding transcription factor activity RNA polymerase II specificCellular componentmicrotubule cytoskeleton nucleoplasm intercellular bridge nucleus fibrillar center cytoplasmBiological processresponse to estradiol regulation of transcription DNA templated positive regulation of cellular response to insulin stimulus mitochondrion organization negative regulation of transcription by RNA polymerase II transcription DNA templated positive regulation of transcription DNA templated cartilage development regulation of cell population proliferation regulation of osteoblast differentiation regulation of osteoclast differentiation regulation of ossification transcription initiation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II steroid hormone mediated signaling pathway intracellular receptor signaling pathwaySources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez2101n aEnsemblENSG00000173153n aUniProtP11474n aRefSeq mRNA NM 001282450NM 001282451NM 004451n aRefSeq protein NP 001269379NP 001269380NP 004442n aLocation UCSC Chr 11 64 31 64 32 Mbn aPubMed search 2 n aWikidataView Edit Human Contents 1 Tissue distribution 2 Function 2 1 Metabolism 2 2 Estrogen signaling 3 Ligands 4 See also 5 References 6 External linksTissue distribution editERRa has wide tissue distribution but it is most highly expressed in tissues that preferentially use fatty acids as energy sources such as kidney heart brown adipose tissue cerebellum intestine and skeletal muscle 6 Recently ERRa has been detected in normal adrenal cortex tissues in which its expression is possibly related to adrenal development with a possible role in fetal adrenal function in DHEAS production in adrenarche and also in steroid production of post adrenarche adult life 7 Function editThe protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor Results of both in vitro and in vivo studies suggest that ERRa is required for the activation of mitochondrial genes as well as increased mitochondrial biogenesis 8 9 This protein acts as a site specific consensus TNAAGGTCA transcription regulator and has been also shown to interact with estrogen and the transcription factor TFIIB by direct protein protein contact The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin osteopontin medium chain acyl coenzyme A dehydrogenase MCAD and thyroid hormone receptor genes It was reported that ERRa can activate reporters containing steroidogenesis factor 1 SF 1 response elements as a result of transient transfection assays 10 and a possible role of ERRa in steroidogenesis with relation to SF 1 was subsequently demonstrated in adrenocortical cells 11 The transcriptional activation of CYP17A1 and SULT2A1 in the adrenal has been proposed as the mechanism of action possibly accounting for the increment in DHEAS serum levels by ERRa 11 ERRa has been suggested to act as a transcriptional activator of CYP11B1 and CYP11B2 which indicates that this nuclear receptor may be required for the production of cortisol and aldosterone in the adrenal gland 12 Metabolism edit ERRa regulates genes involved in mitochondrial biogenesis 13 gluconeogenesis 14 oxidative phosphorylation 15 and fatty acid metabolism 16 and brown adipose tissue thermogenesis 17 18 It was recently identified as an important regulator of the mammalian circadian clock and its output pathways at both transcriptional and physiological levels regulated the expression of transcription factors involved in metabolic homeostasis 19 It has been demonstrated that ERRa is required for the maintenance of diurnal cholesterol glucose insulin bile acid and trygliceride levels as well as locomotor rhythms in mice 19 ERRa is related to mitochondrial function but studies involving ERRa knockout mice suggested that this receptor while dispensable for basal cellular function is definitely necessary to provide the levels of energy necessary to respond to physiological and pathological insults in diverse tissues 5 the lack of that nuclear receptor leading to impaired fat metabolism and absorption 20 Estrogen signaling edit Estrogen receptor alpha ERa and estrogen related receptor alpha ERRa have been found to regulate many of the same genes 21 22 Furthermore ERRa appears to modulate the activity of ERa in various tissues including breast uterus and bone 23 Ligands editNo endogenous ligands of ERRa have been identified to date hence ERRa is classified as an orphan receptor In addition both biochemical and structural studies indicate that ERRa is constitutively active in the absence of ligand 24 ERRa does however interact with the metabolic inducible coactivator PGC1 a in its AF2 region which is sometimes referred to as the protein ligand of ERRa The isoflavone phytoestrogens genistein and daidzein are non selective ERR agonists 25 while XCT790 has been identified as a potent and selective inverse agonist of ERRa 26 SLU PP 332 is a potent agonist of ERRa 27 Cholesterol has recently been found to bind to and activate the ERRa and may be the endogenous ligand for the receptor 28 Moreover the effects of cholesterol statins and bisphosphonates on osteoclastogenesis in bone tissue require ERRa in accordance cholesterol induced bone loss or bisphosphonate osteoprotection is absent in ERRa knockout mice 28 Furthermore statin associated myopathy and suppression of cholesterol induced cytokine secretion by macrophages are reduced by absence or inhibition of ERRa 28 As such modulation of ERRa signaling is a key mediator in the actions of statins by changes in cholesterol levels and bisphosphonates 28 See also editEstrogen related receptorReferences edit a b c GRCh38 Ensembl release 89 ENSG00000173153 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Entrez Gene ESRRA estrogen related receptor alpha a b c Giguere V Yang N Segui P Evans RM January 1988 Identification of a new class of steroid hormone receptors Nature 331 6151 91 4 Bibcode 1988Natur 331 91G doi 10 1038 331091a0 PMID 3267207 S2CID 4275394 a b c Deblois G Giguere V August 2011 Functional and physiological genomics of estrogen related receptors ERRs in health and disease Biochimica et Biophysica Acta BBA Molecular Basis of Disease 1812 8 1032 40 doi 10 1016 j bbadis 2010 12 009 PMID 21172432 Bookout AL Jeong Y Downes M Yu RT Evans RM Mangelsdorf DJ August 2006 Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network Cell 126 4 789 99 doi 10 1016 j cell 2006 06 049 PMC 6211849 PMID 16923397 Felizola SJ Nakamura Y Hui XG Satoh F Morimoto R M McNamara K et al January 2013 Estrogen related receptor a in normal adrenal cortex and adrenocortical tumors involvement in development and oncogenesis Molecular and Cellular Endocrinology 365 2 207 11 doi 10 1016 j mce 2012 10 020 PMC 4097865 PMID 23123734 Schreiber SN Emter R Hock MB Knutti D Cardenas J Podvinec M et al April 2004 The estrogen related receptor alpha ERRalpha functions in PPARgamma coactivator 1alpha PGC 1alpha induced mitochondrial biogenesis Proceedings of the National Academy of Sciences of the United States of America 101 17 6472 7 Bibcode 2004PNAS 101 6472S doi 10 1073 pnas 0308686101 PMC 404069 PMID 15087503 Villena JA Hock MB Chang WY Barcas JE Giguere V Kralli A January 2007 Orphan nuclear receptor estrogen related receptor alpha is essential for adaptive thermogenesis Proceedings of the National Academy of Sciences of the United States of America 104 4 1418 23 Bibcode 2007PNAS 104 1418V doi 10 1073 pnas 0607696104 PMC 1783094 PMID 17229846 Bonnelye E Vanacker JM Dittmar T Begue A Desbiens X Denhardt DT et al June 1997 The ERR 1 orphan receptor is a transcriptional activator expressed during bone development Molecular Endocrinology 11 7 905 16 doi 10 1210 mend 11 7 9948 PMID 9178750 a b Seely J Amigh KS Suzuki T Mayhew B Sasano H Giguere V et al August 2005 Transcriptional regulation of dehydroepiandrosterone sulfotransferase SULT2A1 by estrogen related receptor alpha Endocrinology 146 8 3605 13 doi 10 1210 en 2004 1619 PMID 15878968 Cheng LC Pai TW Li LA January 2012 Regulation of human CYP11B1 and CYP11B2 promoters by transposable elements and conserved cis elements Steroids 77 1 2 100 9 doi 10 1016 j steroids 2011 10 010 PMID 22079243 S2CID 140208125 Wu Z Puigserver P Andersson U Zhang C Adelmant G Mootha V et al July 1999 Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC 1 Cell 98 1 115 24 doi 10 1016 S0092 8674 00 80611 X PMID 10412986 S2CID 16143809 Yoon JC Puigserver P Chen G Donovan J Wu Z Rhee J et al September 2001 Control of hepatic gluconeogenesis through the transcriptional coactivator PGC 1 Nature 413 6852 131 8 Bibcode 2001Natur 413 131Y doi 10 1038 35093050 PMID 11557972 S2CID 11184579 Mootha VK Handschin C Arlow D Xie X St Pierre J Sihag S et al April 2004 Erralpha and Gabpa b specify PGC 1alpha dependent oxidative phosphorylation gene expression that is altered in diabetic muscle Proceedings of the National Academy of Sciences of the United States of America 101 17 6570 5 Bibcode 2004PNAS 101 6570M doi 10 1073 pnas 0401401101 PMC 404086 PMID 15100410 Huss JM Torra IP Staels B Giguere V Kelly DP October 2004 Estrogen related receptor alpha directs peroxisome proliferator activated receptor alpha signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle Molecular and Cellular Biology 24 20 9079 91 doi 10 1128 MCB 24 20 9079 9091 2004 PMC 517878 PMID 15456881 Villena JA Hock MB Chang WY Barcas JE Giguere V Kralli A January 2007 Orphan nuclear receptor estrogen related receptor alpha is essential for adaptive thermogenesis Proceedings of the National Academy of Sciences of the United States of America 104 4 1418 23 Bibcode 2007PNAS 104 1418V doi 10 1073 pnas 0607696104 PMC 1783094 PMID 17229846 Emmett MJ Lim HW Jager J Richter HJ Adlanmerini M Peed LC et al June 2017 Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge Nature 546 7659 544 548 Bibcode 2017Natur 546 544E doi 10 1038 nature22819 PMC 5826652 PMID 28614293 a b Dufour CR Levasseur MP Pham NH Eichner LJ Wilson BJ Charest Marcotte A et al June 2011 Mangelsdorf DJ ed Genomic convergence among ERRa PROX1 and BMAL1 in the control of metabolic clock outputs PLOS Genetics 7 6 e1002143 doi 10 1371 journal pgen 1002143 PMC 3121748 PMID 21731503 Luo J Sladek R Carrier J Bader JA Richard D Giguere V November 2003 Reduced fat mass in mice lacking orphan nuclear receptor estrogen related receptor alpha Molecular and Cellular Biology 23 22 7947 56 doi 10 1128 MCB 23 22 7947 7956 2003 PMC 262360 PMID 14585956 Vanacker JM Bonnelye E Chopin Delannoy S Delmarre C Cavailles V Laudet V May 1999 Transcriptional activities of the orphan nuclear receptor ERR alpha estrogen receptor related receptor alpha Molecular Endocrinology 13 5 764 73 CiteSeerX 10 1 1 321 1698 doi 10 1210 mend 13 5 0281 PMID 10319326 Vanacker JM Pettersson K Gustafsson JA Laudet V August 1999 Transcriptional targets shared by estrogen receptor related receptors ERRs and estrogen receptor ER alpha but not by ERbeta The EMBO Journal 18 15 4270 9 doi 10 1093 emboj 18 15 4270 PMC 1171503 PMID 10428965 Stein RA McDonnell DP December 2006 Estrogen related receptor alpha as a therapeutic target in cancer Endocrine Related Cancer 13 Suppl 1 S25 32 doi 10 1677 erc 1 01292 PMID 17259555 Kallen J Schlaeppi JM Bitsch F Filipuzzi I Schilb A Riou V et al November 2004 Evidence for ligand independent transcriptional activation of the human estrogen related receptor alpha ERRalpha crystal structure of ERRalpha ligand binding domain in complex with peroxisome proliferator activated receptor coactivator 1alpha The Journal of Biological Chemistry 279 47 49330 7 doi 10 1074 jbc M407999200 PMID 15337744 Suetsugi M Su L Karlsberg K Yuan YC Chen S November 2003 Flavone and isoflavone phytoestrogens are agonists of estrogen related receptors Molecular Cancer Research 1 13 981 91 PMID 14638870 Busch BB Stevens WC Martin R Ordentlich P Zhou S Sapp DW et al November 2004 Identification of a selective inverse agonist for the orphan nuclear receptor estrogen related receptor alpha Journal of Medicinal Chemistry 47 23 5593 6 doi 10 1021 jm049334f PMID 15509154 Billon C Schoepke E Avdagic A Chatterjee A Butler AA Elgendy B et al September 2023 A Synthetic ERR Agonist Alleviates Metabolic Syndrome The Journal of Pharmacology and Experimental Therapeutics 388 2 232 240 doi 10 1124 jpet 123 001733 PMC 10801787 PMID 37739806 a b c d Wei W Schwaid AG Wang X Wang X Chen S Chu Q et al March 2016 Ligand Activation of ERRa by Cholesterol Mediates Statin and Bisphosphonate Effects Cell Metabolism 23 3 479 91 doi 10 1016 j cmet 2015 12 010 PMC 4785078 PMID 26777690 External links editFactorBook ERRA Overview of all the structural information available in the PDB for UniProt P11474 Steroid hormone receptor ERR1 at the PDBe KB This article incorporates text from the United States National Library of Medicine which is in the public domain Retrieved from https en wikipedia org w index php title Estrogen related receptor alpha amp oldid 1216233642, wikipedia, wiki, book, books, 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