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Elaine Mardis

April 15, 2024

Elaine R. Mardis (born September 28, 1962) is the co-executive director of the Institute for Genomic Medicine at Nationwide Children's Hospital, where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine.[1] She also is professor of pediatrics at the Ohio State University College of Medicine.[2] Mardis’s research focuses on the genomic characterization of cancer and its implications for cancer medicine.[3] She was part of the team that reported the first next-generation-based sequencing of a whole cancer genome,[4][5] and participated extensively in The Cancer Genome Atlas (TCGA) and the Pediatric Cancer Genome Project (PCGP).[3][6][7][8]

Biography edit

Mardis was born in North Platte, Nebraska. She gained a passion for science at an early age, and credits her father, a chemistry professor for more than 30 years, for nurturing this passion.[9][10]

She received her undergraduate degree in Zoology from the University of Oklahoma in 1984.[1] During her senior year she took a course in biochemistry that was taught by Bruce Roe, PhD, which says opened her eyes to the world of molecular biology.[9] She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr. Roe, who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory.[10] As a result, during her doctoral work Mardis learned the art of DNA sequencing, at a time when few others were doing this.[9][10]

After obtaining her PhD in chemistry and biochemistry in 1989, Mardis did postgraduate work in industry at Bio-Rad Laboratories in Hercules, California.[1]

In 1993, Mardis joined the faculty of Washington University School of Medicine.[1] Over the next 23 years, she held several and academic and leadership roles at the University, including serving as co-director of the McDonnell Genome Institute.[3] In that position, she contributed substantially to the sequencing and analysis of the human genome,[11] and was instrumental in establishing the utility of massively parallel sequencing technologies for understanding cancer biology.[3] Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer, including acute myeloid leukemia,[7][12][13] breast cancer,[14][15] glioblastoma,[16] and lung adenocarcinoma.[17][18] By better defining the landscape of germline and somatic alterations, this research helps drive new strategies for treating cancer, and is central to the concept of precision medicine.

Since joining Nationwide Children's Hospital in 2016, Dr. Mardis has turned the focus of her research to the incorporation of next-generation sequencing assays and established knowledge about cancer genomics into clinical and therapeutic decision-making, and into the design of new approaches to cancer immunotherapy.[3][19][20]

In 2015, Mardis helped launch an open access, precision medicine journal, Molecular Case Studies, in conjunction with Cold Spring Harbor Laboratory Press.[21] She currently serves as Editor-in-Chief.[22] In 2020 she was Deputy Editor-in-Chief of Disease Models & Mechanisms journal, with Elizabeth Patton the Editor-in-Chief.[23]

Mardis was elected as president of the American Association for Cancer Research for 2019–2020.[24]

Awards and honors edit

  • 2010: Scripps Translational Research Award[3]
  • 2011: Distinguished Alumna Award from the College of Arts and Sciences, Oklahoma University[25]
  • 2016: Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American Association for Clinical Chemistry[26]
  • 2017: Precision Medicine World Congress 2017 Luminary Award[27]
  • 2019: Elected to the 2019 class of Fellows of the American Association for Cancer Research (AACR) Academy[28]

References edit

  1. ^ a b c d "Nationwide Children's Hospital: Find a Doctor". Retrieved May 1, 2019.
  2. ^ "The Lantern". 26 June 2018. Retrieved May 1, 2019.
  3. ^ a b c d e f "PMWC Speaker Biography". Retrieved May 1, 2019.
  4. ^ Ley, Timothy J.; Mardis, Elaine R.; Ding, Li; Fulton, Bob; McLellan, Michael D.; Chen, Ken; Dooling, David; Dunford-Shore, Brian H.; McGrath, Sean; Hickenbotham, Matthew; Cook, Lisa; Abbott, Rachel; Larson, David E.; Koboldt, Dan C.; Pohl, Craig; Smith, Scott; Hawkins, Amy; Abbott, Scott; Locke, Devin; Hillier, Ladeana W.; Miner, Tracie; Fulton, Lucinda; Magrini, Vincent; Wylie, Todd; Glasscock, Jarret; Conyers, Joshua; Sander, Nathan; Shi, Xiaoqi; Osborne, John R.; et al. (2008). "DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome". Nature. 456 (7218): 66–72. Bibcode:2008Natur.456...66L. doi:10.1038/nature07485. PMC 2603574. PMID 18987736.
  5. ^ Grady, Denise (November 6, 2008). ""Scientists Decode Set of Cancer Genes." New York Times, November 5, 2008". The New York Times. Retrieved May 1, 2019.
  6. ^ "The Cancer Genome Atlas Timeline & Milestones". National Cancer Institute. 2018-06-13. Retrieved May 1, 2019.
  7. ^ a b Cancer Genome Atlas Research Network; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–1068. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
  8. ^ Zhang, J.; Wu, G.; Miller, C. P.; Tatevossian, R. G.; Dalton, J. D.; Tang, B.; Orisme, W.; Punchihewa, C.; Parker, M.; Qaddoumi, I.; Boop, F. A.; Lu, C.; Kandoth, C.; Ding, L.; Lee, R.; Huether, R.; Chen, X.; Hedlund, E.; Nagahawatte, P.; Rusch, M.; Boggs, K.; Cheng, J.; Becksfort, J.; Ma, J.; Song, G.; Li, Y.; Wei, L.; Wang, J.; Shurtleff, S.; et al. (2013). "Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas". Nature Genetics. 45 (6): 602–612. doi:10.1038/ng.2611. PMC 3727232. PMID 23583981.
  9. ^ a b c Mardis, E.; Dhillon, P. (2014). "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis". Disease Models & Mechanisms. 7 (3): 313–317. doi:10.1242/dmm.015396. PMC 3944491. PMID 24609032.
  10. ^ a b c Arbanas, Caroline (September 10, 2008). "Genome technology wizard". The Source, Washington University in St. Louis. Retrieved May 1, 2019.
  11. ^ Purddy, Michael C. (October 21, 2004). "Genome center is major contributor to 'finished' human genome sequence". Washington University in St. Louis. Retrieved May 1, 2019.
  12. ^ Mardis, Elaine R.; Ding, Li; Dooling, David J.; Larson, David E.; McLellan, Michael D.; Chen, Ken; Koboldt, Daniel C.; Fulton, Robert S.; Delehaunty, Kim D.; McGrath, Sean D.; Fulton, Lucinda A.; Locke, Devin P.; Magrini, Vincent J.; Abbott, Rachel M.; Vickery, Tammi L.; Reed, Jerry S.; Robinson, Jody S.; Wylie, Todd; Smith, Scott M.; Carmichael, Lynn; Eldred, James M.; Harris, Christopher C.; Walker, Jason; Peck, Joshua B.; Du, Feiyu; Dukes, Adam F.; Sanderson, Gabriel E.; Brummett, Anthony M.; Clark, Eric; et al. (2009). "Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome". The New England Journal of Medicine. 361 (11): 1058–1066. doi:10.1056/NEJMoa0903840. PMC 3201812. PMID 19657110.
  13. ^ Ding, Li; Ley, Timothy J.; Larson, David E.; Miller, Christopher A.; Koboldt, Daniel C.; Welch, John S.; Ritchey, Julie K.; Young, Margaret A.; Lamprecht, Tamara; McLellan, Michael D.; McMichael, Joshua F.; Wallis, John W.; Lu, Charles; Shen, Dong; Harris, Christopher C.; Dooling, David J.; Fulton, Robert S.; Fulton, Lucinda L.; Chen, Ken; Schmidt, Heather; Kalicki-Veizer, Joelle; Magrini, Vincent J.; Cook, Lisa; McGrath, Sean D.; Vickery, Tammi L.; Wendl, Michael C.; Heath, Sharon; Watson, Mark A.; Link, Daniel C.; et al. (2012). "Clonal evolution in relapsed acute myeloid leukemia revealed by whole-genome sequencing". Nature. 481 (7382): 506–10. Bibcode:2012Natur.481..506D. doi:10.1038/nature10738. PMC 3267864. PMID 22237025.
  14. ^ Ellis, Matthew J.; Ding, Li; Shen, Dong; Luo, Jingqin; Suman, Vera J.; Wallis, John W.; Van Tine, Brian A.; Hoog, Jeremy; Goiffon, Reece J.; Goldstein, Theodore C.; Ng, Sam; Lin, Li; Crowder, Robert; Snider, Jacqueline; Ballman, Karla; Weber, Jason; Chen, Ken; Koboldt, Daniel C.; Kandoth, Cyriac; Schierding, William S.; McMichael, Joshua F.; Miller, Christopher A.; Lu, Charles; Harris, Christopher C.; McLellan, Michael D.; Wendl, Michael C.; Deschryver, Katherine; Allred, D. Craig; Esserman, Laura; et al. (2012). "Whole-genome analysis informs breast cancer response to aromatase inhibition". Nature. 486 (7403): 353–60. Bibcode:2012Natur.486..353E. doi:10.1038/nature11143. PMC 3383766. PMID 22722193.
  15. ^ Griffith, Obi L.; Spies, Nicholas C.; Anurag, Meenakshi; Griffith, Malachi; Luo, Jingqin; Tu, Dongsheng; Yeo, Belinda; Kunisaki, Jason; Miller, Christopher A.; Krysiak, Kilannin; Hundal, Jasreet; Ainscough, Benjamin J.; Skidmore, Zachary L.; Campbell, Katie; Kumar, Runjun; Fronick, Catrina; Cook, Lisa; Snider, Jacqueline E.; Davies, Sherri; Kavuri, Shyam M.; Chang, Eric C.; Magrini, Vincent; Larson, David E.; Fulton, Robert S.; Liu, Shuzhen; Leung, Samuel; Voduc, David; Bose, Ron; Dowsett, Mitch; et al. (2018). "The prognostic effects of somatic mutations in ER-positive breast cancer". Nature Communications. 9 (1): 3476. Bibcode:2018NatCo...9.3476G. doi:10.1038/s41467-018-05914-x. PMC 6123466. PMID 30181556.
  16. ^ McLendon, Roger; Friedman, Allan; Bigner, Darrell; Van Meir, Erwin G.; Brat, Daniel J.; m. Mastrogianakis, Gena; Olson, Jeffrey J.; Mikkelsen, Tom; Lehman, Norman; Aldape, Ken; Alfred Yung, W. K.; Bogler, Oliver; Vandenberg, Scott; Berger, Mitchel; Prados, Michael; Muzny, Donna; Morgan, Margaret; Scherer, Steve; Sabo, Aniko; Nazareth, Lynn; Lewis, Lora; Hall, Otis; Zhu, Yiming; Ren, Yanru; Alvi, Omar; Yao, Jiqiang; Hawes, Alicia; Jhangiani, Shalini; Fowler, Gerald; et al. (2008). "Comprehensive genomic characterization defines human glioblastoma genes and core pathways". Nature. 455 (7216): 1061–8. Bibcode:2008Natur.455.1061M. doi:10.1038/nature07385. PMC 2671642. PMID 18772890.
  17. ^ Ding, Li; Getz, Gad; Wheeler, David A.; Mardis, Elaine R.; McLellan, Michael D.; Cibulskis, Kristian; Sougnez, Carrie; Greulich, Heidi; Muzny, Donna M.; Morgan, Margaret B.; Fulton, Lucinda; Fulton, Robert S.; Zhang, Qunyuan; Wendl, Michael C.; Lawrence, Michael S.; Larson, David E.; Chen, Ken; Dooling, David J.; Sabo, Aniko; Hawes, Alicia C.; Shen, Hua; Jhangiani, Shalini N.; Lewis, Lora R.; Hall, Otis; Zhu, Yiming; Mathew, Tittu; Ren, Yanru; Yao, Jiqiang; Scherer, Steven E.; et al. (2008). "Somatic mutations affect key pathways in lung adenocarcinoma". Nature. 455 (7216): 1069–75. Bibcode:2008Natur.455.1069D. doi:10.1038/nature07423. PMC 2694412. PMID 18948947.
  18. ^ Wagner, Alex H.; Devarakonda, Siddhartha; Skidmore, Zachary L.; Krysiak, Kilannin; Ramu, Avinash; Trani, Lee; Kunisaki, Jason; Masood, Ashiq; Waqar, Saiama N.; Spies, Nicholas C.; Morgensztern, Daniel; Waligorski, Jason; Ponce, Jennifer; Fulton, Robert S.; Maggi, Leonard B.; Weber, Jason D.; Watson, Mark A.; o'Conor, Christopher J.; Ritter, Jon H.; Olsen, Rachelle R.; Cheng, Haixia; Mukhopadhyay, Anandaroop; Can, Ismail; Cessna, Melissa H.; Oliver, Trudy G.; Mardis, Elaine R.; Wilson, Richard K.; Griffith, Malachi; Griffith, Obi L.; Govindan, Ramaswamy (2018). "Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer". Nature Communications. 9 (1): 3787. Bibcode:2018NatCo...9.3787W. doi:10.1038/s41467-018-06162-9. PMC 6141466. PMID 30224629.
  19. ^ Johanns, Tanner M.; Miller, Christopher A.; Liu, Connor J.; Perrin, Richard J.; Bender, Diane; Kobayashi, Dale K.; Campian, Jian L.; Chicoine, Michael R.; Dacey, Ralph G.; Huang, Jiayi; Fritsch, Edward F.; Gillanders, William E.; Artyomov, Maxim N.; Mardis, Elaine R.; Schreiber, Robert D.; Dunn, Gavin P. (2019). "Detection of neoantigen-specific T cells following a personalized vaccine in a patient with glioblastoma". Oncoimmunology. 8 (4): e1561106. doi:10.1080/2162402x.2018.1561106. PMC 6422384. PMID 30906654.
  20. ^ "Elaine R Mardis, PhD". Ohio State University. Retrieved May 1, 2019.
  21. ^ "Press release. Cold Spring Harbor Laboratory Press" (PDF) (Press release). Retrieved May 1, 2019.
  22. ^ "About Cold Spring Harbor Molecular Case Studies". Retrieved May 1, 2019.
  23. ^ "Editor biographies | Disease Models & Mechanisms | The Company of Biologists | Disease Models & Mechanisms | The Company of Biologists". journals.biologists.com. Retrieved 2021-08-11.
  24. ^ "Elaine R. Mardis, PhD, Named American Association for Cancer Research President-Elect 2018-2019" (Press release). Nationwide Children's Hospital. March 21, 2012. Retrieved May 1, 2019.
  25. ^ "Distinguished Alumni". Oklahoma University. Retrieved May 1, 2019.
  26. ^ "The Morton K. Schwartz Award for Significant Contributions in Cancer Research Diagnostics". AACC. Retrieved May 1, 2019.
  27. ^ "PMWC Speaker biography: Awards". Retrieved May 1, 2019.
  28. ^ "American Association for Cancer Research Announces 2019 Class of Fellows of the AACR Academy". AACR. March 25, 2019. Retrieved May 1, 2019.

External links edit

 
Scholia has an author profile for Elaine Mardis.
  • [Author] PubMed Citations
  • "Elaine Mardis and Richard Wilson: Taking Cancer's Genetic Measure." US News & World Report. 30 June 2009.
  • "Revolutionizing cancer care with next-generation sequencing: an interview with Elaine Mardis." Disease Models & Mechanisms 2014 7: 313-317; doi: 10.1242/dmm.015396
  • "Genetic Clues to Cancer's Spread." Technology Review. 14 April 2010.
  • "Washington University Team Sequences AML Relapse Tumor." GenomeWeb Daily News. 12 May 2010.
  • Nature Podcast. 15 April 2010.
  • "A Conversation about Sequencing Cancer Genomes with Dr. Elaine Mardis." 2010-08-24 at the Wayback Machine NCI Cancer Bulletin. 26 January 2010.

April 15, 2024
elaine, mardis, elaine, mardis, born, september, 1962, executive, director, institute, genomic, medicine, nationwide, children, hospital, where, also, serves, nationwide, foundation, endowed, chair, genomic, medicine, also, professor, pediatrics, ohio, state, . Elaine R Mardis born September 28 1962 is the co executive director of the Institute for Genomic Medicine at Nationwide Children s Hospital where she also serves as the Nationwide Foundation Endowed Chair in Genomic Medicine 1 She also is professor of pediatrics at the Ohio State University College of Medicine 2 Mardis s research focuses on the genomic characterization of cancer and its implications for cancer medicine 3 She was part of the team that reported the first next generation based sequencing of a whole cancer genome 4 5 and participated extensively in The Cancer Genome Atlas TCGA and the Pediatric Cancer Genome Project PCGP 3 6 7 8 Elaine MardisAlma materUniversity of OklahomaScientific careerInstitutionsMcDonnell Genome InstituteWashington University School of Medicine Bio Rad Laboratories Contents 1 Biography 2 Awards and honors 3 References 4 External linksBiography editMardis was born in North Platte Nebraska She gained a passion for science at an early age and credits her father a chemistry professor for more than 30 years for nurturing this passion 9 10 She received her undergraduate degree in Zoology from the University of Oklahoma in 1984 1 During her senior year she took a course in biochemistry that was taught by Bruce Roe PhD which says opened her eyes to the world of molecular biology 9 She stayed at the University of Oklahoma for her doctoral studies under the supervision of Dr Roe who was one of the first academic scientists to have a fluorescent DNA sequencer in the laboratory 10 As a result during her doctoral work Mardis learned the art of DNA sequencing at a time when few others were doing this 9 10 After obtaining her PhD in chemistry and biochemistry in 1989 Mardis did postgraduate work in industry at Bio Rad Laboratories in Hercules California 1 In 1993 Mardis joined the faculty of Washington University School of Medicine 1 Over the next 23 years she held several and academic and leadership roles at the University including serving as co director of the McDonnell Genome Institute 3 In that position she contributed substantially to the sequencing and analysis of the human genome 11 and was instrumental in establishing the utility of massively parallel sequencing technologies for understanding cancer biology 3 Her work in cancer genetics and genomics has provided insights into the genetic drivers of many types of cancer including acute myeloid leukemia 7 12 13 breast cancer 14 15 glioblastoma 16 and lung adenocarcinoma 17 18 By better defining the landscape of germline and somatic alterations this research helps drive new strategies for treating cancer and is central to the concept of precision medicine Since joining Nationwide Children s Hospital in 2016 Dr Mardis has turned the focus of her research to the incorporation of next generation sequencing assays and established knowledge about cancer genomics into clinical and therapeutic decision making and into the design of new approaches to cancer immunotherapy 3 19 20 In 2015 Mardis helped launch an open access precision medicine journal Molecular Case Studies in conjunction with Cold Spring Harbor Laboratory Press 21 She currently serves as Editor in Chief 22 In 2020 she was Deputy Editor in Chief of Disease Models amp Mechanisms journal with Elizabeth Patton the Editor in Chief 23 Mardis was elected as president of the American Association for Cancer Research for 2019 2020 24 Awards and honors edit2010 Scripps Translational Research Award 3 2011 Distinguished Alumna Award from the College of Arts and Sciences Oklahoma University 25 2016 Morton K Schwartz Award for Significant Contributions in Cancer Research Diagnostics from the American Association for Clinical Chemistry 26 2017 Precision Medicine World Congress 2017 Luminary Award 27 2019 Elected to the 2019 class of Fellows of the American Association for Cancer Research AACR Academy 28 References edit a b c d Nationwide Children s Hospital Find a Doctor Retrieved May 1 2019 The Lantern 26 June 2018 Retrieved May 1 2019 a b c d e f PMWC Speaker Biography Retrieved May 1 2019 Ley Timothy J Mardis Elaine R Ding Li Fulton Bob McLellan Michael D Chen Ken Dooling David Dunford Shore Brian H McGrath Sean Hickenbotham Matthew Cook Lisa Abbott Rachel Larson David E Koboldt Dan C Pohl Craig Smith Scott Hawkins Amy Abbott Scott Locke Devin Hillier Ladeana W Miner Tracie Fulton Lucinda Magrini Vincent Wylie Todd Glasscock Jarret Conyers Joshua Sander Nathan Shi Xiaoqi Osborne John R et al 2008 DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome Nature 456 7218 66 72 Bibcode 2008Natur 456 66L doi 10 1038 nature07485 PMC 2603574 PMID 18987736 Grady Denise November 6 2008 Scientists Decode Set of Cancer Genes New York Times November 5 2008 The New York Times Retrieved May 1 2019 The Cancer Genome Atlas Timeline amp Milestones National Cancer Institute 2018 06 13 Retrieved May 1 2019 a b Cancer Genome Atlas Research Network Friedman Allan Bigner Darrell Van Meir Erwin G Brat Daniel J m Mastrogianakis Gena Olson Jeffrey J Mikkelsen Tom Lehman Norman Aldape Ken Alfred Yung W K Bogler Oliver Vandenberg Scott Berger Mitchel Prados Michael Muzny Donna Morgan Margaret Scherer Steve Sabo Aniko Nazareth Lynn Lewis Lora Hall Otis Zhu Yiming Ren Yanru Alvi Omar Yao Jiqiang Hawes Alicia Jhangiani Shalini Fowler Gerald et al 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 7216 1061 1068 Bibcode 2008Natur 455 1061M doi 10 1038 nature07385 PMC 2671642 PMID 18772890 Zhang J Wu G Miller C P Tatevossian R G Dalton J D Tang B Orisme W Punchihewa C Parker M Qaddoumi I Boop F A Lu C Kandoth C Ding L Lee R Huether R Chen X Hedlund E Nagahawatte P Rusch M Boggs K Cheng J Becksfort J Ma J Song G Li Y Wei L Wang J Shurtleff S et al 2013 Whole genome sequencing identifies genetic alterations in pediatric low grade gliomas Nature Genetics 45 6 602 612 doi 10 1038 ng 2611 PMC 3727232 PMID 23583981 a b c Mardis E Dhillon P 2014 Revolutionizing cancer care with next generation sequencing an interview with Elaine Mardis Disease Models amp Mechanisms 7 3 313 317 doi 10 1242 dmm 015396 PMC 3944491 PMID 24609032 a b c Arbanas Caroline September 10 2008 Genome technology wizard The Source Washington University in St Louis Retrieved May 1 2019 Purddy Michael C October 21 2004 Genome center is major contributor to finished human genome sequence Washington University in St Louis Retrieved May 1 2019 Mardis Elaine R Ding Li Dooling David J Larson David E McLellan Michael D Chen Ken Koboldt Daniel C Fulton Robert S Delehaunty Kim D McGrath Sean D Fulton Lucinda A Locke Devin P Magrini Vincent J Abbott Rachel M Vickery Tammi L Reed Jerry S Robinson Jody S Wylie Todd Smith Scott M Carmichael Lynn Eldred James M Harris Christopher C Walker Jason Peck Joshua B Du Feiyu Dukes Adam F Sanderson Gabriel E Brummett Anthony M Clark Eric et al 2009 Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome The New England Journal of Medicine 361 11 1058 1066 doi 10 1056 NEJMoa0903840 PMC 3201812 PMID 19657110 Ding Li Ley Timothy J Larson David E Miller Christopher A Koboldt Daniel C Welch John S Ritchey Julie K Young Margaret A Lamprecht Tamara McLellan Michael D McMichael Joshua F Wallis John W Lu Charles Shen Dong Harris Christopher C Dooling David J Fulton Robert S Fulton Lucinda L Chen Ken Schmidt Heather Kalicki Veizer Joelle Magrini Vincent J Cook Lisa McGrath Sean D Vickery Tammi L Wendl Michael C Heath Sharon Watson Mark A Link Daniel C et al 2012 Clonal evolution in relapsed acute myeloid leukemia revealed by whole genome sequencing Nature 481 7382 506 10 Bibcode 2012Natur 481 506D doi 10 1038 nature10738 PMC 3267864 PMID 22237025 Ellis Matthew J Ding Li Shen Dong Luo Jingqin Suman Vera J Wallis John W Van Tine Brian A Hoog Jeremy Goiffon Reece J Goldstein Theodore C Ng Sam Lin Li Crowder Robert Snider Jacqueline Ballman Karla Weber Jason Chen Ken Koboldt Daniel C Kandoth Cyriac Schierding William S McMichael Joshua F Miller Christopher A Lu Charles Harris Christopher C McLellan Michael D Wendl Michael C Deschryver Katherine Allred D Craig Esserman Laura et al 2012 Whole genome analysis informs breast cancer response to aromatase inhibition Nature 486 7403 353 60 Bibcode 2012Natur 486 353E doi 10 1038 nature11143 PMC 3383766 PMID 22722193 Griffith Obi L Spies Nicholas C Anurag Meenakshi Griffith Malachi Luo Jingqin Tu Dongsheng Yeo Belinda Kunisaki Jason Miller Christopher A Krysiak Kilannin Hundal Jasreet Ainscough Benjamin J Skidmore Zachary L Campbell Katie Kumar Runjun Fronick Catrina Cook Lisa Snider Jacqueline E Davies Sherri Kavuri Shyam M Chang Eric C Magrini Vincent Larson David E Fulton Robert S Liu Shuzhen Leung Samuel Voduc David Bose Ron Dowsett Mitch et al 2018 The prognostic effects of somatic mutations in ER positive breast cancer Nature Communications 9 1 3476 Bibcode 2018NatCo 9 3476G doi 10 1038 s41467 018 05914 x PMC 6123466 PMID 30181556 McLendon Roger Friedman Allan Bigner Darrell Van Meir Erwin G Brat Daniel J m Mastrogianakis Gena Olson Jeffrey J Mikkelsen Tom Lehman Norman Aldape Ken Alfred Yung W K Bogler Oliver Vandenberg Scott Berger Mitchel Prados Michael Muzny Donna Morgan Margaret Scherer Steve Sabo Aniko Nazareth Lynn Lewis Lora Hall Otis Zhu Yiming Ren Yanru Alvi Omar Yao Jiqiang Hawes Alicia Jhangiani Shalini Fowler Gerald et al 2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways Nature 455 7216 1061 8 Bibcode 2008Natur 455 1061M doi 10 1038 nature07385 PMC 2671642 PMID 18772890 Ding Li Getz Gad Wheeler David A Mardis Elaine R McLellan Michael D Cibulskis Kristian Sougnez Carrie Greulich Heidi Muzny Donna M Morgan Margaret B Fulton Lucinda Fulton Robert S Zhang Qunyuan Wendl Michael C Lawrence Michael S Larson David E Chen Ken Dooling David J Sabo Aniko Hawes Alicia C Shen Hua Jhangiani Shalini N Lewis Lora R Hall Otis Zhu Yiming Mathew Tittu Ren Yanru Yao Jiqiang Scherer Steven E et al 2008 Somatic mutations affect key pathways in lung adenocarcinoma Nature 455 7216 1069 75 Bibcode 2008Natur 455 1069D doi 10 1038 nature07423 PMC 2694412 PMID 18948947 Wagner Alex H Devarakonda Siddhartha Skidmore Zachary L Krysiak Kilannin Ramu Avinash Trani Lee Kunisaki Jason Masood Ashiq Waqar Saiama N Spies Nicholas C Morgensztern Daniel Waligorski Jason Ponce Jennifer Fulton Robert S Maggi Leonard B Weber Jason D Watson Mark A o Conor Christopher J Ritter Jon H Olsen Rachelle R Cheng Haixia Mukhopadhyay Anandaroop Can Ismail Cessna Melissa H Oliver Trudy G Mardis Elaine R Wilson Richard K Griffith Malachi Griffith Obi L Govindan Ramaswamy 2018 Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer Nature Communications 9 1 3787 Bibcode 2018NatCo 9 3787W doi 10 1038 s41467 018 06162 9 PMC 6141466 PMID 30224629 Johanns Tanner M Miller Christopher A Liu Connor J Perrin Richard J Bender Diane Kobayashi Dale K Campian Jian L Chicoine Michael R Dacey Ralph G Huang Jiayi Fritsch Edward F Gillanders William E Artyomov Maxim N Mardis Elaine R Schreiber Robert D Dunn Gavin P 2019 Detection of neoantigen specific T cells following a personalized vaccine in a patient with glioblastoma Oncoimmunology 8 4 e1561106 doi 10 1080 2162402x 2018 1561106 PMC 6422384 PMID 30906654 Elaine R Mardis PhD Ohio State University Retrieved May 1 2019 Press release Cold Spring Harbor Laboratory Press PDF Press release Retrieved May 1 2019 About Cold Spring Harbor Molecular Case Studies Retrieved May 1 2019 Editor biographies Disease Models amp Mechanisms The Company of Biologists Disease Models amp Mechanisms The Company of Biologists journals biologists com Retrieved 2021 08 11 Elaine R Mardis PhD Named American Association for Cancer Research President Elect 2018 2019 Press release Nationwide Children s Hospital March 21 2012 Retrieved May 1 2019 Distinguished Alumni Oklahoma University Retrieved May 1 2019 The Morton K Schwartz Award for Significant Contributions in Cancer Research Diagnostics AACC Retrieved May 1 2019 PMWC Speaker biography Awards Retrieved May 1 2019 American Association for Cancer Research Announces 2019 Class of Fellows of the AACR Academy AACR March 25 2019 Retrieved May 1 2019 External links edit nbsp Scholia has an author profile for Elaine Mardis McDonnell Institute Bio Author PubMed Citations Elaine Mardis and Richard Wilson Taking Cancer s Genetic Measure US News amp World Report 30 June 2009 Revolutionizing cancer care with next generation sequencing an interview with Elaine Mardis Disease Models amp Mechanisms 2014 7 313 317 doi 10 1242 dmm 015396 Genetic Clues to Cancer s Spread Technology Review 14 April 2010 Washington University Team Sequences AML Relapse Tumor GenomeWeb Daily News 12 May 2010 Nature Podcast 15 April 2010 A Conversation about Sequencing Cancer Genomes with Dr Elaine Mardis Archived 2010 08 24 at the Wayback Machine NCI Cancer Bulletin 26 January 2010 Retrieved from https en wikipedia org w index php title Elaine Mardis amp oldid 1205527531, wikipedia, wiki, book, books, library,

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