Edwin Goldmann (12 November 1862 – 12 August 1913) was a biomedical researcher and surgeon most famous for his contributions in first characterizing the blood–brain barrier.[1]
Goldmann's mentor, Paul Ehrlich, was studying staining in his bacteriological studies by injecting aniline dyes in several species of animal. While most of the anatomy stained equally well, the brain tissue exhibited less staining in many species. Goldmann discovered that when the dye (namely, trypan blue) was injected directly into the central nervous system instead of into the other organs, the brain would stain equally well as other organs — but the stain would not travel to the rest of the body.
This suggested the presence of a compartmentalization between the cerebrospinal fluid and the vasculature of the rest of the body. This barrier was first hypothesized by a Berlin physician, Max Lewandowsky, in 1900 (prior to Goldmann's empirical evidence).[1]
Edwin Goldmann died from liver cancer in Freiburg on 13 August 1913.[2]
Referencesedit
^ ab"The Late Professor Edwin Goldmann's Investigations on the Central Nervous System by Vital Staining". British Medical Journal. 2 (2753): 871–873. 4 October 1913. ISSN 0007-1447. PMC2345891. PMID 20766814.
^"Doctor Dies a Martyr". The Evening Sun. Berlin. 13 August 1913. p. 2. Retrieved 14 April 2020 – via Newspapers.com.
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edwin, goldmann, november, 1862, august, 1913, biomedical, researcher, surgeon, most, famous, contributions, first, characterizing, blood, brain, barrier, born, 1862, november, 1862burgersdorp, cape, colonydied12, august, 1913, 1913, aged, freiburg, breisgau, . Edwin Goldmann 12 November 1862 12 August 1913 was a biomedical researcher and surgeon most famous for his contributions in first characterizing the blood brain barrier 1 Edwin GoldmannBorn 1862 11 12 12 November 1862Burgersdorp Cape ColonyDied12 August 1913 1913 08 12 aged 50 Freiburg im Breisgau GermanyScientific careerAcademic advisorsPaul EhrlichDiscovery of the blood brain barrier editGoldmann s mentor Paul Ehrlich was studying staining in his bacteriological studies by injecting aniline dyes in several species of animal While most of the anatomy stained equally well the brain tissue exhibited less staining in many species Goldmann discovered that when the dye namely trypan blue was injected directly into the central nervous system instead of into the other organs the brain would stain equally well as other organs but the stain would not travel to the rest of the body This suggested the presence of a compartmentalization between the cerebrospinal fluid and the vasculature of the rest of the body This barrier was first hypothesized by a Berlin physician Max Lewandowsky in 1900 prior to Goldmann s empirical evidence 1 Edwin Goldmann died from liver cancer in Freiburg on 13 August 1913 2 References edit a b The Late Professor Edwin Goldmann s Investigations on the Central Nervous System by Vital Staining British Medical Journal 2 2753 871 873 4 October 1913 ISSN 0007 1447 PMC 2345891 PMID 20766814 Doctor Dies a Martyr The Evening Sun Berlin 13 August 1913 p 2 Retrieved 14 April 2020 via Newspapers com nbsp This article about a biologist is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Edwin Goldmann amp oldid 1216560154, wikipedia, wiki, book, books, library,
