Docercalciferol is the vitamin D2 analogue of alfacalcidol.[3] It undergoes 25-hydroxylation in the liver to become the active ercalcitriol, without the involvement of kidneys.[4]
Referencesedit
^Sprague S M; Ho L T (2002). "Oral doxercalciferol therapy for secondary hyperparathyroidism in a peritoneal dialysis patient". Clinical Nephrology. 58 (2): 155–160. doi:10.5414/cnp58155. PMID 12227689.
^Upton, R. A.; Knutson, J. C.; Bishop, C. W.; LeVan, L. W. (1 April 2003). "Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone". Nephrology Dialysis Transplantation. 18 (4): 750–758. doi:10.1093/ndt/gfg030. PMID 12637645.
^"HECTOROL INJECTION (doxercalciferol)" (PDF). FDA accessdata. Retrieved 21 April 2018.
doxercalciferol, hydroxyergocalciferol, trade, name, hectorol, drug, secondary, hyperparathyroidism, metabolic, bone, disease, synthetic, analog, ergocalciferol, vitamin, suppresses, parathyroid, synthesis, secretion, namesiupac, name, secoergosta, tetraene, d. Doxercalciferol or 1 hydroxyergocalciferol trade name Hectorol is drug for secondary hyperparathyroidism and metabolic bone disease 1 It is a synthetic analog of ergocalciferol vitamin D2 It suppresses parathyroid synthesis and secretion 2 Doxercalciferol NamesIUPAC name 1S 3R 5Z 7E 22E 9 10 Secoergosta 5 7 10 22 tetraene 1 3 diolOther names 1 Hydroxyergocalciferol 1 Hydroxyvitamin D2 1a Hydroxyergocalciferol 1a Hydroxyvitamin D2 Hectorol TSA 840IdentifiersCAS Number 54573 75 0 Y3D model JSmol Interactive imageChEBI CHEBI 4712ChEMBL ChEMBL1200810 NChemSpider 4444554 YDrugBank DB06410 NECHA InfoCard 100 170 997IUPHAR BPS 2790PubChem CID 5281107UNII 3DIZ9LF5Y9 YCompTox Dashboard EPA DTXSID1034214InChI InChI 1S C28H44O2 c1 18 2 19 3 9 10 20 4 25 13 14 26 22 8 7 15 28 25 26 6 11 12 23 16 24 29 17 27 30 21 23 5 h9 12 18 20 24 27 29 30H 5 7 8 13 17H2 1 4 6H3 b10 9 22 11 23 12 t19 20 24 25 26 27 28 m0 s1 YKey HKXBNHCUPKIYDM CGMHZMFXSA N YInChI 1 C28H44O2 c1 18 2 19 3 9 10 20 4 25 13 14 26 22 8 7 15 28 25 26 6 11 12 23 16 24 29 17 27 30 21 23 5 h9 12 18 20 24 27 29 30H 5 7 8 13 17H2 1 4 6H3 b10 9 22 11 23 12 t19 20 24 25 26 27 28 m0 s1Key HKXBNHCUPKIYDM CGMHZMFXBNSMILES O C H 1CC C C C H O C1 C C C2 CCC C 3 C H 2CC C H 3 C H C C C H C C C C C CPropertiesChemical formula C 28H 44O 2Molar mass 412 658 g mol 1PharmacologyATC code H05BX03 WHO Except where otherwise noted data are given for materials in their standard state at 25 C 77 F 100 kPa N verify what is Y N Infobox references Docercalciferol is the vitamin D2 analogue of alfacalcidol 3 It undergoes 25 hydroxylation in the liver to become the active ercalcitriol without the involvement of kidneys 4 References edit Sprague S M Ho L T 2002 Oral doxercalciferol therapy for secondary hyperparathyroidism in a peritoneal dialysis patient Clinical Nephrology 58 2 155 160 doi 10 5414 cnp58155 PMID 12227689 Doxercalciferol Drugs com Upton R A Knutson J C Bishop C W LeVan L W 1 April 2003 Pharmacokinetics of doxercalciferol a new vitamin D analogue that lowers parathyroid hormone Nephrology Dialysis Transplantation 18 4 750 758 doi 10 1093 ndt gfg030 PMID 12637645 HECTOROL INJECTION doxercalciferol PDF FDA accessdata Retrieved 21 April 2018 nbsp This hormonal preparation article is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Doxercalciferol amp oldid 1188984475, wikipedia, wiki, book, books, library,
