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Dexchlorpheniramine

April 12, 2024

Dexchlorpheniramine (trade name Polaramine) is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.[1][2] It is the pharmacologically active dextrorotatory isomer of chlorpheniramine.

Dexchlorpheniramine
Clinical data
Trade namesChlor-trimeton, Polaramine
AHFS/Drugs.comMonograph
MedlinePlusa682543
Routes of
administration		Oral, Intravenous
ATC code
Legal status
Legal status
  • AU: S3 (Pharmacist only)
Identifiers
  • (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-3-ylpropan-1-amine
CAS Number
  • 25523-97-1 Y
PubChem CID
  • 33036
IUPHAR/BPS
  • 1210
DrugBank
  • DB01114 Y
ChemSpider
  • 30576 Y
UNII
  • 3Q9Q0B929N
KEGG
  • D07803 Y
ChEBI
  • CHEBI:4464 Y
ChEMBL
  • ChEMBL1201353 Y
CompTox Dashboard (EPA)
  • DTXSID50180225
ECHA InfoCard100.042.779
Chemical and physical data
FormulaC16H19ClN2
Molar mass274.79 g·mol−1
3D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)[C@@H](c2ncccc2)CCN(C)C
  • InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3/t15-/m0/s1 Y
  • Key:SOYKEARSMXGVTM-HNNXBMFYSA-N Y
  (verify)

It came into medical use in 1959 and was patented in 1962.[3]

Pharmacology edit

Dexchlorpheniramine is an antihistamine, or an antagonist of the histamine H1 receptor. A study found that dexchlorpheniramine had a Ki value of 20 to 30 μM for the muscarinic acetylcholine receptors using rat brain tissue.[4]

References edit

  1. ^ Theunissen EL, Vermeeren A, Ramaekers JG (January 2006). "Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance". British Journal of Clinical Pharmacology. 61 (1): 79–86. doi:10.1111/j.1365-2125.2005.02524.x. PMC 1884990. PMID 16390354.
  2. ^ Ortíz San Román L, Sanavia Morán E, Campos Domínguez M, Peinador García MM (December 2013). "[Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention]". Anales de Pediatria. 79 (6): 400–401. doi:10.1016/j.anpedi.2013.02.014. PMID 23680058.
  3. ^ Fischer J, Ganellin CR (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 547. ISBN 9783527607495.
  4. ^ Yamamura HI, Snyder SH (May 1974). "Muscarinic cholinergic binding in rat brain". Proceedings of the National Academy of Sciences of the United States of America. 71 (5): 1725–1729. Bibcode:1974PNAS...71.1725Y. doi:10.1073/pnas.71.5.1725. PMC 388311. PMID 4151898.

External links edit

  • Polaramine consumer information
  • Polaramine (dexchlorpheniramine) medical facts
 

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.

April 12, 2024
dexchlorpheniramine, trade, name, polaramine, antihistamine, with, anticholinergic, properties, used, treat, allergic, conditions, such, fever, urticaria, pharmacologically, active, dextrorotatory, isomer, chlorpheniramine, clinical, datatrade, nameschlor, tri. Dexchlorpheniramine trade name Polaramine is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria 1 2 It is the pharmacologically active dextrorotatory isomer of chlorpheniramine DexchlorpheniramineClinical dataTrade namesChlor trimeton PolaramineAHFS Drugs comMonographMedlinePlusa682543Routes ofadministrationOral IntravenousATC codeR06AB02 WHO Legal statusLegal statusAU S3 Pharmacist only IdentifiersIUPAC name 3S 3 4 chlorophenyl N N dimethyl 3 pyridin 3 ylpropan 1 amineCAS Number25523 97 1 YPubChem CID33036IUPHAR BPS1210DrugBankDB01114 YChemSpider30576 YUNII3Q9Q0B929NKEGGD07803 YChEBICHEBI 4464 YChEMBLChEMBL1201353 YCompTox Dashboard EPA DTXSID50180225ECHA InfoCard100 042 779Chemical and physical dataFormulaC 16H 19Cl N 2Molar mass274 79 g mol 13D model JSmol Interactive imageSMILES Clc1ccc cc1 C H c2ncccc2 CCN C CInChI InChI 1S C16H19ClN2 c1 19 2 12 10 15 16 5 3 4 11 18 16 13 6 8 14 17 9 7 13 h3 9 11 15H 10 12H2 1 2H3 t15 m0 s1 YKey SOYKEARSMXGVTM HNNXBMFYSA N Y verify It came into medical use in 1959 and was patented in 1962 3 Pharmacology editDexchlorpheniramine is an antihistamine or an antagonist of the histamine H1 receptor A study found that dexchlorpheniramine had a Ki value of 20 to 30 mM for the muscarinic acetylcholine receptors using rat brain tissue 4 References edit Theunissen EL Vermeeren A Ramaekers JG January 2006 Repeated dose effects of mequitazine cetirizine and dexchlorpheniramine on driving and psychomotor performance British Journal of Clinical Pharmacology 61 1 79 86 doi 10 1111 j 1365 2125 2005 02524 x PMC 1884990 PMID 16390354 Ortiz San Roman L Sanavia Moran E Campos Dominguez M Peinador Garcia MM December 2013 Anticholinergic syndrome due to dexchlorpheniramine as a cause of urinary retention Anales de Pediatria 79 6 400 401 doi 10 1016 j anpedi 2013 02 014 PMID 23680058 Fischer J Ganellin CR 2006 Analogue based Drug Discovery John Wiley amp Sons p 547 ISBN 9783527607495 Yamamura HI Snyder SH May 1974 Muscarinic cholinergic binding in rat brain Proceedings of the National Academy of Sciences of the United States of America 71 5 1725 1729 Bibcode 1974PNAS 71 1725Y doi 10 1073 pnas 71 5 1725 PMC 388311 PMID 4151898 External links editPolaramine consumer information Polaramine dexchlorpheniramine medical facts nbsp This drug article relating to the respiratory system is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title Dexchlorpheniramine amp oldid 1168028235, wikipedia, wiki, book, books, library,

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