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David Gorski

March 24, 2023

David Henry Gorski is an American surgical oncologist, professor of surgery at Wayne State University School of Medicine,[1] and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery.[2] He is an outspoken skeptic, and a critic of alternative medicine and the anti-vaccination movement. He is the author of the blog Respectful Insolence, and the managing editor of the website Science-Based Medicine.[3][4][5]

David Gorski
Gorski in 2016
Born
David Henry Gorski
NationalityAmerican
Alma mater
Scientific career
FieldsSurgical oncology
Institutions
Doctoral advisorKenneth Walsh

Early life and education

Gorski attended the University of Michigan, where he received an MD in 1988. In 1989, he entered a residency in general surgery at the University Hospitals of Cleveland. He left residency for a PhD in cellular physiology at Case Western Reserve University, completed in 1994, with a dissertation entitled "Homeobox Gene Expression and Regulation in Vascular Myocytes."[6] Gorski continued his residency (1993–96) and completed a surgical oncology research fellowship (1996–99) at The University of Chicago.[7][8]

Career

Gorski was previously Assistant Professor of Surgery at the Rutgers Cancer Institute of New Jersey and the UMDNJ-Robert Wood Johnson Medical School, in New Brunswick, NJ. He also served as a member of the graduate program in Cell and Developmental Biology at Rutgers University in Piscataway, NJ.[9]

In 2010, he was appointed medical director of the Alexander J. Walt Comprehensive Breast Center at the Barbara Ann Karmanos Cancer Institute. In 2013, he became the co-director of the Michigan Breast Oncology Quality Initiative.[10][11]

Gorski is a Professor of Surgery and Oncology at the Wayne State University School of Medicine,[7] whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer.[7] In 2009, he was appointed the cancer liaison physician for the American College of Surgeons Committee on Cancer.[12] He is listed as a founder of the Institute for Science in Medicine[13] and as a member of the American Society of Clinical Oncology.[14]

In 2007 he received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology.[15] He was awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.[14]

Research

Gorski's article "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies, has been cited over 900 times according to PubMed.[16][17] This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells,"[18] and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments[19] while sustaining tumor regression when combined with specific antibodies and radiation therapy.[20]

Gorski's work with Helena Mauceri and others, published in Nature as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy"[21] led to investigation into the selective destruction of tumor cells, which according to a study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."[22]

His article with Yun Chen "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" investigated into the use of microRNA to regulate angiogenesis[23] led to research by Jason E. Fish's group at the University of California, San Francisco, into the use of microRNA to regulate blood vessel development, and thus limiting tumor growth. Citing Chen and Gorski's research, Fish wrote that "several broadly expressed microRNAs regulate in vitro endothelial cell behavior, including proliferation, migration, and the ability to form capillary networks", and sought to describe the in vivo functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA (miR-126) as the most highly enriched in endothelial cells.[24]

Skepticism of alternative medicine

 
Skeptics Steven Novella, Harriet Hall, David Gorski, and Rachael Dunlop on a panel at The Amaz!ng Meeting 2012

Gorski is a skeptic of alternative medicine. In 2004, he began writing a blog entitled Respectful Insolence under the pen name Orac at Blogspot. Two years later, it was moved to the ScienceBlogs website.[25][26] In 2008 Gorski used his real name when he started blogging at Science-Based Medicine (he continues to use Orac for Respectful Insolence[27][28]). He serves as the managing editor at Science-Based Medicine, where he has posted on issues of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment.[29][30] In 2010, Gorski recounted how members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.[31]

Gorski contributed to the James Randi Education Foundation's series of EBooks: Science Based Medicine Guides.[32] He is a fellow of the Committee for Skeptical Inquiry.[33] He was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013.[34][35] He has also participated in numerous panels on alternative medicine.[36][37][38] He called attention to a paper by John P. A. Ioannidis on problems with published research.[39] Gorski has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies,[40][41] acupuncture,[42] detoxification,[43] and the use of dietary treatment to manage autism.[44]

Gorski has advocated for open research data of clinical trial results and for only using evidence-based medicine to treat disease.[45] He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM), which became the National Center for Complementary and Integrative Health.[30] He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on unproven therapies not supported by science-based evidence,[46][47] and has commented on medical ethics and methods of alternative medicine.[48]

Gorski has criticized popularization of pseudoscience by the media and celebrities such as Oprah Winfrey,[49] Bill Maher,[50] Ann Coulter,[51] and The Huffington Post.[52] In June 2013, he expressed support for healthcare professionals speaking out against poor medical practices and the sale of unproven treatments.[53] Gorski was interviewed by WPRR in 2012.[54] He called the co-sponsorship of Integrative Medicine Day by the American Medical Student Association "quackademic medicine".[55]

Writing for Utne Reader in 2012, David H. Freedman described Gorski as being among the "prickly anti-alternative-medicine warriors."[56]

In 2014, Gorski and fellow skeptic Steven Novella published an article denouncing the study of integrative medicine as harmful to science.[57][58]

Publications

  • Speyer, Cecilia L.; Nassar, Mahdy A.; Hachem, Ali H.; Bukhsh, Miriam A.; Jafry, Waris S.; Khansa, Rafa M.; Gorski, David H. (4 May 2016). "Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1". Breast Cancer Research and Treatment. 157 (2): 217–228. doi:10.1007/s10549-016-3816-x. PMID 27146584. S2CID 23986691.
  • Welch HG, Gorski DH, Albertsen PC (2015). "Trends in Metastatic Breast and Prostate Cancer—Lessons in Cancer Dynamics". N Engl J Med. 373 (18): 1685–1687. doi:10.1056/NEJMp1510443. PMID 26510017.
  • Gorski D. H. (2014). "Integrative oncology: really the best of both worlds?". Nat Rev Cancer. 14 (10): 692–700. doi:10.1038/nrc3822. PMID 25230880. S2CID 33539406.
  • 2018 Pseudoscience: The Conspiracy Against Science "Integrative' Medicine: Integrating Quackery with Science-Based Medicine" :MIT Press: edited by Allison B. Kaufman, James C. Kaufman: ISBN 978-0262037426[59]

References

  1. ^ "David Gorski". Wayne State University – School of Medicine – Cancer Biology Program. Retrieved 9 August 2021.
  2. ^ "David Gorski M.D., Ph.D." Physician Details. Barbara Ann Karmanos Cancer Institute, Wayne State University. 2013. Retrieved 9 August 2021.
  3. ^ Szabo, Lisa (18 June 2013). "How to guard against a quack". USA Today. Retrieved 22 June 2013.
  4. ^ "David H. Gorski, MD, PhD – Managing Editor". Science-Based Medicine. 5 October 2008. Retrieved 10 June 2013.
  5. ^ "Respectful Insolence". RESPECTFUL INSOLENCE. Retrieved 2021-07-09.
  6. ^ a b c . Cancer Biology Graduate Program. Wayne State University School of Medicine. 2013. Archived from the original on 22 July 2012. Retrieved 14 June 2013.
  7. ^ Faculty. Department of Surgery / Detroit Medical Center, Wayne State University. 2005. Archived from the original on 25 January 2013. Retrieved 20 March 2013.
  8. ^ Bepler, Gerold (1 February 2011). "Barbara Ann Karmanos Cancer Center names Dr. David Gorski leader of breast multidisciplinary team". PR Newswire. Retrieved 18 June 2013. {{cite journal}}: Cite journal requires |journal= (help)
  9. ^ . Barbara Ann Kamanos Cancer Institute, Wayne State University. 2013. Archived from the original on 9 October 2019. Retrieved 17 May 2013.
  10. ^ "Karmanos Cancer Center's Dr. David Gorski appointed program co-director of Michigan Breast Oncology Quality Initiative". Karmanos Cancer Institute. July 30, 2013. from the original on August 1, 2017. Retrieved August 2, 2013.
  11. ^ "Dr. David Gorski appointed Cancer Liaison Physician for Karmanos". Prognosis E-News. Wayne State University School of Medicine. 7 January 2009. from the original on August 1, 2017. Retrieved May 17, 2013.
  12. ^ "David H. Gorski, MD, PhD". ISM Fellows. Institute for Science in Medicine. 2011. Retrieved 13 June 2013.
  13. ^ a b (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2008. p. 8. Archived from the original (PDF) on 2012-08-07. Retrieved 2013-06-26. Alt URL (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2009. p. 9. Archived from the original (PDF) on 2012-08-07. Retrieved 2013-06-26. Alt URL (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2010. p. 8. Archived from the original (PDF) on 2012-08-07. Retrieved 2013-06-26. Alt URL
  14. ^ Fisher, Michele (11 June 2007). . University of Medicine and Dentistry of New Jersey. Archived from the original on 5 February 2013. Retrieved 14 June 2013. CINJ scientist receives a near half-million dollars for future breast cancer research. {{cite journal}}: Cite journal requires |journal= (help)
  15. ^ Gorski, David H.; Beckett, Michael A.; Jaskowiak, Nora T.; Calvin, Douglas P.; et al. (15 July 1999). "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation". Cancer Research. 59 (14): 3374–3378. PMID 10416597. Retrieved 21 June 2013.
  16. ^ Related Citations for PubMed (Select 10416597), PubMed, retrieved 28 June 2013
  17. ^ Kerbel, Robert; Folkman, Judah (October 2002). "Clinical translation of angiogenesis inhibitors". Nature Reviews Cancer. 2 (10): 727–739. doi:10.1038/nrc905. PMID 12360276. S2CID 14513505.
  18. ^ Dvorak, Harold F. (1 November 2002). "Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy". Journal of Clinical Oncology. 20 (21): 4368–4380. doi:10.1200/JCO.2002.10.088. PMID 12409337.
  19. ^ Klement, Giannoula; Baruchel, Sylvain; Rak, Janusz; Man, Shan; et al. (15 April 2000). "Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity". Journal of Clinical Investigation. 105 (8): R15–R24. doi:10.1172/JCI8829. PMC 517491. PMID 10772661.
  20. ^ Mauceri, Helena J.; Hanna, Nader N.; Beckett, Michael A.; Gorski, David H.; et al. (16 July 1998). "Combined effects of angiostatin and ionizing radiation in antitumour therapy". Nature. 394 (6690): 287–291. Bibcode:1998Natur.394..287M. doi:10.1038/28412. PMID 9685160. S2CID 4391890.
  21. ^ Semenza, Gregg L. (1999). "Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1". Annual Review of Cell and Developmental Biology. 15 (1): 551–578. doi:10.1146/annurev.cellbio.15.1.551. PMID 10611972.
  22. ^ Chen, Yun; Gorski, David H. (1 February 2008). "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5". Blood. 111 (3): 1217–1226. doi:10.1182/blood-2007-07-104133. PMC 2214763.
  23. ^ Fish, Jason E.; Santoro, Massimo M.; Morton, Sarah U.; Yu, Sangho; et al. (12 August 2008). "miR-126 Regulates Angiogenic Signaling and Vascular Integrity". Developmental Cell. 15 (2): 272–284. doi:10.1016/j.devcel.2008.07.008. PMC 2604134.
  24. ^ Bremner, Doug (19 September 2008). "Blogging doctors rock on!". The Huffington Post. Retrieved 24 June 2013.
  25. ^ Gorski, David. . ScienceBlogs. Archived from the original on 24 June 2013. Retrieved 20 June 2013.
  26. ^ "Who is Orac?". Respectful Insolence. Retrieved 31 July 2018.
  27. ^ Beall, Jeffrey (2018). "Chapter 12: Scientific Soundness and the Problem of Predatory Journals". In Kaufman, Allison B.; Kaufman, James C (eds.). Pseudoscience: The Conspiracy Against Science. MIT Press. ISBN 978-0262344821.
  28. ^ Jones, Val (4 June 2009), Kevin Pho (ed.), "Hostility Towards Scientists and Jenny McCarthy's Latest Video", KevinMD.com, MedPage Today, retrieved 25 June 2013.
  29. ^ a b Specter, Michael (2009). Denialism: How Irrational Thinking Harms the Planet and Threatens Our Lives. Penguin Group US. ISBN 978-1-101-15102-0. Retrieved 21 June 2013.
  30. ^ Gorski, David H. (18 June 2010). "The price of opposing medical pseudoscience". Science-Based Medicine. Retrieved 14 June 2013.
  31. ^ "JREF publishes three volumes on science-based medicine". James Randi Education Foundation. Retrieved 28 June 2013.
    "JREF publishes three more science-based medicine volumes". James Randi Education Foundation. Retrieved 28 June 2013.
    "Science-based medicine Ebooks, volumes 7-12 now available". James Randi Education Foundation. Retrieved 28 June 2013.
  32. ^ "CSI Fellows and Staff". Committee for Skeptical Inquiry. 2009. Retrieved 2 August 2013.
  33. ^ "The Amaz!ing Meeting 2013: Schedule". The Amza!ing Meeting website. James Randi Education Foundation. 2013. Retrieved 24 June 2013.
  34. ^ Novella, Steven (6 March 2009). "Science-Based Medicine Conference". Neurologica blog. New England Skeptical Society. Retrieved 24 June 2013.
    Wagg, Jeffrey (2010). "The Amaz!ng Meeting 8, 2010 Schedule". James Randi Educational Foundation. Retrieved 24 June 2013.
    "Expert panel trashes "alternative medicine" concept". Consumer Health Digest. The National Council Against Health Fraud (12–29). 23 August 2012. Retrieved 25 June 2013.
    "The Amaz!ing Meeting 2012: Program". The Amaz!ng Meeting website. James Randi Education Foundation. 2012. Retrieved 24 June 2013.
  35. ^ "Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience". McGill University Faculty of Science. 18 October 2010. Retrieved 20 June 2013.
  36. ^ "David Gorski — NECSS". Northeast Conference on Science and Skepticism website (NECSS). New England Skeptical Society and NYC Skeptics. Retrieved 24 June 2013.
  37. ^ . CSICon 2012 website. Committee for Skeptical Inquiry. 2012. Archived from the original on 2 September 2013. Retrieved 24 June 2013.
  38. ^ *Roach, Mary; Folger, Tim (2011). The Best American Science and Nature Writing 2011: The Best American Series. Houghton Mifflin Harcourt. pp. 123–124. ISBN 978-0-547-67846-7. Retrieved 21 June 2013.
  39. ^ Page, Leigh (12 June 2013), "What to do when a patient wants 'alternative' medicine", Medscape Business of Medicine, retrieved 25 June 2013.
  40. ^ Munger, Dave (2 September 2009). . Seed. Archived from the original on 14 September 2018. Retrieved 27 June 2013.{{cite news}}: CS1 maint: unfit URL (link)
  41. ^ Salzberg, Steven (15 February 2010), "Battlefield acupuncture: Pseudoscience for wounded troops", Forbes.com, retrieved 25 June 2013.
  42. ^ Lee, Linda (13 April 2012). "Bridal Hunger Games: Losing Weight in Time for the Wedding". The New York Times. Retrieved 25 June 2013.
  43. ^ Hansen, Lacy Jaye (7 December 2012), "The GAPS diet claims you can eat away autism. But can you really?", Diets in Review.com, retrieved 25 June 2013.
  44. ^ Miller, Naseem (16 March 2011) [14 May 2010], "Most drug trial results analyzed by FDA hidden from view", Accountability, The Center for Public Integrity, retrieved 26 June 2013.
  45. ^ Greek, Ray; Menache, Andre (2013). "Systematic reviews of animal models: Methodology versus epistemology". International Journal of Medical Sciences. 10 (3): 206–221. doi:10.7150/ijms.5529. PMC 3558708. PMID 23372426.
  46. ^ Husten, Larry (1 April 2013), "The Raging Debate Over The NIH's TACT Chelation Trial", Forbes.com, retrieved 26 June 2013.
    Berezow, Alex B.; Campbell, Hank (2012). Science Left Behind: Feel-Good Fallacies and the Rise of the Anti-Scientific Left. PublicAffairs. ISBN 978-1-61039-165-8. Retrieved 2013-06-21.
    Kay, Alison J. (2012). What If There's Nothing Wrong?. Balboa Press. p. 283. ISBN 978-1-4525-6147-9. Retrieved 21 June 2013.
  47. ^ Khorana, Alok (16 September 2009), "Alternative medicine and trials of dubious ethicality", OncNotes, Medscape, retrieved 25 June 2013.
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    Keller, Daniel M. (15 February 2012), "Integrative Medicine Use Up, but Outcomes Still Uncertain", Medscape Medical News, retrieved 25 June 2013.
  48. ^ Shomon, Mary (2 June 2009), "Media and bloggers accuse Oprah of medical malpractice", About.com: Thyroid Disease, retrieved 25 June 2013.
    Gorski, David (7 June 2009). "Is Oprah Winfrey giving us bad medicine?". Toronto Star. Retrieved 21 June 2013.
    Amarasingam, Amarnath (25 May 2011). . The Washington Post. Archived from the original on 11 January 2012. Retrieved 21 June 2013.
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  52. ^ Pho, Kevin (15 October 2009), "Two nurses face jail time for reporting a doctor to the Texas Medical Board", KevinMD.com, MedPage Today, retrieved 25 June 2013.
  53. ^ Brayton, Ed (host) (14 August 2012). . Culture Wars Radio (podcast). WPRR, Public Reality Radio. Archived from the original on 13 November 2012. Retrieved 16 June 2013.
  54. ^ "The American Medical Student Association: On "integrating" quackery with science-based medicine | Science-Based Medicine". sciencebasedmedicine.org. 2012-10-22. Retrieved 2022-12-29.
  55. ^ Freedman, David H. (May–June 2012). "Doctors who care: Does alternative medicine work?". Utne Reader. Retrieved 24 June 2013.
  56. ^ Gorski, David H.; Novella, Steven P. (Sep 2014). "Clinical trials of integrative medicine: testing whether magic works?". Trends in Molecular Medicine. 20 (9): 473–6. doi:10.1016/j.molmed.2014.06.007. PMID 25150944.
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  58. ^ Bigliardi, Stefano (2019). "The Advocates of Pseudoscience Are Not Monsters – but Pseudoscience Is". Skeptical Inquirer. Center for Inquiry. 43 (6): 58–59.

External links

  • Respectful Insolence, Gorski's blog
  • David Gorski's articles at Science Based Medicine
  • Gorski's presentation at National Capital Area Skeptics
  • David Gorski publications indexed by Google Scholar
  • Research page at WSU
  • Department of surgery

March 24, 2023
david, gorski, david, henry, gorski, american, surgical, oncologist, professor, surgery, wayne, state, university, school, medicine, surgical, oncologist, barbara, karmanos, cancer, institute, specializing, breast, cancer, surgery, outspoken, skeptic, critic, . David Henry Gorski is an American surgical oncologist professor of surgery at Wayne State University School of Medicine 1 and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute specializing in breast cancer surgery 2 He is an outspoken skeptic and a critic of alternative medicine and the anti vaccination movement He is the author of the blog Respectful Insolence and the managing editor of the website Science Based Medicine 3 4 5 David GorskiGorski in 2016BornDavid Henry GorskiNationalityAmericanAlma materCase Western Reserve University PhD University of Michigan MD Scientific careerFieldsSurgical oncologyInstitutionsWayne State University School of MedicineBarbara Ann Karmanos Cancer InstituteDoctoral advisorKenneth Walsh Contents 1 Early life and education 2 Career 2 1 Research 3 Skepticism of alternative medicine 4 Publications 5 References 6 External linksEarly life and education EditGorski attended the University of Michigan where he received an MD in 1988 In 1989 he entered a residency in general surgery at the University Hospitals of Cleveland He left residency for a PhD in cellular physiology at Case Western Reserve University completed in 1994 with a dissertation entitled Homeobox Gene Expression and Regulation in Vascular Myocytes 6 Gorski continued his residency 1993 96 and completed a surgical oncology research fellowship 1996 99 at The University of Chicago 7 8 Career EditGorski was previously Assistant Professor of Surgery at the Rutgers Cancer Institute of New Jersey and the UMDNJ Robert Wood Johnson Medical School in New Brunswick NJ He also served as a member of the graduate program in Cell and Developmental Biology at Rutgers University in Piscataway NJ 9 In 2010 he was appointed medical director of the Alexander J Walt Comprehensive Breast Center at the Barbara Ann Karmanos Cancer Institute In 2013 he became the co director of the Michigan Breast Oncology Quality Initiative 10 11 Gorski is a Professor of Surgery and Oncology at the Wayne State University School of Medicine 7 whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype as well as the role of metabotropic glutamate receptors in breast cancer 7 In 2009 he was appointed the cancer liaison physician for the American College of Surgeons Committee on Cancer 12 He is listed as a founder of the Institute for Science in Medicine 13 and as a member of the American Society of Clinical Oncology 14 In 2007 he received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology 15 He was awarded research grants by The Breast Cancer Research Foundation in 2008 2009 and 2010 14 Research Edit Gorski s article Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation characterizing the effects of angiogenesis inhibitors on the effectiveness of anti tumor therapies has been cited over 900 times according to PubMed 16 17 This research has been used in anti tumor therapeutic research including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation by preventing repair of radiation damage to endothelial cells 18 and in determining the potential of combinational therapies to allow reduction of the dosages in toxic conventional treatments 19 while sustaining tumor regression when combined with specific antibodies and radiation therapy 20 Gorski s work with Helena Mauceri and others published in Nature as Combined effects of angiostatin and ionizing radiation in antitumour therapy studied the combined effects of angiostatin a protein occurring in several animal species and ionizing radiation in anti tumor therapy 21 led to investigation into the selective destruction of tumor cells which according to a study by Gregg L Semenza citing Mauceri and others are more hypoxic than normal cells allowing for tumor cells to be killed without major systemic side effects 22 His article with Yun Chen Regulation of angiogenesis through a microRNA miR 130a that down regulates antiangiogenic homeobox genes GAX and HOXA5 investigated into the use of microRNA to regulate angiogenesis 23 led to research by Jason E Fish s group at the University of California San Francisco into the use of microRNA to regulate blood vessel development and thus limiting tumor growth Citing Chen and Gorski s research Fish wrote that several broadly expressed microRNAs regulate in vitro endothelial cell behavior including proliferation migration and the ability to form capillary networks and sought to describe the in vivo functionality of a specific set of microRNAs and their targets the group was able to isolate a particular microRNA miR 126 as the most highly enriched in endothelial cells 24 Skepticism of alternative medicine Edit Skeptics Steven Novella Harriet Hall David Gorski and Rachael Dunlop on a panel at The Amaz ng Meeting 2012 Gorski is a skeptic of alternative medicine In 2004 he began writing a blog entitled Respectful Insolence under the pen name Orac at Blogspot Two years later it was moved to the ScienceBlogs website 25 26 In 2008 Gorski used his real name when he started blogging at Science Based Medicine he continues to use Orac for Respectful Insolence 27 28 He serves as the managing editor at Science Based Medicine where he has posted on issues of medicine and pseudoscience including the anti vaccination movement alternative therapies and cancer research and treatment 29 30 In 2010 Gorski recounted how members of the anti vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging 31 Gorski contributed to the James Randi Education Foundation s series of EBooks Science Based Medicine Guides 32 He is a fellow of the Committee for Skeptical Inquiry 33 He was a speaker at The Amaz ng Meeting in 2009 2010 2012 and 2013 34 35 He has also participated in numerous panels on alternative medicine 36 37 38 He called attention to a paper by John P A Ioannidis on problems with published research 39 Gorski has criticized the prevalence of pseudoscience in the medical field including the use of alternative therapies 40 41 acupuncture 42 detoxification 43 and the use of dietary treatment to manage autism 44 Gorski has advocated for open research data of clinical trial results and for only using evidence based medicine to treat disease 45 He has been critical of Senator Tom Harkin s support of the National Center for Complementary and Alternative Medicine NCCAM which became the National Center for Complementary and Integrative Health 30 He has criticized the National Institutes of Health NIH and NCCAM for funding and publishing research on unproven therapies not supported by science based evidence 46 47 and has commented on medical ethics and methods of alternative medicine 48 Gorski has criticized popularization of pseudoscience by the media and celebrities such as Oprah Winfrey 49 Bill Maher 50 Ann Coulter 51 and The Huffington Post 52 In June 2013 he expressed support for healthcare professionals speaking out against poor medical practices and the sale of unproven treatments 53 Gorski was interviewed by WPRR in 2012 54 He called the co sponsorship of Integrative Medicine Day by the American Medical Student Association quackademic medicine 55 Writing for Utne Reader in 2012 David H Freedman described Gorski as being among the prickly anti alternative medicine warriors 56 In 2014 Gorski and fellow skeptic Steven Novella published an article denouncing the study of integrative medicine as harmful to science 57 58 Publications EditSpeyer Cecilia L Nassar Mahdy A Hachem Ali H Bukhsh Miriam A Jafry Waris S Khansa Rafa M Gorski David H 4 May 2016 Riluzole mediates anti tumor properties in breast cancer cells independent of metabotropic glutamate receptor 1 Breast Cancer Research and Treatment 157 2 217 228 doi 10 1007 s10549 016 3816 x PMID 27146584 S2CID 23986691 Welch HG Gorski DH Albertsen PC 2015 Trends in Metastatic Breast and Prostate Cancer Lessons in Cancer Dynamics N Engl J Med 373 18 1685 1687 doi 10 1056 NEJMp1510443 PMID 26510017 Gorski D H 2014 Integrative oncology really the best of both worlds Nat Rev Cancer 14 10 692 700 doi 10 1038 nrc3822 PMID 25230880 S2CID 33539406 2018 Pseudoscience The Conspiracy Against Science Integrative Medicine Integrating Quackery with Science Based Medicine MIT Press edited by Allison B Kaufman James C Kaufman ISBN 978 0262037426 59 References Edit David Gorski Wayne State University School of Medicine Cancer Biology Program Retrieved 9 August 2021 David Gorski M D Ph D Physician Details Barbara Ann Karmanos Cancer Institute Wayne State University 2013 Retrieved 9 August 2021 Szabo Lisa 18 June 2013 How to guard against a quack USA Today Retrieved 22 June 2013 David H Gorski MD PhD Managing Editor Science Based Medicine 5 October 2008 Retrieved 10 June 2013 Respectful Insolence RESPECTFUL INSOLENCE Retrieved 2021 07 09 Gorski D 1994 Homeobox gene expression and regulation in vascular myocytes Case Western Reserve University OCLC 31923610 a b c David H Gorski Cancer Biology Graduate Program Wayne State University School of Medicine 2013 Archived from the original on 22 July 2012 Retrieved 14 June 2013 David Gorski M D Faculty Department of Surgery Detroit Medical Center Wayne State University 2005 Archived from the original on 25 January 2013 Retrieved 20 March 2013 Bepler Gerold 1 February 2011 Barbara Ann Karmanos Cancer Center names Dr David Gorski leader of breast multidisciplinary team PR Newswire Retrieved 18 June 2013 a href Template Cite journal html title Template Cite journal cite journal a Cite journal requires journal help Breast Cancer Program Barbara Ann Kamanos Cancer Institute Wayne State University 2013 Archived from the original on 9 October 2019 Retrieved 17 May 2013 Karmanos Cancer Center s Dr David Gorski appointed program co director of Michigan Breast Oncology Quality Initiative Karmanos Cancer Institute July 30 2013 Archived from the original on August 1 2017 Retrieved August 2 2013 Dr David Gorski appointed Cancer Liaison Physician for Karmanos Prognosis E News Wayne State University School of Medicine 7 January 2009 Archived from the original on August 1 2017 Retrieved May 17 2013 David H Gorski MD PhD ISM Fellows Institute for Science in Medicine 2011 Retrieved 13 June 2013 a b 2007 2008 Grantees PDF Pink Press The Breast Cancer Research Foundation Winter 2008 p 8 Archived from the original PDF on 2012 08 07 Retrieved 2013 06 26 Alt URL 2008 2009 Grantees PDF Pink Press The Breast Cancer Research Foundation Winter 2009 p 9 Archived from the original PDF on 2012 08 07 Retrieved 2013 06 26 Alt URL 2009 2010 Grantees PDF Pink Press The Breast Cancer Research Foundation Winter 2010 p 8 Archived from the original PDF on 2012 08 07 Retrieved 2013 06 26 Alt URL Fisher Michele 11 June 2007 New Jersey surgical oncologist receives prestigious award at international conference University of Medicine and Dentistry of New Jersey Archived from the original on 5 February 2013 Retrieved 14 June 2013 CINJ scientist receives a near half million dollars for future breast cancer research a href Template Cite journal html title Template Cite journal cite journal a Cite journal requires journal help Gorski David H Beckett Michael A Jaskowiak Nora T Calvin Douglas P et al 15 July 1999 Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation Cancer Research 59 14 3374 3378 PMID 10416597 Retrieved 21 June 2013 Related Citations for PubMed Select 10416597 PubMed retrieved 28 June 2013 Kerbel Robert Folkman Judah October 2002 Clinical translation of angiogenesis inhibitors Nature Reviews Cancer 2 10 727 739 doi 10 1038 nrc905 PMID 12360276 S2CID 14513505 Dvorak Harold F 1 November 2002 Vascular Permeability Factor Vascular Endothelial Growth 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