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David Baulcombe

April 12, 2024

Sir David Charles Baulcombe FRS FMedSci[9][10] (born 1952)[7] is a British plant scientist and geneticist. As of 2017 he is a Royal Society Research Professor. From 2007 to 2020 he was Regius Professor of Botany in the Department of Plant Sciences at the University of Cambridge.[3][11][12][13]

Sir David Baulcombe

FRS FMedSci
Born
David Charles Baulcombe

(1952-04-07) 7 April 1952 (age 72)[7]
Solihull, West Midlands
NationalityBritish
Alma mater
Known for
SpouseRose Eden (m. 1976)[7]
Children1 son, 3 daughters[7]
Awards
Scientific career
Fields
Institutions
ThesisThe Processing and Intracellular Transport of Messenger RNA in a Higher Plant (1976)
Doctoral advisorJohn Ingle[4]
Doctoral students
Website
  • plantsci.cam.ac.uk/research/davidbaulcombe
  • www.plantsci.cam.ac.uk/directory/baulcombe-david

Education edit

David Baulcombe was born in Solihull, West Midlands (then Warwickshire). He received his Bachelor of Science degree in botany from the University of Leeds in 1973 at the age of 21. He continued his studies at the University of Edinburgh, where he received his Doctor of Philosophy degree in 1977 for research on Messenger RNA in vascular plants supervised by John Ingle.[4]

Career and research edit

After his PhD, Baulcombe spent the following three years as a postdoctoral fellow in North America, first at McGill University (Montreal, Quebec, Canada) from January 1977 to November 1978, and then at the University of Georgia (Athens, Georgia, United States) until December 1980. Baulcombe returned to the United Kingdom then, where he joined the Plant Breeding Institute (PBI) in Cambridge and started his career as an independent scientist. At the PBI, Baulcombe initially held the position of Higher Scientific Officer, and was promoted to Principal Scientific Officer in April 1986.[14][self-published source?] In August 1988 Baulcombe left Cambridge for Norwich. He joined the Sainsbury Laboratory as a senior research scientist,[15] and also served as head of laboratory between 1990 and 1993 and between 1999 and 2003. In 1998 he was appointed honorary professor at the University of East Anglia, and given a full professorship there in 2002.[14] In March 2007 it was announced that Baulcombe would become the next Professor of Botany at Cambridge University as a Royal Society Research Professor, taking up his post in September 2007.[16] In 2009, the position was renamed "Regius Professor of Botany". In 2020 he was succeeded by Ottoline Leyser.

He serves on several committees and study sections,[17] was elected Member of the European Molecular Biology Organisation in 1997[1] and was president of the International Society of Plant Molecular Biology 2003–2004. As of 2007, he is also a senior advisor for The EMBO Journal.[18] He also served on the Life Sciences jury for the Infosys Prize in 2015.

Baulcombe's research interests and contributions to science are mainly in the fields of virus movement, genetic regulation, disease resistance, and gene silencing.[19][20][21][22][23][24][25][26][27][28][29]

With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA-mediated gene silencing.[30] Baulcombe's group demonstrated that while viruses can induce gene silencing, some viruses encode proteins that suppress gene silencing.[17] After these initial observations in plants, many laboratories around the world searched for the occurrence of this phenomenon in other organisms. In 1998 Craig Mello and Andrew Fire reported a potent gene silencing effect after injecting double stranded RNA into Caenorhabditis elegans.[31] This discovery was particularly notable because it represented the first identification of the causative agent for the phenomenon. Fire and Mello were awarded the Nobel Prize in Physiology or Medicine[32] in 2006 for their work. [33]

With other members of his research group at the Sainsbury Laboratory, Baulcombe also helped unravel the importance of small interfering RNA in epigenetics and in defence against viruses.

Honours and awards edit

In June 2009, Baulcombe was awarded a knighthood by Queen Elizabeth II.[34] Baulcombe resides in Norwich. Baulcombe has also received the following honours and awards:

Baulcombe's nomination for the Royal Society reads

David Baulcombe has made an outstanding contribution to the inter-related areas of plant virology, gene silencing and disease resistance. He discovered a specific signalling system and an antiviral defence system in plants. This led to the development of new technologies that promise to revolutionise gene discovery in plant biology.[10]

Personal life edit

Baulcombe is married and has four children.[7] His interests include music, sailing and hill walking.[14]

References edit

  1. ^ a b c . people.embo.org. Archived from the original on 6 August 2017.
  2. ^ a b . balzan.org. Archived from the original on 22 May 2015. Retrieved 22 May 2015.
  3. ^ a b c d David Baulcombe publications indexed by Google Scholar  
  4. ^ a b Baulcombe, David (1976). The Processing and Intracellular Transport of Messenger RNA in a Higher Plant (1976) (PhD thesis). University of Edinburgh. hdl:1842/14914. EThOS uk.bl.ethos.641386.  
  5. ^ Voinnet, Olivier (2001). Molecular analysis of post-transcriptional gene silencing : mechanisms and roles. copac.jisc.ac.uk (PhD thesis). University of East Anglia. OCLC 556857695. EThOS uk.bl.ethos.390649.
  6. ^ Martienssen, Robert A. (1986). The molecular genetics of alpha-amylase gene families in wheat (Triticum aestivum L.). copac.jisc.ac.uk (PhD thesis). University of Cambridge. OCLC 499910070. EThOS uk.bl.ethos.382600.
  7. ^ a b c d e Anon (2014). "Baulcombe, Prof. Sir David (Charles)". Who's Who (online Oxford University Press ed.). Oxford: A & C Black. doi:10.1093/ww/9780199540884.013.U12688. (Subscription or UK public library membership required.)
  8. ^ Baulcombe, D. (2004). "RNA silencing in plants". Nature. 431 (7006): 356–363. Bibcode:2004Natur.431..356B. doi:10.1038/nature02874. PMID 15372043. S2CID 4421274.
  9. ^ a b Anon (2001). . royalsociety.org. London. Archived from the original on 23 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --. Archived from the original on 25 September 2015. Retrieved 9 March 2016.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  10. ^ a b c "David Baulcombe election certificate EC/2001/03". Royal Society. Archived from the original on 17 January 2014.
  11. ^ David Baulcombe publications indexed by the Scopus bibliographic database. (subscription required)
  12. ^ . in-cites.com. Archived from the original on 25 June 2007.
  13. ^ (PDF). apsnet.org. Archived from the original (PDF) on 22 June 2011.
  14. ^ a b c . Archived from the original on 3 January 2010. Retrieved 15 September 2009.
  15. ^ Baulcombe, D. (2007). "David Baulcombe". Current Biology. 17 (3): R73–R74. doi:10.1016/j.cub.2007.01.022. PMID 17328111. S2CID 20568141.
  16. ^ Cambridge University Department of Plant Sciences news 1 July 2007 at the Wayback Machine
  17. ^ a b American Phytopathological Society 29 September 2007 at the Wayback Machine
  18. ^ . nature.com/emboj. Archived from the original on 25 January 2009.
  19. ^ Hamilton, A.; Voinnet, O.; Chappell, L.; Baulcombe, D. (2002). "Two classes of short interfering RNA in RNA silencing". The EMBO Journal. 21 (17): 4671–4679. doi:10.1093/emboj/cdf464. PMC 125409. PMID 12198169.
  20. ^ Papaefthimiou, I.; Hamilton, A.; Denti, M.; Baulcombe, D.; Tsagris, M.; Tabler, M. (2001). "Replicating potato spindle tuber viroid RNA is accompanied by short RNA fragments that are characteristic of post-transcriptional gene silencing". Nucleic Acids Research. 29 (11): 2395–2400. doi:10.1093/nar/29.11.2395. PMC 55696. PMID 11376158.
  21. ^ Dalmay, T.; Hamilton, A.; Rudd, S.; Angell, S.; Baulcombe, D. (2000). "An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus". Cell. 101 (5): 543–553. doi:10.1016/S0092-8674(00)80864-8. PMID 10850496. S2CID 2103803.
  22. ^ Burton, R.; Gibeaut, D.; Bacic, A.; Findlay, K.; Roberts, K.; Hamilton, A.; Baulcombe, D.; Fincher, G. (2000). "Virus-induced silencing of a plant cellulose synthase gene". The Plant Cell. 12 (5): 691–706. doi:10.1105/tpc.12.5.691. PMC 139921. PMID 10810144.
  23. ^ Dalmay, T.; Hamilton, A.; Mueller, E.; Baulcombe, D. (2000). "Potato virus X amplicons in arabidopsis mediate genetic and epigenetic gene silencing". The Plant Cell. 12 (3): 369–379. doi:10.1105/tpc.12.3.369. PMC 139837. PMID 10715323.
  24. ^ Jones, L.; Hamilton, A.; Voinnet, O.; Thomas, C.; Maule, A.; Baulcombe, D. (1999). "RNA-DNA interactions and DNA methylation in post-transcriptional gene silencing". The Plant Cell. 11 (12): 2291–2301. doi:10.1105/tpc.11.12.2291. PMC 144133. PMID 10590159.
  25. ^ Hamilton, W.; Boccara, M.; Robinson, D.; Baulcombe, D. (1987). "The complete nucleotide sequence of tobacco rattle virus RNA-1". The Journal of General Virology. 68 (10): 2563–2575. doi:10.1099/0022-1317-68-10-2563. PMID 3668507.
  26. ^ Boccara, M.; Hamilton, W.; Baulcombe, D. (1986). "The organisation and interviral homologies of genes at the 3' end of tobacco rattle virus RNA1". The EMBO Journal. 5 (2): 223–229. doi:10.1002/j.1460-2075.1986.tb04202.x. PMC 1166722. PMID 16453668.
  27. ^ Lu, J.; Zhang, C.; Baulcombe, D. C.; Chen, Z. J. (2012). "Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds". Proceedings of the National Academy of Sciences. 109 (14): 5529–5534. Bibcode:2012PNAS..109.5529L. doi:10.1073/pnas.1203094109. PMC 3325730. PMID 22431617.
  28. ^ Baulcombe, D. C.; Saunders, G. R.; Bevan, M. W.; Mayo, M. A.; Harrison, B. D. (1986). "Expression of biologically active viral satellite RNA from the nuclear genome of transformed plants". Nature. 321 (6068): 446. Bibcode:1986Natur.321..446B. doi:10.1038/321446a0. S2CID 4309327.
  29. ^ Achard, P.; Herr, A; Baulcombe, D. C.; Harberd, N. P. (2004). "Modulation of floral development by a gibberellin-regulated microRNA". Development. 131 (14): 3357–65. doi:10.1242/dev.01206. PMID 15226253. S2CID 15553199.
  30. ^ Hamilton, A. J.; Baulcombe, D. (1999). "A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants". Science. 286 (5441): 950–952. doi:10.1126/science.286.5441.950. PMID 10542148.
  31. ^ Fire, A.; Xu, S.; Montgomery, M. K.; Kostas, S. A.; Driver, S. E.; Mello, C. C. (1998). "Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans". Nature. 391 (6669): 806–811. Bibcode:1998Natur.391..806F. doi:10.1038/35888. PMID 9486653. S2CID 4355692.
  32. ^ "No Nobel for You: Top 10 Nobel Snubs: Scientific American Slideshows". scientificamerican. Retrieved 11 September 2012.
  33. ^ Daneholt, Bertil. "Advanced Information: RNA interference". The Nobel Prize in Physiology or Medicine 2006. Retrieved 25 January 2007.
  34. ^ "No. 59090". The London Gazette (Supplement). 13 June 2009. p. 1.
  35. ^ . fi.edu. Archived from the original on 15 May 2008.
  36. ^ . Archived from the original on 15 September 2012. Retrieved 11 September 2012.
  37. ^ "2014 Gruber Genetics Prize Press Release | The Gruber Foundation". gruber.yale.edu. Retrieved 1 February 2018.

April 12, 2024
david, baulcombe, david, charles, baulcombe, fmedsci, born, 1952, british, plant, scientist, geneticist, 2017, update, royal, society, research, professor, from, 2007, 2020, regius, professor, botany, department, plant, sciences, university, cambridge, fmedsci. Sir David Charles Baulcombe FRS FMedSci 9 10 born 1952 7 is a British plant scientist and geneticist As of 2017 update he is a Royal Society Research Professor From 2007 to 2020 he was Regius Professor of Botany in the Department of Plant Sciences at the University of Cambridge 3 11 12 13 Sir David BaulcombeFRS FMedSciBornDavid Charles Baulcombe 1952 04 07 7 April 1952 age 72 7 Solihull West MidlandsNationalityBritishAlma materUniversity of Leeds BSc University of Edinburgh PhD Known forSmall interfering RNA RNA silencing 8 SpouseRose Eden m 1976 7 Children1 son 3 daughters 7 AwardsEMBO Member 1997 1 Wiley Prize 2003 Massry Prize 2005 Royal Medal 2006 Lasker Award 2008 Knight Bachelor 2009 Harvey Prize 2009 Balzan Prize 2012 2 McClintock Prize 2014 Mendel Medal 2017 Scientific careerFieldsRNA silencing 3 Disease resistance 3 Gene expression 3 InstitutionsSainsbury Laboratory University of East Anglia University of Cambridge Trinity College CambridgeThesisThe Processing and Intracellular Transport of Messenger RNA in a Higher Plant 1976 Doctoral advisorJohn Ingle 4 Doctoral studentsOlivier Voinnet 5 Robert Martienssen 6 Websiteplantsci wbr cam wbr ac wbr uk wbr research wbr davidbaulcombe www wbr plantsci wbr cam wbr ac wbr uk wbr directory wbr baulcombe david Contents 1 Education 2 Career and research 2 1 Honours and awards 3 Personal life 4 ReferencesEducation editDavid Baulcombe was born in Solihull West Midlands then Warwickshire He received his Bachelor of Science degree in botany from the University of Leeds in 1973 at the age of 21 He continued his studies at the University of Edinburgh where he received his Doctor of Philosophy degree in 1977 for research on Messenger RNA in vascular plants supervised by John Ingle 4 Career and research editAfter his PhD Baulcombe spent the following three years as a postdoctoral fellow in North America first at McGill University Montreal Quebec Canada from January 1977 to November 1978 and then at the University of Georgia Athens Georgia United States until December 1980 Baulcombe returned to the United Kingdom then where he joined the Plant Breeding Institute PBI in Cambridge and started his career as an independent scientist At the PBI Baulcombe initially held the position of Higher Scientific Officer and was promoted to Principal Scientific Officer in April 1986 14 self published source In August 1988 Baulcombe left Cambridge for Norwich He joined the Sainsbury Laboratory as a senior research scientist 15 and also served as head of laboratory between 1990 and 1993 and between 1999 and 2003 In 1998 he was appointed honorary professor at the University of East Anglia and given a full professorship there in 2002 14 In March 2007 it was announced that Baulcombe would become the next Professor of Botany at Cambridge University as a Royal Society Research Professor taking up his post in September 2007 16 In 2009 the position was renamed Regius Professor of Botany In 2020 he was succeeded by Ottoline Leyser He serves on several committees and study sections 17 was elected Member of the European Molecular Biology Organisation in 1997 1 and was president of the International Society of Plant Molecular Biology 2003 2004 As of 2007 update he is also a senior advisor for The EMBO Journal 18 He also served on the Life Sciences jury for the Infosys Prize in 2015 Baulcombe s research interests and contributions to science are mainly in the fields of virus movement genetic regulation disease resistance and gene silencing 19 20 21 22 23 24 25 26 27 28 29 With Andrew Hamilton he discovered the small interfering RNA that is the specificity determinant in RNA mediated gene silencing 30 Baulcombe s group demonstrated that while viruses can induce gene silencing some viruses encode proteins that suppress gene silencing 17 After these initial observations in plants many laboratories around the world searched for the occurrence of this phenomenon in other organisms In 1998 Craig Mello and Andrew Fire reported a potent gene silencing effect after injecting double stranded RNA into Caenorhabditis elegans 31 This discovery was particularly notable because it represented the first identification of the causative agent for the phenomenon Fire and Mello were awarded the Nobel Prize in Physiology or Medicine 32 in 2006 for their work 33 With other members of his research group at the Sainsbury Laboratory Baulcombe also helped unravel the importance of small interfering RNA in epigenetics and in defence against viruses Honours and awards edit In June 2009 Baulcombe was awarded a knighthood by Queen Elizabeth II 34 Baulcombe resides in Norwich Baulcombe has also received the following honours and awards 1997 elected to EMBO Membership 1 2001 elected Fellow of the Royal Society FRS 9 10 2002 elected Member of the Academia Europaea 2002 recipient of the Ruth Allen Award awarded by the American Phytopathological Society 2002 recipient of the Kumho Science International Award in Plant Molecular Biology and Biotechnology awarded by the Kumho Cultural Foundation Korea 2003 co recipient with Craig Mello Andrew Fire and Thomas Tuschl of the Wiley Prize in the Biomedical Sciences awarded by Rockefeller University 2004 recipient of the M W Beijerinck Virology Prize awarded by the Royal Netherlands Academy of Arts and Sciences 2005 elected Foreign Associate Member of the National Academy of Sciences 2005 co recipient with Craig Mello and Andrew Fire of the Massry Prize awarded by the Massry Foundation and the University of Southern California 2006 recipient of the Royal Society s Royal Medal 2008 co recipient of the Benjamin Franklin Medal in Life Science awarded by the Franklin Institute 35 2008 co recipient with Victor Ambros and Gary Ruvkun of the Albert Lasker Award for Basic Medical Research 2008 appointed Fellow of Trinity College Cambridge 2009 knighted by Queen Elizabeth II in the 2009 Birthday Honours List for services to plant science 2009 recipient of the Harvey Prize granted by the Technion Israeli Institute for Technology 2010 recipient of the Wolf Prize in Agriculture 2012 Balzan Prize 36 for Epigenetics 2 2014 Gruber Prize in Genetics 37 2015 elected Honorary Fellow of the Royal Society of EdinburghBaulcombe s nomination for the Royal Society readsDavid Baulcombe has made an outstanding contribution to the inter related areas of plant virology gene silencing and disease resistance He discovered a specific signalling system and an antiviral defence system in plants This led to the development of new technologies that promise to revolutionise gene discovery in plant biology 10 Personal life editBaulcombe is married and has four children 7 His interests include music sailing and hill walking 14 References edit a b c EMBO member David Baulcombe people embo org Archived from the original on 6 August 2017 a b David Baulcombe International Balzan Prize Foundation balzan org Archived from the original on 22 May 2015 Retrieved 22 May 2015 a b c d David Baulcombe publications indexed by Google Scholar nbsp a b Baulcombe David 1976 The Processing and Intracellular Transport of Messenger RNA in a Higher Plant 1976 PhD thesis University of Edinburgh hdl 1842 14914 EThOS uk bl ethos 641386 nbsp Voinnet Olivier 2001 Molecular analysis of post transcriptional gene silencing mechanisms and roles copac jisc ac uk PhD thesis University of East Anglia OCLC 556857695 EThOS uk bl ethos 390649 Martienssen Robert A 1986 The molecular genetics of alpha amylase gene families in wheat Triticum aestivum L copac jisc ac uk PhD thesis University of Cambridge OCLC 499910070 EThOS uk bl ethos 382600 a b c d e Anon 2014 Baulcombe Prof Sir David Charles Who s Who online Oxford University Press ed Oxford A amp C Black doi 10 1093 ww 9780199540884 013 U12688 Subscription or UK public library membership required Baulcombe D 2004 RNA silencing in plants Nature 431 7006 356 363 Bibcode 2004Natur 431 356B doi 10 1038 nature02874 PMID 15372043 S2CID 4421274 a b Anon 2001 Professor Sir David Baulcombe FMedSci FRS royalsociety org London Archived from the original on 23 November 2015 One or more of the preceding sentences incorporates text from the royalsociety org website where All text published under the heading Biography on Fellow profile pages is available under Creative Commons Attribution 4 0 International License Royal Society Terms conditions and policies Archived from the original on 25 September 2015 Retrieved 9 March 2016 a href Template Cite web html title Template Cite web cite web a CS1 maint bot original URL status unknown link a b c David Baulcombe election certificate EC 2001 03 Royal Society Archived from the original on 17 January 2014 David Baulcombe publications indexed by the Scopus bibliographic database subscription required Interview with Professor Baulcombe from in cites website in cites com Archived from the original on 25 June 2007 Biography from the American Phytopathological Society 2002 Awards p 4 PDF apsnet org Archived from the original PDF on 22 June 2011 a b c David Baulcombe cv Archived from the original on 3 January 2010 Retrieved 15 September 2009 Baulcombe D 2007 David Baulcombe Current Biology 17 3 R73 R74 doi 10 1016 j cub 2007 01 022 PMID 17328111 S2CID 20568141 Cambridge University Department of Plant Sciences news Archived 1 July 2007 at the Wayback Machine a b American Phytopathological Society Archived 29 September 2007 at the Wayback Machine Embo editorial board nature com emboj Archived from the original on 25 January 2009 Hamilton A Voinnet O Chappell L Baulcombe D 2002 Two classes of short interfering RNA in RNA silencing The EMBO Journal 21 17 4671 4679 doi 10 1093 emboj cdf464 PMC 125409 PMID 12198169 Papaefthimiou I Hamilton A Denti M Baulcombe D Tsagris M Tabler M 2001 Replicating potato spindle tuber viroid RNA is accompanied by short RNA fragments that are characteristic of post transcriptional gene silencing Nucleic Acids Research 29 11 2395 2400 doi 10 1093 nar 29 11 2395 PMC 55696 PMID 11376158 Dalmay T Hamilton A Rudd S Angell S Baulcombe D 2000 An RNA dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus Cell 101 5 543 553 doi 10 1016 S0092 8674 00 80864 8 PMID 10850496 S2CID 2103803 Burton R Gibeaut D Bacic A Findlay K Roberts K Hamilton A Baulcombe D Fincher G 2000 Virus induced silencing of a plant cellulose synthase gene The Plant Cell 12 5 691 706 doi 10 1105 tpc 12 5 691 PMC 139921 PMID 10810144 Dalmay T Hamilton A Mueller E Baulcombe D 2000 Potato virus X amplicons in arabidopsis mediate genetic and epigenetic gene silencing The Plant Cell 12 3 369 379 doi 10 1105 tpc 12 3 369 PMC 139837 PMID 10715323 Jones L Hamilton A Voinnet O Thomas C Maule A Baulcombe D 1999 RNA DNA interactions and DNA methylation in post transcriptional gene silencing The Plant Cell 11 12 2291 2301 doi 10 1105 tpc 11 12 2291 PMC 144133 PMID 10590159 Hamilton W Boccara M Robinson D Baulcombe D 1987 The complete nucleotide sequence of tobacco rattle virus RNA 1 The Journal of General Virology 68 10 2563 2575 doi 10 1099 0022 1317 68 10 2563 PMID 3668507 Boccara M Hamilton W Baulcombe D 1986 The organisation and interviral homologies of genes at the 3 end of tobacco rattle virus RNA1 The EMBO Journal 5 2 223 229 doi 10 1002 j 1460 2075 1986 tb04202 x PMC 1166722 PMID 16453668 Lu J Zhang C Baulcombe D C Chen Z J 2012 Maternal siRNAs as regulators of parental genome imbalance and gene expression in endosperm of Arabidopsis seeds Proceedings of the National Academy of Sciences 109 14 5529 5534 Bibcode 2012PNAS 109 5529L doi 10 1073 pnas 1203094109 PMC 3325730 PMID 22431617 Baulcombe D C Saunders G R Bevan M W Mayo M A Harrison B D 1986 Expression of biologically active viral satellite RNA from the nuclear genome of transformed plants Nature 321 6068 446 Bibcode 1986Natur 321 446B doi 10 1038 321446a0 S2CID 4309327 Achard P Herr A Baulcombe D C Harberd N P 2004 Modulation of floral development by a gibberellin regulated microRNA Development 131 14 3357 65 doi 10 1242 dev 01206 PMID 15226253 S2CID 15553199 Hamilton A J Baulcombe D 1999 A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in Plants Science 286 5441 950 952 doi 10 1126 science 286 5441 950 PMID 10542148 Fire A Xu S Montgomery M K Kostas S A Driver S E Mello C C 1998 Potent and specific genetic interference by double stranded RNA in Caenorhabditis elegans Nature 391 6669 806 811 Bibcode 1998Natur 391 806F doi 10 1038 35888 PMID 9486653 S2CID 4355692 No Nobel for You Top 10 Nobel Snubs Scientific American Slideshows scientificamerican Retrieved 11 September 2012 Daneholt Bertil Advanced Information RNA interference The Nobel Prize in Physiology or Medicine 2006 Retrieved 25 January 2007 No 59090 The London Gazette Supplement 13 June 2009 p 1 Franklin Medallist David Baulcombe fi edu Archived from the original on 15 May 2008 Epigenetics researcher a 2012 Balzan prizewinner Laboratory Product News Archived from the original on 15 September 2012 Retrieved 11 September 2012 2014 Gruber Genetics Prize Press Release The Gruber Foundation gruber yale edu Retrieved 1 February 2018 Retrieved from https en wikipedia org w index php title David Baulcombe amp oldid 1196118600, wikipedia, wiki, book, books, library,

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