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Wikipedia

DYNLL2

January 01, 1970

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.[5][6]

DYNLL2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesDYNLL2, DNCL1B, Dlc2, RSPH22, dynein light chain LC8-type 2
External IDsOMIM: 608942; MGI: 1915347; HomoloGene: 115597; GeneCards: DYNLL2; OMA:DYNLL2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

140735

68097

Ensembl

ENSG00000264364

ENSMUSG00000020483

UniProt

Q96FJ2

Q9D0M5

RefSeq (mRNA)

NM_080677

NM_001168471
NM_001168472
NM_026556

RefSeq (protein)

NP_542408

NP_001161943
NP_001161944
NP_080832

Location (UCSC)Chr 17: 58.08 – 58.1 MbChr 11: 87.87 – 87.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions edit

DYNLL2 has been shown to interact with DLG4,[7] C12orf40,[8] DLGAP1,[7] MYO5A[7][9] and BMF.[9][10]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000264364 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020483 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (November 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  6. ^ "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2".
  7. ^ a b c Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; Weinberg R J; Sheng M (June 2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12). UNITED STATES: 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. ISSN 0270-6474. PMC 6772433. PMID 10844022.
  8. ^ Rolland, Thomas; Taşan, Murat; Charloteaux, Benoit; Pevzner, Samuel J.; Zhong, Quan; Sahni, Nidhi; Yi, Song; Lemmens, Irma; Fontanillo, Celia; Mosca, Roberto; Kamburov, Atanas; Ghiassian, Susan D.; Yang, Xinping; Ghamsari, Lila; Balcha, Dawit; Begg, Bridget E.; Braun, Pascal; Brehme, Marc; Broly, Martin P.; Carvunis, Anne-Ruxandra; Convery-Zupan, Dan; Corominas, Roser; Coulombe-Huntington, Jasmin; Dann, Elizabeth; Dreze, Matija; Dricot, Amélie; Fan, Changyu; Franzosa, Eric; Gebreab, Fana; Gutierrez, Bryan J.; Hardy, Madeleine F.; Jin, Mike; Kang, Shuli; Kiros, Ruth; Lin, Guan Ning; Luck, Katja; MacWilliams, Andrew; Menche, Jörg; Murray, Ryan R.; Palagi, Alexandre; Poulin, Matthew M.; Rambout, Xavier; Rasla, John; Reichert, Patrick; Romero, Viviana; Ruyssinck, Elien; Sahalie, Julie M.; Scholz, Annemarie; Shah, Akash A.; Sharma, Amitabh; Shen, Yun; Spirohn, Kerstin; Tam, Stanley; Tejeda, Alexander O.; Trigg, Shelly A.; Twizere, Jean-Claude; Vega, Kerwin; Walsh, Jennifer; Cusick, Michael E.; Xia, Yu; Barabási, Albert-László; Iakoucheva, Lilia M.; Aloy, Patrick; De Las Rivas, Javier; Tavernier, Jan; Calderwood, Michael A.; Hill, David E.; Hao, Tong; Roth, Frederick P.; Vidal, Marc (November 2014). "A Proteome-Scale Map of the Human Interactome Network". Cell. 159 (5): 1212–1226. doi:10.1016/j.cell.2014.10.050. PMC 4266588. PMID 25416956.
  9. ^ a b Puthalakath, H; Villunger A; O'Reilly L A; Beaumont J G; Coultas L; Cheney R E; Huang D C; Strasser A (September 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536). United States: 1829–32. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. ISSN 0036-8075. PMID 11546872. S2CID 5638023.
  10. ^ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (February 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3). England: 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.

Further reading edit

  • Naisbitt S, Valtschanoff J, Allison DW, et al. (2000). "Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein". J. Neurosci. 20 (12): 4524–34. doi:10.1523/JNEUROSCI.20-12-04524.2000. PMC 6772433. PMID 10844022.
  • Haraguchi K, Satoh K, Yanai H, et al. (2001). "The hDLG-associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase". Genes Cells. 5 (11): 905–911. doi:10.1046/j.1365-2443.2000.00374.x. PMID 11122378. S2CID 37107139.
  • Puthalakath H, Villunger A, O'Reilly LA, et al. (2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–32. Bibcode:2001Sci...293.1829P. doi:10.1126/science.1062257. PMID 11546872. S2CID 5638023.
  • Fuhrmann JC, Kins S, Rostaing P, et al. (2002). "Gephyrin interacts with Dynein light chains 1 and 2, components of motor protein complexes". J. Neurosci. 22 (13): 5393–402. doi:10.1523/JNEUROSCI.22-13-05393.2002. PMC 6758200. PMID 12097491.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links edit

  • Overview of all the structural information available in the PDB for UniProt: Q96FJ2 (Dynein light chain 2, cytoplasmic) at the PDBe-KB.
  • Donner J, et al. (2008). "An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders". Biological Psychiatry. 64 (8): 672–680. doi:10.1016/j.biopsych.2008.06.002. PMC 2682432. PMID 18639233.


 

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

January 01, 1970
dynll2, dynein, light, chain, cytoplasmic, protein, that, humans, encoded, gene, available, structurespdbortholog, search, pdbe, rcsblist, codes2xqq, 3p8m, 4d07, 1pwjidentifiersaliases, dncl1b, dlc2, rsph22, dynein, light, chain, type, 2external, idsomim, 6089. Dynein light chain 2 cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene 5 6 DYNLL2Available structuresPDBOrtholog search PDBe RCSBList of PDB id codes2XQQ 3P8M 4D07 1PWJIdentifiersAliasesDYNLL2 DNCL1B Dlc2 RSPH22 dynein light chain LC8 type 2External IDsOMIM 608942 MGI 1915347 HomoloGene 115597 GeneCards DYNLL2 OMA DYNLL2 orthologsGene location Human Chr Chromosome 17 human 1 Band17q22Start58 083 419 bp 1 End58 095 542 bp 1 Gene location Mouse Chr Chromosome 11 mouse 2 Band11 11 CStart87 870 351 bp 2 End87 878 359 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed ininternal globus pallidusspermponssuperior vestibular nucleusventral tegmental areaexternal globus pallidusparietal lobepostcentral gyrussubthalamic nucleussuperior frontal gyrusTop expressed inmotor neuronmammillary bodylateral hypothalamuslateral geniculate nucleusseminiferous tubuleventromedial nucleusmedial vestibular nucleusdorsomedial hypothalamic nucleuscingulate gyruscerebellar vermisMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functioncytoskeletal motor activity protein binding plus end directed microtubule motor activity dynein intermediate chain binding dynein light intermediate chain binding cytoskeletal protein binding protein homodimerization activity protein heterodimerization activity scaffold protein bindingCellular componentcytoplasm cytosol nucleus membrane ciliary tip centrosome microtubule plasma membrane microtubule associated complex dynein complex cytoskeleton mitochondrion cilium myosin V complex cytoplasmic dynein complex myosin complex postsynaptic density postsynapse glutamatergic synapseBiological processmicrotubule based process antigen processing and presentation of exogenous peptide antigen via MHC class II endoplasmic reticulum to Golgi vesicle mediated transport positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway macroautophagy intraciliary transport involved in cilium assembly transport along microtubule cilium assembly sister chromatid cohesion transportSources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez14073568097EnsemblENSG00000264364ENSMUSG00000020483UniProtQ96FJ2Q9D0M5RefSeq mRNA NM 080677NM 001168471NM 001168472NM 026556RefSeq protein NP 542408NP 001161943NP 001161944NP 080832Location UCSC Chr 17 58 08 58 1 MbChr 11 87 87 87 88 MbPubMed search 3 4 WikidataView Edit HumanView Edit Mouse Contents 1 Interactions 2 References 3 Further reading 4 External linksInteractions editDYNLL2 has been shown to interact with DLG4 7 C12orf40 8 DLGAP1 7 MYO5A 7 9 and BMF 9 10 References edit a b c GRCh38 Ensembl release 89 ENSG00000264364 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000020483 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Pfister KK Fisher EM Gibbons IR Hays TS Holzbaur EL McIntosh JR Porter ME Schroer TA Vaughan KT Witman GB King SM Vallee RB November 2005 Cytoplasmic dynein nomenclature J Cell Biol 171 3 411 3 doi 10 1083 jcb 200508078 PMC 2171247 PMID 16260502 Entrez Gene DYNLL2 dynein light chain LC8 type 2 a b c Naisbitt S Valtschanoff J Allison D W Sala C Kim E Craig A M Weinberg R J Sheng M June 2000 Interaction of the postsynaptic density 95 guanylate kinase domain associated protein complex with a light chain of myosin V and dynein J Neurosci 20 12 UNITED STATES 4524 34 doi 10 1523 JNEUROSCI 20 12 04524 2000 ISSN 0270 6474 PMC 6772433 PMID 10844022 Rolland Thomas Tasan Murat Charloteaux Benoit Pevzner Samuel J Zhong Quan Sahni Nidhi Yi Song Lemmens Irma Fontanillo Celia Mosca Roberto Kamburov Atanas Ghiassian Susan D Yang Xinping Ghamsari Lila Balcha Dawit Begg Bridget E Braun Pascal Brehme Marc Broly Martin P Carvunis Anne Ruxandra Convery Zupan Dan Corominas Roser Coulombe Huntington Jasmin Dann Elizabeth Dreze Matija Dricot Amelie Fan Changyu Franzosa Eric Gebreab Fana Gutierrez Bryan J Hardy Madeleine F Jin Mike Kang Shuli Kiros Ruth Lin Guan Ning Luck Katja MacWilliams Andrew Menche Jorg Murray Ryan R Palagi Alexandre Poulin Matthew M Rambout Xavier Rasla John Reichert Patrick Romero Viviana Ruyssinck Elien Sahalie Julie M Scholz Annemarie Shah Akash A Sharma Amitabh Shen Yun Spirohn Kerstin Tam Stanley Tejeda Alexander O Trigg Shelly A Twizere Jean Claude Vega Kerwin Walsh Jennifer Cusick Michael E Xia Yu Barabasi Albert Laszlo Iakoucheva Lilia M Aloy Patrick De Las Rivas Javier Tavernier Jan Calderwood Michael A Hill David E Hao Tong Roth Frederick P Vidal Marc November 2014 A Proteome Scale Map of the Human Interactome Network Cell 159 5 1212 1226 doi 10 1016 j cell 2014 10 050 PMC 4266588 PMID 25416956 a b Puthalakath H Villunger A O Reilly L A Beaumont J G Coultas L Cheney R E Huang D C Strasser A September 2001 Bmf a proapoptotic BH3 only protein regulated by interaction with the myosin V actin motor complex activated by anoikis Science 293 5536 United States 1829 32 Bibcode 2001Sci 293 1829P doi 10 1126 science 1062257 ISSN 0036 8075 PMID 11546872 S2CID 5638023 Day Catherine L Puthalakath Hamsa Skea Gretchen Strasser Andreas Barsukov Igor Lian Lu Yun Huang David C S Hinds Mark G February 2004 Localization of dynein light chains 1 and 2 and their pro apoptotic ligands Biochem J 377 Pt 3 England 597 605 doi 10 1042 BJ20031251 PMC 1223895 PMID 14561217 Further reading editNaisbitt S Valtschanoff J Allison DW et al 2000 Interaction of the postsynaptic density 95 guanylate kinase domain associated protein complex with a light chain of myosin V and dynein J Neurosci 20 12 4524 34 doi 10 1523 JNEUROSCI 20 12 04524 2000 PMC 6772433 PMID 10844022 Haraguchi K Satoh K Yanai H et al 2001 The hDLG associated protein DAP interacts with dynein light chain and neuronal nitric oxide synthase Genes Cells 5 11 905 911 doi 10 1046 j 1365 2443 2000 00374 x PMID 11122378 S2CID 37107139 Puthalakath H Villunger A O Reilly LA et al 2001 Bmf a proapoptotic BH3 only protein regulated by interaction with the myosin V actin motor complex activated by anoikis Science 293 5536 1829 32 Bibcode 2001Sci 293 1829P doi 10 1126 science 1062257 PMID 11546872 S2CID 5638023 Fuhrmann JC Kins S Rostaing P et al 2002 Gephyrin interacts with Dynein light chains 1 and 2 components of motor protein complexes J Neurosci 22 13 5393 402 doi 10 1523 JNEUROSCI 22 13 05393 2002 PMC 6758200 PMID 12097491 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Day CL Puthalakath H Skea G et al 2004 Localization of dynein light chains 1 and 2 and their pro apoptotic ligands Biochem J 377 Pt 3 597 605 doi 10 1042 BJ20031251 PMC 1223895 PMID 14561217 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Rual JF Venkatesan K Hao T et al 2005 Towards a proteome scale map of the human protein protein interaction network Nature 437 7062 1173 8 Bibcode 2005Natur 437 1173R doi 10 1038 nature04209 PMID 16189514 S2CID 4427026 External links editOverview of all the structural information available in the PDB for UniProt Q96FJ2 Dynein light chain 2 cytoplasmic at the PDBe KB Donner J et al 2008 An Association Analysis of Murine Anxiety Genes in Humans Implicates Novel Candidate Genes for Anxiety Disorders Biological Psychiatry 64 8 672 680 doi 10 1016 j biopsych 2008 06 002 PMC 2682432 PMID 18639233 nbsp This article on a gene on human chromosome 17 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w index php title DYNLL2 amp oldid 1148256909, wikipedia, 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