This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. This family has at least six members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7.[6]
Referencesedit
^ abcGRCh38: Ensembl release 89: ENSG00000006377 - Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000029754 - Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC43348. PMID 7907794.
Crackower MA, Scherer SW, Rommens JM, et al. (1997). "Characterization of the split hand/split foot malformation locus SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its expression during limb development". Hum. Mol. Genet. 5 (5): 571–9. doi:10.1093/hmg/5.5.571. PMID 8733122.
Charité J, McFadden DG, Merlo G, et al. (2001). "Role of Dlx6 in regulation of an endothelin-1-dependent, dHAND branchial arch enhancer". Genes Dev. 15 (22): 3039–49. doi:10.1101/gad.931701. PMC312822. PMID 11711438.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID 12477932.
Nabi R, Zhong H, Serajee FJ, Huq AH (2004). "No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism". Am. J. Med. Genet. B Neuropsychiatr. Genet. 119 (1): 98–101. doi:10.1002/ajmg.b.10012. PMID 12707945. S2CID 39985829.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC528928. PMID 15489334.
Schüle B, Li HH, Fisch-Kohl C, et al. (2007). "DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency". Am. J. Hum. Genet. 81 (3): 492–506. doi:10.1086/520063. PMC1950824. PMID 17701895.
This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.
dlx6, homeobox, protein, protein, that, humans, encoded, gene, identifiersaliases, distal, less, homeobox, 6external, idsomim, 600030, 101927, homologene, 87855, genecards, gene, location, human, chromosome, human, band7q21, 3start97, end97, gene, location, mo. Homeobox protein DLX 6 is a protein that in humans is encoded by the DLX6 gene 5 6 DLX6IdentifiersAliasesDLX6 distal less homeobox 6External IDsOMIM 600030 MGI 101927 HomoloGene 87855 GeneCards DLX6Gene location Human Chr Chromosome 7 human 1 Band7q21 3Start97 005 553 bp 1 End97 011 040 bp 1 Gene location Mouse Chr Chromosome 6 mouse 2 Band6 A1 6 2 83 cMStart6 863 334 bp 2 End6 868 568 bp 2 RNA expression patternBgeeHumanMouse ortholog Top expressed inendometriumnucleus accumbenscaudate nucleusputamenoocytespermendothelial cellplacentaAchilles tendonexternal globus pallidusTop expressed insuperior frontal gyrusmedial ganglionic eminenceolfactory tubercleolfactory bulbspermatidcervical looptongueenteric nervous systempharynxglobus pallidusMore reference expression dataBioGPSMore reference expression dataGene ontologyMolecular functionDNA binding transcription factor activity sequence specific DNA binding DNA binding DNA binding transcription factor activity RNA polymerase II specific RNA polymerase II cis regulatory region sequence specific DNA bindingCellular componentnucleusBiological processskeletal system development regulation of transcription DNA templated nervous system development embryonic limb morphogenesis epithelial cell differentiation inner ear morphogenesis anatomical structure formation involved in morphogenesis positive regulation of epithelial cell proliferation roof of mouth development head development multicellular organism development regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase IISources Amigo QuickGOOrthologsSpeciesHumanMouseEntrez175013396EnsemblENSG00000006377ENSMUSG00000029754UniProtP56179P70397RefSeq mRNA NM 005222NM 010057RefSeq protein NP 005213NP 034187Location UCSC Chr 7 97 01 97 01 MbChr 6 6 86 6 87 MbPubMed search 3 4 WikidataView Edit HumanView Edit MouseThis gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal less gene This family has at least six members that encode proteins with roles in forebrain and craniofacial development This gene is in a tail to tail configuration with another member of the family on the long arm of chromosome 7 6 References edit a b c GRCh38 Ensembl release 89 ENSG00000006377 Ensembl May 2017 a b c GRCm38 Ensembl release 89 ENSMUSG00000029754 Ensembl May 2017 Human PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Mouse PubMed Reference National Center for Biotechnology Information U S National Library of Medicine Simeone A Acampora D Pannese M D Esposito M Stornaiuolo A Gulisano M Mallamaci A Kastury K Druck T Huebner K et al Apr 1994 Cloning and characterization of two members of the vertebrate Dlx gene family Proc Natl Acad Sci U S A 91 6 2250 4 Bibcode 1994PNAS 91 2250S doi 10 1073 pnas 91 6 2250 PMC 43348 PMID 7907794 a b Entrez Gene DLX6 distal less homeobox 6 Further reading editCrackower MA Scherer SW Rommens JM et al 1997 Characterization of the split hand split foot malformation locus SHFM1 at 7q21 3 q22 1 and analysis of a candidate gene for its expression during limb development Hum Mol Genet 5 5 571 9 doi 10 1093 hmg 5 5 571 PMID 8733122 Charite J McFadden DG Merlo G et al 2001 Role of Dlx6 in regulation of an endothelin 1 dependent dHAND branchial arch enhancer Genes Dev 15 22 3039 49 doi 10 1101 gad 931701 PMC 312822 PMID 11711438 Depew MJ Lufkin T Rubenstein JL 2002 Specification of jaw subdivisions by Dlx genes Science 298 5592 381 5 doi 10 1126 science 1075703 PMID 12193642 S2CID 10274300 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 Bibcode 2002PNAS 9916899M doi 10 1073 pnas 242603899 PMC 139241 PMID 12477932 Nabi R Zhong H Serajee FJ Huq AH 2004 No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21 q22 and autism Am J Med Genet B Neuropsychiatr Genet 119 1 98 101 doi 10 1002 ajmg b 10012 PMID 12707945 S2CID 39985829 Hillier LW Fulton RS Fulton LA et al 2003 The DNA sequence of human chromosome 7 Nature 424 6945 157 64 Bibcode 2003Natur 424 157H doi 10 1038 nature01782 PMID 12853948 Ota T Suzuki Y Nishikawa T et al 2004 Complete sequencing and characterization of 21 243 full length human cDNAs Nat Genet 36 1 40 5 doi 10 1038 ng1285 PMID 14702039 Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 doi 10 1101 gr 2596504 PMC 528928 PMID 15489334 Schule B Li HH Fisch Kohl C et al 2007 DLX5 and DLX6 expression is biallelic and not modulated by MeCP2 deficiency Am J Hum Genet 81 3 492 506 doi 10 1086 520063 PMC 1950824 PMID 17701895 nbsp This article on a gene on human chromosome 7 is a stub You can help Wikipedia by expanding it vte Retrieved from https en wikipedia org w 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